File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: RNAi therapy for HIV infection: principles and practicalities

TitleRNAi therapy for HIV infection: principles and practicalities
Authors
Issue Date2007
PublisherAdis International Ltd. The Journal's web site is located at http://biodrugs.adisonline.com/
Citation
Biodrugs, 2007, v. 21 n. 1, p. 17-22 How to Cite?
AbstractInside eukaryotic cells, small RNA duplexes, called small interfering RNAs (siRNAs), activate a conserved RNA interference (RNAi) pathway which leads to specific degradation of complementary target mRNAs through base-pairing recognition. As with other viruses, studies have shown that replication of the HIV-1 in cultured cells can be targeted and inhibited by synthetic siRNAs. The relative ease of siRNA design and the versatility of RNAi to target a broad spectrum of mRNAs have led to the promise that drug discovery in the RNAi pathway could be effective against pathogens. This review discusses the current experimental principles that guide the application of RNAi against HIV and describes challenges and limitations that need to be surmounted in order for siRNAs to become practical antiviral drugs. The practical use of RNAi therapy for HIV infection will depend on overcoming several challenges, including the ability to establish long-term expression of siRNA without off-target effects and the capacity to counteract mutant escape viruses. © 2007 Adis Data Information BV. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/152575
ISSN
2015 Impact Factor: 2.867
2015 SCImago Journal Rankings: 0.862
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBennasser, Yen_US
dc.contributor.authorYeung, MLen_US
dc.contributor.authorJeang, KTen_US
dc.date.accessioned2012-07-12T01:51:54Z-
dc.date.available2012-07-12T01:51:54Z-
dc.date.issued2007en_US
dc.identifier.citationBiodrugs, 2007, v. 21 n. 1, p. 17-22en_US
dc.identifier.issn1173-8804en_US
dc.identifier.urihttp://hdl.handle.net/10722/152575-
dc.description.abstractInside eukaryotic cells, small RNA duplexes, called small interfering RNAs (siRNAs), activate a conserved RNA interference (RNAi) pathway which leads to specific degradation of complementary target mRNAs through base-pairing recognition. As with other viruses, studies have shown that replication of the HIV-1 in cultured cells can be targeted and inhibited by synthetic siRNAs. The relative ease of siRNA design and the versatility of RNAi to target a broad spectrum of mRNAs have led to the promise that drug discovery in the RNAi pathway could be effective against pathogens. This review discusses the current experimental principles that guide the application of RNAi against HIV and describes challenges and limitations that need to be surmounted in order for siRNAs to become practical antiviral drugs. The practical use of RNAi therapy for HIV infection will depend on overcoming several challenges, including the ability to establish long-term expression of siRNA without off-target effects and the capacity to counteract mutant escape viruses. © 2007 Adis Data Information BV. All rights reserved.en_US
dc.languageengen_US
dc.publisherAdis International Ltd. The Journal's web site is located at http://biodrugs.adisonline.com/en_US
dc.relation.ispartofBioDrugsen_US
dc.subject.meshHiv Infections - Drug Therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshRna Interferenceen_US
dc.subject.meshRna, Small Interfering - Adverse Effects - Pharmacology - Therapeutic Useen_US
dc.subject.meshVirus Replication - Drug Effectsen_US
dc.titleRNAi therapy for HIV infection: principles and practicalitiesen_US
dc.typeArticleen_US
dc.identifier.emailMan, LY:pmlyeung@hku.hken_US
dc.identifier.authorityMan, LY=rp01402en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.2165/00063030-200721010-00003en_US
dc.identifier.pmid17263586-
dc.identifier.scopuseid_2-s2.0-33846900241en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846900241&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume21en_US
dc.identifier.issue1en_US
dc.identifier.spage17en_US
dc.identifier.epage22en_US
dc.identifier.isiWOS:000244286200003-
dc.publisher.placeNew Zealanden_US
dc.identifier.scopusauthoridBennasser, Y=8335747500en_US
dc.identifier.scopusauthoridMan, LY=15843370500en_US
dc.identifier.scopusauthoridJeang, KT=7004824803en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats