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Article: The effect of modifiable risk factors on pancreatic cancer mortality in populations of the Asia-Pacific region

TitleThe effect of modifiable risk factors on pancreatic cancer mortality in populations of the Asia-Pacific region
Authors
Issue Date2006
Citation
Cancer Epidemiology Biomarkers And Prevention, 2006, v. 15 n. 12, p. 2435-2440 How to Cite?
AbstractBackground: Pancreatic cancer accounts for about 220,000 deaths each year. Known risk factors are smoking and type 2 diabetes. It remains to be seen whether these risk factors are equally important in Asia and whether other modifiable risk factors have important associations with pancreatic cancer. Methods: An individual participant data analysis of 30 cohort studies was carried out, involving 420,310 Asian participants (33% female) and 99,333 from Australia/New Zealand (45% female). Cox proportional hazard models, stratified by study and sex and adjusted for age, were used to quantify risk factors for death from pancreatic cancer. Results: During 3,558,733 person-years of follow-up, there were 324 deaths from pancreatic cancer (54% Asia and 33% female). Mortality rates (per 100,000 person-years) from pancreatic cancer were 10 for men and 8 for women. The following are age-adjusted hazard ratios (95% confidence interval) for death from pancreatic cancer: for current smoking, 1.61 (1.12-2.32); for diabetes, 1.76 (1.15-2.69); for a 2-cm increase in waist circumference, 1.08 (1.02-1.14). All three relationships remained significant (P < 0.05) after adjustment for other risk factors. There was no evidence of heterogeneity in the strength of these associations between either cohorts from Asia and Australia/New Zealand or between the sexes. In men, the combination of cigarette smoking and diabetes more than doubled the likelihood of pancreatic cancer (2.47; 95% confidence interval, 1.17-5.21) in both regions. Conclusions: Smoking, obesity, and diabetes are important and are potentially modifiable risk factors for pancreatic cancer in populations of the Asia-Pacific region. Activities to prevent them can be expected to lead to a major reduction in the number of deaths from this cancer, particularly in Asia with its enormous population. Copyright © 2006 American Association for Cancer Research.
Persistent Identifierhttp://hdl.handle.net/10722/151634
ISSN
2014 Impact Factor: 4.125
2013 SCImago Journal Rankings: 2.774
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAnsaryMoghaddam, Aen_US
dc.contributor.authorHuxley, Ren_US
dc.contributor.authorBarzi, Fen_US
dc.contributor.authorLawes, Cen_US
dc.contributor.authorOhkubo, Ten_US
dc.contributor.authorFang, Xen_US
dc.contributor.authorJee, SHen_US
dc.contributor.authorWoodward, Men_US
dc.contributor.authorOkayama, Aen_US
dc.contributor.authorUeshima, Hen_US
dc.contributor.authorMaegawa, Hen_US
dc.contributor.authorAoki, Nen_US
dc.contributor.authorNakamura, Men_US
dc.contributor.authorKubo, Nen_US
dc.contributor.authorYamada, Ten_US
dc.contributor.authorWu, ZSen_US
dc.contributor.authorYao, CHen_US
dc.contributor.authorAndrews, Gen_US
dc.contributor.authorWelborn, TAen_US
dc.contributor.authorTang, Zen_US
dc.contributor.authorLiu, LSen_US
dc.contributor.authorXie, JXen_US
dc.contributor.authorNorton, Ren_US
dc.contributor.authorAmeratunga, Sen_US
dc.contributor.authorMacmahon, Sen_US
dc.contributor.authorWhitlock, Gen_US
dc.contributor.authorKnuiman, MWen_US
dc.contributor.authorChristensen, Hen_US
dc.contributor.authorZhou, Jen_US
dc.contributor.authorYu, XHen_US
dc.contributor.authorWu, XGen_US
dc.contributor.authorTamakoshi, Aen_US
dc.contributor.authorPan, WHen_US
dc.contributor.authorSritara, Pen_US
dc.contributor.authorWu, ZLen_US
dc.contributor.authorChen, LQen_US
dc.contributor.authorShan, GLen_US
dc.contributor.authorGu, DFen_US
dc.contributor.authorDuan, XFen_US
dc.contributor.authorJackson, Ren_US
dc.contributor.authorLi, YHen_US
dc.contributor.authorLam, THen_US
dc.contributor.authorJiang, CQen_US
dc.contributor.authorFujishima, Men_US
dc.contributor.authorKiyohara, Yen_US
dc.contributor.authorIwamoto, Hen_US
dc.contributor.authorWoo, Jen_US
dc.contributor.authorHo, SCen_US
dc.contributor.authorHong, Zen_US
dc.contributor.authorHuang, MSen_US
dc.contributor.authorZhou, Ben_US
dc.contributor.authorFuh, JLen_US
dc.contributor.authorKita, Yen_US
dc.contributor.authorChoudhury, SRen_US
dc.contributor.authorSuh, Ien_US
dc.contributor.authorKim, ISen_US
dc.contributor.authorGiles, Gen_US
dc.contributor.authorHashimoto, Ten_US
dc.contributor.authorSakata, Ken_US
dc.contributor.authorDobson, Aen_US
dc.contributor.authorImai, Yen_US
dc.contributor.authorHozawa, Aen_US
dc.contributor.authorJamrozik, Ken_US
dc.contributor.authorHobbs, Men_US
dc.contributor.authorBroadhurst, Ren_US
dc.contributor.authorNakachi, Ken_US
dc.contributor.authorFang, XHen_US
dc.contributor.authorLi, SCen_US
dc.contributor.authorYang, QDen_US
dc.contributor.authorChen, ZMen_US
dc.contributor.authorTanaka, Hen_US
dc.contributor.authorNozaki, Aen_US
dc.contributor.authorHoribe, Hen_US
dc.contributor.authorMatsutani, Yen_US
dc.contributor.authorKagaya, Men_US
dc.contributor.authorHughes, Ken_US
dc.contributor.authorLee, Jen_US
dc.contributor.authorHeng, Den_US
dc.contributor.authorChew, SKen_US
dc.contributor.authorZhou, BFen_US
dc.contributor.authorZhang, HYen_US
dc.contributor.authorShimamoto, Ken_US
dc.contributor.authorSaitoh, Sen_US
dc.contributor.authorLi, ZZen_US
dc.contributor.authorNorman, Pen_US
dc.contributor.authorHe, Yen_US
dc.contributor.authorYao, SXen_US
dc.date.accessioned2012-06-26T06:25:47Z-
dc.date.available2012-06-26T06:25:47Z-
dc.date.issued2006en_US
dc.identifier.citationCancer Epidemiology Biomarkers And Prevention, 2006, v. 15 n. 12, p. 2435-2440en_US
dc.identifier.issn1055-9965en_US
dc.identifier.urihttp://hdl.handle.net/10722/151634-
dc.description.abstractBackground: Pancreatic cancer accounts for about 220,000 deaths each year. Known risk factors are smoking and type 2 diabetes. It remains to be seen whether these risk factors are equally important in Asia and whether other modifiable risk factors have important associations with pancreatic cancer. Methods: An individual participant data analysis of 30 cohort studies was carried out, involving 420,310 Asian participants (33% female) and 99,333 from Australia/New Zealand (45% female). Cox proportional hazard models, stratified by study and sex and adjusted for age, were used to quantify risk factors for death from pancreatic cancer. Results: During 3,558,733 person-years of follow-up, there were 324 deaths from pancreatic cancer (54% Asia and 33% female). Mortality rates (per 100,000 person-years) from pancreatic cancer were 10 for men and 8 for women. The following are age-adjusted hazard ratios (95% confidence interval) for death from pancreatic cancer: for current smoking, 1.61 (1.12-2.32); for diabetes, 1.76 (1.15-2.69); for a 2-cm increase in waist circumference, 1.08 (1.02-1.14). All three relationships remained significant (P < 0.05) after adjustment for other risk factors. There was no evidence of heterogeneity in the strength of these associations between either cohorts from Asia and Australia/New Zealand or between the sexes. In men, the combination of cigarette smoking and diabetes more than doubled the likelihood of pancreatic cancer (2.47; 95% confidence interval, 1.17-5.21) in both regions. Conclusions: Smoking, obesity, and diabetes are important and are potentially modifiable risk factors for pancreatic cancer in populations of the Asia-Pacific region. Activities to prevent them can be expected to lead to a major reduction in the number of deaths from this cancer, particularly in Asia with its enormous population. Copyright © 2006 American Association for Cancer Research.en_US
dc.languageengen_US
dc.relation.ispartofCancer Epidemiology Biomarkers and Preventionen_US
dc.subject.meshAsia - Epidemiologyen_US
dc.subject.meshAustralia - Epidemiologyen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshDiabetes Complications - Epidemiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNew Zealand - Epidemiologyen_US
dc.subject.meshObesity - Epidemiologyen_US
dc.subject.meshPancreatic Neoplasms - Epidemiology - Etiology - Mortalityen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSmoking - Epidemiologyen_US
dc.titleThe effect of modifiable risk factors on pancreatic cancer mortality in populations of the Asia-Pacific regionen_US
dc.typeArticleen_US
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1158/1055-9965.EPI-06-0368en_US
dc.identifier.pmid17164367-
dc.identifier.scopuseid_2-s2.0-33846026720en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846026720&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume15en_US
dc.identifier.issue12en_US
dc.identifier.spage2435en_US
dc.identifier.epage2440en_US
dc.identifier.isiWOS:000242984400019-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridAnsaryMoghaddam, A=8608489600en_US
dc.identifier.scopusauthoridHuxley, R=6701828350en_US
dc.identifier.scopusauthoridBarzi, F=7003545543en_US
dc.identifier.scopusauthoridLawes, C=6602516713en_US
dc.identifier.scopusauthoridOhkubo, T=7201618716en_US
dc.identifier.scopusauthoridFang, X=15834725000en_US
dc.identifier.scopusauthoridJee, SH=16039275900en_US
dc.identifier.scopusauthoridWoodward, M=7102510958en_US
dc.identifier.scopusauthoridOkayama, A=35300529100en_US
dc.identifier.scopusauthoridUeshima, H=7005129002en_US
dc.identifier.scopusauthoridMaegawa, H=7005198303en_US
dc.identifier.scopusauthoridAoki, N=7401716495en_US
dc.identifier.scopusauthoridNakamura, M=7405345581en_US
dc.identifier.scopusauthoridKubo, N=7102513194en_US
dc.identifier.scopusauthoridYamada, T=53869779900en_US
dc.identifier.scopusauthoridWu, ZS=7501411359en_US
dc.identifier.scopusauthoridYao, CH=7201495948en_US
dc.identifier.scopusauthoridAndrews, G=53868664800en_US
dc.identifier.scopusauthoridWelborn, TA=7005408607en_US
dc.identifier.scopusauthoridTang, Z=53869479100en_US
dc.identifier.scopusauthoridLiu, LS=53869232800en_US
dc.identifier.scopusauthoridXie, JX=7402994954en_US
dc.identifier.scopusauthoridNorton, R=18344863600en_US
dc.identifier.scopusauthoridAmeratunga, S=6701716378en_US
dc.identifier.scopusauthoridMacMahon, S=24312201200en_US
dc.identifier.scopusauthoridWhitlock, G=7004159442en_US
dc.identifier.scopusauthoridKnuiman, MW=7005404334en_US
dc.identifier.scopusauthoridChristensen, H=7401664499en_US
dc.identifier.scopusauthoridZhou, J=53869700900en_US
dc.identifier.scopusauthoridYu, XH=7404114656en_US
dc.identifier.scopusauthoridWu, XG=53869736100en_US
dc.identifier.scopusauthoridTamakoshi, A=7006797376en_US
dc.identifier.scopusauthoridPan, WH=7402219783en_US
dc.identifier.scopusauthoridSritara, P=6602366631en_US
dc.identifier.scopusauthoridWu, ZL=15053584200en_US
dc.identifier.scopusauthoridChen, LQ=53868723200en_US
dc.identifier.scopusauthoridShan, GL=7005942365en_US
dc.identifier.scopusauthoridGu, DF=7202151958en_US
dc.identifier.scopusauthoridDuan, XF=7202708945en_US
dc.identifier.scopusauthoridJackson, R=21737108700en_US
dc.identifier.scopusauthoridLi, YH=53869373600en_US
dc.identifier.scopusauthoridLam, TH=7202522876en_US
dc.identifier.scopusauthoridJiang, CQ=10639500500en_US
dc.identifier.scopusauthoridFujishima, M=35352934700en_US
dc.identifier.scopusauthoridKiyohara, Y=7005335984en_US
dc.identifier.scopusauthoridIwamoto, H=7202028291en_US
dc.identifier.scopusauthoridWoo, J=36040369400en_US
dc.identifier.scopusauthoridHo, SC=53869094600en_US
dc.identifier.scopusauthoridHong, Z=7201414497en_US
dc.identifier.scopusauthoridHuang, MS=8902885500en_US
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dc.identifier.scopusauthoridFuh, JL=35227302000en_US
dc.identifier.scopusauthoridKita, Y=7202729333en_US
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dc.identifier.scopusauthoridSuh, I=7101988200en_US
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dc.identifier.scopusauthoridSakata, K=35227840700en_US
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dc.identifier.scopusauthoridHozawa, A=7003868341en_US
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dc.identifier.scopusauthoridYang, QD=7404076103en_US
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dc.identifier.scopusauthoridTanaka, H=7406596794en_US
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dc.identifier.scopusauthoridKagaya, M=7006577657en_US
dc.identifier.scopusauthoridHughes, K=7202448794en_US
dc.identifier.scopusauthoridLee, J=7601468324en_US
dc.identifier.scopusauthoridHeng, D=6701509730en_US
dc.identifier.scopusauthoridChew, SK=7202524627en_US
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dc.identifier.scopusauthoridHe, Y=53868903200en_US
dc.identifier.scopusauthoridYao, SX=35231647800en_US

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