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Article: White blood cell subsets are associated with carotid intima-media thickness and pulse wave velocity in an older Chinese population: the Guangzhou Biobank Cohort Study

TitleWhite blood cell subsets are associated with carotid intima-media thickness and pulse wave velocity in an older Chinese population: the Guangzhou Biobank Cohort Study
Authors
Issue Date2011
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhh
Citation
Journal Of Human Hypertension, 2012, v. 26 n. 8, p. 485-492 How to Cite?
AbstractCross-sectional associations between white blood cell (WBC) count, lymphocyte and granulocyte numbers, and carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (PWV) were examined in a novel older Chinese community sample. A total of 817 men and 760 women from a sub-study of the Guangzhou Biobank Cohort Study had a full blood count measured by an automated hematology analyzer, carotid IMT by B-mode ultrasonography and brachial-ankle PWV by a non-invasive automatic waveform analyzer. Following adjustment for confounders, WBC count (β=0.07, P<0.001) and granulocyte (β=0.07, P<0.001) number were significantly positively related to PWV, but not lymphocyte number. Similarly, WBC count (β=0.08, P=0.03), lymphocyte (β=0.08, P=0.002) and granulocyte (β=0.03, P=0.04) number were significantly positively associated with carotid IMT, but only the association with lymphocyte count survived correction for other cardiovascular risk factors. In conclusion, higher WBC, particularly lymphocyte and granulocyte, count could be used, respectively, as markers of cardiovascular disease risk, measured through indicators of atherosclerosis and arterial stiffness. The associations for WBC count previously observed by others were likely driven by higher granulocytes; an index of systemic inflammation.Journal of Human Hypertension advance online publication, 9 June 2011; doi:10.1038/jhh.2011.58.
Persistent Identifierhttp://hdl.handle.net/10722/151743
ISSN
2014 Impact Factor: 2.700
2014 SCImago Journal Rankings: 0.833
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China/Research Grants Council30518001
HKU720/05
University of Hong Kong Foundation for Education and Science, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
University of Birmingham, UK
Funding Information:

The study is funded by the National Natural Science Foundation of China/Research Grants Council (No. 30518001; HKU720/05) grant. The main cohort study was funded by The University of Hong Kong Foundation for Education and Science, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and The University of Birmingham, UK. The Guangzhou Cohort Study-Cardiovascular Disease Subcohort (GBCS-CVD) investigators include Guangzhou No. 12 Hospital: Jie Ming Lin, Bin Liu, Xiao Jun Yue, Chao Qiang Jiang (Co-PI); The University of Hong Kong: Bernard MY Cheung, Tai Hing Lam (Co-PI); The Chinese University of Hong Kong: Brian Tomlinson, Ka Sing Wong; The University of Birmingham: Kar Keung Cheng, Shahrad Taheri, Paramjit Gill, Greg YH Lip, G Neil Thomas (Co-PI).

 

DC FieldValueLanguage
dc.contributor.authorPhillips, ACen_US
dc.contributor.authorJiang, CQen_US
dc.contributor.authorThomas, GNen_US
dc.contributor.authorLin, JMen_US
dc.contributor.authorYue, XJen_US
dc.contributor.authorCheng, KKen_US
dc.contributor.authorJin, YLen_US
dc.contributor.authorZhang, WSen_US
dc.contributor.authorLam, THen_US
dc.date.accessioned2012-06-26T06:27:46Z-
dc.date.available2012-06-26T06:27:46Z-
dc.date.issued2011en_US
dc.identifier.citationJournal Of Human Hypertension, 2012, v. 26 n. 8, p. 485-492en_US
dc.identifier.issn0950-9240en_US
dc.identifier.urihttp://hdl.handle.net/10722/151743-
dc.description.abstractCross-sectional associations between white blood cell (WBC) count, lymphocyte and granulocyte numbers, and carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (PWV) were examined in a novel older Chinese community sample. A total of 817 men and 760 women from a sub-study of the Guangzhou Biobank Cohort Study had a full blood count measured by an automated hematology analyzer, carotid IMT by B-mode ultrasonography and brachial-ankle PWV by a non-invasive automatic waveform analyzer. Following adjustment for confounders, WBC count (β=0.07, P<0.001) and granulocyte (β=0.07, P<0.001) number were significantly positively related to PWV, but not lymphocyte number. Similarly, WBC count (β=0.08, P=0.03), lymphocyte (β=0.08, P=0.002) and granulocyte (β=0.03, P=0.04) number were significantly positively associated with carotid IMT, but only the association with lymphocyte count survived correction for other cardiovascular risk factors. In conclusion, higher WBC, particularly lymphocyte and granulocyte, count could be used, respectively, as markers of cardiovascular disease risk, measured through indicators of atherosclerosis and arterial stiffness. The associations for WBC count previously observed by others were likely driven by higher granulocytes; an index of systemic inflammation.Journal of Human Hypertension advance online publication, 9 June 2011; doi:10.1038/jhh.2011.58.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhhen_US
dc.relation.ispartofJournal of Human Hypertensionen_US
dc.titleWhite blood cell subsets are associated with carotid intima-media thickness and pulse wave velocity in an older Chinese population: the Guangzhou Biobank Cohort Studyen_US
dc.typeArticleen_US
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/jhh.2011.58en_US
dc.identifier.pmid21654852-
dc.identifier.scopuseid_2-s2.0-84863865986en_US
dc.identifier.hkuros228133-
dc.identifier.isiWOS:000306360500003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridPhillips, AC=8632552800en_US
dc.identifier.scopusauthoridJiang, CQ=10639500500en_US
dc.identifier.scopusauthoridThomas, GN=35465269900en_US
dc.identifier.scopusauthoridLin, JM=35763917400en_US
dc.identifier.scopusauthoridYue, XJ=35410971600en_US
dc.identifier.scopusauthoridCheng, KK=7402997800en_US
dc.identifier.scopusauthoridJin, YL=35558481400en_US
dc.identifier.scopusauthoridZhang, WS=24464616400en_US
dc.identifier.scopusauthoridLam, TH=7202522876en_US
dc.identifier.citeulike9437668-

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