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Article: The effect of modifiable risk factors on pancreatic cancer mortality in populations of the Asia-Pacific region
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TitleThe effect of modifiable risk factors on pancreatic cancer mortality in populations of the Asia-Pacific region
 
AuthorsAnsaryMoghaddam, A3
Huxley, R3 1
Barzi, F3
Lawes, C7
Ohkubo, T6
Fang, X10
Jee, SH4
Woodward, M3
Okayama, A
Ueshima, H
Maegawa, H
Aoki, N
Nakamura, M
Kubo, N
Yamada, T
Wu, ZS9
Yao, CH
Andrews, G
Welborn, TA
Tang, Z
Liu, LS2
Xie, JX2
Norton, R8
Ameratunga, S8
Macmahon, S8
Whitlock, G8
Knuiman, MW
Christensen, H
Zhou, J
Yu, XH
Wu, XG
Tamakoshi, A
Pan, WH
Sritara, P5
Wu, ZL
Chen, LQ
Shan, GL
Gu, DF
Duan, XF
Jackson, R
Li, YH
Lam, TH
Jiang, CQ
Fujishima, M
Kiyohara, Y
Iwamoto, H
Woo, J
Ho, SC
Hong, Z
Huang, MS
Zhou, B
Fuh, JL
Kita, Y
Choudhury, SR
Suh, I
Kim, IS
Giles, G
Hashimoto, T
Sakata, K
Dobson, A
Imai, Y
Hozawa, A
Jamrozik, K
Hobbs, M
Broadhurst, R
Nakachi, K
Fang, XH
Li, SC
Yang, QD
Chen, ZM
Tanaka, H
Nozaki, A
Horibe, H
Matsutani, Y
Kagaya, M
Hughes, K
Lee, J
Heng, D
Chew, SK
Zhou, BF
Zhang, HY
Shimamoto, K
Saitoh, S
Li, ZZ
Norman, P
He, Y
Yao, SX
 
Issue Date2006
 
CitationCancer Epidemiology Biomarkers And Prevention, 2006, v. 15 n. 12, p. 2435-2440 [How to Cite?]
DOI: http://dx.doi.org/10.1158/1055-9965.EPI-06-0368
 
AbstractBackground: Pancreatic cancer accounts for about 220,000 deaths each year. Known risk factors are smoking and type 2 diabetes. It remains to be seen whether these risk factors are equally important in Asia and whether other modifiable risk factors have important associations with pancreatic cancer. Methods: An individual participant data analysis of 30 cohort studies was carried out, involving 420,310 Asian participants (33% female) and 99,333 from Australia/New Zealand (45% female). Cox proportional hazard models, stratified by study and sex and adjusted for age, were used to quantify risk factors for death from pancreatic cancer. Results: During 3,558,733 person-years of follow-up, there were 324 deaths from pancreatic cancer (54% Asia and 33% female). Mortality rates (per 100,000 person-years) from pancreatic cancer were 10 for men and 8 for women. The following are age-adjusted hazard ratios (95% confidence interval) for death from pancreatic cancer: for current smoking, 1.61 (1.12-2.32); for diabetes, 1.76 (1.15-2.69); for a 2-cm increase in waist circumference, 1.08 (1.02-1.14). All three relationships remained significant (P < 0.05) after adjustment for other risk factors. There was no evidence of heterogeneity in the strength of these associations between either cohorts from Asia and Australia/New Zealand or between the sexes. In men, the combination of cigarette smoking and diabetes more than doubled the likelihood of pancreatic cancer (2.47; 95% confidence interval, 1.17-5.21) in both regions. Conclusions: Smoking, obesity, and diabetes are important and are potentially modifiable risk factors for pancreatic cancer in populations of the Asia-Pacific region. Activities to prevent them can be expected to lead to a major reduction in the number of deaths from this cancer, particularly in Asia with its enormous population. Copyright © 2006 American Association for Cancer Research.
 
ISSN1055-9965
2012 Impact Factor: 4.559
2012 SCImago Journal Rankings: 2.235
 
DOIhttp://dx.doi.org/10.1158/1055-9965.EPI-06-0368
 
ISI Accession Number IDWOS:000242984400019
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorAnsaryMoghaddam, A
 
dc.contributor.authorHuxley, R
 
dc.contributor.authorBarzi, F
 
dc.contributor.authorLawes, C
 
dc.contributor.authorOhkubo, T
 
dc.contributor.authorFang, X
 
dc.contributor.authorJee, SH
 
dc.contributor.authorWoodward, M
 
dc.contributor.authorOkayama, A
 
dc.contributor.authorUeshima, H
 
dc.contributor.authorMaegawa, H
 
dc.contributor.authorAoki, N
 
dc.contributor.authorNakamura, M
 
dc.contributor.authorKubo, N
 
dc.contributor.authorYamada, T
 
dc.contributor.authorWu, ZS
 
dc.contributor.authorYao, CH
 
dc.contributor.authorAndrews, G
 
dc.contributor.authorWelborn, TA
 
dc.contributor.authorTang, Z
 
dc.contributor.authorLiu, LS
 
dc.contributor.authorXie, JX
 
dc.contributor.authorNorton, R
 
dc.contributor.authorAmeratunga, S
 
dc.contributor.authorMacmahon, S
 
dc.contributor.authorWhitlock, G
 
dc.contributor.authorKnuiman, MW
 
dc.contributor.authorChristensen, H
 
dc.contributor.authorZhou, J
 
dc.contributor.authorYu, XH
 
dc.contributor.authorWu, XG
 
dc.contributor.authorTamakoshi, A
 
dc.contributor.authorPan, WH
 
dc.contributor.authorSritara, P
 
dc.contributor.authorWu, ZL
 
dc.contributor.authorChen, LQ
 
dc.contributor.authorShan, GL
 
dc.contributor.authorGu, DF
 
dc.contributor.authorDuan, XF
 
dc.contributor.authorJackson, R
 
dc.contributor.authorLi, YH
 
dc.contributor.authorLam, TH
 
dc.contributor.authorJiang, CQ
 
dc.contributor.authorFujishima, M
 
dc.contributor.authorKiyohara, Y
 
dc.contributor.authorIwamoto, H
 
dc.contributor.authorWoo, J
 
dc.contributor.authorHo, SC
 
dc.contributor.authorHong, Z
 
dc.contributor.authorHuang, MS
 
dc.contributor.authorZhou, B
 
dc.contributor.authorFuh, JL
 
dc.contributor.authorKita, Y
 
dc.contributor.authorChoudhury, SR
 
dc.contributor.authorSuh, I
 
dc.contributor.authorKim, IS
 
dc.contributor.authorGiles, G
 
dc.contributor.authorHashimoto, T
 
dc.contributor.authorSakata, K
 
dc.contributor.authorDobson, A
 
dc.contributor.authorImai, Y
 
dc.contributor.authorHozawa, A
 
dc.contributor.authorJamrozik, K
 
dc.contributor.authorHobbs, M
 
dc.contributor.authorBroadhurst, R
 
dc.contributor.authorNakachi, K
 
dc.contributor.authorFang, XH
 
dc.contributor.authorLi, SC
 
dc.contributor.authorYang, QD
 
dc.contributor.authorChen, ZM
 
dc.contributor.authorTanaka, H
 
dc.contributor.authorNozaki, A
 
dc.contributor.authorHoribe, H
 
dc.contributor.authorMatsutani, Y
 
dc.contributor.authorKagaya, M
 
dc.contributor.authorHughes, K
 
dc.contributor.authorLee, J
 
dc.contributor.authorHeng, D
 
dc.contributor.authorChew, SK
 
dc.contributor.authorZhou, BF
 
dc.contributor.authorZhang, HY
 
dc.contributor.authorShimamoto, K
 
dc.contributor.authorSaitoh, S
 
dc.contributor.authorLi, ZZ
 
dc.contributor.authorNorman, P
 
dc.contributor.authorHe, Y
 
dc.contributor.authorYao, SX
 
dc.date.accessioned2012-06-26T06:25:47Z
 
dc.date.available2012-06-26T06:25:47Z
 
dc.date.issued2006
 
dc.description.abstractBackground: Pancreatic cancer accounts for about 220,000 deaths each year. Known risk factors are smoking and type 2 diabetes. It remains to be seen whether these risk factors are equally important in Asia and whether other modifiable risk factors have important associations with pancreatic cancer. Methods: An individual participant data analysis of 30 cohort studies was carried out, involving 420,310 Asian participants (33% female) and 99,333 from Australia/New Zealand (45% female). Cox proportional hazard models, stratified by study and sex and adjusted for age, were used to quantify risk factors for death from pancreatic cancer. Results: During 3,558,733 person-years of follow-up, there were 324 deaths from pancreatic cancer (54% Asia and 33% female). Mortality rates (per 100,000 person-years) from pancreatic cancer were 10 for men and 8 for women. The following are age-adjusted hazard ratios (95% confidence interval) for death from pancreatic cancer: for current smoking, 1.61 (1.12-2.32); for diabetes, 1.76 (1.15-2.69); for a 2-cm increase in waist circumference, 1.08 (1.02-1.14). All three relationships remained significant (P < 0.05) after adjustment for other risk factors. There was no evidence of heterogeneity in the strength of these associations between either cohorts from Asia and Australia/New Zealand or between the sexes. In men, the combination of cigarette smoking and diabetes more than doubled the likelihood of pancreatic cancer (2.47; 95% confidence interval, 1.17-5.21) in both regions. Conclusions: Smoking, obesity, and diabetes are important and are potentially modifiable risk factors for pancreatic cancer in populations of the Asia-Pacific region. Activities to prevent them can be expected to lead to a major reduction in the number of deaths from this cancer, particularly in Asia with its enormous population. Copyright © 2006 American Association for Cancer Research.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationCancer Epidemiology Biomarkers And Prevention, 2006, v. 15 n. 12, p. 2435-2440 [How to Cite?]
DOI: http://dx.doi.org/10.1158/1055-9965.EPI-06-0368
 
dc.identifier.doihttp://dx.doi.org/10.1158/1055-9965.EPI-06-0368
 
dc.identifier.epage2440
 
dc.identifier.isiWOS:000242984400019
 
dc.identifier.issn1055-9965
2012 Impact Factor: 4.559
2012 SCImago Journal Rankings: 2.235
 
dc.identifier.issue12
 
dc.identifier.pmid17164367
 
dc.identifier.scopuseid_2-s2.0-33846026720
 
dc.identifier.spage2435
 
dc.identifier.urihttp://hdl.handle.net/10722/151634
 
dc.identifier.volume15
 
dc.languageeng
 
dc.publisher.placeUnited States
 
dc.relation.ispartofCancer Epidemiology Biomarkers and Prevention
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAsia - Epidemiology
 
dc.subject.meshAustralia - Epidemiology
 
dc.subject.meshCohort Studies
 
dc.subject.meshDiabetes Complications - Epidemiology
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshNew Zealand - Epidemiology
 
dc.subject.meshObesity - Epidemiology
 
dc.subject.meshPancreatic Neoplasms - Epidemiology - Etiology - Mortality
 
dc.subject.meshRisk Factors
 
dc.subject.meshSmoking - Epidemiology
 
dc.titleThe effect of modifiable risk factors on pancreatic cancer mortality in populations of the Asia-Pacific region
 
dc.typeArticle
 
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<contributor.author>Huxley, R</contributor.author>
<contributor.author>Barzi, F</contributor.author>
<contributor.author>Lawes, C</contributor.author>
<contributor.author>Ohkubo, T</contributor.author>
<contributor.author>Fang, X</contributor.author>
<contributor.author>Jee, SH</contributor.author>
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<contributor.author>Okayama, A</contributor.author>
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<contributor.author>Xie, JX</contributor.author>
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<contributor.author>Ameratunga, S</contributor.author>
<contributor.author>Macmahon, S</contributor.author>
<contributor.author>Whitlock, G</contributor.author>
<contributor.author>Knuiman, MW</contributor.author>
<contributor.author>Christensen, H</contributor.author>
<contributor.author>Zhou, J</contributor.author>
<contributor.author>Yu, XH</contributor.author>
<contributor.author>Wu, XG</contributor.author>
<contributor.author>Tamakoshi, A</contributor.author>
<contributor.author>Pan, WH</contributor.author>
<contributor.author>Sritara, P</contributor.author>
<contributor.author>Wu, ZL</contributor.author>
<contributor.author>Chen, LQ</contributor.author>
<contributor.author>Shan, GL</contributor.author>
<contributor.author>Gu, DF</contributor.author>
<contributor.author>Duan, XF</contributor.author>
<contributor.author>Jackson, R</contributor.author>
<contributor.author>Li, YH</contributor.author>
<contributor.author>Lam, TH</contributor.author>
<contributor.author>Jiang, CQ</contributor.author>
<contributor.author>Fujishima, M</contributor.author>
<contributor.author>Kiyohara, Y</contributor.author>
<contributor.author>Iwamoto, H</contributor.author>
<contributor.author>Woo, J</contributor.author>
<contributor.author>Ho, SC</contributor.author>
<contributor.author>Hong, Z</contributor.author>
<contributor.author>Huang, MS</contributor.author>
<contributor.author>Zhou, B</contributor.author>
<contributor.author>Fuh, JL</contributor.author>
<contributor.author>Kita, Y</contributor.author>
<contributor.author>Choudhury, SR</contributor.author>
<contributor.author>Suh, I</contributor.author>
<contributor.author>Kim, IS</contributor.author>
<contributor.author>Giles, G</contributor.author>
<contributor.author>Hashimoto, T</contributor.author>
<contributor.author>Sakata, K</contributor.author>
<contributor.author>Dobson, A</contributor.author>
<contributor.author>Imai, Y</contributor.author>
<contributor.author>Hozawa, A</contributor.author>
<contributor.author>Jamrozik, K</contributor.author>
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<contributor.author>Chen, ZM</contributor.author>
<contributor.author>Tanaka, H</contributor.author>
<contributor.author>Nozaki, A</contributor.author>
<contributor.author>Horibe, H</contributor.author>
<contributor.author>Matsutani, Y</contributor.author>
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<contributor.author>Heng, D</contributor.author>
<contributor.author>Chew, SK</contributor.author>
<contributor.author>Zhou, BF</contributor.author>
<contributor.author>Zhang, HY</contributor.author>
<contributor.author>Shimamoto, K</contributor.author>
<contributor.author>Saitoh, S</contributor.author>
<contributor.author>Li, ZZ</contributor.author>
<contributor.author>Norman, P</contributor.author>
<contributor.author>He, Y</contributor.author>
<contributor.author>Yao, SX</contributor.author>
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<identifier.uri>http://hdl.handle.net/10722/151634</identifier.uri>
<description.abstract>Background: Pancreatic cancer accounts for about 220,000 deaths each year. Known risk factors are smoking and type 2 diabetes. It remains to be seen whether these risk factors are equally important in Asia and whether other modifiable risk factors have important associations with pancreatic cancer. Methods: An individual participant data analysis of 30 cohort studies was carried out, involving 420,310 Asian participants (33% female) and 99,333 from Australia/New Zealand (45% female). Cox proportional hazard models, stratified by study and sex and adjusted for age, were used to quantify risk factors for death from pancreatic cancer. Results: During 3,558,733 person-years of follow-up, there were 324 deaths from pancreatic cancer (54% Asia and 33% female). Mortality rates (per 100,000 person-years) from pancreatic cancer were 10 for men and 8 for women. The following are age-adjusted hazard ratios (95% confidence interval) for death from pancreatic cancer: for current smoking, 1.61 (1.12-2.32); for diabetes, 1.76 (1.15-2.69); for a 2-cm increase in waist circumference, 1.08 (1.02-1.14). All three relationships remained significant (P &lt; 0.05) after adjustment for other risk factors. There was no evidence of heterogeneity in the strength of these associations between either cohorts from Asia and Australia/New Zealand or between the sexes. In men, the combination of cigarette smoking and diabetes more than doubled the likelihood of pancreatic cancer (2.47; 95% confidence interval, 1.17-5.21) in both regions. Conclusions: Smoking, obesity, and diabetes are important and are potentially modifiable risk factors for pancreatic cancer in populations of the Asia-Pacific region. Activities to prevent them can be expected to lead to a major reduction in the number of deaths from this cancer, particularly in Asia with its enormous population. Copyright &#169; 2006 American Association for Cancer Research.</description.abstract>
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<subject.mesh>Female</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Male</subject.mesh>
<subject.mesh>Middle Aged</subject.mesh>
<subject.mesh>New Zealand - Epidemiology</subject.mesh>
<subject.mesh>Obesity - Epidemiology</subject.mesh>
<subject.mesh>Pancreatic Neoplasms - Epidemiology - Etiology - Mortality</subject.mesh>
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<subject.mesh>Smoking - Epidemiology</subject.mesh>
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Author Affiliations
  1. George Institute for International Health
  2. Capital Iron and Steel Company Hospital Cohort
  3. University of Sydney
  4. Yonsei University
  5. Korean Medical Insurance Company
  6. Ohasama Hospital
  7. University of Auckland Clinical Trials Research Unit
  8. Capital Iron and Steel Company
  9. National Heart Foundation of Australia
  10. Capital Medical University China