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Article: DNA methylation of microRNA genes in multiple myeloma

TitleDNA methylation of microRNA genes in multiple myeloma
Authors
Wong, KYHuang, XChim, CS
Issue Date2012
PublisherOxford University Press. The Journal's web site is located at http://carcin.oxfordjournals.org/
Citation
Carcinogenesis, 2012, v. 33 n. 9, p. 1629-1638 How to Cite?
DOI: http://dx.doi.org/10.1093/carcin/bgs212
AbstractDNA methylation is one of the heritable epigenetic modifications, leading to repressed gene expressions and consequent phenotypic alterations without changing the DNA sequence. MicroRNA (miRNA) is a novel class of short non-coding RNA molecules regulating a wide range of cellular functions through translational repression of their target genes. Recently, epigenetic dysregulation of tumor-suppressor miRNA genes by promoter DNA methylation has been implicated in human cancers, including multiple myeloma (MM). This article presents a brief overview of the pathogenesis of MM, the role of DNA methylation in cancer biology, methods of DNA methylation analysis, miRNA biology and dysregulation of miRNAs in MM and summaries the current data on the role of DNA methylation of tumor-suppressive miRNAs in MM.
Persistent Identifierhttp://hdl.handle.net/10722/152732
ISSN
0143-3334
2021 Impact Factor: 4.741
2020 SCImago Journal Rankings: 1.688
ISI Accession Number ID
WOS:000308007600002

 

DC FieldValueLanguage
dc.contributor.authorWong, KYen_US
dc.contributor.authorHuang, Xen_US
dc.contributor.authorChim, CSen_US
dc.date.accessioned2012-07-16T09:47:24Z-
dc.date.available2012-07-16T09:47:24Z-
dc.date.issued2012en_US
dc.identifier.citationCarcinogenesis, 2012, v. 33 n. 9, p. 1629-1638en_US
dc.identifier.issn0143-3334-
dc.identifier.urihttp://hdl.handle.net/10722/152732-
dc.description.abstractDNA methylation is one of the heritable epigenetic modifications, leading to repressed gene expressions and consequent phenotypic alterations without changing the DNA sequence. MicroRNA (miRNA) is a novel class of short non-coding RNA molecules regulating a wide range of cellular functions through translational repression of their target genes. Recently, epigenetic dysregulation of tumor-suppressor miRNA genes by promoter DNA methylation has been implicated in human cancers, including multiple myeloma (MM). This article presents a brief overview of the pathogenesis of MM, the role of DNA methylation in cancer biology, methods of DNA methylation analysis, miRNA biology and dysregulation of miRNAs in MM and summaries the current data on the role of DNA methylation of tumor-suppressive miRNAs in MM.-
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://carcin.oxfordjournals.org/-
dc.relation.ispartofCarcinogenesisen_US
dc.rightsThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Carcinogenesis following peer review. The definitive publisher-authenticated version Carcinogenesis, 2012, v. 33 n. 9, p. 1629-1638 is available online at: http://carcin.oxfordjournals.org/content/33/9/1629-
dc.subject.meshDNA Methylation-
dc.subject.meshGene Expression Regulation, Neoplastic-
dc.subject.meshMicroRNAs - genetics-
dc.subject.meshMultiple Myeloma - etiology - genetics - pathology-
dc.subject.meshNeoplasm Staging-
dc.titleDNA methylation of microRNA genes in multiple myelomaen_US
dc.typeArticleen_US
dc.identifier.emailWong, KY: kwanumu@hku.hken_US
dc.identifier.emailChim, CS: jcschim@hku.hken_US
dc.identifier.authorityChim, JCS=rp00408en_US
dc.description.naturepostprint-
dc.identifier.doi10.1093/carcin/bgs212-
dc.identifier.pmid22715154-
dc.identifier.scopuseid_2-s2.0-84865566726-
dc.identifier.hkuros200869en_US
dc.identifier.volume33-
dc.identifier.issue9-
dc.identifier.spage1629en_US
dc.identifier.epage1638en_US
dc.identifier.isiWOS:000308007600002-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0143-3334-

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