Article: Increased serum levels of advanced glycation end-products is associated with severity of sleep disordered breathing but not insulin sensitivity in non-diabetic men with obstructive sleep apnoea.
| Title | Increased serum levels of advanced glycation end-products is associated with severity of sleep disordered breathing but not insulin sensitivity in non-diabetic men with obstructive sleep apnoea. | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Lam, JCM1 Tan, KCB1 Lai, AYK1 Lam, DCL1 Ip, MSM1 | ||||||
| Issue Date | 2012 | ||||||
| Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/sleep | ||||||
| Citation | Sleep Medicine, 2012, v. 13 n. 1, p. 15-20 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.sleep.2011.07.015 | ||||||
| Abstract | BACKGROUND: Patients with diabetes mellitus are known to have increased serum levels of advanced glycation end-products (AGEs), and this is also associated with insulin resistance. This study aimed to investigate the relationship between serum AGEs and insulin sensitivity in non-diabetic subjects with obstructive sleep apnoea (OSA). METHODS: Adult males with no known comorbidities were recruited from the sleep clinic of a university teaching hospital. They underwent overnight in-laboratory polysomnography. Fasting blood was taken to measure serum AGE and plasma glucose levels. Insulin sensitivity was estimated using the short insulin tolerance test. RESULTS: In total, 105 subjects with a mean age of 43.5 (standard deviation [SD] 9.2)years, mean body mass index of 27.1 (SD 4.0)kg/m(2), and median apnoea-hypopnoea index (AHI) of 17 (interquartile range 5-46) were analysed. Serum AGE levels were significantly higher in subjects with OSA (AHI >/=5), compared with those without OSA (AHI <5) (3.9 [SD 1.2] vs. 3.2 [SD 0.8]mug/ml, respectively; P=0.037) after adjusting for confounders. AGE levels were positively correlated with AHI (r=0.318, P=0.001), but not with insulin sensitivity. AGE levels decreased in subjects with moderate-to-severe OSA who received continuous positive airway pressure (CPAP) treatment for three months (n=18, P=0.017). CONCLUSIONS: Serum AGE levels correlate with AHI in non-diabetic adult males. This relationship cannot be explained by insulin sensitivity. Supporting the hypothesis of a direct relationship between AHI and AGEs, AGE levels were found to decline with CPAP therapy. | ||||||
| ISSN | 1389-9457 2011 Impact Factor: 3.4 2011 SCImago Journal Rankings: 0.173 | ||||||
| DOI | http://dx.doi.org/10.1016/j.sleep.2011.07.015 | ||||||
| ISI Accession Number ID | WOS:000300131900005
Funding Information: The authors wish to thank Ms. Pui Pui Ku for manual scoring of all polysomnograms. This study was supported by a grant award from the Committee of Research and Conference Grants, The University of Hong Kong, Hong Kong Research Grant Council (HKU7582/06M). | ||||||
| References | References in Scopus |
| dc.contributor.author | Lam, JCM | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Tan, KCB | ||||||
| dc.contributor.author | Lai, AYK | ||||||
| dc.contributor.author | Lam, DCL | ||||||
| dc.contributor.author | Ip, MSM | ||||||
| dc.date.accessioned | 2012-07-16T09:47:36Z | ||||||
| dc.date.available | 2012-07-16T09:47:36Z | ||||||
| dc.date.issued | 2012 | ||||||
| dc.description.abstract | BACKGROUND: Patients with diabetes mellitus are known to have increased serum levels of advanced glycation end-products (AGEs), and this is also associated with insulin resistance. This study aimed to investigate the relationship between serum AGEs and insulin sensitivity in non-diabetic subjects with obstructive sleep apnoea (OSA). METHODS: Adult males with no known comorbidities were recruited from the sleep clinic of a university teaching hospital. They underwent overnight in-laboratory polysomnography. Fasting blood was taken to measure serum AGE and plasma glucose levels. Insulin sensitivity was estimated using the short insulin tolerance test. RESULTS: In total, 105 subjects with a mean age of 43.5 (standard deviation [SD] 9.2)years, mean body mass index of 27.1 (SD 4.0)kg/m(2), and median apnoea-hypopnoea index (AHI) of 17 (interquartile range 5-46) were analysed. Serum AGE levels were significantly higher in subjects with OSA (AHI >/=5), compared with those without OSA (AHI <5) (3.9 [SD 1.2] vs. 3.2 [SD 0.8]mug/ml, respectively; P=0.037) after adjusting for confounders. AGE levels were positively correlated with AHI (r=0.318, P=0.001), but not with insulin sensitivity. AGE levels decreased in subjects with moderate-to-severe OSA who received continuous positive airway pressure (CPAP) treatment for three months (n=18, P=0.017). CONCLUSIONS: Serum AGE levels correlate with AHI in non-diabetic adult males. This relationship cannot be explained by insulin sensitivity. Supporting the hypothesis of a direct relationship between AHI and AGEs, AGE levels were found to decline with CPAP therapy. | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | Sleep Medicine, 2012, v. 13 n. 1, p. 15-20 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.sleep.2011.07.015 | ||||||
| dc.identifier.citeulike | 10122709 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1016/j.sleep.2011.07.015 | ||||||
| dc.identifier.epage | 20 | ||||||
| dc.identifier.hkuros | 201507 | ||||||
| dc.identifier.isi | WOS:000300131900005
Funding Information: The authors wish to thank Ms. Pui Pui Ku for manual scoring of all polysomnograms. This study was supported by a grant award from the Committee of Research and Conference Grants, The University of Hong Kong, Hong Kong Research Grant Council (HKU7582/06M). | ||||||
| dc.identifier.issn | 1389-9457 2011 Impact Factor: 3.4 2011 SCImago Journal Rankings: 0.173 | ||||||
| dc.identifier.issue | 1 | ||||||
| dc.identifier.pmid | 22137116 | ||||||
| dc.identifier.scopus | eid_2-s2.0-84355161923 | ||||||
| dc.identifier.spage | 15 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/152762 | ||||||
| dc.identifier.volume | 13 | ||||||
| dc.language | eng | ||||||
| dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/sleep | ||||||
| dc.publisher.place | Netherlands | ||||||
| dc.relation.ispartof | Sleep Medicine | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.subject.mesh | Blood Glucose - analysis | ||||||
| dc.subject.mesh | Glycosylation End Products, Advanced - blood | ||||||
| dc.subject.mesh | Insulin Resistance - physiology | ||||||
| dc.subject.mesh | Sleep Apnea Syndromes - blood - physiopathology | ||||||
| dc.subject.mesh | Sleep Apnea, Obstructive - blood - physiopathology - therapy | ||||||
| dc.title | Increased serum levels of advanced glycation end-products is associated with severity of sleep disordered breathing but not insulin sensitivity in non-diabetic men with obstructive sleep apnoea. | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong