Article: Childhood meat eating and inflammatory markers: The Guangzhou Biobank Cohort Study

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TitleChildhood meat eating and inflammatory markers: The Guangzhou Biobank Cohort Study
AuthorsSchooling, CM1 2
Jiang, CQ4
Lam, TH1
Zhang, WS4
Cheng, KK3
Leung, GM1
KeywordsCardiovascular Disease
Childhood Nutrition
China
Developing Country
Inflammation
Sex
White Blood Cell Count
Issue Date2011
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcpublichealth/
CitationBMC Public Health, 2011, v. 11, article no. 345 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1471-2458-11-345
AbstractBackground: We hypothesized that socio-economic development could, via nutritionally driven levels of pubertal sex-steroids, promote a pro-inflammatory state among men but not women in developing countries. We tested this hypothesis, using recalled childhood meat eating as a proxy for childhood nutrition, in southern China. Methods. We used multivariable linear regression in the Guangzhou Biobank Cohort Study phase 3 (2006-8) to examine the adjusted associations of recalled childhood meat eating, <1/week (n = 5,023), about once per week (n = 3,592) and almost daily (n = 1,252), with white blood cell count and its differentials among older (50 years) men (n = 2,498) and women (n = 7,369). Results: Adjusted for age, childhood socio-economic position, education and smoking, childhood meat eating had sex-specific associations with white blood cell count and lymphocyte count, but not granulocyte count. Men with childhood meat eating almost daily compared to <1/week had higher white blood cell count (0.33 10 9/L, 95% confidence interval (CI) 0.10 to 0.56) and higher lymphocyte count (0.16 10 9/L, 95% CI 0.07 to 0.25). Adjustment for obesity slightly attenuated these associations. Conclusion: If confirmed, this hypothesis implies that economic development and the associated improvements in nutrition at puberty may be less beneficial among men than women; consistent with the widening sex differentials in life expectancy with economic development. © 2011 Schooling et al; licensee BioMed Central Ltd.
ISSN1471-2458
2011 Impact Factor: 1.997
2011 SCImago Journal Rankings: 0.138
DOIhttp://dx.doi.org/10.1186/1471-2458-11-345
ISI Accession Number IDWOS:000291974700001
Funding AgencyGrant Number
University of Hong Kong Foundation for Development and Research, Hong Kong
University of Hong Kong University Research Committee Strategic Research Theme Public Health, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
University of Birmingham, Birmingham, UK
Funding Information:

The Guangzhou Biobank Cohort Study investigators include: Guangzhou No. 12 Hospital: WS Zhang, M Cao, T Zhu, B Liu, CQ Jiang (Co-PI); The University of Hong Kong: CM Schooling, SM McGhee, GM Leung, R Fielding, TH Lam (Co-PI); The University of Birmingham: P Adab, GN Thomas, KK Cheng (Co-PI). This work was supported by the University of Hong Kong Foundation for Development and Research, Hong Kong; The University of Hong Kong University Research Committee Strategic Research Theme Public Health, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and The University of Birmingham, Birmingham, UK. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

PubMed Central IDPMC3121633
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorSchooling, CM
dc.contributor.authorJiang, CQ
dc.contributor.authorLam, TH
dc.contributor.authorZhang, WS
dc.contributor.authorCheng, KK
dc.contributor.authorLeung, GM
dc.date.accessioned2012-06-26T06:27:43Z
dc.date.available2012-06-26T06:27:43Z
dc.date.issued2011
dc.description.abstractBackground: We hypothesized that socio-economic development could, via nutritionally driven levels of pubertal sex-steroids, promote a pro-inflammatory state among men but not women in developing countries. We tested this hypothesis, using recalled childhood meat eating as a proxy for childhood nutrition, in southern China. Methods. We used multivariable linear regression in the Guangzhou Biobank Cohort Study phase 3 (2006-8) to examine the adjusted associations of recalled childhood meat eating, <1/week (n = 5,023), about once per week (n = 3,592) and almost daily (n = 1,252), with white blood cell count and its differentials among older (50 years) men (n = 2,498) and women (n = 7,369). Results: Adjusted for age, childhood socio-economic position, education and smoking, childhood meat eating had sex-specific associations with white blood cell count and lymphocyte count, but not granulocyte count. Men with childhood meat eating almost daily compared to <1/week had higher white blood cell count (0.33 10 9/L, 95% confidence interval (CI) 0.10 to 0.56) and higher lymphocyte count (0.16 10 9/L, 95% CI 0.07 to 0.25). Adjustment for obesity slightly attenuated these associations. Conclusion: If confirmed, this hypothesis implies that economic development and the associated improvements in nutrition at puberty may be less beneficial among men than women; consistent with the widening sex differentials in life expectancy with economic development. © 2011 Schooling et al; licensee BioMed Central Ltd.
dc.description.naturepublished_or_final_version
dc.identifier.citationBMC Public Health, 2011, v. 11, article no. 345 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1471-2458-11-345
dc.identifier.doihttp://dx.doi.org/10.1186/1471-2458-11-345
dc.identifier.hkuros199601
dc.identifier.isiWOS:000291974700001
Funding AgencyGrant Number
University of Hong Kong Foundation for Development and Research, Hong Kong
University of Hong Kong University Research Committee Strategic Research Theme Public Health, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
University of Birmingham, Birmingham, UK
Funding Information:

The Guangzhou Biobank Cohort Study investigators include: Guangzhou No. 12 Hospital: WS Zhang, M Cao, T Zhu, B Liu, CQ Jiang (Co-PI); The University of Hong Kong: CM Schooling, SM McGhee, GM Leung, R Fielding, TH Lam (Co-PI); The University of Birmingham: P Adab, GN Thomas, KK Cheng (Co-PI). This work was supported by the University of Hong Kong Foundation for Development and Research, Hong Kong; The University of Hong Kong University Research Committee Strategic Research Theme Public Health, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and The University of Birmingham, Birmingham, UK. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

dc.identifier.issn1471-2458
2011 Impact Factor: 1.997
2011 SCImago Journal Rankings: 0.138
dc.identifier.pmcidPMC3121633
dc.identifier.pmid21595911
dc.identifier.scopuseid_2-s2.0-79956016806
dc.identifier.urihttp://hdl.handle.net/10722/151738
dc.identifier.volume11
dc.languageeng
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcpublichealth/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofBMC Public Health
dc.relation.referencesReferences in Scopus
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subjectCardiovascular Disease
dc.subjectChildhood Nutrition
dc.subjectChina
dc.subjectDeveloping Country
dc.subjectInflammation
dc.subjectSex
dc.subjectWhite Blood Cell Count
dc.titleChildhood meat eating and inflammatory markers: The Guangzhou Biobank Cohort Study
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. City University of New York
  3. University of Birmingham
  4. null