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Article: The pharmacogenetics of the response to warfarin in Chinese

TitleThe pharmacogenetics of the response to warfarin in Chinese
Authors
Issue Date2012
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJCP
Citation
British Journal Of Clinical Pharmacology, 2012, v. 73 n. 3, p. 340-347 How to Cite?
AbstractWarfarin is a commonly used oral anticoagulant with a narrow therapeutic range and large interindividual variability in daily dose. Compared with Caucasians, Chinese are known to require lower doses of warfarin. Differences between Caucasians and Chinese in the allelic frequencies of two genes, CYP2C9 and VKORC1, largely explain the difference in dose requirement. There are other genetic polymorphisms that may further explain the response to warfarin. The VKORC1 genotype is an important determinant of response to warfarin in Chinese, but some genetic variants found in other ethnic groups that have a large effect on warfarin response and dosing are not commonly found in Chinese. Therefore, it is important to recognize and beware of ethnic differences in the pharmacogenetics of the response to warfarin, especially in the design of algorithms to aid dosing in clinical practice. © 2011 The Authors. British Journal of Clinical Pharmacology © 2011 The British Pharmacological Society.
Persistent Identifierhttp://hdl.handle.net/10722/152743
ISSN
2015 Impact Factor: 3.83
2015 SCImago Journal Rankings: 1.486
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, MPSen_HK
dc.contributor.authorCheung, BMYen_HK
dc.date.accessioned2012-07-16T09:47:29Z-
dc.date.available2012-07-16T09:47:29Z-
dc.date.issued2012en_HK
dc.identifier.citationBritish Journal Of Clinical Pharmacology, 2012, v. 73 n. 3, p. 340-347en_HK
dc.identifier.issn0306-5251en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152743-
dc.description.abstractWarfarin is a commonly used oral anticoagulant with a narrow therapeutic range and large interindividual variability in daily dose. Compared with Caucasians, Chinese are known to require lower doses of warfarin. Differences between Caucasians and Chinese in the allelic frequencies of two genes, CYP2C9 and VKORC1, largely explain the difference in dose requirement. There are other genetic polymorphisms that may further explain the response to warfarin. The VKORC1 genotype is an important determinant of response to warfarin in Chinese, but some genetic variants found in other ethnic groups that have a large effect on warfarin response and dosing are not commonly found in Chinese. Therefore, it is important to recognize and beware of ethnic differences in the pharmacogenetics of the response to warfarin, especially in the design of algorithms to aid dosing in clinical practice. © 2011 The Authors. British Journal of Clinical Pharmacology © 2011 The British Pharmacological Society.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJCPen_HK
dc.relation.ispartofBritish Journal of Clinical Pharmacologyen_HK
dc.subject.meshAlgorithmsen_HK
dc.subject.meshAnticoagulants - administration & dosageen_HK
dc.subject.meshAryl Hydrocarbon Hydroxylases - geneticsen_HK
dc.subject.meshAsian Continental Ancestry Group - geneticsen_HK
dc.subject.meshDose-Response Relationship, Drugen_HK
dc.subject.meshEuropean Continental Ancestry Group - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMixed Function Oxygenases - geneticsen_HK
dc.subject.meshPharmacogeneticsen_HK
dc.subject.meshPolymorphism, Geneticen_HK
dc.subject.meshWarfarin - administration & dosageen_HK
dc.titleThe pharmacogenetics of the response to warfarin in Chineseen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1365-2125.2011.04097.xen_HK
dc.identifier.pmid22023024-
dc.identifier.scopuseid_2-s2.0-84857018427en_HK
dc.identifier.hkuros201113en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84857018427&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume73en_HK
dc.identifier.issue3en_HK
dc.identifier.spage340en_HK
dc.identifier.epage347en_HK
dc.identifier.isiWOS:000300446400003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLam, MPS=54989440600en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.customcontrol.immutablecsl 130312-

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