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Article: Body mass index and cardiovascular disease in the Asia-Pacific Region: An overview of 33 cohorts involving 310 000 participants

TitleBody mass index and cardiovascular disease in the Asia-Pacific Region: An overview of 33 cohorts involving 310 000 participants
Authors
KeywordsAsia
Body mass index
Cardiovascular disease
Cohort study
Obesity
Overview
Issue Date2004
PublisherOxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/
Citation
International Journal Of Epidemiology, 2004, v. 33 n. 4, p. 751-758 How to Cite?
AbstractBackground. Few prospective data from the Asia-Pacific region are available relating body mass index (BMI) to the risks of stroke and ischaemic heart disease (IHD). Our objective was to assess the age-, sex-, and region-specific associations of BMI with cardiovascular disease using individual participant data from prospective studies in the Asia-Pacific region. Methods. Studies were identified from literature searches, proceedings of meetings, and personal communication. All studies had at least 5000 person-years of follow-up. Hazard ratios were calculated from Cox models, stratified by sex and cohort, and adjusted for age at risk and smoking. The first 3 years of follow-up were excluded in order to reduce confounding due to disease at baseline. Results. A total of 33 cohort studies, including 310 283 participants, contributed 2 148 354 person-years of follow-up, during which 3332 stroke and 2073 IHD events were observed. There were continuous positive associations between baseline BMI and the risks of ischaemic stroke, haemorrhagic stroke, and IHD, with each 2 kg/m 2 lower BMI associated a 12% (95% CI: 9, 15%) lower risk of ischaemic stroke, 8% (95% CI: 4, 12%) lower risk in haemorrhagic stroke, and 11% (95% CI: 9, 13%) lower risk of IHD. The strengths of all associations were strongly age dependent, and there was no significant difference between Asian and Australasian cohorts. Conclusions. This overview provides the most reliable estimates to date of the associations between BMI and cardiovascular disease in the Asia-Pacific region, and the first direct comparisons within the region. Continuous relationships of approximately equal strength are evident in both Asian and Australasian populations. These results indicate considerable potential for cardiovascular disease reduction with population-wide lowering of BMI. © International Epidemiological Association 2004; all rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/151653
ISSN
2021 Impact Factor: 9.685
2020 SCImago Journal Rankings: 3.406
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNi Mhurchu, Cen_US
dc.contributor.authorRodgers, Aen_US
dc.contributor.authorPan, WHen_US
dc.contributor.authorGu, DFen_US
dc.contributor.authorWoodward, Men_US
dc.contributor.authorParag, Ven_US
dc.contributor.authorLin, Ren_US
dc.contributor.authorBennett, DAen_US
dc.contributor.authorVander Hoorn, Sen_US
dc.contributor.authorBarzi, Fen_US
dc.contributor.authorMacmahon, Sen_US
dc.contributor.authorLam, THen_US
dc.contributor.authorLawes, Cen_US
dc.contributor.authorSuh, Ien_US
dc.contributor.authorUeshima, Hen_US
dc.contributor.authorOkayama, Aen_US
dc.contributor.authorMaegawa, Hen_US
dc.contributor.authorAoki, Nen_US
dc.contributor.authorNakamura, Men_US
dc.contributor.authorKubo, Nen_US
dc.contributor.authorYamada, Ten_US
dc.contributor.authorWu, ZSen_US
dc.contributor.authorYao, CHen_US
dc.contributor.authorLiu, LSen_US
dc.contributor.authorXie, JXen_US
dc.contributor.authorKnuiman, MWen_US
dc.contributor.authorChristensen, Hen_US
dc.contributor.authorWu, XGen_US
dc.contributor.authorZhou, Jen_US
dc.contributor.authorYu, XHen_US
dc.contributor.authorTamakoshi, Aen_US
dc.contributor.authorWu, ZLen_US
dc.contributor.authorChen, LQen_US
dc.contributor.authorShan, GLen_US
dc.contributor.authorDuan, XFen_US
dc.contributor.authorNorton, Ren_US
dc.contributor.authorWhitlock, Gen_US
dc.contributor.authorJackson, Ren_US
dc.contributor.authorFujishima, Men_US
dc.contributor.authorKiyohara, Yen_US
dc.contributor.authorIwamoto, Hen_US
dc.contributor.authorWoo, Jen_US
dc.contributor.authorHo, Sen_US
dc.contributor.authorHong, Zen_US
dc.contributor.authorHuang, MSen_US
dc.contributor.authorZhou, Ben_US
dc.contributor.authorFuh, JLen_US
dc.contributor.authorKita, Yen_US
dc.contributor.authorChoudhury, SRen_US
dc.contributor.authorJee, SHen_US
dc.contributor.authorKim, ISen_US
dc.contributor.authorGiles, Gen_US
dc.contributor.authorHashimoto, Ten_US
dc.contributor.authorSakata, Ken_US
dc.contributor.authorImai, Yen_US
dc.contributor.authorOhkubo, Ten_US
dc.contributor.authorHozawa, Aen_US
dc.contributor.authorJamrozik, Ken_US
dc.contributor.authorHobbs, Men_US
dc.contributor.authorBroadhurst, Ren_US
dc.contributor.authorNakachi, Ken_US
dc.contributor.authorFang, XHen_US
dc.contributor.authorLi, SCen_US
dc.contributor.authorYang, QDen_US
dc.contributor.authorChen, ZMen_US
dc.contributor.authorTanaka, Hen_US
dc.contributor.authorNozaki, Aen_US
dc.contributor.authorHoribe, Hen_US
dc.contributor.authorMatsutani, Yen_US
dc.contributor.authorKagaya, Men_US
dc.contributor.authorHughes, Ken_US
dc.contributor.authorLee, Jen_US
dc.contributor.authorHeng, Den_US
dc.contributor.authorZhou, BFen_US
dc.contributor.authorZhang, HYen_US
dc.contributor.authorShimamoto, Ken_US
dc.contributor.authorSaitoh, Sen_US
dc.contributor.authorLi, ZZen_US
dc.contributor.authorZhang, HYen_US
dc.contributor.authorHe, Yen_US
dc.contributor.authorYao, SXen_US
dc.date.accessioned2012-06-26T06:26:04Z-
dc.date.available2012-06-26T06:26:04Z-
dc.date.issued2004en_US
dc.identifier.citationInternational Journal Of Epidemiology, 2004, v. 33 n. 4, p. 751-758en_US
dc.identifier.issn0300-5771en_US
dc.identifier.urihttp://hdl.handle.net/10722/151653-
dc.description.abstractBackground. Few prospective data from the Asia-Pacific region are available relating body mass index (BMI) to the risks of stroke and ischaemic heart disease (IHD). Our objective was to assess the age-, sex-, and region-specific associations of BMI with cardiovascular disease using individual participant data from prospective studies in the Asia-Pacific region. Methods. Studies were identified from literature searches, proceedings of meetings, and personal communication. All studies had at least 5000 person-years of follow-up. Hazard ratios were calculated from Cox models, stratified by sex and cohort, and adjusted for age at risk and smoking. The first 3 years of follow-up were excluded in order to reduce confounding due to disease at baseline. Results. A total of 33 cohort studies, including 310 283 participants, contributed 2 148 354 person-years of follow-up, during which 3332 stroke and 2073 IHD events were observed. There were continuous positive associations between baseline BMI and the risks of ischaemic stroke, haemorrhagic stroke, and IHD, with each 2 kg/m 2 lower BMI associated a 12% (95% CI: 9, 15%) lower risk of ischaemic stroke, 8% (95% CI: 4, 12%) lower risk in haemorrhagic stroke, and 11% (95% CI: 9, 13%) lower risk of IHD. The strengths of all associations were strongly age dependent, and there was no significant difference between Asian and Australasian cohorts. Conclusions. This overview provides the most reliable estimates to date of the associations between BMI and cardiovascular disease in the Asia-Pacific region, and the first direct comparisons within the region. Continuous relationships of approximately equal strength are evident in both Asian and Australasian populations. These results indicate considerable potential for cardiovascular disease reduction with population-wide lowering of BMI. © International Epidemiological Association 2004; all rights reserved.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/en_US
dc.relation.ispartofInternational Journal of Epidemiologyen_US
dc.subjectAsia-
dc.subjectBody mass index-
dc.subjectCardiovascular disease-
dc.subjectCohort study-
dc.subjectObesity-
dc.subjectOverview-
dc.subject.meshAsia - Epidemiologyen_US
dc.subject.meshAustralia - Epidemiologyen_US
dc.subject.meshBody Mass Indexen_US
dc.subject.meshCardiovascular Diseases - Epidemiology - Etiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNew Zealand - Epidemiologyen_US
dc.subject.meshProportional Hazards Modelsen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRisken_US
dc.titleBody mass index and cardiovascular disease in the Asia-Pacific Region: An overview of 33 cohorts involving 310 000 participantsen_US
dc.typeArticleen_US
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/ije/dyh163en_US
dc.identifier.pmid15105409-
dc.identifier.scopuseid_2-s2.0-4644341787en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4644341787&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume33en_US
dc.identifier.issue4en_US
dc.identifier.spage751en_US
dc.identifier.epage758en_US
dc.identifier.isiWOS:000223944100023-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridNi Mhurchu, C=6603276614en_US
dc.identifier.scopusauthoridRodgers, A=7102805144en_US
dc.identifier.scopusauthoridPan, WH=7402219783en_US
dc.identifier.scopusauthoridGu, DF=7202151958en_US
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dc.identifier.scopusauthoridVander Hoorn, S=6602752361en_US
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dc.identifier.scopusauthoridMacMahon, S=24312201200en_US
dc.identifier.scopusauthoridLam, TH=7202522876en_US
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dc.identifier.scopusauthoridSuh, I=7101988200en_US
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dc.identifier.scopusauthoridOkayama, A=35300529100en_US
dc.identifier.scopusauthoridMaegawa, H=7005198303en_US
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dc.identifier.scopusauthoridKnuiman, MW=7005404334en_US
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dc.identifier.scopusauthoridWu, ZL=15053584200en_US
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dc.identifier.issnl0300-5771-

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