File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Phenotypic and functional characterization of human γδT-cell subsets in response to influenza a viruses

TitlePhenotypic and functional characterization of human γδT-cell subsets in response to influenza a viruses
Authors
Issue Date2012
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2012, v. 205 n. 11, p. 1646-1653 How to Cite?
AbstractLike αβT cells, human γδ T cells also have different subsets with distinct characteristics. Whether human Vγ9Vδ2 T cells have functionally different subsets in response to influenza A (fluA) viruses remains unknown. In this study, we show for the first time that both central (CD45RA -CD27 +) and effector (CD45RA -CD27 -) memory Vγ9Vδ2 T cells have similar levels of immediate interferon (IFN) γ and cytotoxic responses to human and avian fluA virus-infected cells. In contrast, CD56 + V9γV2 γδ T cells have significantly higher cytotoxicity against fluA virus-infected cells compared with their CD56 - counterparts, whereas both subsets have similar γδ IFN-responses. We further demonstrate that the CD16-dependent degranulation pathway, but not antibody-dependent cell-mediated cytotoxicity, contribute to the superior cytotoxicity of CD56 + V9γVδ2 T cells. Our study provides further evidence for the phenotypic and functional characterization of human Vγ9Vδ2 γδ T-cell subsets during fluA virus infection and may help improve the γδ T-cell-based immunotherapy for viral infection. © 2012 The Author.
Persistent Identifierhttp://hdl.handle.net/10722/152768
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID
Funding AgencyGrant Number
Area of Excellence program on influenza
University Grants Committee of the Hong Kong SAR, ChinaAoE/M-12/06
Research Grants Council of Hong KongHKU 777108M
HKU777407
HKU768108
HKU781211
Food and Health Bureau of the Hong Kong SAR07060482
HK-09-03-05
Funding Information:

This work was supported by the Area of Excellence program on influenza supported by the University Grants Committee of the Hong Kong SAR, China (Project AoE/M-12/06); General Research Fund, Research Grants Council of Hong Kong (grants HKU 777108M, HKU777407, HKU768108, HKU781211); and Research Fund for the Control of Infectious Diseases of the Food and Health Bureau of the Hong Kong SAR (grants 07060482 and HK-09-03-05).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorQin, Gen_HK
dc.contributor.authorLiu, Yen_HK
dc.contributor.authorZheng, Jen_HK
dc.contributor.authorXiang, Zen_HK
dc.contributor.authorNg, IHYen_HK
dc.contributor.authorMalik Peiris, JSen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorTu, Wen_HK
dc.date.accessioned2012-07-16T09:47:58Z-
dc.date.available2012-07-16T09:47:58Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of Infectious Diseases, 2012, v. 205 n. 11, p. 1646-1653en_HK
dc.identifier.issn0022-1899en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152768-
dc.description.abstractLike αβT cells, human γδ T cells also have different subsets with distinct characteristics. Whether human Vγ9Vδ2 T cells have functionally different subsets in response to influenza A (fluA) viruses remains unknown. In this study, we show for the first time that both central (CD45RA -CD27 +) and effector (CD45RA -CD27 -) memory Vγ9Vδ2 T cells have similar levels of immediate interferon (IFN) γ and cytotoxic responses to human and avian fluA virus-infected cells. In contrast, CD56 + V9γV2 γδ T cells have significantly higher cytotoxicity against fluA virus-infected cells compared with their CD56 - counterparts, whereas both subsets have similar γδ IFN-responses. We further demonstrate that the CD16-dependent degranulation pathway, but not antibody-dependent cell-mediated cytotoxicity, contribute to the superior cytotoxicity of CD56 + V9γVδ2 T cells. Our study provides further evidence for the phenotypic and functional characterization of human Vγ9Vδ2 γδ T-cell subsets during fluA virus infection and may help improve the γδ T-cell-based immunotherapy for viral infection. © 2012 The Author.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.orgen_HK
dc.relation.ispartofJournal of Infectious Diseasesen_HK
dc.subject.meshAntigens, CD27 - analysis-
dc.subject.meshAntigens, CD45 - analysis-
dc.subject.meshInfluenza A virus - immunology-
dc.subject.meshInfluenza, Human - immunology - virology-
dc.subject.meshT-Lymphocyte Subsets - immunology-
dc.titlePhenotypic and functional characterization of human γδT-cell subsets in response to influenza a virusesen_HK
dc.typeArticleen_HK
dc.identifier.emailMalik Peiris, JS: malik@hkucc.hku.hken_HK
dc.identifier.emailLau, YL: lauylung@hku.hken_HK
dc.identifier.emailTu, W: wwtu@hku.hken_HK
dc.identifier.authorityMalik Peiris, JS=rp00410en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.authorityTu, W=rp00416en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/infdis/jis253en_HK
dc.identifier.pmid22457284-
dc.identifier.scopuseid_2-s2.0-84861075014en_HK
dc.identifier.hkuros200713en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84861075014&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume205en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1646en_HK
dc.identifier.epage1653en_HK
dc.identifier.eissn1537-6613-
dc.identifier.isiWOS:000304065600009-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.relation.projectHumanized mouse as a model to study the antiviral activity of human gammadelta-T cells against human and avian influenza A viruses in vivo-
dc.relation.projectThe Role of Natural Killer Cells in the Pathogenesis of Avian Influenza Virus Infection-
dc.identifier.scopusauthoridQin, G=35085420900en_HK
dc.identifier.scopusauthoridLiu, Y=54919723200en_HK
dc.identifier.scopusauthoridZheng, J=55217878700en_HK
dc.identifier.scopusauthoridXiang, Z=37032263900en_HK
dc.identifier.scopusauthoridNg, IHY=8671050800en_HK
dc.identifier.scopusauthoridMalik Peiris, JS=7005486823en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridTu, W=7006479236en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats