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Article: Bone regeneration: Importance of local pH - Strontium-doped borosilicate scaffold
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TitleBone regeneration: Importance of local pH - Strontium-doped borosilicate scaffold
 
AuthorsShen, Y3
Liu, W2
Wen, C2
Pan, H2 1
Wang, T2
Darvell, BW4
Lu, WW2 1
Huang, W5
 
KeywordsAlkaline environment
Alkaline ph
Biological response
Bone regeneration
Bone substitutes
 
Issue Date2012
 
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/jm/index.asp
 
CitationJournal Of Materials Chemistry, 2012, v. 22 n. 17, p. 8662-8670 [How to Cite?]
DOI: http://dx.doi.org/10.1039/c2jm16141a
 
AbstractThe effect of local pH on bone regeneration has never been properly studied or discussed. However, using a microelectrode, the pH on the surface of implant materials, rather than in the bulk, is measurable so that the biological response based on the local environment can be studied. It was found that the osteoblast viability was significantly enhanced with an increase of pH, to an optimum level at ∼pH 8-8.5; in contrast, the activity fell markedly below pH 6. The effect of strontium on osteoblast proliferation was further increased at pH ∼8, suggesting a possible new approach for enhancing its activity in the treatment of osteoporosis. No stimulation of osteoblast proliferation was found for boron at normal physiological pH but, surprisingly, such an effect was found at pH 8.5. For the degradation of strontium-doped borosilicate, the ambient alkaline pH not only enhanced the activity of strontium and boron, but also facilitated the nucleation of apatite, as indicated by the newly formed bony tissue. Consequently, appropriately designed biomaterials, which create such an ideal ambient alkaline environment for bone regeneration, may be crucial aspects for bone substitutes. © The Royal Society of Chemistry 2012.
 
ISSN0959-9428
2013 Impact Factor: 6.626
 
DOIhttp://dx.doi.org/10.1039/c2jm16141a
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorShen, Y
 
dc.contributor.authorLiu, W
 
dc.contributor.authorWen, C
 
dc.contributor.authorPan, H
 
dc.contributor.authorWang, T
 
dc.contributor.authorDarvell, BW
 
dc.contributor.authorLu, WW
 
dc.contributor.authorHuang, W
 
dc.date.accessioned2012-07-16T09:43:37Z
 
dc.date.available2012-07-16T09:43:37Z
 
dc.date.issued2012
 
dc.description.abstractThe effect of local pH on bone regeneration has never been properly studied or discussed. However, using a microelectrode, the pH on the surface of implant materials, rather than in the bulk, is measurable so that the biological response based on the local environment can be studied. It was found that the osteoblast viability was significantly enhanced with an increase of pH, to an optimum level at ∼pH 8-8.5; in contrast, the activity fell markedly below pH 6. The effect of strontium on osteoblast proliferation was further increased at pH ∼8, suggesting a possible new approach for enhancing its activity in the treatment of osteoporosis. No stimulation of osteoblast proliferation was found for boron at normal physiological pH but, surprisingly, such an effect was found at pH 8.5. For the degradation of strontium-doped borosilicate, the ambient alkaline pH not only enhanced the activity of strontium and boron, but also facilitated the nucleation of apatite, as indicated by the newly formed bony tissue. Consequently, appropriately designed biomaterials, which create such an ideal ambient alkaline environment for bone regeneration, may be crucial aspects for bone substitutes. © The Royal Society of Chemistry 2012.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Materials Chemistry, 2012, v. 22 n. 17, p. 8662-8670 [How to Cite?]
DOI: http://dx.doi.org/10.1039/c2jm16141a
 
dc.identifier.doihttp://dx.doi.org/10.1039/c2jm16141a
 
dc.identifier.eissn1364-5501
 
dc.identifier.epage8670
 
dc.identifier.hkuros200619
 
dc.identifier.issn0959-9428
2013 Impact Factor: 6.626
 
dc.identifier.issue17
 
dc.identifier.scopuseid_2-s2.0-84859743396
 
dc.identifier.spage8662
 
dc.identifier.urihttp://hdl.handle.net/10722/152592
 
dc.identifier.volume22
 
dc.languageeng
 
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/jm/index.asp
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofJournal of Materials Chemistry
 
dc.relation.referencesReferences in Scopus
 
dc.subjectAlkaline environment
 
dc.subjectAlkaline ph
 
dc.subjectBiological response
 
dc.subjectBone regeneration
 
dc.subjectBone substitutes
 
dc.titleBone regeneration: Importance of local pH - Strontium-doped borosilicate scaffold
 
dc.typeArticle
 
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<contributor.author>Pan, H</contributor.author>
<contributor.author>Wang, T</contributor.author>
<contributor.author>Darvell, BW</contributor.author>
<contributor.author>Lu, WW</contributor.author>
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Author Affiliations
  1. Shenzhen Institute of Advanced Technology
  2. The University of Hong Kong
  3. Shanghai Jiaotong University
  4. Dental Materials Science
  5. Tongji University