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Article: Diabetic control and risk of tuberculosis: a cohort study.
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TitleDiabetic control and risk of tuberculosis: a cohort study.
 
AuthorsLeung, CC1
Lam, TH1
Chan, WM1
Yew, WW1
Ho, KS1
Leung, GM1
Law, WS1
Tam, CM1
Chan, CK1
Chang, KC1
 
Issue Date2008
 
CitationAmerican Journal Of Epidemiology, 2008, v. 167 n. 12, p. 1486-1494 [How to Cite?]
 
AbstractDiabetes mellitus is associated with tuberculosis. A cohort of 42,116 clients aged 65 years or more, enrolled at 18 Elderly Health Service centers in Hong Kong in 2000, were followed up prospectively through the territory-wide tuberculosis registry for development of tuberculosis from 3 months after enrollment to December 31, 2005, by use of their identity card numbers as unique identifier. The effects of diabetes mellitus and diabetic control on tuberculosis risk were assessed with adjustment for sociodemographic and other background variables. Diabetes mellitus was associated with a modest increase in the risk of active, culture-confirmed, and pulmonary (with or without extrapulmonary involvement) but not extrapulmonary (with or without pulmonary involvement) tuberculosis, with adjusted hazard ratios of 1.77 (95% confidence interval: 1.41, 2.24), 1.91 (95% confidence interval: 1.45, 2.52), 1.89 (95% confidence interval: 1.48, 2.42), and 1.00 (95% confidence interval: 0.54, 1.86), respectively. Diabetic subjects with hemoglobin A1c <7% at enrollment were not at increased risk. Among diabetic subjects, higher risks of active, culture-confirmed, and pulmonary but not extrapulmonary tuberculosis were observed with baseline hemoglobin A1c > or =7% (vs. <7%), with adjusted hazard ratios of 3.11 (95% confidence interval: 1.63, 5.92), 3.08 (95% confidence interval: 1.44, 6.57), 3.63 (95% confidence interval: 1.79, 7.33), and 0.77 (95% confidence interval: 0.18, 3.35), respectively.
 
ISSN1476-6256
2013 SCImago Journal Rankings: 2.971
 
ISI Accession Number IDWOS:000256755900012
 
DC FieldValue
dc.contributor.authorLeung, CC
 
dc.contributor.authorLam, TH
 
dc.contributor.authorChan, WM
 
dc.contributor.authorYew, WW
 
dc.contributor.authorHo, KS
 
dc.contributor.authorLeung, GM
 
dc.contributor.authorLaw, WS
 
dc.contributor.authorTam, CM
 
dc.contributor.authorChan, CK
 
dc.contributor.authorChang, KC
 
dc.date.accessioned2012-06-26T06:25:59Z
 
dc.date.available2012-06-26T06:25:59Z
 
dc.date.issued2008
 
dc.description.abstractDiabetes mellitus is associated with tuberculosis. A cohort of 42,116 clients aged 65 years or more, enrolled at 18 Elderly Health Service centers in Hong Kong in 2000, were followed up prospectively through the territory-wide tuberculosis registry for development of tuberculosis from 3 months after enrollment to December 31, 2005, by use of their identity card numbers as unique identifier. The effects of diabetes mellitus and diabetic control on tuberculosis risk were assessed with adjustment for sociodemographic and other background variables. Diabetes mellitus was associated with a modest increase in the risk of active, culture-confirmed, and pulmonary (with or without extrapulmonary involvement) but not extrapulmonary (with or without pulmonary involvement) tuberculosis, with adjusted hazard ratios of 1.77 (95% confidence interval: 1.41, 2.24), 1.91 (95% confidence interval: 1.45, 2.52), 1.89 (95% confidence interval: 1.48, 2.42), and 1.00 (95% confidence interval: 0.54, 1.86), respectively. Diabetic subjects with hemoglobin A1c <7% at enrollment were not at increased risk. Among diabetic subjects, higher risks of active, culture-confirmed, and pulmonary but not extrapulmonary tuberculosis were observed with baseline hemoglobin A1c > or =7% (vs. <7%), with adjusted hazard ratios of 3.11 (95% confidence interval: 1.63, 5.92), 3.08 (95% confidence interval: 1.44, 6.57), 3.63 (95% confidence interval: 1.79, 7.33), and 0.77 (95% confidence interval: 0.18, 3.35), respectively.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationAmerican Journal Of Epidemiology, 2008, v. 167 n. 12, p. 1486-1494 [How to Cite?]
 
dc.identifier.epage1494
 
dc.identifier.hkuros144565
 
dc.identifier.isiWOS:000256755900012
 
dc.identifier.issn1476-6256
2013 SCImago Journal Rankings: 2.971
 
dc.identifier.issue12
 
dc.identifier.pmid18400769
 
dc.identifier.scopuseid_2-s2.0-46249105296
 
dc.identifier.spage1486
 
dc.identifier.urihttp://hdl.handle.net/10722/151652
 
dc.identifier.volume167
 
dc.languageeng
 
dc.relation.ispartofAmerican journal of epidemiology
 
dc.subject.meshAged
 
dc.subject.meshAged, 80 And Over
 
dc.subject.meshConfidence Intervals
 
dc.subject.meshDiabetes Mellitus - Epidemiology
 
dc.subject.meshFemale
 
dc.subject.meshHemoglobin A, Glycosylated - Metabolism
 
dc.subject.meshHong Kong - Epidemiology
 
dc.subject.meshHumans
 
dc.subject.meshIncidence
 
dc.subject.meshMale
 
dc.subject.meshOdds Ratio
 
dc.subject.meshPrevalence
 
dc.subject.meshProspective Studies
 
dc.subject.meshRegistries
 
dc.subject.meshRisk Assessment
 
dc.subject.meshRisk Factors
 
dc.subject.meshTuberculosis - Epidemiology
 
dc.subject.meshTuberculosis, Pulmonary - Epidemiology
 
dc.titleDiabetic control and risk of tuberculosis: a cohort study.
 
dc.typeArticle
 
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<contributor.author>Lam, TH</contributor.author>
<contributor.author>Chan, WM</contributor.author>
<contributor.author>Yew, WW</contributor.author>
<contributor.author>Ho, KS</contributor.author>
<contributor.author>Leung, GM</contributor.author>
<contributor.author>Law, WS</contributor.author>
<contributor.author>Tam, CM</contributor.author>
<contributor.author>Chan, CK</contributor.author>
<contributor.author>Chang, KC</contributor.author>
<date.accessioned>2012-06-26T06:25:59Z</date.accessioned>
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<description.abstract>Diabetes mellitus is associated with tuberculosis. A cohort of 42,116 clients aged 65 years or more, enrolled at 18 Elderly Health Service centers in Hong Kong in 2000, were followed up prospectively through the territory-wide tuberculosis registry for development of tuberculosis from 3 months after enrollment to December 31, 2005, by use of their identity card numbers as unique identifier. The effects of diabetes mellitus and diabetic control on tuberculosis risk were assessed with adjustment for sociodemographic and other background variables. Diabetes mellitus was associated with a modest increase in the risk of active, culture-confirmed, and pulmonary (with or without extrapulmonary involvement) but not extrapulmonary (with or without pulmonary involvement) tuberculosis, with adjusted hazard ratios of 1.77 (95% confidence interval: 1.41, 2.24), 1.91 (95% confidence interval: 1.45, 2.52), 1.89 (95% confidence interval: 1.48, 2.42), and 1.00 (95% confidence interval: 0.54, 1.86), respectively. Diabetic subjects with hemoglobin A1c &lt;7% at enrollment were not at increased risk. Among diabetic subjects, higher risks of active, culture-confirmed, and pulmonary but not extrapulmonary tuberculosis were observed with baseline hemoglobin A1c &gt; or =7% (vs. &lt;7%), with adjusted hazard ratios of 3.11 (95% confidence interval: 1.63, 5.92), 3.08 (95% confidence interval: 1.44, 6.57), 3.63 (95% confidence interval: 1.79, 7.33), and 0.77 (95% confidence interval: 0.18, 3.35), respectively.</description.abstract>
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Author Affiliations
  1. Tuberculosis and Chest Service