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Article: Body mass index and cardiovascular disease in the Asia-Pacific Region: An overview of 33 cohorts involving 310 000 participants
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TitleBody mass index and cardiovascular disease in the Asia-Pacific Region: An overview of 33 cohorts involving 310 000 participants
 
AuthorsNi Mhurchu, C3
Rodgers, A3
Pan, WH7
Gu, DF6
Woodward, M2
Parag, V
Lin, R
Bennett, DA
Vander Hoorn, S
Barzi, F
Macmahon, S
Lam, TH
Lawes, C
Suh, I
Ueshima, H
Okayama, A
Maegawa, H
Aoki, N
Nakamura, M
Kubo, N
Yamada, T
Wu, ZS
Yao, CH
Liu, LS8
Xie, JX8
Knuiman, MW
Christensen, H4
Wu, XG5
Zhou, J
Yu, XH
Tamakoshi, A1
Wu, ZL
Chen, LQ
Shan, GL
Duan, XF
Norton, R
Whitlock, G
Jackson, R
Fujishima, M
Kiyohara, Y
Iwamoto, H
Woo, J
Ho, S
Hong, Z
Huang, MS
Zhou, B
Fuh, JL
Kita, Y
Choudhury, SR
Jee, SH
Kim, IS
Giles, G
Hashimoto, T
Sakata, K
Imai, Y
Ohkubo, T
Hozawa, A
Jamrozik, K
Hobbs, M
Broadhurst, R
Nakachi, K
Fang, XH
Li, SC
Yang, QD
Chen, ZM
Tanaka, H
Nozaki, A
Horibe, H
Matsutani, Y
Kagaya, M
Hughes, K
Lee, J
Heng, D
Zhou, BF
Zhang, HY
Shimamoto, K
Saitoh, S
Li, ZZ
Zhang, HY
He, Y
Yao, SX
 
Issue Date2004
 
PublisherOxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/
 
CitationInternational Journal Of Epidemiology, 2004, v. 33 n. 4, p. 751-758 [How to Cite?]
DOI: http://dx.doi.org/10.1093/ije/dyh163
 
AbstractBackground. Few prospective data from the Asia-Pacific region are available relating body mass index (BMI) to the risks of stroke and ischaemic heart disease (IHD). Our objective was to assess the age-, sex-, and region-specific associations of BMI with cardiovascular disease using individual participant data from prospective studies in the Asia-Pacific region. Methods. Studies were identified from literature searches, proceedings of meetings, and personal communication. All studies had at least 5000 person-years of follow-up. Hazard ratios were calculated from Cox models, stratified by sex and cohort, and adjusted for age at risk and smoking. The first 3 years of follow-up were excluded in order to reduce confounding due to disease at baseline. Results. A total of 33 cohort studies, including 310 283 participants, contributed 2 148 354 person-years of follow-up, during which 3332 stroke and 2073 IHD events were observed. There were continuous positive associations between baseline BMI and the risks of ischaemic stroke, haemorrhagic stroke, and IHD, with each 2 kg/m 2 lower BMI associated a 12% (95% CI: 9, 15%) lower risk of ischaemic stroke, 8% (95% CI: 4, 12%) lower risk in haemorrhagic stroke, and 11% (95% CI: 9, 13%) lower risk of IHD. The strengths of all associations were strongly age dependent, and there was no significant difference between Asian and Australasian cohorts. Conclusions. This overview provides the most reliable estimates to date of the associations between BMI and cardiovascular disease in the Asia-Pacific region, and the first direct comparisons within the region. Continuous relationships of approximately equal strength are evident in both Asian and Australasian populations. These results indicate considerable potential for cardiovascular disease reduction with population-wide lowering of BMI. © International Epidemiological Association 2004; all rights reserved.
 
ISSN0300-5771
2013 Impact Factor: 9.197
2013 SCImago Journal Rankings: 4.074
 
DOIhttp://dx.doi.org/10.1093/ije/dyh163
 
ISI Accession Number IDWOS:000223944100023
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorNi Mhurchu, C
 
dc.contributor.authorRodgers, A
 
dc.contributor.authorPan, WH
 
dc.contributor.authorGu, DF
 
dc.contributor.authorWoodward, M
 
dc.contributor.authorParag, V
 
dc.contributor.authorLin, R
 
dc.contributor.authorBennett, DA
 
dc.contributor.authorVander Hoorn, S
 
dc.contributor.authorBarzi, F
 
dc.contributor.authorMacmahon, S
 
dc.contributor.authorLam, TH
 
dc.contributor.authorLawes, C
 
dc.contributor.authorSuh, I
 
dc.contributor.authorUeshima, H
 
dc.contributor.authorOkayama, A
 
dc.contributor.authorMaegawa, H
 
dc.contributor.authorAoki, N
 
dc.contributor.authorNakamura, M
 
dc.contributor.authorKubo, N
 
dc.contributor.authorYamada, T
 
dc.contributor.authorWu, ZS
 
dc.contributor.authorYao, CH
 
dc.contributor.authorLiu, LS
 
dc.contributor.authorXie, JX
 
dc.contributor.authorKnuiman, MW
 
dc.contributor.authorChristensen, H
 
dc.contributor.authorWu, XG
 
dc.contributor.authorZhou, J
 
dc.contributor.authorYu, XH
 
dc.contributor.authorTamakoshi, A
 
dc.contributor.authorWu, ZL
 
dc.contributor.authorChen, LQ
 
dc.contributor.authorShan, GL
 
dc.contributor.authorDuan, XF
 
dc.contributor.authorNorton, R
 
dc.contributor.authorWhitlock, G
 
dc.contributor.authorJackson, R
 
dc.contributor.authorFujishima, M
 
dc.contributor.authorKiyohara, Y
 
dc.contributor.authorIwamoto, H
 
dc.contributor.authorWoo, J
 
dc.contributor.authorHo, S
 
dc.contributor.authorHong, Z
 
dc.contributor.authorHuang, MS
 
dc.contributor.authorZhou, B
 
dc.contributor.authorFuh, JL
 
dc.contributor.authorKita, Y
 
dc.contributor.authorChoudhury, SR
 
dc.contributor.authorJee, SH
 
dc.contributor.authorKim, IS
 
dc.contributor.authorGiles, G
 
dc.contributor.authorHashimoto, T
 
dc.contributor.authorSakata, K
 
dc.contributor.authorImai, Y
 
dc.contributor.authorOhkubo, T
 
dc.contributor.authorHozawa, A
 
dc.contributor.authorJamrozik, K
 
dc.contributor.authorHobbs, M
 
dc.contributor.authorBroadhurst, R
 
dc.contributor.authorNakachi, K
 
dc.contributor.authorFang, XH
 
dc.contributor.authorLi, SC
 
dc.contributor.authorYang, QD
 
dc.contributor.authorChen, ZM
 
dc.contributor.authorTanaka, H
 
dc.contributor.authorNozaki, A
 
dc.contributor.authorHoribe, H
 
dc.contributor.authorMatsutani, Y
 
dc.contributor.authorKagaya, M
 
dc.contributor.authorHughes, K
 
dc.contributor.authorLee, J
 
dc.contributor.authorHeng, D
 
dc.contributor.authorZhou, BF
 
dc.contributor.authorZhang, HY
 
dc.contributor.authorShimamoto, K
 
dc.contributor.authorSaitoh, S
 
dc.contributor.authorLi, ZZ
 
dc.contributor.authorZhang, HY
 
dc.contributor.authorHe, Y
 
dc.contributor.authorYao, SX
 
dc.date.accessioned2012-06-26T06:26:04Z
 
dc.date.available2012-06-26T06:26:04Z
 
dc.date.issued2004
 
dc.description.abstractBackground. Few prospective data from the Asia-Pacific region are available relating body mass index (BMI) to the risks of stroke and ischaemic heart disease (IHD). Our objective was to assess the age-, sex-, and region-specific associations of BMI with cardiovascular disease using individual participant data from prospective studies in the Asia-Pacific region. Methods. Studies were identified from literature searches, proceedings of meetings, and personal communication. All studies had at least 5000 person-years of follow-up. Hazard ratios were calculated from Cox models, stratified by sex and cohort, and adjusted for age at risk and smoking. The first 3 years of follow-up were excluded in order to reduce confounding due to disease at baseline. Results. A total of 33 cohort studies, including 310 283 participants, contributed 2 148 354 person-years of follow-up, during which 3332 stroke and 2073 IHD events were observed. There were continuous positive associations between baseline BMI and the risks of ischaemic stroke, haemorrhagic stroke, and IHD, with each 2 kg/m 2 lower BMI associated a 12% (95% CI: 9, 15%) lower risk of ischaemic stroke, 8% (95% CI: 4, 12%) lower risk in haemorrhagic stroke, and 11% (95% CI: 9, 13%) lower risk of IHD. The strengths of all associations were strongly age dependent, and there was no significant difference between Asian and Australasian cohorts. Conclusions. This overview provides the most reliable estimates to date of the associations between BMI and cardiovascular disease in the Asia-Pacific region, and the first direct comparisons within the region. Continuous relationships of approximately equal strength are evident in both Asian and Australasian populations. These results indicate considerable potential for cardiovascular disease reduction with population-wide lowering of BMI. © International Epidemiological Association 2004; all rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationInternational Journal Of Epidemiology, 2004, v. 33 n. 4, p. 751-758 [How to Cite?]
DOI: http://dx.doi.org/10.1093/ije/dyh163
 
dc.identifier.doihttp://dx.doi.org/10.1093/ije/dyh163
 
dc.identifier.epage758
 
dc.identifier.isiWOS:000223944100023
 
dc.identifier.issn0300-5771
2013 Impact Factor: 9.197
2013 SCImago Journal Rankings: 4.074
 
dc.identifier.issue4
 
dc.identifier.pmid15105409
 
dc.identifier.scopuseid_2-s2.0-4644341787
 
dc.identifier.spage751
 
dc.identifier.urihttp://hdl.handle.net/10722/151653
 
dc.identifier.volume33
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofInternational Journal of Epidemiology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAsia - Epidemiology
 
dc.subject.meshAustralia - Epidemiology
 
dc.subject.meshBody Mass Index
 
dc.subject.meshCardiovascular Diseases - Epidemiology - Etiology
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshNew Zealand - Epidemiology
 
dc.subject.meshProportional Hazards Models
 
dc.subject.meshProspective Studies
 
dc.subject.meshRisk
 
dc.titleBody mass index and cardiovascular disease in the Asia-Pacific Region: An overview of 33 cohorts involving 310 000 participants
 
dc.typeArticle
 
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<contributor.author>Rodgers, A</contributor.author>
<contributor.author>Pan, WH</contributor.author>
<contributor.author>Gu, DF</contributor.author>
<contributor.author>Woodward, M</contributor.author>
<contributor.author>Parag, V</contributor.author>
<contributor.author>Lin, R</contributor.author>
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<contributor.author>Zhou, J</contributor.author>
<contributor.author>Yu, XH</contributor.author>
<contributor.author>Tamakoshi, A</contributor.author>
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<description.abstract>Background. Few prospective data from the Asia-Pacific region are available relating body mass index (BMI) to the risks of stroke and ischaemic heart disease (IHD). Our objective was to assess the age-, sex-, and region-specific associations of BMI with cardiovascular disease using individual participant data from prospective studies in the Asia-Pacific region. Methods. Studies were identified from literature searches, proceedings of meetings, and personal communication. All studies had at least 5000 person-years of follow-up. Hazard ratios were calculated from Cox models, stratified by sex and cohort, and adjusted for age at risk and smoking. The first 3 years of follow-up were excluded in order to reduce confounding due to disease at baseline. Results. A total of 33 cohort studies, including 310 283 participants, contributed 2 148 354 person-years of follow-up, during which 3332 stroke and 2073 IHD events were observed. There were continuous positive associations between baseline BMI and the risks of ischaemic stroke, haemorrhagic stroke, and IHD, with each 2 kg/m 2 lower BMI associated a 12% (95% CI: 9, 15%) lower risk of ischaemic stroke, 8% (95% CI: 4, 12%) lower risk in haemorrhagic stroke, and 11% (95% CI: 9, 13%) lower risk of IHD. The strengths of all associations were strongly age dependent, and there was no significant difference between Asian and Australasian cohorts. Conclusions. This overview provides the most reliable estimates to date of the associations between BMI and cardiovascular disease in the Asia-Pacific region, and the first direct comparisons within the region. Continuous relationships of approximately equal strength are evident in both Asian and Australasian populations. These results indicate considerable potential for cardiovascular disease reduction with population-wide lowering of BMI. &#169; International Epidemiological Association 2004; all rights reserved.</description.abstract>
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<subject.mesh>Male</subject.mesh>
<subject.mesh>Middle Aged</subject.mesh>
<subject.mesh>New Zealand - Epidemiology</subject.mesh>
<subject.mesh>Proportional Hazards Models</subject.mesh>
<subject.mesh>Prospective Studies</subject.mesh>
<subject.mesh>Risk</subject.mesh>
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Author Affiliations
  1. Civil Service Workers
  2. University of Sydney
  3. University of Auckland Clinical Trials Research Unit
  4. Canberra-Queanbeyan
  5. Capital Iron and Steel Company
  6. Fuwai Hospital
  7. Institute of Biomedical Sciences Academia Sinica Taiwan
  8. Beijing Steelworkers