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Conference Paper: CNS regeneration after chronic injury using a self-assembled nano material

TitleCNS regeneration after chronic injury using a self-assembled nano material
Authors
KeywordsChronic CNS regeneration
In vivo
MEMRI
MnCl 2
Self-assembled materials
Issue Date2011
Citation
Technical Proceedings Of The 2011 Nsti Nanotechnology Conference And Expo, Nsti-Nanotech 2011, 2011, v. 3, p. 424-427 How to Cite?
AbstractTo speed up the process of central nervous system (CNS) recovery after injury, the need for real-time measurement of axon regeneration in vivo is essential to assess the extent of injury, as well as the optimal timing and delivery of therapeutics and rehabilitation. It was necessary to develop a chronic animal model with an in vivo measurement technique to provide a real-time monitoring and feedback system. Using non-invasive magnetic resonance imaging (MRI) and a manganese (MnCl 2) contrast agent we show a successful chronic injury model to measure CNS regeneration. We also show that a chronic optic tract (OT) lesion is able to heal, and axons are able to regenerate, when treated with a self-assembling nanofiber peptide scaffold (SAPNS). With the combination of the injury model and the time series of scans we were able to show how they can be combined to produce a system that can be used to follow regenerationin vivo to provide real-time feedback during every stage of the regeneration process. We also were able to show that rengeration can be effected 100 days post injury when applied to the chronic wound.
Persistent Identifierhttp://hdl.handle.net/10722/152060
References

 

DC FieldValueLanguage
dc.contributor.authorLiang, YXen_HK
dc.contributor.authorCheung, SWHen_HK
dc.contributor.authorChan, KCWen_HK
dc.contributor.authorWu, EXen_HK
dc.contributor.authorTay, DKCen_HK
dc.contributor.authorEllisBehnke, RGen_HK
dc.date.accessioned2012-06-26T06:33:52Z-
dc.date.available2012-06-26T06:33:52Z-
dc.date.issued2011en_HK
dc.identifier.citationTechnical Proceedings Of The 2011 Nsti Nanotechnology Conference And Expo, Nsti-Nanotech 2011, 2011, v. 3, p. 424-427en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152060-
dc.description.abstractTo speed up the process of central nervous system (CNS) recovery after injury, the need for real-time measurement of axon regeneration in vivo is essential to assess the extent of injury, as well as the optimal timing and delivery of therapeutics and rehabilitation. It was necessary to develop a chronic animal model with an in vivo measurement technique to provide a real-time monitoring and feedback system. Using non-invasive magnetic resonance imaging (MRI) and a manganese (MnCl 2) contrast agent we show a successful chronic injury model to measure CNS regeneration. We also show that a chronic optic tract (OT) lesion is able to heal, and axons are able to regenerate, when treated with a self-assembling nanofiber peptide scaffold (SAPNS). With the combination of the injury model and the time series of scans we were able to show how they can be combined to produce a system that can be used to follow regenerationin vivo to provide real-time feedback during every stage of the regeneration process. We also were able to show that rengeration can be effected 100 days post injury when applied to the chronic wound.en_HK
dc.languageengen_US
dc.relation.ispartofTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011en_HK
dc.subjectChronic CNS regenerationen_HK
dc.subjectIn vivoen_HK
dc.subjectMEMRIen_HK
dc.subjectMnCl 2en_HK
dc.subjectSelf-assembled materialsen_HK
dc.titleCNS regeneration after chronic injury using a self-assembled nano materialen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLiang, YX: yxliang@hkucc.hku.hken_HK
dc.identifier.emailCheung, SWH: sunnycwh@hku.hken_HK
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_HK
dc.identifier.emailTay, DKC: dkctay@hkucc.hku.hken_HK
dc.identifier.emailEllisBehnke, RG: rutledg@mit.eduen_HK
dc.identifier.authorityLiang, YX=rp00510en_HK
dc.identifier.authorityCheung, SWH=rp00246en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.identifier.authorityTay, DKC=rp00336en_HK
dc.identifier.authorityEllisBehnke, RG=rp00252en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-81455132753en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-81455132753&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume3en_HK
dc.identifier.spage424en_HK
dc.identifier.epage427en_HK
dc.identifier.scopusauthoridLiang, YX=55479398500en_HK
dc.identifier.scopusauthoridCheung, SWH=36152058800en_HK
dc.identifier.scopusauthoridChan, KCW=34968940300en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.scopusauthoridTay, DKC=55392935900en_HK
dc.identifier.scopusauthoridEllisBehnke, RG=8548055200en_HK

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