File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Distribution of fibrinogen level and its relationship with age, body mass index, smoking and other risk factors of coronary heart disease in healthy Hong Kong Chinese

TitleDistribution of fibrinogen level and its relationship with age, body mass index, smoking and other risk factors of coronary heart disease in healthy Hong Kong Chinese
Authors
Issue Date1996
Citation
Fibrinolysis, 1996, v. 10 SUPPL. 1, p. 15 How to Cite?
AbstractTo investigate the distribution of fibrinogen level in healthy Hong Kong Chinese and to explore the relationships of fibrinogen level with other risk factors of coronary heart disease, we aimed to measure plasma fibrinogen in 3000 subjects aged 25-74 years. A standardized questionnaire was used in telephone interview of randomly selected subjects. The subjects were then invited to Queen Mary Hospital (a teaching hospital of the University of Hong Kong) for physical examination and blood taking. The preliminary results in 563 subjects from Hong Kong Island (one of the three regions of Hong Kong) showed that: (1) Fibrinogen level was normally distributed with a slight skew towards the lower levels. Women had a significantly higher mean than men: 2.52 (SD=0.49) g/L vs 2.40 (SD=0.56) g/L (P<0.01). The 5th and 95th percentiles were 1.86 g/L and 3.46 g/L in women and 1.59 g/L and 3.36 g/L in men, respectively. (2) Multiple regression analysis showed that in men, age and smoking (cumulative dose) were positively, and high density lipoprotein cholesterol was negatively related to fibrinogen level. In women, age, low density lipoprotein cholesterol, body mass index and smoking were all positively related to fibrinogen level. (3) The fibrinogen level increased with non-smoker, exsmoker and current smoker status but the trend was not statistically significant. (4) In male current smokers, those who started to smoke before the age of 16 years had higher fibrinogen levels than those who started later (2.81 g/L vs 2.42 g/L, P<0.05). In conclusion, fibrinogen levels in Chinese appear to be similar to those in Japanese and are lower than those in Caucasians, but there are similar correlations with other risk factors for coronary heart disease such as age, body mass index, smoking and lower levels of high density lipoprotein cholesterol. © Pearson Professional Ltd 1996.
Persistent Identifierhttp://hdl.handle.net/10722/151638
ISSN
2003 Impact Factor: 0.5
2000 SCImago Journal Rankings: 0.378

 

DC FieldValueLanguage
dc.contributor.authorJanus, EDen_US
dc.contributor.authorLiu, LJen_US
dc.contributor.authorBourke, Cen_US
dc.contributor.authorLam, THen_US
dc.contributor.authorHedley, AJen_US
dc.date.accessioned2012-06-26T06:25:50Z-
dc.date.available2012-06-26T06:25:50Z-
dc.date.issued1996en_US
dc.identifier.citationFibrinolysis, 1996, v. 10 SUPPL. 1, p. 15en_US
dc.identifier.issn0268-9499en_US
dc.identifier.urihttp://hdl.handle.net/10722/151638-
dc.description.abstractTo investigate the distribution of fibrinogen level in healthy Hong Kong Chinese and to explore the relationships of fibrinogen level with other risk factors of coronary heart disease, we aimed to measure plasma fibrinogen in 3000 subjects aged 25-74 years. A standardized questionnaire was used in telephone interview of randomly selected subjects. The subjects were then invited to Queen Mary Hospital (a teaching hospital of the University of Hong Kong) for physical examination and blood taking. The preliminary results in 563 subjects from Hong Kong Island (one of the three regions of Hong Kong) showed that: (1) Fibrinogen level was normally distributed with a slight skew towards the lower levels. Women had a significantly higher mean than men: 2.52 (SD=0.49) g/L vs 2.40 (SD=0.56) g/L (P<0.01). The 5th and 95th percentiles were 1.86 g/L and 3.46 g/L in women and 1.59 g/L and 3.36 g/L in men, respectively. (2) Multiple regression analysis showed that in men, age and smoking (cumulative dose) were positively, and high density lipoprotein cholesterol was negatively related to fibrinogen level. In women, age, low density lipoprotein cholesterol, body mass index and smoking were all positively related to fibrinogen level. (3) The fibrinogen level increased with non-smoker, exsmoker and current smoker status but the trend was not statistically significant. (4) In male current smokers, those who started to smoke before the age of 16 years had higher fibrinogen levels than those who started later (2.81 g/L vs 2.42 g/L, P<0.05). In conclusion, fibrinogen levels in Chinese appear to be similar to those in Japanese and are lower than those in Caucasians, but there are similar correlations with other risk factors for coronary heart disease such as age, body mass index, smoking and lower levels of high density lipoprotein cholesterol. © Pearson Professional Ltd 1996.en_US
dc.languageengen_US
dc.relation.ispartofFibrinolysisen_US
dc.titleDistribution of fibrinogen level and its relationship with age, body mass index, smoking and other risk factors of coronary heart disease in healthy Hong Kong Chineseen_US
dc.typeArticleen_US
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_US
dc.identifier.emailHedley, AJ:hrmrajh@hkucc.hku.hken_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.identifier.authorityHedley, AJ=rp00357en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-33846683041en_US
dc.identifier.volume10en_US
dc.identifier.issueSUPPL. 1en_US
dc.identifier.spage15en_US
dc.identifier.scopusauthoridJanus, ED=7006936536en_US
dc.identifier.scopusauthoridLiu, LJ=7405257119en_US
dc.identifier.scopusauthoridBourke, C=7004240621en_US
dc.identifier.scopusauthoridLam, TH=7202522876en_US
dc.identifier.scopusauthoridHedley, AJ=7102584095en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats