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Article: Discovery of seven novel mammalian and avian coronaviruses in the genus Deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus

TitleDiscovery of seven novel mammalian and avian coronaviruses in the genus Deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus
Authors
Issue Date2012
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal of Virology, 2012, v. 86 n. 7, p. 3995-4008 How to Cite?
AbstractRecently, we reported the discovery of three novel coronaviruses, bulbul coronavirus HKU11, thrush coronavirus HKU12, and munia coronavirus HKU13, which were identified as representatives of a novel genus, Deltacoronavirus, in the subfamily Coronavirinae. In this territory-wide molecular epidemiology study involving 3,137 mammals and 3,298 birds, we discovered seven additional novel deltacoronaviruses in pigs and birds, which we named porcine coronavirus HKU15, white-eye coronavirus HKU16, sparrow coronavirus HKU17, magpie robin coronavirus HKU18, night heron coronavirus HKU19, wigeon coronavirus HKU20, and common moorhen coronavirus HKU21. Complete genome sequencing and comparative genome analysis showed that the avian and mammalian deltacoronaviruses have similar genome characteristics and structures. They all have relatively small genomes (25.421 to 26.674 kb), the smallest among all coronaviruses. They all have a single papain-like protease domain in the nsp3 gene; an accessory gene, NS6 open reading frame (ORF), located between the M and N genes; and a variable number of accessory genes (up to four) downstream of the N gene. Moreover, they all have the same putative transcription regulatory sequence of ACACCA. Molecular clock analysis showed that the most recent common ancestor of all coronaviruses was estimated at approximately 8100 BC, and those of Alphacoronavirus, Betacoronavirus, Gammacoronavirus, and Deltacoronavirus were at approximately 2400 BC, 3300 BC, 2800 BC, and 3000 BC, respectively. From our studies, it appears that bats and birds, the warm blooded flying vertebrates, are ideal hosts for the coronavirus gene source, bats for Alphacoronavirus and Betacoronavirus and birds for Gammacoronavirus and Deltacoronavirus, to fuel coronavirus evolution and dissemination.
Persistent Identifierhttp://hdl.handle.net/10722/152582
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Research Grant CouncilHKU 780709 M
University of Hong Kong
Tung Wah Group of Hospitals Fund for Research in Infectious Diseases
HKSAR Research Fund for the Control of Infectious Diseases of the Health, Welfare and Food Bureau
Shaw Foundation
Funding Information:

We are grateful to the generous support of Hui Hoy and Hui Ming in the genomic sequencing platform and Eunice Lam for her generous donation to emerging infectious disease research. This work is partly supported by Research Grant Council grant HKU 780709 M; University Development Fund and Outstanding Young Researcher Award, The University of Hong Kong; The Tung Wah Group of Hospitals Fund for Research in Infectious Diseases; the HKSAR Research Fund for the Control of Infectious Diseases of the Health, Welfare and Food Bureau; and the Shaw Foundation.

References

 

DC FieldValueLanguage
dc.contributor.authorWoo, PCYen_US
dc.contributor.authorLau, SKPen_US
dc.contributor.authorLam, CSFen_US
dc.contributor.authorLau, CCYen_US
dc.contributor.authorTsang, AKLen_US
dc.contributor.authorLau, JHNen_US
dc.contributor.authorBai, Ren_US
dc.contributor.authorTeng, JLLen_US
dc.contributor.authorTsang, CCCen_US
dc.contributor.authorWang, Men_US
dc.contributor.authorZheng, BJen_US
dc.contributor.authorChan, KHen_US
dc.contributor.authorYuen, KYen_US
dc.date.accessioned2012-07-12T08:55:53Z-
dc.date.available2012-07-12T08:55:53Z-
dc.date.issued2012en_US
dc.identifier.citationJournal of Virology, 2012, v. 86 n. 7, p. 3995-4008en_US
dc.identifier.issn0022-538Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/152582-
dc.description.abstractRecently, we reported the discovery of three novel coronaviruses, bulbul coronavirus HKU11, thrush coronavirus HKU12, and munia coronavirus HKU13, which were identified as representatives of a novel genus, Deltacoronavirus, in the subfamily Coronavirinae. In this territory-wide molecular epidemiology study involving 3,137 mammals and 3,298 birds, we discovered seven additional novel deltacoronaviruses in pigs and birds, which we named porcine coronavirus HKU15, white-eye coronavirus HKU16, sparrow coronavirus HKU17, magpie robin coronavirus HKU18, night heron coronavirus HKU19, wigeon coronavirus HKU20, and common moorhen coronavirus HKU21. Complete genome sequencing and comparative genome analysis showed that the avian and mammalian deltacoronaviruses have similar genome characteristics and structures. They all have relatively small genomes (25.421 to 26.674 kb), the smallest among all coronaviruses. They all have a single papain-like protease domain in the nsp3 gene; an accessory gene, NS6 open reading frame (ORF), located between the M and N genes; and a variable number of accessory genes (up to four) downstream of the N gene. Moreover, they all have the same putative transcription regulatory sequence of ACACCA. Molecular clock analysis showed that the most recent common ancestor of all coronaviruses was estimated at approximately 8100 BC, and those of Alphacoronavirus, Betacoronavirus, Gammacoronavirus, and Deltacoronavirus were at approximately 2400 BC, 3300 BC, 2800 BC, and 3000 BC, respectively. From our studies, it appears that bats and birds, the warm blooded flying vertebrates, are ideal hosts for the coronavirus gene source, bats for Alphacoronavirus and Betacoronavirus and birds for Gammacoronavirus and Deltacoronavirus, to fuel coronavirus evolution and dissemination.en_US
dc.languageengen_US
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_US
dc.relation.ispartofJournal of Virologyen_US
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.-
dc.rightsCopyright © American Society for Microbiology, [Journal of Virology, 2012, v. 86 n. 7, p. 3995-4008]-
dc.subject.meshBird Diseases - virologyen_US
dc.subject.meshChiroptera - virologyen_US
dc.subject.meshCoronaviridae - classification - genetics - isolation and purificationen_US
dc.subject.meshCoronaviridae Infections - veterinary - virologyen_US
dc.subject.meshMammals - virologyen_US
dc.titleDiscovery of seven novel mammalian and avian coronaviruses in the genus Deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirusen_US
dc.typeArticleen_US
dc.identifier.emailWoo, PCY: pcywoo@hkucc.hku.hken_US
dc.identifier.emailLau, SKP: skplau@hkucc.hku.hken_US
dc.identifier.emailLam, CSF: csflam@hkucc.hku.hk-
dc.identifier.emailLau, CCY: candylau@graduate.hku.hk-
dc.identifier.emailTsang, AKL: h0365593@hkucc.hku.hk-
dc.identifier.emailTeng, JLL: llteng@hku.hk-
dc.identifier.emailZheng, BJ: bzheng@hkucc.hku.hk-
dc.identifier.emailChan, KH: chankh2@hkucc.hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.authorityTeng, JLL=rp00277en_US
dc.identifier.authorityYuen, KY=rp00366en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1128/JVI.06540-11en_US
dc.identifier.pmid22278237en_US
dc.identifier.pmcidPMC3302495-
dc.identifier.scopuseid_2-s2.0-84861307149en_US
dc.identifier.hkuros204128-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84861307149&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume86en_US
dc.identifier.issue7en_US
dc.identifier.spage3995en_US
dc.identifier.epage4008en_US
dc.identifier.eissn1098-5514-
dc.identifier.isiWOS:000301371500055-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYuen, KY=36078079100en_US
dc.identifier.scopusauthoridChan, KH=7406034307en_US
dc.identifier.scopusauthoridZheng, BJ=54935584800en_US
dc.identifier.scopusauthoridWang, M=55018738000en_US
dc.identifier.scopusauthoridTsang, CCC=55224297500en_US
dc.identifier.scopusauthoridTeng, JLL=55224168400en_US
dc.identifier.scopusauthoridBai, R=54896689400en_US
dc.identifier.scopusauthoridLau, JHN=55224048900en_US
dc.identifier.scopusauthoridTsang, AKL=7006979247en_US
dc.identifier.scopusauthoridLau, CCY=55224205700en_US
dc.identifier.scopusauthoridLam, CSF=25950267400en_US
dc.identifier.scopusauthoridLau, SKP=54944624200en_US
dc.identifier.scopusauthoridWoo, PCY=55177222700en_US

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