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Article: A synopsis of current care of thalassaemia major patients in Hong Kong
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TitleA synopsis of current care of thalassaemia major patients in Hong Kong
 
AuthorsAu, WY8
Lee, V5
Lau, CW3
Yau, J4
Chan, D7
Chan, EYT1
Cheung, WWW8
Ha, SY8
Kho, B6
Lee, CY9
Li, RCH3
Li, CK5
Lin, SY7
Ling, ASC2
Mak, V2
Sun, L6
Wong, KHF2
Wong, R5
Yuen, HL4
 
Issue Date2011
 
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
 
CitationHong Kong Medical Journal, 2011, v. 17 n. 4, p. 261-266 [How to Cite?]
 
AbstractOBJECTIVE: To provide a synopsis of current thalassaemia major patient care in Hong Kong. DESIGN: Retrospective study. SETTING: All haematology units of the Hospital Authority in Hong Kong. PATIENTS: All patients with thalassaemia major with regular transfusion. RESULTS: To date, there were 363 thalassaemia major patients under the care of the Hospital Authority. Prenatal diagnosis has helped to reduce the number of indigenous new cases, but in recent years immigrant cases are appearing. The patients have a mean age of 23 (range, 1-52) years, and 78% of them are adults. In 2009, they received 18 782 units of blood. This accounted for 9.5% of all blood consumption from the Hong Kong Red Cross. In the past, cardiac iron overload was the major cause of death (65%) and few patients survived beyond the age of 45 years. The availability of cardiac iron assessment by magnetic resonance imaging (T2 MRI) to direct the use of oral deferiprone chelation has reduced the prevalence of heart failure and cardiac haemosiderosis, which should reduce mortality and improve life expectancy. CONCLUSION: The future for thalassaemia care in Hong Kong is bright. With better transfusion and chelation, it should be possible to avoid growth and endocrine deficiencies in younger patients.
 
DescriptionAuthor Chinese name: WY Au 區永仁, Vincent Lee 李偉生, CW Lau 劉靜華, Jeffrey Yau 丘炳華, Desmond Chan 陳振榮, Eric YT Chan 陳日東, Winnie WW Cheung 張永慧, SY Ha 夏修賢, Bonnie Kho 許紫珊, CY Lee 李靜賢, Rever CH Li 李澤荷, CK Li 李志光, SY Lin 連錫營, Alvin SC Ling 凌紹祥, Vivien Mak 麥慧敏, Lina Sun 孫偉芬, Kris HF Wong 黃鴻勳, Raymond Wong 王紹明, HL Yuen 袁煦樑
 
ISSN1024-2708
2012 SCImago Journal Rankings: 0.255
 
DC FieldValue
dc.contributor.authorAu, WY
 
dc.contributor.authorLee, V
 
dc.contributor.authorLau, CW
 
dc.contributor.authorYau, J
 
dc.contributor.authorChan, D
 
dc.contributor.authorChan, EYT
 
dc.contributor.authorCheung, WWW
 
dc.contributor.authorHa, SY
 
dc.contributor.authorKho, B
 
dc.contributor.authorLee, CY
 
dc.contributor.authorLi, RCH
 
dc.contributor.authorLi, CK
 
dc.contributor.authorLin, SY
 
dc.contributor.authorLing, ASC
 
dc.contributor.authorMak, V
 
dc.contributor.authorSun, L
 
dc.contributor.authorWong, KHF
 
dc.contributor.authorWong, R
 
dc.contributor.authorYuen, HL
 
dc.date.accessioned2012-07-16T09:47:22Z
 
dc.date.available2012-07-16T09:47:22Z
 
dc.date.issued2011
 
dc.description.abstractOBJECTIVE: To provide a synopsis of current thalassaemia major patient care in Hong Kong. DESIGN: Retrospective study. SETTING: All haematology units of the Hospital Authority in Hong Kong. PATIENTS: All patients with thalassaemia major with regular transfusion. RESULTS: To date, there were 363 thalassaemia major patients under the care of the Hospital Authority. Prenatal diagnosis has helped to reduce the number of indigenous new cases, but in recent years immigrant cases are appearing. The patients have a mean age of 23 (range, 1-52) years, and 78% of them are adults. In 2009, they received 18 782 units of blood. This accounted for 9.5% of all blood consumption from the Hong Kong Red Cross. In the past, cardiac iron overload was the major cause of death (65%) and few patients survived beyond the age of 45 years. The availability of cardiac iron assessment by magnetic resonance imaging (T2 MRI) to direct the use of oral deferiprone chelation has reduced the prevalence of heart failure and cardiac haemosiderosis, which should reduce mortality and improve life expectancy. CONCLUSION: The future for thalassaemia care in Hong Kong is bright. With better transfusion and chelation, it should be possible to avoid growth and endocrine deficiencies in younger patients.
 
dc.description.naturepublished_or_final_version
 
dc.descriptionAuthor Chinese name: WY Au 區永仁, Vincent Lee 李偉生, CW Lau 劉靜華, Jeffrey Yau 丘炳華, Desmond Chan 陳振榮, Eric YT Chan 陳日東, Winnie WW Cheung 張永慧, SY Ha 夏修賢, Bonnie Kho 許紫珊, CY Lee 李靜賢, Rever CH Li 李澤荷, CK Li 李志光, SY Lin 連錫營, Alvin SC Ling 凌紹祥, Vivien Mak 麥慧敏, Lina Sun 孫偉芬, Kris HF Wong 黃鴻勳, Raymond Wong 王紹明, HL Yuen 袁煦樑
 
dc.identifier.citationHong Kong Medical Journal, 2011, v. 17 n. 4, p. 261-266 [How to Cite?]
 
dc.identifier.epage266
 
dc.identifier.hkuros200825
 
dc.identifier.issn1024-2708
2012 SCImago Journal Rankings: 0.255
 
dc.identifier.issue4
 
dc.identifier.pmid21813892
 
dc.identifier.scopuseid_2-s2.0-80052925400
 
dc.identifier.spage261
 
dc.identifier.urihttp://hdl.handle.net/10722/152728
 
dc.identifier.volume17
 
dc.languageeng
 
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
 
dc.publisher.placeHong Kong
 
dc.relation.ispartofHong Kong Medical Journal
 
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshErythrocyte Transfusion
 
dc.subject.meshIron Overload - etiology
 
dc.subject.meshOsteoporosis - etiology
 
dc.subject.meshRetrospective Studies
 
dc.subject.meshThalassemia - complications - mortality - therapy
 
dc.titleA synopsis of current care of thalassaemia major patients in Hong Kong
 
dc.typeArticle
 
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<contributor.author>Lee, V</contributor.author>
<contributor.author>Lau, CW</contributor.author>
<contributor.author>Yau, J</contributor.author>
<contributor.author>Chan, D</contributor.author>
<contributor.author>Chan, EYT</contributor.author>
<contributor.author>Cheung, WWW</contributor.author>
<contributor.author>Ha, SY</contributor.author>
<contributor.author>Kho, B</contributor.author>
<contributor.author>Lee, CY</contributor.author>
<contributor.author>Li, RCH</contributor.author>
<contributor.author>Li, CK</contributor.author>
<contributor.author>Lin, SY</contributor.author>
<contributor.author>Ling, ASC</contributor.author>
<contributor.author>Mak, V</contributor.author>
<contributor.author>Sun, L</contributor.author>
<contributor.author>Wong, KHF</contributor.author>
<contributor.author>Wong, R</contributor.author>
<contributor.author>Yuen, HL</contributor.author>
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<description.abstract>OBJECTIVE: To provide a synopsis of current thalassaemia major patient care in Hong Kong. DESIGN: Retrospective study. SETTING: All haematology units of the Hospital Authority in Hong Kong. PATIENTS: All patients with thalassaemia major with regular transfusion. RESULTS: To date, there were 363 thalassaemia major patients under the care of the Hospital Authority. Prenatal diagnosis has helped to reduce the number of indigenous new cases, but in recent years immigrant cases are appearing. The patients have a mean age of 23 (range, 1-52) years, and 78% of them are adults. In 2009, they received 18 782 units of blood. This accounted for 9.5% of all blood consumption from the Hong Kong Red Cross. In the past, cardiac iron overload was the major cause of death (65%) and few patients survived beyond the age of 45 years. The availability of cardiac iron assessment by magnetic resonance imaging (T2 MRI) to direct the use of oral deferiprone chelation has reduced the prevalence of heart failure and cardiac haemosiderosis, which should reduce mortality and improve life expectancy. CONCLUSION: The future for thalassaemia care in Hong Kong is bright. With better transfusion and chelation, it should be possible to avoid growth and endocrine deficiencies in younger patients.</description.abstract>
<language>eng</language>
<publisher>Hong Kong Academy of Medicine Press. The Journal&apos;s web site is located at http://www.hkmj.org.hk</publisher>
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<rights>Hong Kong Medical Journal. Copyright &#169; Hong Kong Academy of Medicine Press.</rights>
<rights>Creative Commons: Attribution 3.0 Hong Kong License</rights>
<subject.mesh>Erythrocyte Transfusion</subject.mesh>
<subject.mesh>Iron Overload - etiology</subject.mesh>
<subject.mesh>Osteoporosis - etiology</subject.mesh>
<subject.mesh>Retrospective Studies</subject.mesh>
<subject.mesh>Thalassemia - complications - mortality - therapy</subject.mesh>
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Author Affiliations
  1. Kwong Wah Hospital
  2. Princess Margaret Hospital Hong Kong
  3. Tuen Mun Hospital
  4. Queen Elizabeth Hospital Hong Kong
  5. Prince of Wales Hospital Hong Kong
  6. Pamela Youde Nethersole Eastern Hospital
  7. United Christian Hospital Hong Kong
  8. Queen Mary Hospital Hong Kong
  9. Caritas Medical Centre Hong Kong