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Conference Paper: Forever young: How to control the elongation, differentiation, and proliferation of cells using nanotechnology

TitleForever young: How to control the elongation, differentiation, and proliferation of cells using nanotechnology
Authors
KeywordsBrain
Growth control
Nanotechnology
Neural precursors
PC12
Regeneration
Schwann cells
Self-assembling nanofiber scaffold (sapns)
Spinal cord
Stem cells
Tissue engineering
Issue Date2009
Citation
Cell Transplantation, 2009, v. 18 n. 9, p. 1047-1058 How to Cite?
AbstractWithin the emerging field of stem cells there is a need for an environment that can regulate cell activity, to slow down differentiation or proliferation, in vitro or in vivo while remaining invisible to the immune system. By creating a nanoenvironment surrounding PC12 cells, Schwann cells, and neural precursor cells (NPCs), we were able to control the proliferation, elongation, differentiation, and maturation in vitro. We extended the method, using self-assembling nanofiber scaffold (SAPNS), to living animals with implants in the brain and spinal cord. Here we show that when cells are placed in a defined system we can delay their proliferation, differentiation, and maturation depending on the density of the cell population, density of the matrix, and the local environment. A combination of SAPNS and young cells can be implanted into the central nervous system (CNS), eliminating the need for immunosuppressants. Copyright © 2009 Cognizant Comm. Corp.
Persistent Identifierhttp://hdl.handle.net/10722/152059
ISSN
2015 Impact Factor: 3.427
2015 SCImago Journal Rankings: 1.161
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorEllisBehnke, RGen_HK
dc.contributor.authorLiang, YXen_HK
dc.contributor.authorGuo, Jen_HK
dc.contributor.authorTay, DKCen_HK
dc.contributor.authorSchneider, GEen_HK
dc.contributor.authorTeather, LAen_HK
dc.contributor.authorWu, Wen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2012-06-26T06:33:51Z-
dc.date.available2012-06-26T06:33:51Z-
dc.date.issued2009en_HK
dc.identifier.citationCell Transplantation, 2009, v. 18 n. 9, p. 1047-1058en_US
dc.identifier.issn0963-6897en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152059-
dc.description.abstractWithin the emerging field of stem cells there is a need for an environment that can regulate cell activity, to slow down differentiation or proliferation, in vitro or in vivo while remaining invisible to the immune system. By creating a nanoenvironment surrounding PC12 cells, Schwann cells, and neural precursor cells (NPCs), we were able to control the proliferation, elongation, differentiation, and maturation in vitro. We extended the method, using self-assembling nanofiber scaffold (SAPNS), to living animals with implants in the brain and spinal cord. Here we show that when cells are placed in a defined system we can delay their proliferation, differentiation, and maturation depending on the density of the cell population, density of the matrix, and the local environment. A combination of SAPNS and young cells can be implanted into the central nervous system (CNS), eliminating the need for immunosuppressants. Copyright © 2009 Cognizant Comm. Corp.en_HK
dc.languageengen_US
dc.relation.ispartofCell Transplantationen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectBrainen_HK
dc.subjectGrowth controlen_HK
dc.subjectNanotechnologyen_HK
dc.subjectNeural precursorsen_HK
dc.subjectPC12en_HK
dc.subjectRegenerationen_HK
dc.subjectSchwann cellsen_HK
dc.subjectSelf-assembling nanofiber scaffold (sapns)en_HK
dc.subjectSpinal corden_HK
dc.subjectStem cellsen_HK
dc.subjectTissue engineeringen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshBrain - Cytologyen_US
dc.subject.meshCell Differentiation - Genetics - Physiologyen_US
dc.subject.meshCell Proliferationen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshMesocricetusen_US
dc.subject.meshNanofibersen_US
dc.subject.meshNanotechnology - Methodsen_US
dc.subject.meshNeurons - Cytologyen_US
dc.subject.meshPc12 Cells - Cytologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshRats, Transgenicen_US
dc.subject.meshSchwann Cells - Cytologyen_US
dc.subject.meshSpinal Cord - Cytologyen_US
dc.subject.meshTissue Engineering - Methodsen_US
dc.subject.meshTissue Scaffolds - Chemistryen_US
dc.titleForever young: How to control the elongation, differentiation, and proliferation of cells using nanotechnologyen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailEllisBehnke, RG: rutledg@mit.eduen_HK
dc.identifier.emailLiang, YX: yxliang@hkucc.hku.hken_HK
dc.identifier.emailTay, DKC: dkctay@hkucc.hku.hken_HK
dc.identifier.emailWu, W: wtwu@hkucc.hku.hken_HK
dc.identifier.emailSo, KF: hrmaskf@hku.hken_HK
dc.identifier.authorityEllisBehnke, RG=rp00252en_HK
dc.identifier.authorityLiang, YX=rp00510en_HK
dc.identifier.authorityTay, DKC=rp00336en_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.3727/096368909X471242en_HK
dc.identifier.pmid20040141-
dc.identifier.scopuseid_2-s2.0-74049118068en_HK
dc.identifier.hkuros162718-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-74049118068&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1047en_HK
dc.identifier.epage1058en_HK
dc.identifier.isiWOS:000273699100010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridEllisBehnke, RG=8548055200en_HK
dc.identifier.scopusauthoridLiang, YX=55479398500en_HK
dc.identifier.scopusauthoridGuo, J=7404488603en_HK
dc.identifier.scopusauthoridTay, DKC=55392935900en_HK
dc.identifier.scopusauthoridSchneider, GE=55057824300en_HK
dc.identifier.scopusauthoridTeather, LA=6602829059en_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.citeulike6473022-

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