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Article: Childhood meat eating and inflammatory markers: The Guangzhou Biobank Cohort Study
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TitleChildhood meat eating and inflammatory markers: The Guangzhou Biobank Cohort Study
 
AuthorsSchooling, CM1 2
Jiang, CQ4
Lam, TH1
Zhang, WS4
Cheng, KK3
Leung, GM1
 
KeywordsCardiovascular Disease
Childhood Nutrition
China
Developing Country
Inflammation
Sex
White Blood Cell Count
 
Issue Date2011
 
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcpublichealth/
 
CitationBMC Public Health, 2011, v. 11, article no. 345 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1471-2458-11-345
 
AbstractBackground: We hypothesized that socio-economic development could, via nutritionally driven levels of pubertal sex-steroids, promote a pro-inflammatory state among men but not women in developing countries. We tested this hypothesis, using recalled childhood meat eating as a proxy for childhood nutrition, in southern China. Methods. We used multivariable linear regression in the Guangzhou Biobank Cohort Study phase 3 (2006-8) to examine the adjusted associations of recalled childhood meat eating, <1/week (n = 5,023), about once per week (n = 3,592) and almost daily (n = 1,252), with white blood cell count and its differentials among older (50 years) men (n = 2,498) and women (n = 7,369). Results: Adjusted for age, childhood socio-economic position, education and smoking, childhood meat eating had sex-specific associations with white blood cell count and lymphocyte count, but not granulocyte count. Men with childhood meat eating almost daily compared to <1/week had higher white blood cell count (0.33 10 9/L, 95% confidence interval (CI) 0.10 to 0.56) and higher lymphocyte count (0.16 10 9/L, 95% CI 0.07 to 0.25). Adjustment for obesity slightly attenuated these associations. Conclusion: If confirmed, this hypothesis implies that economic development and the associated improvements in nutrition at puberty may be less beneficial among men than women; consistent with the widening sex differentials in life expectancy with economic development. © 2011 Schooling et al; licensee BioMed Central Ltd.
 
ISSN1471-2458
2013 Impact Factor: 2.321
2013 SCImago Journal Rankings: 1.233
 
DOIhttp://dx.doi.org/10.1186/1471-2458-11-345
 
PubMed Central IDPMC3121633
 
ISI Accession Number IDWOS:000291974700001
Funding AgencyGrant Number
University of Hong Kong Foundation for Development and Research, Hong Kong
University of Hong Kong University Research Committee Strategic Research Theme Public Health, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
University of Birmingham, Birmingham, UK
Funding Information:

The Guangzhou Biobank Cohort Study investigators include: Guangzhou No. 12 Hospital: WS Zhang, M Cao, T Zhu, B Liu, CQ Jiang (Co-PI); The University of Hong Kong: CM Schooling, SM McGhee, GM Leung, R Fielding, TH Lam (Co-PI); The University of Birmingham: P Adab, GN Thomas, KK Cheng (Co-PI). This work was supported by the University of Hong Kong Foundation for Development and Research, Hong Kong; The University of Hong Kong University Research Committee Strategic Research Theme Public Health, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and The University of Birmingham, Birmingham, UK. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorSchooling, CM
 
dc.contributor.authorJiang, CQ
 
dc.contributor.authorLam, TH
 
dc.contributor.authorZhang, WS
 
dc.contributor.authorCheng, KK
 
dc.contributor.authorLeung, GM
 
dc.date.accessioned2012-06-26T06:27:43Z
 
dc.date.available2012-06-26T06:27:43Z
 
dc.date.issued2011
 
dc.description.abstractBackground: We hypothesized that socio-economic development could, via nutritionally driven levels of pubertal sex-steroids, promote a pro-inflammatory state among men but not women in developing countries. We tested this hypothesis, using recalled childhood meat eating as a proxy for childhood nutrition, in southern China. Methods. We used multivariable linear regression in the Guangzhou Biobank Cohort Study phase 3 (2006-8) to examine the adjusted associations of recalled childhood meat eating, <1/week (n = 5,023), about once per week (n = 3,592) and almost daily (n = 1,252), with white blood cell count and its differentials among older (50 years) men (n = 2,498) and women (n = 7,369). Results: Adjusted for age, childhood socio-economic position, education and smoking, childhood meat eating had sex-specific associations with white blood cell count and lymphocyte count, but not granulocyte count. Men with childhood meat eating almost daily compared to <1/week had higher white blood cell count (0.33 10 9/L, 95% confidence interval (CI) 0.10 to 0.56) and higher lymphocyte count (0.16 10 9/L, 95% CI 0.07 to 0.25). Adjustment for obesity slightly attenuated these associations. Conclusion: If confirmed, this hypothesis implies that economic development and the associated improvements in nutrition at puberty may be less beneficial among men than women; consistent with the widening sex differentials in life expectancy with economic development. © 2011 Schooling et al; licensee BioMed Central Ltd.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationBMC Public Health, 2011, v. 11, article no. 345 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1471-2458-11-345
 
dc.identifier.doihttp://dx.doi.org/10.1186/1471-2458-11-345
 
dc.identifier.hkuros199601
 
dc.identifier.isiWOS:000291974700001
Funding AgencyGrant Number
University of Hong Kong Foundation for Development and Research, Hong Kong
University of Hong Kong University Research Committee Strategic Research Theme Public Health, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
University of Birmingham, Birmingham, UK
Funding Information:

The Guangzhou Biobank Cohort Study investigators include: Guangzhou No. 12 Hospital: WS Zhang, M Cao, T Zhu, B Liu, CQ Jiang (Co-PI); The University of Hong Kong: CM Schooling, SM McGhee, GM Leung, R Fielding, TH Lam (Co-PI); The University of Birmingham: P Adab, GN Thomas, KK Cheng (Co-PI). This work was supported by the University of Hong Kong Foundation for Development and Research, Hong Kong; The University of Hong Kong University Research Committee Strategic Research Theme Public Health, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and The University of Birmingham, Birmingham, UK. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

 
dc.identifier.issn1471-2458
2013 Impact Factor: 2.321
2013 SCImago Journal Rankings: 1.233
 
dc.identifier.pmcidPMC3121633
 
dc.identifier.pmid21595911
 
dc.identifier.scopuseid_2-s2.0-79956016806
 
dc.identifier.urihttp://hdl.handle.net/10722/151738
 
dc.identifier.volume11
 
dc.languageeng
 
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcpublichealth/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofBMC Public Health
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectCardiovascular Disease
 
dc.subjectChildhood Nutrition
 
dc.subjectChina
 
dc.subjectDeveloping Country
 
dc.subjectInflammation
 
dc.subjectSex
 
dc.subjectWhite Blood Cell Count
 
dc.titleChildhood meat eating and inflammatory markers: The Guangzhou Biobank Cohort Study
 
dc.typeArticle
 
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<contributor.author>Cheng, KK</contributor.author>
<contributor.author>Leung, GM</contributor.author>
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<description.abstract>Background: We hypothesized that socio-economic development could, via nutritionally driven levels of pubertal sex-steroids, promote a pro-inflammatory state among men but not women in developing countries. We tested this hypothesis, using recalled childhood meat eating as a proxy for childhood nutrition, in southern China. Methods. We used multivariable linear regression in the Guangzhou Biobank Cohort Study phase 3 (2006-8) to examine the adjusted associations of recalled childhood meat eating, &lt;1/week (n = 5,023), about once per week (n = 3,592) and almost daily (n = 1,252), with white blood cell count and its differentials among older (50 years) men (n = 2,498) and women (n = 7,369). Results: Adjusted for age, childhood socio-economic position, education and smoking, childhood meat eating had sex-specific associations with white blood cell count and lymphocyte count, but not granulocyte count. Men with childhood meat eating almost daily compared to &lt;1/week had higher white blood cell count (0.33 10 9/L, 95% confidence interval (CI) 0.10 to 0.56) and higher lymphocyte count (0.16 10 9/L, 95% CI 0.07 to 0.25). Adjustment for obesity slightly attenuated these associations. Conclusion: If confirmed, this hypothesis implies that economic development and the associated improvements in nutrition at puberty may be less beneficial among men than women; consistent with the widening sex differentials in life expectancy with economic development. &#169; 2011 Schooling et al; licensee BioMed Central Ltd.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. City University of New York
  3. University of Birmingham
  4. Guangzhou Number 12 Hospital