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Article: Effect of carotid atherosclerosis on mild cognitive impairment

TitleEffect of carotid atherosclerosis on mild cognitive impairment
Authors
KeywordsCarotid Artery Diseases
Cognition Disorders
Memory
Mental Status Schedule
Issue Date2010
Citation
Chinese Journal Of Neurology, 2010, v. 43 n. 9, p. 617-621 How to Cite?
AbstractObjective: To examine the effect of carotid atherosclerosis on mild cognitive impairment (MCI). Methods: 1886 relatively healthy Guangzhou residents without history of stroke, myocardial infarction, pulmonary heart disease and malignant tumor were recruited in this study by simple random selection. MCI and carotid color ultrasound were measured in these subjects by using the Mini Mental State Examination (MMSE), the 10-word list learning task (CWL) and common carotid artery intima-medial thickness (IMT) as indicators. Results: (1) The 300 (15.9%) subjects with MCI were identified. No significant difference in MCI prevalence between the sexes was identified. (2) Significant associations between CWL and traditional cardiovascular risk factors, such as older age, smoking and increased waist circumference, blood pressure and lipids were found. (3) After adjusting for multiple potential confounders, increasing IMT was significantly associated with both decreased CWL (β=-1.05, 95% CI: -1.73 - -0.36) and MMSE score (β=-0.95, 95% CI: -1.67--0.23). (4) After adjusting for age, sex, education, physical activity, smoking, waist circumference and high- and low-density lipoprotein cholesterol, IMT was significantly thicker in the MCI group than the normal (0.76 mm vs 0.74 mm, F=6.9, P < 0.01). Conclusions: The severity of MCI was significantly and linearly associated with increased IMT, suggesting that preventing atherosclerosis may help to reduce the incidence and development of dementia.
Persistent Identifierhttp://hdl.handle.net/10722/151773
ISSN
2015 SCImago Journal Rankings: 0.103
References

 

DC FieldValueLanguage
dc.contributor.authorJiang, CQen_US
dc.contributor.authorXu, Len_US
dc.contributor.authorLam, TQen_US
dc.contributor.authorLin, JMen_US
dc.contributor.authorLiu, Ben_US
dc.contributor.authorJin, YLen_US
dc.contributor.authorZhang, WSen_US
dc.contributor.authorYue, XJen_US
dc.contributor.authorCheng, KKen_US
dc.contributor.authorThomas, GNen_US
dc.date.accessioned2012-06-26T06:28:13Z-
dc.date.available2012-06-26T06:28:13Z-
dc.date.issued2010en_US
dc.identifier.citationChinese Journal Of Neurology, 2010, v. 43 n. 9, p. 617-621en_US
dc.identifier.issn1006-7876en_US
dc.identifier.urihttp://hdl.handle.net/10722/151773-
dc.description.abstractObjective: To examine the effect of carotid atherosclerosis on mild cognitive impairment (MCI). Methods: 1886 relatively healthy Guangzhou residents without history of stroke, myocardial infarction, pulmonary heart disease and malignant tumor were recruited in this study by simple random selection. MCI and carotid color ultrasound were measured in these subjects by using the Mini Mental State Examination (MMSE), the 10-word list learning task (CWL) and common carotid artery intima-medial thickness (IMT) as indicators. Results: (1) The 300 (15.9%) subjects with MCI were identified. No significant difference in MCI prevalence between the sexes was identified. (2) Significant associations between CWL and traditional cardiovascular risk factors, such as older age, smoking and increased waist circumference, blood pressure and lipids were found. (3) After adjusting for multiple potential confounders, increasing IMT was significantly associated with both decreased CWL (β=-1.05, 95% CI: -1.73 - -0.36) and MMSE score (β=-0.95, 95% CI: -1.67--0.23). (4) After adjusting for age, sex, education, physical activity, smoking, waist circumference and high- and low-density lipoprotein cholesterol, IMT was significantly thicker in the MCI group than the normal (0.76 mm vs 0.74 mm, F=6.9, P < 0.01). Conclusions: The severity of MCI was significantly and linearly associated with increased IMT, suggesting that preventing atherosclerosis may help to reduce the incidence and development of dementia.en_US
dc.languageengen_US
dc.relation.ispartofChinese Journal of Neurologyen_US
dc.subjectCarotid Artery Diseasesen_US
dc.subjectCognition Disordersen_US
dc.subjectMemoryen_US
dc.subjectMental Status Scheduleen_US
dc.titleEffect of carotid atherosclerosis on mild cognitive impairmenten_US
dc.typeArticleen_US
dc.identifier.emailLam, TQ:hrmrlth@hkucc.hku.hken_US
dc.identifier.authorityLam, TQ=rp00326en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.3760/cma.j.issn.1006-7876.2010.09.005en_US
dc.identifier.scopuseid_2-s2.0-84860623350en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84860623350&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume43en_US
dc.identifier.issue9en_US
dc.identifier.spage617en_US
dc.identifier.epage621en_US
dc.identifier.scopusauthoridJiang, CQ=10639500500en_US
dc.identifier.scopusauthoridXu, L=53878780900en_US
dc.identifier.scopusauthoridLam, TQ=7202522876en_US
dc.identifier.scopusauthoridLin, JM=55209071900en_US
dc.identifier.scopusauthoridLiu, B=55209095000en_US
dc.identifier.scopusauthoridJin, YL=35558481400en_US
dc.identifier.scopusauthoridZhang, WS=13410704100en_US
dc.identifier.scopusauthoridYue, XJ=55208326600en_US
dc.identifier.scopusauthoridCheng, KK=7402997800en_US
dc.identifier.scopusauthoridThomas, GN=35465269900en_US

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