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Article: White blood cell subsets are associated with carotid intima-media thickness and pulse wave velocity in an older Chinese population: the Guangzhou Biobank Cohort Study
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TitleWhite blood cell subsets are associated with carotid intima-media thickness and pulse wave velocity in an older Chinese population: the Guangzhou Biobank Cohort Study
 
AuthorsPhillips, AC2
Jiang, CQ3
Thomas, GN2
Lin, JM3
Yue, XJ3
Cheng, KK2
Jin, YL3
Zhang, WS3
Lam, TH1
 
Issue Date2011
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhh
 
CitationJournal Of Human Hypertension, 2012, v. 26 n. 8, p. 485-492 [How to Cite?]
DOI: http://dx.doi.org/10.1038/jhh.2011.58
 
AbstractCross-sectional associations between white blood cell (WBC) count, lymphocyte and granulocyte numbers, and carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (PWV) were examined in a novel older Chinese community sample. A total of 817 men and 760 women from a sub-study of the Guangzhou Biobank Cohort Study had a full blood count measured by an automated hematology analyzer, carotid IMT by B-mode ultrasonography and brachial-ankle PWV by a non-invasive automatic waveform analyzer. Following adjustment for confounders, WBC count (β=0.07, P<0.001) and granulocyte (β=0.07, P<0.001) number were significantly positively related to PWV, but not lymphocyte number. Similarly, WBC count (β=0.08, P=0.03), lymphocyte (β=0.08, P=0.002) and granulocyte (β=0.03, P=0.04) number were significantly positively associated with carotid IMT, but only the association with lymphocyte count survived correction for other cardiovascular risk factors. In conclusion, higher WBC, particularly lymphocyte and granulocyte, count could be used, respectively, as markers of cardiovascular disease risk, measured through indicators of atherosclerosis and arterial stiffness. The associations for WBC count previously observed by others were likely driven by higher granulocytes; an index of systemic inflammation.Journal of Human Hypertension advance online publication, 9 June 2011; doi:10.1038/jhh.2011.58.
 
ISSN0950-9240
2013 Impact Factor: 2.692
2013 SCImago Journal Rankings: 1.177
 
DOIhttp://dx.doi.org/10.1038/jhh.2011.58
 
ISI Accession Number IDWOS:000306360500003
Funding AgencyGrant Number
National Natural Science Foundation of China/Research Grants Council30518001
HKU720/05
University of Hong Kong Foundation for Education and Science, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
University of Birmingham, UK
Funding Information:

The study is funded by the National Natural Science Foundation of China/Research Grants Council (No. 30518001; HKU720/05) grant. The main cohort study was funded by The University of Hong Kong Foundation for Education and Science, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and The University of Birmingham, UK. The Guangzhou Cohort Study-Cardiovascular Disease Subcohort (GBCS-CVD) investigators include Guangzhou No. 12 Hospital: Jie Ming Lin, Bin Liu, Xiao Jun Yue, Chao Qiang Jiang (Co-PI); The University of Hong Kong: Bernard MY Cheung, Tai Hing Lam (Co-PI); The Chinese University of Hong Kong: Brian Tomlinson, Ka Sing Wong; The University of Birmingham: Kar Keung Cheng, Shahrad Taheri, Paramjit Gill, Greg YH Lip, G Neil Thomas (Co-PI).

 
DC FieldValue
dc.contributor.authorPhillips, AC
 
dc.contributor.authorJiang, CQ
 
dc.contributor.authorThomas, GN
 
dc.contributor.authorLin, JM
 
dc.contributor.authorYue, XJ
 
dc.contributor.authorCheng, KK
 
dc.contributor.authorJin, YL
 
dc.contributor.authorZhang, WS
 
dc.contributor.authorLam, TH
 
dc.date.accessioned2012-06-26T06:27:46Z
 
dc.date.available2012-06-26T06:27:46Z
 
dc.date.issued2011
 
dc.description.abstractCross-sectional associations between white blood cell (WBC) count, lymphocyte and granulocyte numbers, and carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (PWV) were examined in a novel older Chinese community sample. A total of 817 men and 760 women from a sub-study of the Guangzhou Biobank Cohort Study had a full blood count measured by an automated hematology analyzer, carotid IMT by B-mode ultrasonography and brachial-ankle PWV by a non-invasive automatic waveform analyzer. Following adjustment for confounders, WBC count (β=0.07, P<0.001) and granulocyte (β=0.07, P<0.001) number were significantly positively related to PWV, but not lymphocyte number. Similarly, WBC count (β=0.08, P=0.03), lymphocyte (β=0.08, P=0.002) and granulocyte (β=0.03, P=0.04) number were significantly positively associated with carotid IMT, but only the association with lymphocyte count survived correction for other cardiovascular risk factors. In conclusion, higher WBC, particularly lymphocyte and granulocyte, count could be used, respectively, as markers of cardiovascular disease risk, measured through indicators of atherosclerosis and arterial stiffness. The associations for WBC count previously observed by others were likely driven by higher granulocytes; an index of systemic inflammation.Journal of Human Hypertension advance online publication, 9 June 2011; doi:10.1038/jhh.2011.58.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Human Hypertension, 2012, v. 26 n. 8, p. 485-492 [How to Cite?]
DOI: http://dx.doi.org/10.1038/jhh.2011.58
 
dc.identifier.citeulike9437668
 
dc.identifier.doihttp://dx.doi.org/10.1038/jhh.2011.58
 
dc.identifier.hkuros228133
 
dc.identifier.isiWOS:000306360500003
Funding AgencyGrant Number
National Natural Science Foundation of China/Research Grants Council30518001
HKU720/05
University of Hong Kong Foundation for Education and Science, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
University of Birmingham, UK
Funding Information:

The study is funded by the National Natural Science Foundation of China/Research Grants Council (No. 30518001; HKU720/05) grant. The main cohort study was funded by The University of Hong Kong Foundation for Education and Science, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and The University of Birmingham, UK. The Guangzhou Cohort Study-Cardiovascular Disease Subcohort (GBCS-CVD) investigators include Guangzhou No. 12 Hospital: Jie Ming Lin, Bin Liu, Xiao Jun Yue, Chao Qiang Jiang (Co-PI); The University of Hong Kong: Bernard MY Cheung, Tai Hing Lam (Co-PI); The Chinese University of Hong Kong: Brian Tomlinson, Ka Sing Wong; The University of Birmingham: Kar Keung Cheng, Shahrad Taheri, Paramjit Gill, Greg YH Lip, G Neil Thomas (Co-PI).

 
dc.identifier.issn0950-9240
2013 Impact Factor: 2.692
2013 SCImago Journal Rankings: 1.177
 
dc.identifier.pmid21654852
 
dc.identifier.scopuseid_2-s2.0-84863865986
 
dc.identifier.urihttp://hdl.handle.net/10722/151743
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhh
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofJournal of Human Hypertension
 
dc.titleWhite blood cell subsets are associated with carotid intima-media thickness and pulse wave velocity in an older Chinese population: the Guangzhou Biobank Cohort Study
 
dc.typeArticle
 
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<contributor.author>Lin, JM</contributor.author>
<contributor.author>Yue, XJ</contributor.author>
<contributor.author>Cheng, KK</contributor.author>
<contributor.author>Jin, YL</contributor.author>
<contributor.author>Zhang, WS</contributor.author>
<contributor.author>Lam, TH</contributor.author>
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Author Affiliations
  1. The University of Hong Kong
  2. University of Birmingham
  3. Guangzhou No. 12 Hospital