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Article: Curcumin alters the migratory phenotype of nasopharyngeal carcinoma cells through up-regulation of E-cadherin

TitleCurcumin alters the migratory phenotype of nasopharyngeal carcinoma cells through up-regulation of E-cadherin
Authors
KeywordsCurcumin
E-cadherin
Migration
Nasopharyngeal carcinoma
NF-κB
Issue Date2010
PublisherInternational Institute of Anticancer Research. The Journal's web site is located at http://ar.iiarjournals.org/
Citation
Anticancer Research, 2010, v. 30 n. 7, p. 2851-2856 How to Cite?
AbstractBackground: Curcumin is a natural polyphenol. It is a potent suppressor of nuclear factor kappa B (NF-κB). High NF-κB levels have suppressive effect on E-cadherin (molecule related to cell-cell adhesion) in nasopharyngeal carcinoma (NPC) cells. We hypothesized that suppressing NF-κB by curcumin could up-regulate E-cadherin expression in NPC cells. Materials and Methods: NPC cell lines HK1 and HONE1 were used. Real-time quantitative PCR and Western blotting were used to examine the expression changes of NF-κB and E-cadherin. A mouse xenograft model was used to validate the results. Results: With curcumin treatment, NF-κB was down-regulated and E-cadherin was up-regulated in NPC cells. The negative correlation of NF-κB and E-cadherin was confirmed in the mouse xenograft model. Conclusion: Our results suggest that curcumin could be used in preventing NPC migration by suppressing NF-KB and activating E-cadherin expression.
Persistent Identifierhttp://hdl.handle.net/10722/152618
ISSN
2015 Impact Factor: 1.895
2015 SCImago Journal Rankings: 0.815
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, TSen_HK
dc.contributor.authorChan, WSen_HK
dc.contributor.authorLi, CHen_HK
dc.contributor.authorLiu, RWMen_HK
dc.contributor.authorTang, WWYen_HK
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorTsang, RKYen_HK
dc.contributor.authorHo, WKen_HK
dc.contributor.authorWei, WIen_HK
dc.contributor.authorChan, JYWen_HK
dc.date.accessioned2012-07-16T09:44:11Z-
dc.date.available2012-07-16T09:44:11Z-
dc.date.issued2010en_HK
dc.identifier.citationAnticancer Research, 2010, v. 30 n. 7, p. 2851-2856en_HK
dc.identifier.issn0250-7005en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152618-
dc.description.abstractBackground: Curcumin is a natural polyphenol. It is a potent suppressor of nuclear factor kappa B (NF-κB). High NF-κB levels have suppressive effect on E-cadherin (molecule related to cell-cell adhesion) in nasopharyngeal carcinoma (NPC) cells. We hypothesized that suppressing NF-κB by curcumin could up-regulate E-cadherin expression in NPC cells. Materials and Methods: NPC cell lines HK1 and HONE1 were used. Real-time quantitative PCR and Western blotting were used to examine the expression changes of NF-κB and E-cadherin. A mouse xenograft model was used to validate the results. Results: With curcumin treatment, NF-κB was down-regulated and E-cadherin was up-regulated in NPC cells. The negative correlation of NF-κB and E-cadherin was confirmed in the mouse xenograft model. Conclusion: Our results suggest that curcumin could be used in preventing NPC migration by suppressing NF-KB and activating E-cadherin expression.en_HK
dc.languageengen_US
dc.publisherInternational Institute of Anticancer Research. The Journal's web site is located at http://ar.iiarjournals.org/en_HK
dc.relation.ispartofAnticancer Researchen_HK
dc.subjectCurcuminen_HK
dc.subjectE-cadherinen_HK
dc.subjectMigrationen_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.subjectNF-κBen_HK
dc.titleCurcumin alters the migratory phenotype of nasopharyngeal carcinoma cells through up-regulation of E-cadherinen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, TS: thiansze@graduate.hku.hken_HK
dc.identifier.emailTsao, SW: gswtsao@hkucc.hku.hken_HK
dc.identifier.emailTsang, RKY: rkytsang@hku.hken_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.emailChan, JYW: jywchan1@hku.hken_HK
dc.identifier.authorityWong, TS=rp00478en_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.identifier.authorityTsang, RKY=rp01386en_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.identifier.authorityChan, JYW=rp01314en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid20683022-
dc.identifier.scopuseid_2-s2.0-77955822805en_HK
dc.identifier.hkuros200701en_US
dc.identifier.hkuros191735-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955822805&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume30en_HK
dc.identifier.issue7en_HK
dc.identifier.spage2851en_HK
dc.identifier.epage2856en_HK
dc.identifier.isiWOS:000280796400051-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridWong, TS=7403531328en_HK
dc.identifier.scopusauthoridChan, WS=36467852300en_HK
dc.identifier.scopusauthoridLi, CH=7501678957en_HK
dc.identifier.scopusauthoridLiu, RWM=36468735500en_HK
dc.identifier.scopusauthoridTang, WWY=36469039200en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridTsang, RKY=7102940058en_HK
dc.identifier.scopusauthoridHo, WK=7402968844en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK
dc.identifier.scopusauthoridChan, JYW=27171772200en_HK

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