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- Publisher Website: 10.2165/00063030-200721010-00003
- Scopus: eid_2-s2.0-33846900241
- PMID: 17263586
- WOS: WOS:000244286200003
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Article: RNAi therapy for HIV infection: principles and practicalities
Title | RNAi therapy for HIV infection: principles and practicalities |
---|---|
Authors | |
Issue Date | 2007 |
Publisher | Adis International Ltd. The Journal's web site is located at http://biodrugs.adisonline.com/ |
Citation | Biodrugs, 2007, v. 21 n. 1, p. 17-22 How to Cite? |
Abstract | Inside eukaryotic cells, small RNA duplexes, called small interfering RNAs (siRNAs), activate a conserved RNA interference (RNAi) pathway which leads to specific degradation of complementary target mRNAs through base-pairing recognition. As with other viruses, studies have shown that replication of the HIV-1 in cultured cells can be targeted and inhibited by synthetic siRNAs. The relative ease of siRNA design and the versatility of RNAi to target a broad spectrum of mRNAs have led to the promise that drug discovery in the RNAi pathway could be effective against pathogens. This review discusses the current experimental principles that guide the application of RNAi against HIV and describes challenges and limitations that need to be surmounted in order for siRNAs to become practical antiviral drugs. The practical use of RNAi therapy for HIV infection will depend on overcoming several challenges, including the ability to establish long-term expression of siRNA without off-target effects and the capacity to counteract mutant escape viruses. © 2007 Adis Data Information BV. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/152575 |
ISSN | 2023 Impact Factor: 5.4 2023 SCImago Journal Rankings: 1.796 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bennasser, Y | en_US |
dc.contributor.author | Yeung, ML | en_US |
dc.contributor.author | Jeang, KT | en_US |
dc.date.accessioned | 2012-07-12T01:51:54Z | - |
dc.date.available | 2012-07-12T01:51:54Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.citation | Biodrugs, 2007, v. 21 n. 1, p. 17-22 | en_US |
dc.identifier.issn | 1173-8804 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/152575 | - |
dc.description.abstract | Inside eukaryotic cells, small RNA duplexes, called small interfering RNAs (siRNAs), activate a conserved RNA interference (RNAi) pathway which leads to specific degradation of complementary target mRNAs through base-pairing recognition. As with other viruses, studies have shown that replication of the HIV-1 in cultured cells can be targeted and inhibited by synthetic siRNAs. The relative ease of siRNA design and the versatility of RNAi to target a broad spectrum of mRNAs have led to the promise that drug discovery in the RNAi pathway could be effective against pathogens. This review discusses the current experimental principles that guide the application of RNAi against HIV and describes challenges and limitations that need to be surmounted in order for siRNAs to become practical antiviral drugs. The practical use of RNAi therapy for HIV infection will depend on overcoming several challenges, including the ability to establish long-term expression of siRNA without off-target effects and the capacity to counteract mutant escape viruses. © 2007 Adis Data Information BV. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Adis International Ltd. The Journal's web site is located at http://biodrugs.adisonline.com/ | en_US |
dc.relation.ispartof | BioDrugs | en_US |
dc.subject.mesh | Hiv Infections - Drug Therapy | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Rna Interference | en_US |
dc.subject.mesh | Rna, Small Interfering - Adverse Effects - Pharmacology - Therapeutic Use | en_US |
dc.subject.mesh | Virus Replication - Drug Effects | en_US |
dc.title | RNAi therapy for HIV infection: principles and practicalities | en_US |
dc.type | Article | en_US |
dc.identifier.email | Man, LY:pmlyeung@hku.hk | en_US |
dc.identifier.authority | Man, LY=rp01402 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.2165/00063030-200721010-00003 | en_US |
dc.identifier.pmid | 17263586 | - |
dc.identifier.scopus | eid_2-s2.0-33846900241 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33846900241&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 21 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 17 | en_US |
dc.identifier.epage | 22 | en_US |
dc.identifier.isi | WOS:000244286200003 | - |
dc.publisher.place | New Zealand | en_US |
dc.identifier.scopusauthorid | Bennasser, Y=8335747500 | en_US |
dc.identifier.scopusauthorid | Man, LY=15843370500 | en_US |
dc.identifier.scopusauthorid | Jeang, KT=7004824803 | en_US |
dc.identifier.issnl | 1173-8804 | - |