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Conference Paper: Diffusion tensor MR study of optic nerve degeneration in glaucoma

TitleDiffusion tensor MR study of optic nerve degeneration in glaucoma
Authors
KeywordsDiffusivity
DTI
Glaucoma
Neurodegeneration
Issue Date2007
Citation
Annual International Conference Of The Ieee Engineering In Medicine And Biology - Proceedings, 2007, p. 4312-4315 How to Cite?
AbstractAxonal degeneration has been known to occur in the optic nerve (ON) of rat glaucoma model. Recently, quantitative diffusion tensor imaging (DTI) has been developed to investigate various white matter diseases in vivo. In this study, longitudinal DTI was thus employed to study such animal model in the present study. The results showed that radial diffusivity (λ⊥) and fractional anisotropy (FA) of the glaucomatous ON (gON) was increasing and decreasing respectively with time after glaucoma induction, whereas there was no significant change in the axial diffusivity (λ//). Supported by the histological staining of the ON, such changes in the two DTI-derived parameters were attributed to the 10% decrease in the axonal density of the gON as compared to nON. It was shown for the first time that DTI can be sensitive enough to detect axonal degeneration in rat glaucoma model. DTI therefore holds promise for reliable diagnoses and assessment of the glaucoma disease in human upon careful interpretation of the DTI-derived directional diffusivities. © 2007 IEEE.
Persistent Identifierhttp://hdl.handle.net/10722/152058
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorHui, ESen_HK
dc.contributor.authorFu, QLen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2012-06-26T06:33:50Z-
dc.date.available2012-06-26T06:33:50Z-
dc.date.issued2007en_HK
dc.identifier.citationAnnual International Conference Of The Ieee Engineering In Medicine And Biology - Proceedings, 2007, p. 4312-4315en_HK
dc.identifier.issn0589-1019en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152058-
dc.description.abstractAxonal degeneration has been known to occur in the optic nerve (ON) of rat glaucoma model. Recently, quantitative diffusion tensor imaging (DTI) has been developed to investigate various white matter diseases in vivo. In this study, longitudinal DTI was thus employed to study such animal model in the present study. The results showed that radial diffusivity (λ⊥) and fractional anisotropy (FA) of the glaucomatous ON (gON) was increasing and decreasing respectively with time after glaucoma induction, whereas there was no significant change in the axial diffusivity (λ//). Supported by the histological staining of the ON, such changes in the two DTI-derived parameters were attributed to the 10% decrease in the axonal density of the gON as compared to nON. It was shown for the first time that DTI can be sensitive enough to detect axonal degeneration in rat glaucoma model. DTI therefore holds promise for reliable diagnoses and assessment of the glaucoma disease in human upon careful interpretation of the DTI-derived directional diffusivities. © 2007 IEEE.en_HK
dc.languageengen_US
dc.relation.ispartofAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedingsen_HK
dc.subjectDiffusivityen_HK
dc.subjectDTIen_HK
dc.subjectGlaucomaen_HK
dc.subjectNeurodegenerationen_HK
dc.titleDiffusion tensor MR study of optic nerve degeneration in glaucomaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1109/IEMBS.2007.4353290en_HK
dc.identifier.pmid18002956-
dc.identifier.scopuseid_2-s2.0-57649225851en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-57649225851&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.spage4312en_HK
dc.identifier.epage4315en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHui, ES=16175117100en_HK
dc.identifier.scopusauthoridFu, QL=23388762000en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

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