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Article: Maturation profile of inferior olivary neurons expressing ionotropic glutamate receptors in rats: role in coding linear accelerations

TitleMaturation profile of inferior olivary neurons expressing ionotropic glutamate receptors in rats: role in coding linear accelerations
Authors
KeywordsGlutamate receptor
Gravity
Inferior olive
Postnatal
Spatial map
Vestibular system
Issue Date2013
Citation
Brain Structure And Function, 2013, v. 218 n. 4, p. 833-850 How to Cite?
AbstractUsing sinusoidal oscillations of linear acceleration along both the horizontal and vertical planes to stimulate otolith organs in the inner ear, we charted the postnatal time at which responsive neurons in the rat inferior olive (IO) first showed Fos expression, an indicator of neuronal recruitment into the otolith circuit. Neurons in subnucleus dorsomedial cell column (DMCC) were activated by vertical stimulation as early as P9 and by horizontal (interaural) stimulation as early as P11. By P13, neurons in the β subnucleus of IO (IOβ) became responsive to horizontal stimulation along the interaural and antero-posterior directions. By P21, neurons in the rostral IOβ became also responsive to vertical stimulation, but those in the caudal IOβ remained responsive only to horizontal stimulation. Nearly all functionally activated neurons in DMCC and IOβ were immunopositive for the NR1 subunit of the NMDA receptor and the GluR2/3 subunit of the AMPA receptor. In situ hybridization studies further indicated abundant mRNA signals of the glutamate receptor subunits by the end of the second postnatal week. This is reinforced by whole-cell patch-clamp data in which glutamate receptor-mediated miniature excitatory postsynaptic currents of rostral IOβ neurons showed postnatal increase in amplitude, reaching the adult level by P14. Further, these neurons exhibited subthreshold oscillations in membrane potential as from P14. Taken together, our results support that ionotropic glutamate receptors in the IO enable postnatal coding of gravity-related information and that the rostral IOβ is the only IO subnucleus that encodes spatial orientations in 3-D. © 2012 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/152627
ISSN
2015 Impact Factor: 5.811
2015 SCImago Journal Rankings: 2.035
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Cen_HK
dc.contributor.authorHan, Len_HK
dc.contributor.authorMa, CWen_HK
dc.contributor.authorLai, SKen_HK
dc.contributor.authorLai, CHen_HK
dc.contributor.authorShum, DKYen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2012-07-16T09:44:29Z-
dc.date.available2012-07-16T09:44:29Z-
dc.date.issued2013en_HK
dc.identifier.citationBrain Structure And Function, 2013, v. 218 n. 4, p. 833-850en_HK
dc.identifier.issn1863-2653en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152627-
dc.description.abstractUsing sinusoidal oscillations of linear acceleration along both the horizontal and vertical planes to stimulate otolith organs in the inner ear, we charted the postnatal time at which responsive neurons in the rat inferior olive (IO) first showed Fos expression, an indicator of neuronal recruitment into the otolith circuit. Neurons in subnucleus dorsomedial cell column (DMCC) were activated by vertical stimulation as early as P9 and by horizontal (interaural) stimulation as early as P11. By P13, neurons in the β subnucleus of IO (IOβ) became responsive to horizontal stimulation along the interaural and antero-posterior directions. By P21, neurons in the rostral IOβ became also responsive to vertical stimulation, but those in the caudal IOβ remained responsive only to horizontal stimulation. Nearly all functionally activated neurons in DMCC and IOβ were immunopositive for the NR1 subunit of the NMDA receptor and the GluR2/3 subunit of the AMPA receptor. In situ hybridization studies further indicated abundant mRNA signals of the glutamate receptor subunits by the end of the second postnatal week. This is reinforced by whole-cell patch-clamp data in which glutamate receptor-mediated miniature excitatory postsynaptic currents of rostral IOβ neurons showed postnatal increase in amplitude, reaching the adult level by P14. Further, these neurons exhibited subthreshold oscillations in membrane potential as from P14. Taken together, our results support that ionotropic glutamate receptors in the IO enable postnatal coding of gravity-related information and that the rostral IOβ is the only IO subnucleus that encodes spatial orientations in 3-D. © 2012 The Author(s).en_HK
dc.languageengen_US
dc.relation.ispartofBrain Structure and Functionen_HK
dc.subjectGlutamate receptoren_HK
dc.subjectGravityen_HK
dc.subjectInferior oliveen_HK
dc.subjectPostnatalen_HK
dc.subjectSpatial mapen_HK
dc.subjectVestibular systemen_HK
dc.titleMaturation profile of inferior olivary neurons expressing ionotropic glutamate receptors in rats: role in coding linear accelerationsen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.emailLi, C: lic5@hkusua.hku.hk-
dc.identifier.emailHan, L: rahanlei@hku.hk-
dc.identifier.emailMa, CW: cwma2010@hku.hk-
dc.identifier.emailLai, SK: estherlai@hkusua.hku.hk-
dc.identifier.emailLai, CH: chlaib@hku.hk-
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hk-
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00429-012-0432-3en_HK
dc.identifier.pmid22706760-
dc.identifier.scopuseid_2-s2.0-84879793608en_HK
dc.identifier.hkuros216605-
dc.identifier.spage833en_HK
dc.identifier.epage850en_HK
dc.identifier.eissn1863-2661-
dc.identifier.isiWOS:000321067200001-
dc.identifier.scopusauthoridLi, C=55250746600en_HK
dc.identifier.scopusauthoridHan, L=55250734900en_HK
dc.identifier.scopusauthoridMa, CW=15765898900en_HK
dc.identifier.scopusauthoridLai, SK=7402937165en_HK
dc.identifier.scopusauthoridLai, CH=55250804300en_HK
dc.identifier.scopusauthoridShum, DKY=55250364000en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK
dc.identifier.citeulike10816964-

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