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Article: Body mass index and cardiovascular disease in the Asia-Pacific Region: An overview of 33 cohorts involving 310 000 participants

TitleBody mass index and cardiovascular disease in the Asia-Pacific Region: An overview of 33 cohorts involving 310 000 participants
Authors
Issue Date2004
PublisherOxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/
Citation
International Journal Of Epidemiology, 2004, v. 33 n. 4, p. 751-758 How to Cite?
Abstract
Background. Few prospective data from the Asia-Pacific region are available relating body mass index (BMI) to the risks of stroke and ischaemic heart disease (IHD). Our objective was to assess the age-, sex-, and region-specific associations of BMI with cardiovascular disease using individual participant data from prospective studies in the Asia-Pacific region. Methods. Studies were identified from literature searches, proceedings of meetings, and personal communication. All studies had at least 5000 person-years of follow-up. Hazard ratios were calculated from Cox models, stratified by sex and cohort, and adjusted for age at risk and smoking. The first 3 years of follow-up were excluded in order to reduce confounding due to disease at baseline. Results. A total of 33 cohort studies, including 310 283 participants, contributed 2 148 354 person-years of follow-up, during which 3332 stroke and 2073 IHD events were observed. There were continuous positive associations between baseline BMI and the risks of ischaemic stroke, haemorrhagic stroke, and IHD, with each 2 kg/m 2 lower BMI associated a 12% (95% CI: 9, 15%) lower risk of ischaemic stroke, 8% (95% CI: 4, 12%) lower risk in haemorrhagic stroke, and 11% (95% CI: 9, 13%) lower risk of IHD. The strengths of all associations were strongly age dependent, and there was no significant difference between Asian and Australasian cohorts. Conclusions. This overview provides the most reliable estimates to date of the associations between BMI and cardiovascular disease in the Asia-Pacific region, and the first direct comparisons within the region. Continuous relationships of approximately equal strength are evident in both Asian and Australasian populations. These results indicate considerable potential for cardiovascular disease reduction with population-wide lowering of BMI. © International Epidemiological Association 2004; all rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/151653
ISSN
2013 Impact Factor: 9.197
2013 SCImago Journal Rankings: 4.074
ISI Accession Number ID
References

 

Author Affiliations
  1. Civil Service Workers
  2. University of Sydney
  3. University of Auckland Clinical Trials Research Unit
  4. Canberra-Queanbeyan
  5. Capital Iron and Steel Company
  6. Fuwai Hospital
  7. Institute of Biomedical Sciences Academia Sinica Taiwan
  8. Beijing Steelworkers
DC FieldValueLanguage
dc.contributor.authorNi Mhurchu, Cen_US
dc.contributor.authorRodgers, Aen_US
dc.contributor.authorPan, WHen_US
dc.contributor.authorGu, DFen_US
dc.contributor.authorWoodward, Men_US
dc.contributor.authorParag, Ven_US
dc.contributor.authorLin, Ren_US
dc.contributor.authorBennett, DAen_US
dc.contributor.authorVander Hoorn, Sen_US
dc.contributor.authorBarzi, Fen_US
dc.contributor.authorMacmahon, Sen_US
dc.contributor.authorLam, THen_US
dc.contributor.authorLawes, Cen_US
dc.contributor.authorSuh, Ien_US
dc.contributor.authorUeshima, Hen_US
dc.contributor.authorOkayama, Aen_US
dc.contributor.authorMaegawa, Hen_US
dc.contributor.authorAoki, Nen_US
dc.contributor.authorNakamura, Men_US
dc.contributor.authorKubo, Nen_US
dc.contributor.authorYamada, Ten_US
dc.contributor.authorWu, ZSen_US
dc.contributor.authorYao, CHen_US
dc.contributor.authorLiu, LSen_US
dc.contributor.authorXie, JXen_US
dc.contributor.authorKnuiman, MWen_US
dc.contributor.authorChristensen, Hen_US
dc.contributor.authorWu, XGen_US
dc.contributor.authorZhou, Jen_US
dc.contributor.authorYu, XHen_US
dc.contributor.authorTamakoshi, Aen_US
dc.contributor.authorWu, ZLen_US
dc.contributor.authorChen, LQen_US
dc.contributor.authorShan, GLen_US
dc.contributor.authorDuan, XFen_US
dc.contributor.authorNorton, Ren_US
dc.contributor.authorWhitlock, Gen_US
dc.contributor.authorJackson, Ren_US
dc.contributor.authorFujishima, Men_US
dc.contributor.authorKiyohara, Yen_US
dc.contributor.authorIwamoto, Hen_US
dc.contributor.authorWoo, Jen_US
dc.contributor.authorHo, Sen_US
dc.contributor.authorHong, Zen_US
dc.contributor.authorHuang, MSen_US
dc.contributor.authorZhou, Ben_US
dc.contributor.authorFuh, JLen_US
dc.contributor.authorKita, Yen_US
dc.contributor.authorChoudhury, SRen_US
dc.contributor.authorJee, SHen_US
dc.contributor.authorKim, ISen_US
dc.contributor.authorGiles, Gen_US
dc.contributor.authorHashimoto, Ten_US
dc.contributor.authorSakata, Ken_US
dc.contributor.authorImai, Yen_US
dc.contributor.authorOhkubo, Ten_US
dc.contributor.authorHozawa, Aen_US
dc.contributor.authorJamrozik, Ken_US
dc.contributor.authorHobbs, Men_US
dc.contributor.authorBroadhurst, Ren_US
dc.contributor.authorNakachi, Ken_US
dc.contributor.authorFang, XHen_US
dc.contributor.authorLi, SCen_US
dc.contributor.authorYang, QDen_US
dc.contributor.authorChen, ZMen_US
dc.contributor.authorTanaka, Hen_US
dc.contributor.authorNozaki, Aen_US
dc.contributor.authorHoribe, Hen_US
dc.contributor.authorMatsutani, Yen_US
dc.contributor.authorKagaya, Men_US
dc.contributor.authorHughes, Ken_US
dc.contributor.authorLee, Jen_US
dc.contributor.authorHeng, Den_US
dc.contributor.authorZhou, BFen_US
dc.contributor.authorZhang, HYen_US
dc.contributor.authorShimamoto, Ken_US
dc.contributor.authorSaitoh, Sen_US
dc.contributor.authorLi, ZZen_US
dc.contributor.authorZhang, HYen_US
dc.contributor.authorHe, Yen_US
dc.contributor.authorYao, SXen_US
dc.date.accessioned2012-06-26T06:26:04Z-
dc.date.available2012-06-26T06:26:04Z-
dc.date.issued2004en_US
dc.identifier.citationInternational Journal Of Epidemiology, 2004, v. 33 n. 4, p. 751-758en_US
dc.identifier.issn0300-5771en_US
dc.identifier.urihttp://hdl.handle.net/10722/151653-
dc.description.abstractBackground. Few prospective data from the Asia-Pacific region are available relating body mass index (BMI) to the risks of stroke and ischaemic heart disease (IHD). Our objective was to assess the age-, sex-, and region-specific associations of BMI with cardiovascular disease using individual participant data from prospective studies in the Asia-Pacific region. Methods. Studies were identified from literature searches, proceedings of meetings, and personal communication. All studies had at least 5000 person-years of follow-up. Hazard ratios were calculated from Cox models, stratified by sex and cohort, and adjusted for age at risk and smoking. The first 3 years of follow-up were excluded in order to reduce confounding due to disease at baseline. Results. A total of 33 cohort studies, including 310 283 participants, contributed 2 148 354 person-years of follow-up, during which 3332 stroke and 2073 IHD events were observed. There were continuous positive associations between baseline BMI and the risks of ischaemic stroke, haemorrhagic stroke, and IHD, with each 2 kg/m 2 lower BMI associated a 12% (95% CI: 9, 15%) lower risk of ischaemic stroke, 8% (95% CI: 4, 12%) lower risk in haemorrhagic stroke, and 11% (95% CI: 9, 13%) lower risk of IHD. The strengths of all associations were strongly age dependent, and there was no significant difference between Asian and Australasian cohorts. Conclusions. This overview provides the most reliable estimates to date of the associations between BMI and cardiovascular disease in the Asia-Pacific region, and the first direct comparisons within the region. Continuous relationships of approximately equal strength are evident in both Asian and Australasian populations. These results indicate considerable potential for cardiovascular disease reduction with population-wide lowering of BMI. © International Epidemiological Association 2004; all rights reserved.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/en_US
dc.relation.ispartofInternational Journal of Epidemiologyen_US
dc.subject.meshAsia - Epidemiologyen_US
dc.subject.meshAustralia - Epidemiologyen_US
dc.subject.meshBody Mass Indexen_US
dc.subject.meshCardiovascular Diseases - Epidemiology - Etiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNew Zealand - Epidemiologyen_US
dc.subject.meshProportional Hazards Modelsen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRisken_US
dc.titleBody mass index and cardiovascular disease in the Asia-Pacific Region: An overview of 33 cohorts involving 310 000 participantsen_US
dc.typeArticleen_US
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/ije/dyh163en_US
dc.identifier.pmid15105409en_US
dc.identifier.scopuseid_2-s2.0-4644341787en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4644341787&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume33en_US
dc.identifier.issue4en_US
dc.identifier.spage751en_US
dc.identifier.epage758en_US
dc.identifier.isiWOS:000223944100023-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridNi Mhurchu, C=6603276614en_US
dc.identifier.scopusauthoridRodgers, A=7102805144en_US
dc.identifier.scopusauthoridPan, WH=7402219783en_US
dc.identifier.scopusauthoridGu, DF=7202151958en_US
dc.identifier.scopusauthoridWoodward, M=7102510958en_US
dc.identifier.scopusauthoridParag, V=8924488300en_US
dc.identifier.scopusauthoridLin, R=27171610000en_US
dc.identifier.scopusauthoridBennett, DA=35420095800en_US
dc.identifier.scopusauthoridVander Hoorn, S=6602752361en_US
dc.identifier.scopusauthoridBarzi, F=7003545543en_US
dc.identifier.scopusauthoridMacMahon, S=24312201200en_US
dc.identifier.scopusauthoridLam, TH=7202522876en_US
dc.identifier.scopusauthoridLawes, C=6602516713en_US
dc.identifier.scopusauthoridSuh, I=7101988200en_US
dc.identifier.scopusauthoridUeshima, H=7005129002en_US
dc.identifier.scopusauthoridOkayama, A=35300529100en_US
dc.identifier.scopusauthoridMaegawa, H=7005198303en_US
dc.identifier.scopusauthoridAoki, N=7401716495en_US
dc.identifier.scopusauthoridNakamura, M=7405345581en_US
dc.identifier.scopusauthoridKubo, N=7102513194en_US
dc.identifier.scopusauthoridYamada, T=7405973529en_US
dc.identifier.scopusauthoridWu, ZS=7501411359en_US
dc.identifier.scopusauthoridYao, CH=7201495948en_US
dc.identifier.scopusauthoridLiu, LS=7405259104en_US
dc.identifier.scopusauthoridXie, JX=7402994954en_US
dc.identifier.scopusauthoridKnuiman, MW=7005404334en_US
dc.identifier.scopusauthoridChristensen, H=7401664499en_US
dc.identifier.scopusauthoridWu, XG=7407065596en_US
dc.identifier.scopusauthoridZhou, J=35228239600en_US
dc.identifier.scopusauthoridYu, XH=7404114656en_US
dc.identifier.scopusauthoridTamakoshi, A=7006797376en_US
dc.identifier.scopusauthoridWu, ZL=15053584200en_US
dc.identifier.scopusauthoridChen, LQ=10040762900en_US
dc.identifier.scopusauthoridShan, GL=7005942365en_US
dc.identifier.scopusauthoridDuan, XF=7202708945en_US
dc.identifier.scopusauthoridNorton, R=7202155574en_US
dc.identifier.scopusauthoridWhitlock, G=7004159442en_US
dc.identifier.scopusauthoridJackson, R=7404309778en_US
dc.identifier.scopusauthoridFujishima, M=35352934700en_US
dc.identifier.scopusauthoridKiyohara, Y=7005335984en_US
dc.identifier.scopusauthoridIwamoto, H=7202028291en_US
dc.identifier.scopusauthoridWoo, J=36040369400en_US
dc.identifier.scopusauthoridHo, S=7403716908en_US
dc.identifier.scopusauthoridHong, Z=7201414497en_US
dc.identifier.scopusauthoridHuang, MS=8902885500en_US
dc.identifier.scopusauthoridZhou, B=7401906952en_US
dc.identifier.scopusauthoridFuh, JL=35227302000en_US
dc.identifier.scopusauthoridKita, Y=7202729333en_US
dc.identifier.scopusauthoridChoudhury, SR=7102715678en_US
dc.identifier.scopusauthoridJee, SH=16039275900en_US
dc.identifier.scopusauthoridKim, IS=36079546600en_US
dc.identifier.scopusauthoridGiles, G=7103091133en_US
dc.identifier.scopusauthoridHashimoto, T=26426009500en_US
dc.identifier.scopusauthoridSakata, K=35227840700en_US
dc.identifier.scopusauthoridImai, Y=36050693700en_US
dc.identifier.scopusauthoridOhkubo, T=7201618716en_US
dc.identifier.scopusauthoridHozawa, A=7003868341en_US
dc.identifier.scopusauthoridJamrozik, K=26426193300en_US
dc.identifier.scopusauthoridHobbs, M=7101710506en_US
dc.identifier.scopusauthoridBroadhurst, R=35556509100en_US
dc.identifier.scopusauthoridNakachi, K=8749947000en_US
dc.identifier.scopusauthoridFang, XH=15834725000en_US
dc.identifier.scopusauthoridLi, SC=7409237355en_US
dc.identifier.scopusauthoridYang, QD=7404076103en_US
dc.identifier.scopusauthoridChen, ZM=7409483946en_US
dc.identifier.scopusauthoridTanaka, H=7406598393en_US
dc.identifier.scopusauthoridNozaki, A=7006414963en_US
dc.identifier.scopusauthoridHoribe, H=7005739955en_US
dc.identifier.scopusauthoridMatsutani, Y=8892298100en_US
dc.identifier.scopusauthoridKagaya, M=7006577657en_US
dc.identifier.scopusauthoridHughes, K=7202448794en_US
dc.identifier.scopusauthoridLee, J=27168586100en_US
dc.identifier.scopusauthoridHeng, D=6701509730en_US
dc.identifier.scopusauthoridZhou, BF=7401907215en_US
dc.identifier.scopusauthoridZhang, HY=36072165300en_US
dc.identifier.scopusauthoridShimamoto, K=35354538200en_US
dc.identifier.scopusauthoridSaitoh, S=7203038980en_US
dc.identifier.scopusauthoridLi, ZZ=7409083923en_US
dc.identifier.scopusauthoridZhang, HY=16938039100en_US
dc.identifier.scopusauthoridHe, Y=7404942229en_US
dc.identifier.scopusauthoridYao, SX=35231647800en_US

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