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Article: Interferon dysregulation and virus-induced cell death in avian influenza H5N1 virus infections.

TitleInterferon dysregulation and virus-induced cell death in avian influenza H5N1 virus infections.
Authors
Issue Date2012
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
Citation
Hong Kong Medical Journal, 2012, v. 18 suppl. 2, p. 12-16 How to Cite?
Abstract1. Hyper-induction of cytokines and chemokines was found in human blood macrophages infected with the avian influenza H5N1 and H9N2/G1 viruses, as compared to those infected with human influenza H1N1 virus. 2. IRF3 played a significant role in the hyperinduction of cytokines including IFN-β, IFN-λ1,IFN-α subtypes, MCP-1, and TNF-α, and also played a part in subsequent cytokine-induced cell signalling cascades. 3. Compared with H1N1 viruses, avian influenza viruses including H5N1/97 and its precursors triggered a caspase-mediated but delayed apoptotic response in human macrophages. 4. Therapies that can minimise immunopathology-associated dysregulation of innate immunity without impairing effective host defence may be valuable adjuncts to antiviral therapy.
Persistent Identifierhttp://hdl.handle.net/10722/152777
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorLee, DCen_HK
dc.contributor.authorLaw, AHen_HK
dc.contributor.authorHui, Ken_HK
dc.contributor.authorTam, AHen_HK
dc.contributor.authorPeiris, JSen_HK
dc.contributor.authorLau, ASen_HK
dc.date.accessioned2012-07-16T09:48:02Z-
dc.date.available2012-07-16T09:48:02Z-
dc.date.issued2012en_HK
dc.identifier.citationHong Kong Medical Journal, 2012, v. 18 suppl. 2, p. 12-16en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152777-
dc.description.abstract1. Hyper-induction of cytokines and chemokines was found in human blood macrophages infected with the avian influenza H5N1 and H9N2/G1 viruses, as compared to those infected with human influenza H1N1 virus. 2. IRF3 played a significant role in the hyperinduction of cytokines including IFN-β, IFN-λ1,IFN-α subtypes, MCP-1, and TNF-α, and also played a part in subsequent cytokine-induced cell signalling cascades. 3. Compared with H1N1 viruses, avian influenza viruses including H5N1/97 and its precursors triggered a caspase-mediated but delayed apoptotic response in human macrophages. 4. Therapies that can minimise immunopathology-associated dysregulation of innate immunity without impairing effective host defence may be valuable adjuncts to antiviral therapy.en_HK
dc.languageengen_US
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.htmlen_HK
dc.relation.ispartofHong Kong Medical Journalen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.subject.meshApoptosis-
dc.subject.meshCytokines - biosynthesis - genetics-
dc.subject.meshInfluenza A Virus, H5N1 Subtype-
dc.subject.meshInfluenza, Human - metabolism-
dc.subject.meshInterferon Regulatory Factor-3 - genetics - metabolism-
dc.titleInterferon dysregulation and virus-induced cell death in avian influenza H5N1 virus infections.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=18 &issue=Suppl 2&spage=&epage=&date=2012&atitle=Interferon+dysregulation+and+virus-induced+cell+death+in+avian+influenza+H5N1+virus+infections.en_US
dc.identifier.emailPeiris, JS: malik@hkucc.hku.hken_HK
dc.identifier.emailLau, AS: asylau@hku.hken_HK
dc.identifier.authorityPeiris, JS=rp00410en_HK
dc.identifier.authorityLau, AS=rp00474en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.pmid22311354-
dc.identifier.scopuseid_2-s2.0-84861557680en_HK
dc.identifier.hkuros200846en_US
dc.identifier.volume18en_HK
dc.identifier.issuesuppl. 2-
dc.identifier.spage12en_HK
dc.identifier.epage16en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridLee, DC=55232829400en_HK
dc.identifier.scopusauthoridLaw, AH=8692488400en_HK
dc.identifier.scopusauthoridHui, K=24492032000en_HK
dc.identifier.scopusauthoridTam, AH=55232137700en_HK
dc.identifier.scopusauthoridPeiris, JS=7005486823en_HK
dc.identifier.scopusauthoridLau, AS=7202626202en_HK

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