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Article: Diabetic control and risk of tuberculosis: a cohort study.

TitleDiabetic control and risk of tuberculosis: a cohort study.
Authors
Issue Date2008
Citation
American Journal Of Epidemiology, 2008, v. 167 n. 12, p. 1486-1494 How to Cite?
Abstract
Diabetes mellitus is associated with tuberculosis. A cohort of 42,116 clients aged 65 years or more, enrolled at 18 Elderly Health Service centers in Hong Kong in 2000, were followed up prospectively through the territory-wide tuberculosis registry for development of tuberculosis from 3 months after enrollment to December 31, 2005, by use of their identity card numbers as unique identifier. The effects of diabetes mellitus and diabetic control on tuberculosis risk were assessed with adjustment for sociodemographic and other background variables. Diabetes mellitus was associated with a modest increase in the risk of active, culture-confirmed, and pulmonary (with or without extrapulmonary involvement) but not extrapulmonary (with or without pulmonary involvement) tuberculosis, with adjusted hazard ratios of 1.77 (95% confidence interval: 1.41, 2.24), 1.91 (95% confidence interval: 1.45, 2.52), 1.89 (95% confidence interval: 1.48, 2.42), and 1.00 (95% confidence interval: 0.54, 1.86), respectively. Diabetic subjects with hemoglobin A1c <7% at enrollment were not at increased risk. Among diabetic subjects, higher risks of active, culture-confirmed, and pulmonary but not extrapulmonary tuberculosis were observed with baseline hemoglobin A1c > or =7% (vs. <7%), with adjusted hazard ratios of 3.11 (95% confidence interval: 1.63, 5.92), 3.08 (95% confidence interval: 1.44, 6.57), 3.63 (95% confidence interval: 1.79, 7.33), and 0.77 (95% confidence interval: 0.18, 3.35), respectively.
Persistent Identifierhttp://hdl.handle.net/10722/151652
ISSN
2013 SCImago Journal Rankings: 2.971
ISI Accession Number ID

 

Author Affiliations
  1. Tuberculosis and Chest Service
DC FieldValueLanguage
dc.contributor.authorLeung, CCen_US
dc.contributor.authorLam, THen_US
dc.contributor.authorChan, WMen_US
dc.contributor.authorYew, WWen_US
dc.contributor.authorHo, KSen_US
dc.contributor.authorLeung, GMen_US
dc.contributor.authorLaw, WSen_US
dc.contributor.authorTam, CMen_US
dc.contributor.authorChan, CKen_US
dc.contributor.authorChang, KCen_US
dc.date.accessioned2012-06-26T06:25:59Z-
dc.date.available2012-06-26T06:25:59Z-
dc.date.issued2008en_US
dc.identifier.citationAmerican Journal Of Epidemiology, 2008, v. 167 n. 12, p. 1486-1494en_US
dc.identifier.issn1476-6256en_US
dc.identifier.urihttp://hdl.handle.net/10722/151652-
dc.description.abstractDiabetes mellitus is associated with tuberculosis. A cohort of 42,116 clients aged 65 years or more, enrolled at 18 Elderly Health Service centers in Hong Kong in 2000, were followed up prospectively through the territory-wide tuberculosis registry for development of tuberculosis from 3 months after enrollment to December 31, 2005, by use of their identity card numbers as unique identifier. The effects of diabetes mellitus and diabetic control on tuberculosis risk were assessed with adjustment for sociodemographic and other background variables. Diabetes mellitus was associated with a modest increase in the risk of active, culture-confirmed, and pulmonary (with or without extrapulmonary involvement) but not extrapulmonary (with or without pulmonary involvement) tuberculosis, with adjusted hazard ratios of 1.77 (95% confidence interval: 1.41, 2.24), 1.91 (95% confidence interval: 1.45, 2.52), 1.89 (95% confidence interval: 1.48, 2.42), and 1.00 (95% confidence interval: 0.54, 1.86), respectively. Diabetic subjects with hemoglobin A1c <7% at enrollment were not at increased risk. Among diabetic subjects, higher risks of active, culture-confirmed, and pulmonary but not extrapulmonary tuberculosis were observed with baseline hemoglobin A1c > or =7% (vs. <7%), with adjusted hazard ratios of 3.11 (95% confidence interval: 1.63, 5.92), 3.08 (95% confidence interval: 1.44, 6.57), 3.63 (95% confidence interval: 1.79, 7.33), and 0.77 (95% confidence interval: 0.18, 3.35), respectively.en_US
dc.languageengen_US
dc.relation.ispartofAmerican journal of epidemiologyen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshConfidence Intervalsen_US
dc.subject.meshDiabetes Mellitus - Epidemiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHemoglobin A, Glycosylated - Metabolismen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshMaleen_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRegistriesen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshTuberculosis - Epidemiologyen_US
dc.subject.meshTuberculosis, Pulmonary - Epidemiologyen_US
dc.titleDiabetic control and risk of tuberculosis: a cohort study.en_US
dc.typeArticleen_US
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_US
dc.identifier.emailLeung, GM:gmleung@hku.hken_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.identifier.authorityLeung, GM=rp00460en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid18400769en_US
dc.identifier.scopuseid_2-s2.0-46249105296en_US
dc.identifier.hkuros144565-
dc.identifier.volume167en_US
dc.identifier.issue12en_US
dc.identifier.spage1486en_US
dc.identifier.epage1494en_US
dc.identifier.isiWOS:000256755900012-
dc.identifier.scopusauthoridLeung, CC=7402612644en_US
dc.identifier.scopusauthoridLam, TH=7202522876en_US
dc.identifier.scopusauthoridChan, WM=7403914485en_US
dc.identifier.scopusauthoridYew, WW=7005934631en_US
dc.identifier.scopusauthoridHo, KS=7403581605en_US
dc.identifier.scopusauthoridLeung, GM=7007159841en_US
dc.identifier.scopusauthoridLaw, WS=7103147875en_US
dc.identifier.scopusauthoridTam, CM=7201442997en_US
dc.identifier.scopusauthoridChan, CK=7404813960en_US
dc.identifier.scopusauthoridChang, KC=7404878870en_US

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