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Article: Distinct roles of myeloid and plasmacytoid dendritic cells in systemic lupus erythematosus

TitleDistinct roles of myeloid and plasmacytoid dendritic cells in systemic lupus erythematosus
Authors
KeywordsType-I interferon
Toll-like receptors
Systemic lupus erythematosus
MicroRNA
Dendritic cells
Issue Date2012
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/autrev
Citation
Autoimmunity Reviews, 2012, v. 11 n. 12, p. 890-897 How to Cite?
AbstractDendritic cells (DCs) constitute a heterogeneous population of professional antigen presenting cells which are the initiators and key regulators for both immunity and tolerance induction. The significance and impact of DC biology in contemporary immunology and medical research is heightened by the award of the 2011 Nobel Prize for Medicine and Physiology to Ralf Steinman for his discovery and subsequent work on the role of DC in adaptive immunity. As a central regulator of immune responses, DCs also play a pivotal role in the pathogenesis of chronic inflammatory autoimmune conditions such as systemic lupus erythematosus (SLE). In this review, we will focus on the respective role of the two major subsets of blood DC, namely myeloid (m)-DC and plasmacytoid (p)-DC, in SLE immunopathogenesis. Accumulating evidence has highlighted pDCs as the culprit for SLE pathogenesis, mainly through type-I interferon production. Latest findings in the field also decipher the mechanisms by which pDCs interact with neutrophils and platelets and contribute to SLE development. The recent surge of interest in studying microRNA regulation in SLE pathogenesis will also be discussed. © 2012 Elsevier B.V.
DescriptionReview
Persistent Identifierhttp://hdl.handle.net/10722/152763
ISSN
2015 Impact Factor: 8.49
2015 SCImago Journal Rankings: 2.260
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, VSFen_HK
dc.contributor.authorNie, YJen_HK
dc.contributor.authorShen, Nen_HK
dc.contributor.authorYan, Sen_HK
dc.contributor.authorMok, MYen_HK
dc.contributor.authorLau, CSen_HK
dc.date.accessioned2012-07-16T09:47:36Z-
dc.date.available2012-07-16T09:47:36Z-
dc.date.issued2012en_HK
dc.identifier.citationAutoimmunity Reviews, 2012, v. 11 n. 12, p. 890-897en_HK
dc.identifier.issn1568-9972en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152763-
dc.descriptionReview-
dc.description.abstractDendritic cells (DCs) constitute a heterogeneous population of professional antigen presenting cells which are the initiators and key regulators for both immunity and tolerance induction. The significance and impact of DC biology in contemporary immunology and medical research is heightened by the award of the 2011 Nobel Prize for Medicine and Physiology to Ralf Steinman for his discovery and subsequent work on the role of DC in adaptive immunity. As a central regulator of immune responses, DCs also play a pivotal role in the pathogenesis of chronic inflammatory autoimmune conditions such as systemic lupus erythematosus (SLE). In this review, we will focus on the respective role of the two major subsets of blood DC, namely myeloid (m)-DC and plasmacytoid (p)-DC, in SLE immunopathogenesis. Accumulating evidence has highlighted pDCs as the culprit for SLE pathogenesis, mainly through type-I interferon production. Latest findings in the field also decipher the mechanisms by which pDCs interact with neutrophils and platelets and contribute to SLE development. The recent surge of interest in studying microRNA regulation in SLE pathogenesis will also be discussed. © 2012 Elsevier B.V.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/autreven_HK
dc.relation.ispartofAutoimmunity Reviewsen_HK
dc.subjectType-I interferonen_HK
dc.subjectToll-like receptorsen_HK
dc.subjectSystemic lupus erythematosusen_HK
dc.subjectMicroRNAen_HK
dc.subjectDendritic cellsen_HK
dc.subject.meshAnimals-
dc.subject.meshDendritic cells - immunology-
dc.subject.meshInterferon type I - immunology-
dc.subject.meshLupus erythematosus, Systemic - genetics - immunology-
dc.subject.meshMyeloid cells - immunology-
dc.subject.meshAntigen presentation-
dc.subject.meshCell communication-
dc.subject.meshHumans-
dc.subject.meshBlood platelets - immunology-
dc.subject.meshMicroRNAs - genetics-
dc.subject.meshNeutrophils - immunology-
dc.titleDistinct roles of myeloid and plasmacytoid dendritic cells in systemic lupus erythematosusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1873-0183 (Electronic)1568-9972 (Linkin&volume=&spage=&epage=&date=2012&atitle=Distinct+roles+of+myeloid+and+plasmacytoid+dendritic+cells+in+systemic+lupus+erythematosusen_US
dc.identifier.emailChan, VSF: sfvchan@hku.hken_HK
dc.identifier.emailMok, MY: temy@hkucc.hku.hken_HK
dc.identifier.emailLau, CS: cslau@hku.hk-
dc.identifier.authorityChan, VSF=rp01459en_HK
dc.identifier.authorityMok, MY=rp00490en_HK
dc.identifier.authorityLau, CS=rp01348-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.autrev.2012.03.004en_HK
dc.identifier.pmid22503660-
dc.identifier.scopuseid_2-s2.0-84866533031en_HK
dc.identifier.hkuros201595en_US
dc.identifier.volume11-
dc.identifier.issue12-
dc.identifier.spage890-
dc.identifier.epage897-
dc.identifier.isiWOS:000310255800008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridMok, MY=55178218400en_HK
dc.identifier.scopusauthoridYan, S=55178535600en_HK
dc.identifier.scopusauthoridShen, N=7102785475en_HK
dc.identifier.scopusauthoridNie, YJ=55178320000en_HK
dc.identifier.scopusauthoridChan, VSF=35200370000en_HK
dc.identifier.citeulike10493193-

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