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Article: Prior TB, smoking, and airflow obstruction: A cross-sectional analysis of the Guangzhou Biobank Cohort Study

TitlePrior TB, smoking, and airflow obstruction: A cross-sectional analysis of the Guangzhou Biobank Cohort Study
Authors
Issue Date2010
PublisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org
Citation
Chest, 2010, v. 137 n. 3, p. 593-600 How to Cite?
AbstractBackground: Prior pulmonary TB has been shown to be associated with a higher risk of airflow obstruction, which is the hallmark of COPD, but whether smoking modifi es this relationship is unclear. We investigated the relationships between prior TB, smoking, and airflow obstruction in a Chinese population sample. Methods: Participants in the Guangzhou Biobank Cohort Study underwent spirometry, chest radiography, and a structured interview on lifestyle and exposures. Prior TB was defi ned as the presence of radiologic evidence suggestive of inactive TB. Airflow obstruction was based on spirometric criteria. Results: The prevalence of prior TB in this sample (N = 8,066, mean age: 61.9 years) was 24.2%. After controlling for sex, age, and smoking exposure, prior TB remained independently associated with an increased risk of airflow obstruction (odds ratio = 1.37; 95% CI, 1.13-1.67). Further adjustment for exposure to passive smoking, biomass fuel, and dust did not alter the relationship. Smoking did not modify the relationship between prior TB and airflow obstruction. Conclusions: Prior TB is an independent risk factor for airflow obstruction, which may partly explain the higher prevalence of COPD in China. Clinicians should be aware of this long-term risk in individuals with prior TB, irrespective of smoking status, particularly in patients from countries with a high TB burden. © 2010 American College of Chest Physicians.
Persistent Identifierhttp://hdl.handle.net/10722/151704
ISSN
2015 Impact Factor: 5.94
2015 SCImago Journal Rankings: 3.176
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong Foundation for Educational Development and Research
Guangzhou Public Health Bureau
Guangzhou Science and Technology Bureau
University of Birmingham
Funding Information:

The Guangzhou Biobank Cohort Study was funded by The University of Hong Kong Foundation for Educational Development and Research, the Guangzhou Public Health Bureau, the Guangzhou Science and Technology Bureau, and The University of Birmingham.

References

 

DC FieldValueLanguage
dc.contributor.authorLam, HKBen_US
dc.contributor.authorJiang, CQen_US
dc.contributor.authorJordan, REen_US
dc.contributor.authorMiller, MRen_US
dc.contributor.authorZhang, WSen_US
dc.contributor.authorCheng, KKen_US
dc.contributor.authorLam, THen_US
dc.contributor.authorAdab, Pen_US
dc.date.accessioned2012-06-26T06:26:49Z-
dc.date.available2012-06-26T06:26:49Z-
dc.date.issued2010en_US
dc.identifier.citationChest, 2010, v. 137 n. 3, p. 593-600en_US
dc.identifier.issn0012-3692en_US
dc.identifier.urihttp://hdl.handle.net/10722/151704-
dc.description.abstractBackground: Prior pulmonary TB has been shown to be associated with a higher risk of airflow obstruction, which is the hallmark of COPD, but whether smoking modifi es this relationship is unclear. We investigated the relationships between prior TB, smoking, and airflow obstruction in a Chinese population sample. Methods: Participants in the Guangzhou Biobank Cohort Study underwent spirometry, chest radiography, and a structured interview on lifestyle and exposures. Prior TB was defi ned as the presence of radiologic evidence suggestive of inactive TB. Airflow obstruction was based on spirometric criteria. Results: The prevalence of prior TB in this sample (N = 8,066, mean age: 61.9 years) was 24.2%. After controlling for sex, age, and smoking exposure, prior TB remained independently associated with an increased risk of airflow obstruction (odds ratio = 1.37; 95% CI, 1.13-1.67). Further adjustment for exposure to passive smoking, biomass fuel, and dust did not alter the relationship. Smoking did not modify the relationship between prior TB and airflow obstruction. Conclusions: Prior TB is an independent risk factor for airflow obstruction, which may partly explain the higher prevalence of COPD in China. Clinicians should be aware of this long-term risk in individuals with prior TB, irrespective of smoking status, particularly in patients from countries with a high TB burden. © 2010 American College of Chest Physicians.en_US
dc.languageengen_US
dc.publisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.orgen_US
dc.relation.ispartofChesten_US
dc.subject.meshAirway Obstruction - Diagnosis - Epidemiology - Etiologyen_US
dc.subject.meshConfidence Intervalsen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshPrognosisen_US
dc.subject.meshRadiography, Thoracicen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSmoking - Adverse Effects - Epidemiologyen_US
dc.subject.meshSpirometryen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTuberculosis, Pulmonary - Complications - Epidemiologyen_US
dc.titlePrior TB, smoking, and airflow obstruction: A cross-sectional analysis of the Guangzhou Biobank Cohort Studyen_US
dc.typeArticleen_US
dc.identifier.emailLam, HKB: hubert_hk@hotmail.com-
dc.identifier.emailJiang, CQ: cqjiang@HKUCC.hku.hk-
dc.identifier.emailZhang, W: zhangws9@HKUCC-COM.hku.hk-
dc.identifier.emailCheng, KK: chengkk@HKUCC.hku.hk-
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hk-
dc.identifier.emailAdab, P: padab@hkucc.hku.hk-
dc.identifier.authorityLam, TH=rp00326en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1378/chest.09-1435en_US
dc.identifier.pmid19820078-
dc.identifier.scopuseid_2-s2.0-77949497052en_US
dc.identifier.hkuros169097-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77949497052&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume137en_US
dc.identifier.issue3en_US
dc.identifier.spage593en_US
dc.identifier.epage600en_US
dc.identifier.isiWOS:000275477100015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLam, KBH=35168055500en_US
dc.identifier.scopusauthoridJiang, CQ=10639500500en_US
dc.identifier.scopusauthoridJordan, RE=7401610864en_US
dc.identifier.scopusauthoridMiller, MR=9239618200en_US
dc.identifier.scopusauthoridZhang, WS=13410704100en_US
dc.identifier.scopusauthoridCheng, KK=7402997800en_US
dc.identifier.scopusauthoridLam, TH=7202522876en_US
dc.identifier.scopusauthoridAdab, P=6601949045en_US
dc.identifier.citeulike6719640-
dc.customcontrol.immutablesml 130313-

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