File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Airflow obstruction and metabolic syndrome: The Guangzhou Biobank Cohort Study

TitleAirflow obstruction and metabolic syndrome: The Guangzhou Biobank Cohort Study
Authors
Issue Date2010
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
Citation
European Respiratory Journal, 2010, v. 35 n. 2, p. 317-323 How to Cite?
AbstractThere is some evidence that chronic obstructive pulmonary disease (COPD) and metabolic syndrome may be related, perhaps through systemic inflammation, which is common to both. However, the association between the two conditions has not yet been clearly shown. The present study involved 7,358 adults aged ≥50 yrs from a population-based survey who underwent spirometry, a structured interview and measurement of fasting metabolic marker levels. Airflow obstruction (forced expiratory volume in 1 s/forced vital capacity ratio of less than the lower limit of normal) was present in 6.7%, and the International Diabetes Federation metabolic syndrome criteria were met by 20.0%. The risk of metabolic syndrome was higher in those with airflow obstruction than in those without (odds ratio (OR) 1.47; 95% confidence interval (CI) 1.12-1.92), after controlling for potential confounders. Of the five components of metabolic syndrome, only central obesity was significantly associated with airflow obstruction (OR 1.43; 95% CI 1.09-1.88) after adjusting for body mass index. A similar association was observed in both never and current smokers. In this Chinese sample, airflow obstruction was associated with metabolic syndrome, and, in particular, its central obesity component. This may help explain the increased risk of cardiovascular diseases in COPD, and so could guide future clinical practice. Copyright©ERS Journals Ltd 2010.
Persistent Identifierhttp://hdl.handle.net/10722/151695
ISSN
2015 Impact Factor: 8.332
2015 SCImago Journal Rankings: 3.204
ISI Accession Number ID
Funding AgencyGrant Number
The University of Hong Kong Foundation for Educational Development and Research (Hong Kong)
Guangzhou Public Health Bureau
Guangzhou Science and Technology Bureau (both Guangzhou, China)
University of Birmingham (Birmingham, UK)
Funding Information:

This study was funded by The University of Hong Kong Foundation for Educational Development and Research (Hong Kong); the Guangzhou Public Health Bureau and the Guangzhou Science and Technology Bureau (both Guangzhou, China); and the University of Birmingham (Birmingham, UK).

References

 

DC FieldValueLanguage
dc.contributor.authorLam, KBHen_US
dc.contributor.authorJordan, REen_US
dc.contributor.authorJiang, CQen_US
dc.contributor.authorThomas, GNen_US
dc.contributor.authorMiller, MRen_US
dc.contributor.authorZhang, WSen_US
dc.contributor.authorLam, THen_US
dc.contributor.authorCheng, KKen_US
dc.contributor.authorAdab, Pen_US
dc.date.accessioned2012-06-26T06:26:45Z-
dc.date.available2012-06-26T06:26:45Z-
dc.date.issued2010en_US
dc.identifier.citationEuropean Respiratory Journal, 2010, v. 35 n. 2, p. 317-323en_US
dc.identifier.issn0903-1936en_US
dc.identifier.urihttp://hdl.handle.net/10722/151695-
dc.description.abstractThere is some evidence that chronic obstructive pulmonary disease (COPD) and metabolic syndrome may be related, perhaps through systemic inflammation, which is common to both. However, the association between the two conditions has not yet been clearly shown. The present study involved 7,358 adults aged ≥50 yrs from a population-based survey who underwent spirometry, a structured interview and measurement of fasting metabolic marker levels. Airflow obstruction (forced expiratory volume in 1 s/forced vital capacity ratio of less than the lower limit of normal) was present in 6.7%, and the International Diabetes Federation metabolic syndrome criteria were met by 20.0%. The risk of metabolic syndrome was higher in those with airflow obstruction than in those without (odds ratio (OR) 1.47; 95% confidence interval (CI) 1.12-1.92), after controlling for potential confounders. Of the five components of metabolic syndrome, only central obesity was significantly associated with airflow obstruction (OR 1.43; 95% CI 1.09-1.88) after adjusting for body mass index. A similar association was observed in both never and current smokers. In this Chinese sample, airflow obstruction was associated with metabolic syndrome, and, in particular, its central obesity component. This may help explain the increased risk of cardiovascular diseases in COPD, and so could guide future clinical practice. Copyright©ERS Journals Ltd 2010.en_US
dc.languageengen_US
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.comen_US
dc.relation.ispartofEuropean Respiratory Journalen_US
dc.subject.meshAgeden_US
dc.subject.meshBody Mass Indexen_US
dc.subject.meshChinaen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshForced Expiratory Volumeen_US
dc.subject.meshHumansen_US
dc.subject.meshInflammationen_US
dc.subject.meshLung - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMetabolic Syndrome X - Complications - Diagnosisen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshObesity - Complicationsen_US
dc.subject.meshPulmonary Disease, Chronic Obstructive - Complications - Diagnosisen_US
dc.subject.meshRisken_US
dc.subject.meshSpirometry - Methodsen_US
dc.subject.meshVital Capacityen_US
dc.titleAirflow obstruction and metabolic syndrome: The Guangzhou Biobank Cohort Studyen_US
dc.typeArticleen_US
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1183/09031936.00024709en_US
dc.identifier.pmid19574332-
dc.identifier.scopuseid_2-s2.0-76149126470en_US
dc.identifier.hkuros168842-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-76149126470&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume35en_US
dc.identifier.issue2en_US
dc.identifier.spage317en_US
dc.identifier.epage323en_US
dc.identifier.isiWOS:000274559900014-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridLam, KBH=20433798600en_US
dc.identifier.scopusauthoridJordan, RE=7401610864en_US
dc.identifier.scopusauthoridJiang, CQ=10639500500en_US
dc.identifier.scopusauthoridThomas, GN=35465269900en_US
dc.identifier.scopusauthoridMiller, MR=9239618200en_US
dc.identifier.scopusauthoridZhang, WS=20434989700en_US
dc.identifier.scopusauthoridLam, TH=7202522876en_US
dc.identifier.scopusauthoridCheng, KK=7402997800en_US
dc.identifier.scopusauthoridAdab, P=6601949045en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats