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Article: Roles for MicroRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1

TitleRoles for MicroRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1
Authors
Issue Date2008
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 2008, v. 68 n. 21, p. 8976-8985 How to Cite?
AbstractA role for microRNAs (miRNA) in human T-cell leukemia virus 1 (HTLV-1)-mediated cellular transformation has not been described. Here,we profiled miRNA expression in HTLV-1-transformed human T-cell lines and primary peripheral blood mononuclear cells from adult T-cell leukemia patients. Analyses of 11 different profiles revealed six miRNAs that were consistently up-regulated. Two of the up-regulated miRNAs (miR-93 and miR-130b) target the 3′ untranslated region (3′UTR) of the mRNA for a tumor suppressor protein, tumor protein 53-induced nuclear protein 1 (TP53INP1). A low expression level of TP53INP1 protein was found in HTLV-1-transformed cells. Additionally,when antagomirs were used to knock down miR-93 and miR-130b in these cells, the expression of TP53INP1 was increased, suggesting that the latter is regulated inside cells by the former. A role for TP53INP1 in regulating cell growth was established by experiments that showed that enhanced TP53INP1 expression increased apoptosis. Collectively,the findings implicate a miR-93/miR-130b-TP53INP1 axis that affects the proliferation and survival of HTLV-1-infected/transformed cells. ©2008 American Association for Cancer Research.
Persistent Identifierhttp://hdl.handle.net/10722/152578
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID
Funding AgencyGrant Number
National Institute of Allergy and Infectious Diseases/NIH
NIH
Funding Information:

Work in K-T. Jeang's laboratory is supported by intramural National Institute of Allergy and Infectious Diseases/NIH funds and funding from the NIH IATAP program.

 

DC FieldValueLanguage
dc.contributor.authorYeung, MLen_US
dc.contributor.authorYasunaga, JIen_US
dc.contributor.authorBennasser, Yen_US
dc.contributor.authorDusetti, Nen_US
dc.contributor.authorHarris, Den_US
dc.contributor.authorAhmad, Nen_US
dc.contributor.authorMatsuoka, Men_US
dc.contributor.authorJeang, KTen_US
dc.date.accessioned2012-07-12T01:51:58Z-
dc.date.available2012-07-12T01:51:58Z-
dc.date.issued2008en_US
dc.identifier.citationCancer Research, 2008, v. 68 n. 21, p. 8976-8985en_US
dc.identifier.issn0008-5472en_US
dc.identifier.urihttp://hdl.handle.net/10722/152578-
dc.description.abstractA role for microRNAs (miRNA) in human T-cell leukemia virus 1 (HTLV-1)-mediated cellular transformation has not been described. Here,we profiled miRNA expression in HTLV-1-transformed human T-cell lines and primary peripheral blood mononuclear cells from adult T-cell leukemia patients. Analyses of 11 different profiles revealed six miRNAs that were consistently up-regulated. Two of the up-regulated miRNAs (miR-93 and miR-130b) target the 3′ untranslated region (3′UTR) of the mRNA for a tumor suppressor protein, tumor protein 53-induced nuclear protein 1 (TP53INP1). A low expression level of TP53INP1 protein was found in HTLV-1-transformed cells. Additionally,when antagomirs were used to knock down miR-93 and miR-130b in these cells, the expression of TP53INP1 was increased, suggesting that the latter is regulated inside cells by the former. A role for TP53INP1 in regulating cell growth was established by experiments that showed that enhanced TP53INP1 expression increased apoptosis. Collectively,the findings implicate a miR-93/miR-130b-TP53INP1 axis that affects the proliferation and survival of HTLV-1-infected/transformed cells. ©2008 American Association for Cancer Research.en_US
dc.languageengen_US
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_US
dc.relation.ispartofCancer Researchen_US
dc.titleRoles for MicroRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1en_US
dc.typeArticleen_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1158/0008-5472.CAN-08-0769en_US
dc.identifier.pmid18974142-
dc.identifier.scopuseid_2-s2.0-55349109615en_US
dc.identifier.volume68en_US
dc.identifier.issue21en_US
dc.identifier.spage8976en_US
dc.identifier.epage8985en_US
dc.identifier.isiWOS:000260698900040-
dc.publisher.placeUnited Statesen_US

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