Article: Bone regeneration: Importance of local pH - Strontium-doped borosilicate scaffold

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TitleBone regeneration: Importance of local pH - Strontium-doped borosilicate scaffold
AuthorsShen, Y2
Liu, W1
Wen, C1
Pan, H1 4
Wang, T1
Darvell, BW3
Lu, WW1 4
Huang, W5
KeywordsAlkaline environment
Alkaline ph
Biological response
Bone regeneration
Bone substitutes
Issue Date2012
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/jm/index.asp
CitationJournal Of Materials Chemistry, 2012, v. 22 n. 17, p. 8662-8670 [How to Cite?]
DOI: http://dx.doi.org/10.1039/c2jm16141a
AbstractThe effect of local pH on bone regeneration has never been properly studied or discussed. However, using a microelectrode, the pH on the surface of implant materials, rather than in the bulk, is measurable so that the biological response based on the local environment can be studied. It was found that the osteoblast viability was significantly enhanced with an increase of pH, to an optimum level at ∼pH 8-8.5; in contrast, the activity fell markedly below pH 6. The effect of strontium on osteoblast proliferation was further increased at pH ∼8, suggesting a possible new approach for enhancing its activity in the treatment of osteoporosis. No stimulation of osteoblast proliferation was found for boron at normal physiological pH but, surprisingly, such an effect was found at pH 8.5. For the degradation of strontium-doped borosilicate, the ambient alkaline pH not only enhanced the activity of strontium and boron, but also facilitated the nucleation of apatite, as indicated by the newly formed bony tissue. Consequently, appropriately designed biomaterials, which create such an ideal ambient alkaline environment for bone regeneration, may be crucial aspects for bone substitutes. © The Royal Society of Chemistry 2012.
ISSN0959-9428
2011 Impact Factor: 5.968
2011 SCImago Journal Rankings: 0.496
DOIhttp://dx.doi.org/10.1039/c2jm16141a
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorShen, Y
dc.contributor.authorLiu, W
dc.contributor.authorWen, C
dc.contributor.authorPan, H
dc.contributor.authorWang, T
dc.contributor.authorDarvell, BW
dc.contributor.authorLu, WW
dc.contributor.authorHuang, W
dc.date.accessioned2012-07-16T09:43:37Z
dc.date.available2012-07-16T09:43:37Z
dc.date.issued2012
dc.description.abstractThe effect of local pH on bone regeneration has never been properly studied or discussed. However, using a microelectrode, the pH on the surface of implant materials, rather than in the bulk, is measurable so that the biological response based on the local environment can be studied. It was found that the osteoblast viability was significantly enhanced with an increase of pH, to an optimum level at ∼pH 8-8.5; in contrast, the activity fell markedly below pH 6. The effect of strontium on osteoblast proliferation was further increased at pH ∼8, suggesting a possible new approach for enhancing its activity in the treatment of osteoporosis. No stimulation of osteoblast proliferation was found for boron at normal physiological pH but, surprisingly, such an effect was found at pH 8.5. For the degradation of strontium-doped borosilicate, the ambient alkaline pH not only enhanced the activity of strontium and boron, but also facilitated the nucleation of apatite, as indicated by the newly formed bony tissue. Consequently, appropriately designed biomaterials, which create such an ideal ambient alkaline environment for bone regeneration, may be crucial aspects for bone substitutes. © The Royal Society of Chemistry 2012.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Materials Chemistry, 2012, v. 22 n. 17, p. 8662-8670 [How to Cite?]
DOI: http://dx.doi.org/10.1039/c2jm16141a
dc.identifier.doihttp://dx.doi.org/10.1039/c2jm16141a
dc.identifier.epage8670
dc.identifier.hkuros200619
dc.identifier.issn0959-9428
2011 Impact Factor: 5.968
2011 SCImago Journal Rankings: 0.496
dc.identifier.issue17
dc.identifier.scopuseid_2-s2.0-84859743396
dc.identifier.spage8662
dc.identifier.urihttp://hdl.handle.net/10722/152592
dc.identifier.volume22
dc.languageeng
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/jm/index.asp
dc.publisher.placeUnited Kingdom
dc.relation.ispartofJournal of Materials Chemistry
dc.relation.referencesReferences in Scopus
dc.subjectAlkaline environment
dc.subjectAlkaline ph
dc.subjectBiological response
dc.subjectBone regeneration
dc.subjectBone substitutes
dc.titleBone regeneration: Importance of local pH - Strontium-doped borosilicate scaffold
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Shanghai Jiaotong University
  3. Dental Materials Science
  4. Chinese Academy of Sciences
  5. Tongji University