Article: Diabetic control and risk of tuberculosis: a cohort study.
| Title | Diabetic control and risk of tuberculosis: a cohort study. |
|---|---|
| Authors | Leung, CC1 Lam, TH1 Chan, WM1 Yew, WW1 Ho, KS1 Leung, GM1 Law, WS1 Tam, CM1 Chan, CK1 Chang, KC1 |
| Issue Date | 2008 |
| Citation | American Journal Of Epidemiology, 2008, v. 167 n. 12, p. 1486-1494 [How to Cite?] |
| Abstract | Diabetes mellitus is associated with tuberculosis. A cohort of 42,116 clients aged 65 years or more, enrolled at 18 Elderly Health Service centers in Hong Kong in 2000, were followed up prospectively through the territory-wide tuberculosis registry for development of tuberculosis from 3 months after enrollment to December 31, 2005, by use of their identity card numbers as unique identifier. The effects of diabetes mellitus and diabetic control on tuberculosis risk were assessed with adjustment for sociodemographic and other background variables. Diabetes mellitus was associated with a modest increase in the risk of active, culture-confirmed, and pulmonary (with or without extrapulmonary involvement) but not extrapulmonary (with or without pulmonary involvement) tuberculosis, with adjusted hazard ratios of 1.77 (95% confidence interval: 1.41, 2.24), 1.91 (95% confidence interval: 1.45, 2.52), 1.89 (95% confidence interval: 1.48, 2.42), and 1.00 (95% confidence interval: 0.54, 1.86), respectively. Diabetic subjects with hemoglobin A1c <7% at enrollment were not at increased risk. Among diabetic subjects, higher risks of active, culture-confirmed, and pulmonary but not extrapulmonary tuberculosis were observed with baseline hemoglobin A1c > or =7% (vs. <7%), with adjusted hazard ratios of 3.11 (95% confidence interval: 1.63, 5.92), 3.08 (95% confidence interval: 1.44, 6.57), 3.63 (95% confidence interval: 1.79, 7.33), and 0.77 (95% confidence interval: 0.18, 3.35), respectively. |
| ISSN | 1476-6256 2011 SCImago Journal Rankings: 0.526 |
| ISI Accession Number ID | WOS:000256755900012 |
| dc.contributor.author | Leung, CC |
|---|---|
| dc.contributor.author | Lam, TH |
| dc.contributor.author | Chan, WM |
| dc.contributor.author | Yew, WW |
| dc.contributor.author | Ho, KS |
| dc.contributor.author | Leung, GM |
| dc.contributor.author | Law, WS |
| dc.contributor.author | Tam, CM |
| dc.contributor.author | Chan, CK |
| dc.contributor.author | Chang, KC |
| dc.date.accessioned | 2012-06-26T06:25:59Z |
| dc.date.available | 2012-06-26T06:25:59Z |
| dc.date.issued | 2008 |
| dc.description.abstract | Diabetes mellitus is associated with tuberculosis. A cohort of 42,116 clients aged 65 years or more, enrolled at 18 Elderly Health Service centers in Hong Kong in 2000, were followed up prospectively through the territory-wide tuberculosis registry for development of tuberculosis from 3 months after enrollment to December 31, 2005, by use of their identity card numbers as unique identifier. The effects of diabetes mellitus and diabetic control on tuberculosis risk were assessed with adjustment for sociodemographic and other background variables. Diabetes mellitus was associated with a modest increase in the risk of active, culture-confirmed, and pulmonary (with or without extrapulmonary involvement) but not extrapulmonary (with or without pulmonary involvement) tuberculosis, with adjusted hazard ratios of 1.77 (95% confidence interval: 1.41, 2.24), 1.91 (95% confidence interval: 1.45, 2.52), 1.89 (95% confidence interval: 1.48, 2.42), and 1.00 (95% confidence interval: 0.54, 1.86), respectively. Diabetic subjects with hemoglobin A1c <7% at enrollment were not at increased risk. Among diabetic subjects, higher risks of active, culture-confirmed, and pulmonary but not extrapulmonary tuberculosis were observed with baseline hemoglobin A1c > or =7% (vs. <7%), with adjusted hazard ratios of 3.11 (95% confidence interval: 1.63, 5.92), 3.08 (95% confidence interval: 1.44, 6.57), 3.63 (95% confidence interval: 1.79, 7.33), and 0.77 (95% confidence interval: 0.18, 3.35), respectively. |
| dc.description.nature | Link_to_subscribed_fulltext |
| dc.identifier.citation | American Journal Of Epidemiology, 2008, v. 167 n. 12, p. 1486-1494 [How to Cite?] |
| dc.identifier.epage | 1494 |
| dc.identifier.hkuros | 144565 |
| dc.identifier.isi | WOS:000256755900012 |
| dc.identifier.issn | 1476-6256 2011 SCImago Journal Rankings: 0.526 |
| dc.identifier.issue | 12 |
| dc.identifier.pmid | 18400769 |
| dc.identifier.scopus | eid_2-s2.0-46249105296 |
| dc.identifier.spage | 1486 |
| dc.identifier.uri | http://hdl.handle.net/10722/151652 |
| dc.identifier.volume | 167 |
| dc.language | eng |
| dc.relation.ispartof | American journal of epidemiology |
| dc.subject.mesh | Aged |
| dc.subject.mesh | Aged, 80 And Over |
| dc.subject.mesh | Confidence Intervals |
| dc.subject.mesh | Diabetes Mellitus - Epidemiology |
| dc.subject.mesh | Female |
| dc.subject.mesh | Hemoglobin A, Glycosylated - Metabolism |
| dc.subject.mesh | Hong Kong - Epidemiology |
| dc.subject.mesh | Humans |
| dc.subject.mesh | Incidence |
| dc.subject.mesh | Male |
| dc.subject.mesh | Odds Ratio |
| dc.subject.mesh | Prevalence |
| dc.subject.mesh | Prospective Studies |
| dc.subject.mesh | Registries |
| dc.subject.mesh | Risk Assessment |
| dc.subject.mesh | Risk Factors |
| dc.subject.mesh | Tuberculosis - Epidemiology |
| dc.subject.mesh | Tuberculosis, Pulmonary - Epidemiology |
| dc.title | Diabetic control and risk of tuberculosis: a cohort study. |
| dc.type | Article |
Author Affiliations
- Tuberculosis and Chest Service