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Article: Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development

TitleTumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development
Authors
Issue Date2007
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2007, v. 104 n. 41, p. 16170-16175 How to Cite?
Abstract
Pancreatic cancer is a disease with an extremely poor prognosis. Tumor protein 53-induced nuclear protein 1 (TP53INP1) is a proapoptotic stress-induced p53 target gene. In this article, we show by immunohistochemical analysis that TP53INP1 expression is dramatically reduced in pancreatic ductal adenocarcinoma (PDAC) and this decrease occurs early during pancreatic cancer development. TP53INP1 reexpression in the pancreatic cancer-derived cell line MiaPaCa2 strongly reduced its capacity to form s.c., i.p., and intrapancreatic tumors in nude mice. This anti-tumoral capacity is, at least in part, due to the induction of caspase 3-mediated apoptosis. In addition, TP53INP1 -/- mouse embryonic fibroblasts (MEFs) transformed with a retrovirus expressing E1A/ras V12 oncoproteins developed bigger tumors than TP53INP1 +/+ transformed MEFs or TP53INP1 -/- transformed MEFs with restored TP53INP1 expression. Finally, TP53INP1 expression is repressed by the oncogenic micro RNA miR-155, which is overexpressed in PDAC cells. TP53INP1 is a previously unknown miR-155 target presenting anti-tumoral activity. © 2007 by The National Academy of Sciences of the USA.
Persistent Identifierhttp://hdl.handle.net/10722/152576
ISSN
2013 Impact Factor: 9.809
ISI Accession Number ID

 

Author Affiliations
  1. Aix Marseille Université
  2. Kanazawa Medical University
  3. Università degli Studi di Palermo
  4. Inserm
  5. National Institute of Allergy and Infectious Diseases
  6. Vancouver General Hospital
DC FieldValueLanguage
dc.contributor.authorGironella, Men_US
dc.contributor.authorSeux, Men_US
dc.contributor.authorXie, MJen_US
dc.contributor.authorCano, Cen_US
dc.contributor.authorTomasini, Ren_US
dc.contributor.authorGommeaux, Jen_US
dc.contributor.authorGarcia, Sen_US
dc.contributor.authorNowak, Jen_US
dc.contributor.authorYeung, MLen_US
dc.contributor.authorJeang, KTen_US
dc.contributor.authorChaix, Aen_US
dc.contributor.authorFazli, Len_US
dc.contributor.authorMotoo, Yen_US
dc.contributor.authorWang, Qen_US
dc.contributor.authorRocchi, Pen_US
dc.contributor.authorRusso, Aen_US
dc.contributor.authorGleave, Men_US
dc.contributor.authorDagorn, JCen_US
dc.contributor.authorIovanna, JLen_US
dc.contributor.authorCarrier, Aen_US
dc.contributor.authorPébusque, MJen_US
dc.contributor.authorDusetti, NJen_US
dc.date.accessioned2012-07-12T01:51:56Z-
dc.date.available2012-07-12T01:51:56Z-
dc.date.issued2007en_US
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2007, v. 104 n. 41, p. 16170-16175en_US
dc.identifier.issn0027-8424en_US
dc.identifier.urihttp://hdl.handle.net/10722/152576-
dc.description.abstractPancreatic cancer is a disease with an extremely poor prognosis. Tumor protein 53-induced nuclear protein 1 (TP53INP1) is a proapoptotic stress-induced p53 target gene. In this article, we show by immunohistochemical analysis that TP53INP1 expression is dramatically reduced in pancreatic ductal adenocarcinoma (PDAC) and this decrease occurs early during pancreatic cancer development. TP53INP1 reexpression in the pancreatic cancer-derived cell line MiaPaCa2 strongly reduced its capacity to form s.c., i.p., and intrapancreatic tumors in nude mice. This anti-tumoral capacity is, at least in part, due to the induction of caspase 3-mediated apoptosis. In addition, TP53INP1 -/- mouse embryonic fibroblasts (MEFs) transformed with a retrovirus expressing E1A/ras V12 oncoproteins developed bigger tumors than TP53INP1 +/+ transformed MEFs or TP53INP1 -/- transformed MEFs with restored TP53INP1 expression. Finally, TP53INP1 expression is repressed by the oncogenic micro RNA miR-155, which is overexpressed in PDAC cells. TP53INP1 is a previously unknown miR-155 target presenting anti-tumoral activity. © 2007 by The National Academy of Sciences of the USA.en_US
dc.languageengen_US
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_US
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.titleTumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor developmenten_US
dc.typeArticleen_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1073/pnas.0703942104en_US
dc.identifier.pmid17911264-
dc.identifier.scopuseid_2-s2.0-36048952786en_US
dc.identifier.volume104en_US
dc.identifier.issue41en_US
dc.identifier.spage16170en_US
dc.identifier.epage16175en_US
dc.identifier.isiWOS:000250128800037-
dc.publisher.placeUnited Statesen_US
dc.identifier.citeulike2795096-

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