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Article: Blood pressure is a major risk factor for renal death: An analysis of 560 352 participants from the asia-pacific region

TitleBlood pressure is a major risk factor for renal death: An analysis of 560 352 participants from the asia-pacific region
Authors
Issue Date2009
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/
Citation
Hypertension, 2009, v. 54 n. 3, p. 509-515 How to Cite?
AbstractChronic kidney disease is a major worldwide public health problem that causes substantial morbidity and mortality. Studies from the Asia-Pacific region have reported some of the highest chronic kidney disease prevalence rates in the world, but access to dialysis is limited in many countries, making it imperative to identify high-risk individuals. We performed a participant-level data overview of prospective studies conducted in the Asia-Pacific region to quantify the magnitude and direction of the associations between putative risk factors and renal death. Age- and sex-adjusted Cox proportional hazards models were applied to pooled data from 35 studies to calculate hazard ratios (95% CIs) for renal death associated with a standardized change in risk factors. Among 560 352 participants followed for a median of 6.8 years, a total of 420 renal deaths were observed. Continuous and positive associations among systolic blood pressure, diastolic blood pressure, fasting blood glucose, and total cholesterol levels with renal death were observed, as well as a continuous but inverse association with high-density lipoprotein cholesterol. Systolic blood pressure was the strongest risk factor for renal death with each SD increase in systolic blood pressure (19 mm Hg) associated with >80% higher risk (hazard ratio: 1.84; 95% CI: 1.60 to 2.12). Neither cigarette smoking nor excess weight was related to the risk of renal death (P>0.10). The results were similar for cohorts in Asia and Australia. These results suggest that primary prevention strategies for renal disease should focus on individuals with elevated blood pressure, diabetes mellitus, and dyslipidemia. © 2009 American Heart Association, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/151682
ISSN
2015 Impact Factor: 6.294
2015 SCImago Journal Rankings: 3.702
ISI Accession Number ID
Funding AgencyGrant Number
National Health and Medical Research Council of Australia358395
Pfizer Inc.
Heart Foundation of Australia Astra Zeneca Fellowship
National Heart Foundation of Australia
National Health and Medical Research Council of Australia
Funding Information:

The Asia Pacific Cohort Studies Collaboration has received support from a National Health and Medical Research Council of Australia program grant (358395) and an unrestricted educational grant from Pfizer Inc. V. P. holds a Heart Foundation of Australia Astra Zeneca Fellowship, R. H. is supported by a Career Development Award from the National Heart Foundation of Australia, and A. C. holds a Senior Research Fellowship from the National Health and Medical Research Council of Australia.

References

 

DC FieldValueLanguage
dc.contributor.authorO'seaghdha, CMen_US
dc.contributor.authorPerkovic, Ven_US
dc.contributor.authorLam, THen_US
dc.contributor.authorMcginn, Sen_US
dc.contributor.authorBarzi, Fen_US
dc.contributor.authorGu, DFen_US
dc.contributor.authorCass, Aen_US
dc.contributor.authorSuh, Ien_US
dc.contributor.authorMuntner, Pen_US
dc.contributor.authorGiles, GGen_US
dc.contributor.authorUeshima, Hen_US
dc.contributor.authorWoodward, Men_US
dc.contributor.authorHuxley, Ren_US
dc.date.accessioned2012-06-26T06:26:35Z-
dc.date.available2012-06-26T06:26:35Z-
dc.date.issued2009en_US
dc.identifier.citationHypertension, 2009, v. 54 n. 3, p. 509-515en_US
dc.identifier.issn0194-911Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/151682-
dc.description.abstractChronic kidney disease is a major worldwide public health problem that causes substantial morbidity and mortality. Studies from the Asia-Pacific region have reported some of the highest chronic kidney disease prevalence rates in the world, but access to dialysis is limited in many countries, making it imperative to identify high-risk individuals. We performed a participant-level data overview of prospective studies conducted in the Asia-Pacific region to quantify the magnitude and direction of the associations between putative risk factors and renal death. Age- and sex-adjusted Cox proportional hazards models were applied to pooled data from 35 studies to calculate hazard ratios (95% CIs) for renal death associated with a standardized change in risk factors. Among 560 352 participants followed for a median of 6.8 years, a total of 420 renal deaths were observed. Continuous and positive associations among systolic blood pressure, diastolic blood pressure, fasting blood glucose, and total cholesterol levels with renal death were observed, as well as a continuous but inverse association with high-density lipoprotein cholesterol. Systolic blood pressure was the strongest risk factor for renal death with each SD increase in systolic blood pressure (19 mm Hg) associated with >80% higher risk (hazard ratio: 1.84; 95% CI: 1.60 to 2.12). Neither cigarette smoking nor excess weight was related to the risk of renal death (P>0.10). The results were similar for cohorts in Asia and Australia. These results suggest that primary prevention strategies for renal disease should focus on individuals with elevated blood pressure, diabetes mellitus, and dyslipidemia. © 2009 American Heart Association, Inc.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/en_US
dc.relation.ispartofHypertensionen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAsiaen_US
dc.subject.meshAustraliaen_US
dc.subject.meshBlood Glucose - Analysisen_US
dc.subject.meshBlood Pressure - Physiologyen_US
dc.subject.meshCause Of Deathen_US
dc.subject.meshCholesterol - Blooden_US
dc.subject.meshCholesterol, Hdl - Blooden_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshDiabetes Mellitus - Blood - Physiopathologyen_US
dc.subject.meshFasting - Blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney Failure, Chronic - Blood - Mortality - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOutcome Assessment (Health Care) - Statistics & Numerical Dataen_US
dc.subject.meshProportional Hazards Modelsen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSurvival Rateen_US
dc.titleBlood pressure is a major risk factor for renal death: An analysis of 560 352 participants from the asia-pacific regionen_US
dc.typeArticleen_US
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1161/HYPERTENSIONAHA.108.128413en_US
dc.identifier.pmid19597042-
dc.identifier.scopuseid_2-s2.0-70349251478en_US
dc.identifier.hkuros164042-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70349251478&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume54en_US
dc.identifier.issue3en_US
dc.identifier.spage509en_US
dc.identifier.epage515en_US
dc.identifier.isiWOS:000269089100019-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridO'Seaghdha, CM=11639106300en_US
dc.identifier.scopusauthoridPerkovic, V=22135866300en_US
dc.identifier.scopusauthoridLam, TH=7202522876en_US
dc.identifier.scopusauthoridMcGinn, S=7003958723en_US
dc.identifier.scopusauthoridBarzi, F=7003545543en_US
dc.identifier.scopusauthoridGu, DF=7202151958en_US
dc.identifier.scopusauthoridCass, A=7102500090en_US
dc.identifier.scopusauthoridSuh, I=7101988200en_US
dc.identifier.scopusauthoridMuntner, P=7003615149en_US
dc.identifier.scopusauthoridGiles, GG=7103091133en_US
dc.identifier.scopusauthoridUeshima, H=7005129002en_US
dc.identifier.scopusauthoridWoodward, M=7102510958en_US
dc.identifier.scopusauthoridHuxley, R=6701828350en_US
dc.identifier.citeulike9854553-

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