Article: Body mass index and cardiovascular disease in the Asia-Pacific Region: An overview of 33 cohorts involving 310 000 participants

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TitleBody mass index and cardiovascular disease in the Asia-Pacific Region: An overview of 33 cohorts involving 310 000 participants
AuthorsNi Mhurchu, C3
Rodgers, A3
Pan, WH8
Gu, DF6
Woodward, M2
Parag, V
Lin, R
Bennett, DA
Vander Hoorn, S
Barzi, F
Macmahon, S
Lam, TH
Lawes, C
Suh, I
Ueshima, H
Okayama, A
Maegawa, H
Aoki, N
Nakamura, M
Kubo, N
Yamada, T
Wu, ZS
Yao, CH
Liu, LS7
Xie, JX7
Knuiman, MW
Christensen, H4
Wu, XG5
Zhou, J
Yu, XH
Tamakoshi, A1
Wu, ZL
Chen, LQ
Shan, GL
Duan, XF
Norton, R
Whitlock, G
Jackson, R
Fujishima, M
Kiyohara, Y
Iwamoto, H
Woo, J
Ho, S
Hong, Z
Huang, MS
Zhou, B
Fuh, JL
Kita, Y
Choudhury, SR
Jee, SH
Kim, IS
Giles, G
Hashimoto, T
Sakata, K
Imai, Y
Ohkubo, T
Hozawa, A
Jamrozik, K
Hobbs, M
Broadhurst, R
Nakachi, K
Fang, XH
Li, SC
Yang, QD
Chen, ZM
Tanaka, H
Nozaki, A
Horibe, H
Matsutani, Y
Kagaya, M
Hughes, K
Lee, J
Heng, D
Zhou, BF
Zhang, HY
Shimamoto, K
Saitoh, S
Li, ZZ
Zhang, HY
He, Y
Yao, SX
Issue Date2004
PublisherOxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/
CitationInternational Journal Of Epidemiology, 2004, v. 33 n. 4, p. 751-758 [How to Cite?]
DOI: http://dx.doi.org/10.1093/ije/dyh163
AbstractBackground. Few prospective data from the Asia-Pacific region are available relating body mass index (BMI) to the risks of stroke and ischaemic heart disease (IHD). Our objective was to assess the age-, sex-, and region-specific associations of BMI with cardiovascular disease using individual participant data from prospective studies in the Asia-Pacific region. Methods. Studies were identified from literature searches, proceedings of meetings, and personal communication. All studies had at least 5000 person-years of follow-up. Hazard ratios were calculated from Cox models, stratified by sex and cohort, and adjusted for age at risk and smoking. The first 3 years of follow-up were excluded in order to reduce confounding due to disease at baseline. Results. A total of 33 cohort studies, including 310 283 participants, contributed 2 148 354 person-years of follow-up, during which 3332 stroke and 2073 IHD events were observed. There were continuous positive associations between baseline BMI and the risks of ischaemic stroke, haemorrhagic stroke, and IHD, with each 2 kg/m 2 lower BMI associated a 12% (95% CI: 9, 15%) lower risk of ischaemic stroke, 8% (95% CI: 4, 12%) lower risk in haemorrhagic stroke, and 11% (95% CI: 9, 13%) lower risk of IHD. The strengths of all associations were strongly age dependent, and there was no significant difference between Asian and Australasian cohorts. Conclusions. This overview provides the most reliable estimates to date of the associations between BMI and cardiovascular disease in the Asia-Pacific region, and the first direct comparisons within the region. Continuous relationships of approximately equal strength are evident in both Asian and Australasian populations. These results indicate considerable potential for cardiovascular disease reduction with population-wide lowering of BMI. © International Epidemiological Association 2004; all rights reserved.
ISSN0300-5771
2011 Impact Factor: 6.414
2011 SCImago Journal Rankings: 0.527
DOIhttp://dx.doi.org/10.1093/ije/dyh163
ISI Accession Number IDWOS:000223944100023
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorNi Mhurchu, C
dc.contributor.authorRodgers, A
dc.contributor.authorPan, WH
dc.contributor.authorGu, DF
dc.contributor.authorWoodward, M
dc.contributor.authorParag, V
dc.contributor.authorLin, R
dc.contributor.authorBennett, DA
dc.contributor.authorVander Hoorn, S
dc.contributor.authorBarzi, F
dc.contributor.authorMacmahon, S
dc.contributor.authorLam, TH
dc.contributor.authorLawes, C
dc.contributor.authorSuh, I
dc.contributor.authorUeshima, H
dc.contributor.authorOkayama, A
dc.contributor.authorMaegawa, H
dc.contributor.authorAoki, N
dc.contributor.authorNakamura, M
dc.contributor.authorKubo, N
dc.contributor.authorYamada, T
dc.contributor.authorWu, ZS
dc.contributor.authorYao, CH
dc.contributor.authorLiu, LS
dc.contributor.authorXie, JX
dc.contributor.authorKnuiman, MW
dc.contributor.authorChristensen, H
dc.contributor.authorWu, XG
dc.contributor.authorZhou, J
dc.contributor.authorYu, XH
dc.contributor.authorTamakoshi, A
dc.contributor.authorWu, ZL
dc.contributor.authorChen, LQ
dc.contributor.authorShan, GL
dc.contributor.authorDuan, XF
dc.contributor.authorNorton, R
dc.contributor.authorWhitlock, G
dc.contributor.authorJackson, R
dc.contributor.authorFujishima, M
dc.contributor.authorKiyohara, Y
dc.contributor.authorIwamoto, H
dc.contributor.authorWoo, J
dc.contributor.authorHo, S
dc.contributor.authorHong, Z
dc.contributor.authorHuang, MS
dc.contributor.authorZhou, B
dc.contributor.authorFuh, JL
dc.contributor.authorKita, Y
dc.contributor.authorChoudhury, SR
dc.contributor.authorJee, SH
dc.contributor.authorKim, IS
dc.contributor.authorGiles, G
dc.contributor.authorHashimoto, T
dc.contributor.authorSakata, K
dc.contributor.authorImai, Y
dc.contributor.authorOhkubo, T
dc.contributor.authorHozawa, A
dc.contributor.authorJamrozik, K
dc.contributor.authorHobbs, M
dc.contributor.authorBroadhurst, R
dc.contributor.authorNakachi, K
dc.contributor.authorFang, XH
dc.contributor.authorLi, SC
dc.contributor.authorYang, QD
dc.contributor.authorChen, ZM
dc.contributor.authorTanaka, H
dc.contributor.authorNozaki, A
dc.contributor.authorHoribe, H
dc.contributor.authorMatsutani, Y
dc.contributor.authorKagaya, M
dc.contributor.authorHughes, K
dc.contributor.authorLee, J
dc.contributor.authorHeng, D
dc.contributor.authorZhou, BF
dc.contributor.authorZhang, HY
dc.contributor.authorShimamoto, K
dc.contributor.authorSaitoh, S
dc.contributor.authorLi, ZZ
dc.contributor.authorZhang, HY
dc.contributor.authorHe, Y
dc.contributor.authorYao, SX
dc.date.accessioned2012-06-26T06:26:04Z
dc.date.available2012-06-26T06:26:04Z
dc.date.issued2004
dc.description.abstractBackground. Few prospective data from the Asia-Pacific region are available relating body mass index (BMI) to the risks of stroke and ischaemic heart disease (IHD). Our objective was to assess the age-, sex-, and region-specific associations of BMI with cardiovascular disease using individual participant data from prospective studies in the Asia-Pacific region. Methods. Studies were identified from literature searches, proceedings of meetings, and personal communication. All studies had at least 5000 person-years of follow-up. Hazard ratios were calculated from Cox models, stratified by sex and cohort, and adjusted for age at risk and smoking. The first 3 years of follow-up were excluded in order to reduce confounding due to disease at baseline. Results. A total of 33 cohort studies, including 310 283 participants, contributed 2 148 354 person-years of follow-up, during which 3332 stroke and 2073 IHD events were observed. There were continuous positive associations between baseline BMI and the risks of ischaemic stroke, haemorrhagic stroke, and IHD, with each 2 kg/m 2 lower BMI associated a 12% (95% CI: 9, 15%) lower risk of ischaemic stroke, 8% (95% CI: 4, 12%) lower risk in haemorrhagic stroke, and 11% (95% CI: 9, 13%) lower risk of IHD. The strengths of all associations were strongly age dependent, and there was no significant difference between Asian and Australasian cohorts. Conclusions. This overview provides the most reliable estimates to date of the associations between BMI and cardiovascular disease in the Asia-Pacific region, and the first direct comparisons within the region. Continuous relationships of approximately equal strength are evident in both Asian and Australasian populations. These results indicate considerable potential for cardiovascular disease reduction with population-wide lowering of BMI. © International Epidemiological Association 2004; all rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationInternational Journal Of Epidemiology, 2004, v. 33 n. 4, p. 751-758 [How to Cite?]
DOI: http://dx.doi.org/10.1093/ije/dyh163
dc.identifier.doihttp://dx.doi.org/10.1093/ije/dyh163
dc.identifier.epage758
dc.identifier.isiWOS:000223944100023
dc.identifier.issn0300-5771
2011 Impact Factor: 6.414
2011 SCImago Journal Rankings: 0.527
dc.identifier.issue4
dc.identifier.pmid15105409
dc.identifier.scopuseid_2-s2.0-4644341787
dc.identifier.spage751
dc.identifier.urihttp://hdl.handle.net/10722/151653
dc.identifier.volume33
dc.languageeng
dc.publisherOxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofInternational Journal of Epidemiology
dc.relation.referencesReferences in Scopus
dc.subject.meshAsia - Epidemiology
dc.subject.meshAustralia - Epidemiology
dc.subject.meshBody Mass Index
dc.subject.meshCardiovascular Diseases - Epidemiology - Etiology
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNew Zealand - Epidemiology
dc.subject.meshProportional Hazards Models
dc.subject.meshProspective Studies
dc.subject.meshRisk
dc.titleBody mass index and cardiovascular disease in the Asia-Pacific Region: An overview of 33 cohorts involving 310 000 participants
dc.typeArticle
Author Affiliations
  1. Civil Service Workers
  2. University of Sydney
  3. University of Auckland
  4. Canberra-Queanbeyan
  5. Capital Iron and Steel Company
  6. Fuwai Hospital
  7. Beijing Steelworkers
  8. Institute of Biomedical Sciences Academia Sinica Taiwan