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Article: Bone regeneration: Importance of local pH - Strontium-doped borosilicate scaffold

TitleBone regeneration: Importance of local pH - Strontium-doped borosilicate scaffold
Authors
KeywordsAlkaline environment
Alkaline ph
Biological response
Bone regeneration
Bone substitutes
Issue Date2012
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/jm/index.asp
Citation
Journal Of Materials Chemistry, 2012, v. 22 n. 17, p. 8662-8670 How to Cite?
AbstractThe effect of local pH on bone regeneration has never been properly studied or discussed. However, using a microelectrode, the pH on the surface of implant materials, rather than in the bulk, is measurable so that the biological response based on the local environment can be studied. It was found that the osteoblast viability was significantly enhanced with an increase of pH, to an optimum level at ∼pH 8-8.5; in contrast, the activity fell markedly below pH 6. The effect of strontium on osteoblast proliferation was further increased at pH ∼8, suggesting a possible new approach for enhancing its activity in the treatment of osteoporosis. No stimulation of osteoblast proliferation was found for boron at normal physiological pH but, surprisingly, such an effect was found at pH 8.5. For the degradation of strontium-doped borosilicate, the ambient alkaline pH not only enhanced the activity of strontium and boron, but also facilitated the nucleation of apatite, as indicated by the newly formed bony tissue. Consequently, appropriately designed biomaterials, which create such an ideal ambient alkaline environment for bone regeneration, may be crucial aspects for bone substitutes. © The Royal Society of Chemistry 2012.
Persistent Identifierhttp://hdl.handle.net/10722/152592
ISSN
2013 Impact Factor: 6.626
2014 SCImago Journal Rankings: 2.264
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShen, Yen_HK
dc.contributor.authorLiu, Wen_HK
dc.contributor.authorWen, Cen_HK
dc.contributor.authorPan, Hen_HK
dc.contributor.authorWang, Ten_HK
dc.contributor.authorDarvell, BWen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorHuang, Wen_HK
dc.date.accessioned2012-07-16T09:43:37Z-
dc.date.available2012-07-16T09:43:37Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of Materials Chemistry, 2012, v. 22 n. 17, p. 8662-8670en_HK
dc.identifier.issn0959-9428en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152592-
dc.description.abstractThe effect of local pH on bone regeneration has never been properly studied or discussed. However, using a microelectrode, the pH on the surface of implant materials, rather than in the bulk, is measurable so that the biological response based on the local environment can be studied. It was found that the osteoblast viability was significantly enhanced with an increase of pH, to an optimum level at ∼pH 8-8.5; in contrast, the activity fell markedly below pH 6. The effect of strontium on osteoblast proliferation was further increased at pH ∼8, suggesting a possible new approach for enhancing its activity in the treatment of osteoporosis. No stimulation of osteoblast proliferation was found for boron at normal physiological pH but, surprisingly, such an effect was found at pH 8.5. For the degradation of strontium-doped borosilicate, the ambient alkaline pH not only enhanced the activity of strontium and boron, but also facilitated the nucleation of apatite, as indicated by the newly formed bony tissue. Consequently, appropriately designed biomaterials, which create such an ideal ambient alkaline environment for bone regeneration, may be crucial aspects for bone substitutes. © The Royal Society of Chemistry 2012.en_HK
dc.languageengen_US
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/jm/index.aspen_HK
dc.relation.ispartofJournal of Materials Chemistryen_HK
dc.subjectAlkaline environment-
dc.subjectAlkaline ph-
dc.subjectBiological response-
dc.subjectBone regeneration-
dc.subjectBone substitutes-
dc.titleBone regeneration: Importance of local pH - Strontium-doped borosilicate scaffolden_HK
dc.typeArticleen_HK
dc.identifier.emailPan, H: haobo@hku.hken_HK
dc.identifier.emailDarvell, BW: b.w.darvell@hku.hken_HK
dc.identifier.authorityPan, H=rp01564en_HK
dc.identifier.authorityDarvell, BW=rp00007en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/c2jm16141aen_HK
dc.identifier.scopuseid_2-s2.0-84859743396en_HK
dc.identifier.hkuros200619en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84859743396&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue17en_HK
dc.identifier.spage8662en_HK
dc.identifier.epage8670en_HK
dc.identifier.eissn1364-5501-
dc.identifier.isiWOS:000302367500068-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridShen, Y=55492340800en_HK
dc.identifier.scopusauthoridLiu, W=26656769100en_HK
dc.identifier.scopusauthoridWen, C=36731630800en_HK
dc.identifier.scopusauthoridPan, H=7403295092en_HK
dc.identifier.scopusauthoridWang, T=11840122500en_HK
dc.identifier.scopusauthoridDarvell, BW=7005953926en_HK
dc.identifier.scopusauthoridLu, WW=54989091200en_HK
dc.identifier.scopusauthoridHuang, W=7407905904en_HK

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