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Article: Increased serum levels of advanced glycation end-products is associated with severity of sleep disordered breathing but not insulin sensitivity in non-diabetic men with obstructive sleep apnoea.

TitleIncreased serum levels of advanced glycation end-products is associated with severity of sleep disordered breathing but not insulin sensitivity in non-diabetic men with obstructive sleep apnoea.
Authors
Issue Date2012
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/sleep
Citation
Sleep Medicine, 2012, v. 13 n. 1, p. 15-20 How to Cite?
Abstract
BACKGROUND: Patients with diabetes mellitus are known to have increased serum levels of advanced glycation end-products (AGEs), and this is also associated with insulin resistance. This study aimed to investigate the relationship between serum AGEs and insulin sensitivity in non-diabetic subjects with obstructive sleep apnoea (OSA). METHODS: Adult males with no known comorbidities were recruited from the sleep clinic of a university teaching hospital. They underwent overnight in-laboratory polysomnography. Fasting blood was taken to measure serum AGE and plasma glucose levels. Insulin sensitivity was estimated using the short insulin tolerance test. RESULTS: In total, 105 subjects with a mean age of 43.5 (standard deviation [SD] 9.2)years, mean body mass index of 27.1 (SD 4.0)kg/m(2), and median apnoea-hypopnoea index (AHI) of 17 (interquartile range 5-46) were analysed. Serum AGE levels were significantly higher in subjects with OSA (AHI >/=5), compared with those without OSA (AHI <5) (3.9 [SD 1.2] vs. 3.2 [SD 0.8]mug/ml, respectively; P=0.037) after adjusting for confounders. AGE levels were positively correlated with AHI (r=0.318, P=0.001), but not with insulin sensitivity. AGE levels decreased in subjects with moderate-to-severe OSA who received continuous positive airway pressure (CPAP) treatment for three months (n=18, P=0.017). CONCLUSIONS: Serum AGE levels correlate with AHI in non-diabetic adult males. This relationship cannot be explained by insulin sensitivity. Supporting the hypothesis of a direct relationship between AHI and AGEs, AGE levels were found to decline with CPAP therapy.
Persistent Identifierhttp://hdl.handle.net/10722/152762
ISSN
2013 Impact Factor: 3.100
2013 SCImago Journal Rankings: 1.391
ISI Accession Number ID
Funding AgencyGrant Number
Committee of Research
University of Hong Kong, Hong Kong Research Grant CouncilHKU7582/06M
Funding Information:

The authors wish to thank Ms. Pui Pui Ku for manual scoring of all polysomnograms. This study was supported by a grant award from the Committee of Research and Conference Grants, The University of Hong Kong, Hong Kong Research Grant Council (HKU7582/06M).

References

 

DC FieldValueLanguage
dc.contributor.authorLam, JCMen_HK
dc.contributor.authorTan, KCBen_HK
dc.contributor.authorLai, AYKen_HK
dc.contributor.authorLam, CLDen_HK
dc.contributor.authorIp, MSMen_HK
dc.date.accessioned2012-07-16T09:47:36Z-
dc.date.available2012-07-16T09:47:36Z-
dc.date.issued2012en_HK
dc.identifier.citationSleep Medicine, 2012, v. 13 n. 1, p. 15-20en_HK
dc.identifier.issn1389-9457en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152762-
dc.description.abstractBACKGROUND: Patients with diabetes mellitus are known to have increased serum levels of advanced glycation end-products (AGEs), and this is also associated with insulin resistance. This study aimed to investigate the relationship between serum AGEs and insulin sensitivity in non-diabetic subjects with obstructive sleep apnoea (OSA). METHODS: Adult males with no known comorbidities were recruited from the sleep clinic of a university teaching hospital. They underwent overnight in-laboratory polysomnography. Fasting blood was taken to measure serum AGE and plasma glucose levels. Insulin sensitivity was estimated using the short insulin tolerance test. RESULTS: In total, 105 subjects with a mean age of 43.5 (standard deviation [SD] 9.2)years, mean body mass index of 27.1 (SD 4.0)kg/m(2), and median apnoea-hypopnoea index (AHI) of 17 (interquartile range 5-46) were analysed. Serum AGE levels were significantly higher in subjects with OSA (AHI >/=5), compared with those without OSA (AHI <5) (3.9 [SD 1.2] vs. 3.2 [SD 0.8]mug/ml, respectively; P=0.037) after adjusting for confounders. AGE levels were positively correlated with AHI (r=0.318, P=0.001), but not with insulin sensitivity. AGE levels decreased in subjects with moderate-to-severe OSA who received continuous positive airway pressure (CPAP) treatment for three months (n=18, P=0.017). CONCLUSIONS: Serum AGE levels correlate with AHI in non-diabetic adult males. This relationship cannot be explained by insulin sensitivity. Supporting the hypothesis of a direct relationship between AHI and AGEs, AGE levels were found to decline with CPAP therapy.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/sleepen_HK
dc.relation.ispartofSleep Medicineen_HK
dc.subject.meshBlood Glucose - analysisen_HK
dc.subject.meshGlycosylation End Products, Advanced - blooden_HK
dc.subject.meshInsulin Resistance - physiologyen_HK
dc.subject.meshSleep Apnea Syndromes - blood - physiopathologyen_HK
dc.subject.meshSleep Apnea, Obstructive - blood - physiopathology - therapyen_HK
dc.titleIncreased serum levels of advanced glycation end-products is associated with severity of sleep disordered breathing but not insulin sensitivity in non-diabetic men with obstructive sleep apnoea.en_HK
dc.typeArticleen_HK
dc.identifier.emailLam, JCM: lamcmj@hku.hken_HK
dc.identifier.emailTan, KCB: kcbtan@hku.hken_HK
dc.identifier.emailLai, AYK: agneslai@hku.hken_HK
dc.identifier.emailLam, DCL: dcllam@hku.hk-
dc.identifier.emailIp, MSM: msmip@hku.hk-
dc.identifier.authorityTan, KCB=rp00402en_HK
dc.identifier.authorityLam, DCL=rp01345en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.sleep.2011.07.015en_HK
dc.identifier.pmid22137116en_HK
dc.identifier.scopuseid_2-s2.0-84355161923en_HK
dc.identifier.hkuros201507en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84355161923&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue1en_HK
dc.identifier.spage15en_HK
dc.identifier.epage20en_HK
dc.identifier.isiWOS:000300131900005-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK
dc.identifier.scopusauthoridLam, DCL=7201749615en_HK
dc.identifier.scopusauthoridLai, AYK=25641477800en_HK
dc.identifier.scopusauthoridTan, KCB=8082703100en_HK
dc.identifier.scopusauthoridLam, JCM=25923453500en_HK
dc.identifier.citeulike10122709-

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