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Article: Viral genetic sequence variations in pandemic H1N1/2009 and seasonal H3N2 influenza viruses within an individual, a household and a community

TitleViral genetic sequence variations in pandemic H1N1/2009 and seasonal H3N2 influenza viruses within an individual, a household and a community
Authors
KeywordsEpidemiology
Influenza virus
Pandemic H1N1
Sequence variation
Issue Date2011
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jcv
Citation
Journal of Clinical Virology, 2011, v. 52 n. 2, p. 146-150 How to Cite?
Abstract
Background: There are few data in the literature on viral sequence variation between host generations/successive transmission events. Relatively little is known about the sequence heterogeneity of the influenza viruses transmitted within families. Objectives: To study the molecular epidemiology of influenza virus and to determine the sequence variation within an individual, a household and a community during the first wave of influenza pandemic in 2009. Study design: A prospective study of household transmission of influenza A in Hong Kong was conducted during the pandemic in 2009. The HA and NA sequences of pandemic and seasonal influenza A viral isolates identified in this household transmission study were sequences and analyzed. Results: Our results indicated that there were multiple introductions of influenza viruses into Hong Kong. Sequence analysis of these isolates suggested that members of these family clusters acquired the infection by household transmissions. Interestingly, unlike those concluded from previous household transmission studies, we observed sequence variations between sequential samples from the same person and also within the same household. Conclusions: Family clusters of influenza A viral infection are predominantly the result of secondary transmission within a household. Our results also suggested that the intra-host viral sequence variation might be more common that than previously thought. © 2011 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/151754
ISSN
2013 Impact Factor: 3.466
2013 SCImago Journal Rankings: 1.812
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
University Grants Committee Hong KongAoE/M-12/06
Food and Health Bureau, the NIH (NIAID)HHS-N266200700005C
N01-AI-70005
Harvard Center for Communicable Disease Dynamics from the National Institute of General Medical SciencesU54 GM088558
Funding Information:

This study was supported by the Area of Excellence Scheme of the University Grants Committee Hong Kong (AoE/M-12/06), the Research Fund for the Control of Infectious Disease Commissioned Project from Food and Health Bureau, the NIH (NIAID contracts HHS-N266200700005C and N01-AI-70005), and the Harvard Center for Communicable Disease Dynamics from the National Institute of General Medical Sciences (grant number U54 GM088558). The funding bodies were not involved in the collection, analysis and interpretation of data, the writing of the manuscript, or the decision to submit for publication. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of General Medical Sciences or the National Institutes of Health.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorPoon, LLMen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorChu, DKWen_HK
dc.contributor.authorFung, CCYen_HK
dc.contributor.authorCheng, CKYen_HK
dc.contributor.authorIp, DKMen_HK
dc.contributor.authorLeung, GMen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorCowling, BJen_HK
dc.date.accessioned2012-06-26T06:27:52Z-
dc.date.available2012-06-26T06:27:52Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal of Clinical Virology, 2011, v. 52 n. 2, p. 146-150en_HK
dc.identifier.issn1386-6532en_HK
dc.identifier.urihttp://hdl.handle.net/10722/151754-
dc.description.abstractBackground: There are few data in the literature on viral sequence variation between host generations/successive transmission events. Relatively little is known about the sequence heterogeneity of the influenza viruses transmitted within families. Objectives: To study the molecular epidemiology of influenza virus and to determine the sequence variation within an individual, a household and a community during the first wave of influenza pandemic in 2009. Study design: A prospective study of household transmission of influenza A in Hong Kong was conducted during the pandemic in 2009. The HA and NA sequences of pandemic and seasonal influenza A viral isolates identified in this household transmission study were sequences and analyzed. Results: Our results indicated that there were multiple introductions of influenza viruses into Hong Kong. Sequence analysis of these isolates suggested that members of these family clusters acquired the infection by household transmissions. Interestingly, unlike those concluded from previous household transmission studies, we observed sequence variations between sequential samples from the same person and also within the same household. Conclusions: Family clusters of influenza A viral infection are predominantly the result of secondary transmission within a household. Our results also suggested that the intra-host viral sequence variation might be more common that than previously thought. © 2011 Elsevier B.V.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jcven_HK
dc.relation.ispartofJournal of Clinical Virologyen_HK
dc.subjectEpidemiologyen_HK
dc.subjectInfluenza virusen_HK
dc.subjectPandemic H1N1en_HK
dc.subjectSequence variationen_HK
dc.subject.meshFamily Characteristicsen_US
dc.subject.meshGenetic Variationen_US
dc.subject.meshHemagglutinin Glycoproteins, Influenza Virus - Geneticsen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInfluenza A Virus, H1n1 Subtype - Classification - Genetics - Isolation & Purificationen_US
dc.subject.meshInfluenza A Virus, H3n2 Subtype - Classification - Genetics - Isolation & Purificationen_US
dc.subject.meshInfluenza, Human - Epidemiology - Virologyen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshNeuraminidase - Geneticsen_US
dc.subject.meshPandemicsen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshResidence Characteristicsen_US
dc.subject.meshSeasonsen_US
dc.subject.meshViral Proteins - Geneticsen_US
dc.titleViral genetic sequence variations in pandemic H1N1/2009 and seasonal H3N2 influenza viruses within an individual, a household and a communityen_HK
dc.typeArticleen_HK
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_HK
dc.identifier.emailChan, KH: chankh2@hkucc.hku.hken_HK
dc.identifier.emailChu, KW: dkwchu@hku.hken_HK
dc.identifier.emailFung, CCY: ccyfung@hku.hken_HK
dc.identifier.emailCheng, KY: chengkyc@hkucc.hku.hken_HK
dc.identifier.emailIp, DKM: dkmip@hku.hk-
dc.identifier.emailLeung, GM: gmleung@hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.authorityPoon, LLM=rp00484en_HK
dc.identifier.authorityIp, DKM=rp00256en_HK
dc.identifier.authorityLeung, GM=rp00460en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityCowling, BJ=rp01326en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1016/j.jcv.2011.06.022en_HK
dc.identifier.pmid21802983en_HK
dc.identifier.pmcidPMC3175291-
dc.identifier.scopuseid_2-s2.0-80052714037en_HK
dc.identifier.hkuros203694-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052714037&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume52en_HK
dc.identifier.issue2en_HK
dc.identifier.spage146en_HK
dc.identifier.epage150en_HK
dc.identifier.isiWOS:000295535500017-
dc.publisher.placeNetherlandsen_HK
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridPoon, LLM=7005441747en_HK
dc.identifier.scopusauthoridChan, KH=37116702500en_HK
dc.identifier.scopusauthoridChu, DKW=7201734326en_HK
dc.identifier.scopusauthoridFung, CCY=55197922400en_HK
dc.identifier.scopusauthoridCheng, CKY=24474272100en_HK
dc.identifier.scopusauthoridIp, DKM=35117701600en_HK
dc.identifier.scopusauthoridLeung, GM=7007159841en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridCowling, BJ=8644765500en_HK
dc.identifier.citeulike9628374-

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