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Article: The effect of modifiable risk factors on pancreatic cancer mortality in populations of the Asia-Pacific region

TitleThe effect of modifiable risk factors on pancreatic cancer mortality in populations of the Asia-Pacific region
Authors
Issue Date2006
Citation
Cancer Epidemiology Biomarkers And Prevention, 2006, v. 15 n. 12, p. 2435-2440 How to Cite?
Abstract
Background: Pancreatic cancer accounts for about 220,000 deaths each year. Known risk factors are smoking and type 2 diabetes. It remains to be seen whether these risk factors are equally important in Asia and whether other modifiable risk factors have important associations with pancreatic cancer. Methods: An individual participant data analysis of 30 cohort studies was carried out, involving 420,310 Asian participants (33% female) and 99,333 from Australia/New Zealand (45% female). Cox proportional hazard models, stratified by study and sex and adjusted for age, were used to quantify risk factors for death from pancreatic cancer. Results: During 3,558,733 person-years of follow-up, there were 324 deaths from pancreatic cancer (54% Asia and 33% female). Mortality rates (per 100,000 person-years) from pancreatic cancer were 10 for men and 8 for women. The following are age-adjusted hazard ratios (95% confidence interval) for death from pancreatic cancer: for current smoking, 1.61 (1.12-2.32); for diabetes, 1.76 (1.15-2.69); for a 2-cm increase in waist circumference, 1.08 (1.02-1.14). All three relationships remained significant (P < 0.05) after adjustment for other risk factors. There was no evidence of heterogeneity in the strength of these associations between either cohorts from Asia and Australia/New Zealand or between the sexes. In men, the combination of cigarette smoking and diabetes more than doubled the likelihood of pancreatic cancer (2.47; 95% confidence interval, 1.17-5.21) in both regions. Conclusions: Smoking, obesity, and diabetes are important and are potentially modifiable risk factors for pancreatic cancer in populations of the Asia-Pacific region. Activities to prevent them can be expected to lead to a major reduction in the number of deaths from this cancer, particularly in Asia with its enormous population. Copyright © 2006 American Association for Cancer Research.
Persistent Identifierhttp://hdl.handle.net/10722/151634
ISSN
2013 Impact Factor: 4.324
2013 SCImago Journal Rankings: 2.774
ISI Accession Number ID
References

 

Author Affiliations
  1. George Institute for International Health
  2. Capital Iron and Steel Company Hospital Cohort
  3. University of Sydney
  4. Yonsei University
  5. Korean Medical Insurance Company
  6. Ohasama Hospital
  7. University of Auckland Clinical Trials Research Unit
  8. Capital Iron and Steel Company
  9. National Heart Foundation of Australia
  10. Capital Medical University China
DC FieldValueLanguage
dc.contributor.authorAnsaryMoghaddam, Aen_US
dc.contributor.authorHuxley, Ren_US
dc.contributor.authorBarzi, Fen_US
dc.contributor.authorLawes, Cen_US
dc.contributor.authorOhkubo, Ten_US
dc.contributor.authorFang, Xen_US
dc.contributor.authorJee, SHen_US
dc.contributor.authorWoodward, Men_US
dc.contributor.authorOkayama, Aen_US
dc.contributor.authorUeshima, Hen_US
dc.contributor.authorMaegawa, Hen_US
dc.contributor.authorAoki, Nen_US
dc.contributor.authorNakamura, Men_US
dc.contributor.authorKubo, Nen_US
dc.contributor.authorYamada, Ten_US
dc.contributor.authorWu, ZSen_US
dc.contributor.authorYao, CHen_US
dc.contributor.authorAndrews, Gen_US
dc.contributor.authorWelborn, TAen_US
dc.contributor.authorTang, Zen_US
dc.contributor.authorLiu, LSen_US
dc.contributor.authorXie, JXen_US
dc.contributor.authorNorton, Ren_US
dc.contributor.authorAmeratunga, Sen_US
dc.contributor.authorMacmahon, Sen_US
dc.contributor.authorWhitlock, Gen_US
dc.contributor.authorKnuiman, MWen_US
dc.contributor.authorChristensen, Hen_US
dc.contributor.authorZhou, Jen_US
dc.contributor.authorYu, XHen_US
dc.contributor.authorWu, XGen_US
dc.contributor.authorTamakoshi, Aen_US
dc.contributor.authorPan, WHen_US
dc.contributor.authorSritara, Pen_US
dc.contributor.authorWu, ZLen_US
dc.contributor.authorChen, LQen_US
dc.contributor.authorShan, GLen_US
dc.contributor.authorGu, DFen_US
dc.contributor.authorDuan, XFen_US
dc.contributor.authorJackson, Ren_US
dc.contributor.authorLi, YHen_US
dc.contributor.authorLam, THen_US
dc.contributor.authorJiang, CQen_US
dc.contributor.authorFujishima, Men_US
dc.contributor.authorKiyohara, Yen_US
dc.contributor.authorIwamoto, Hen_US
dc.contributor.authorWoo, Jen_US
dc.contributor.authorHo, SCen_US
dc.contributor.authorHong, Zen_US
dc.contributor.authorHuang, MSen_US
dc.contributor.authorZhou, Ben_US
dc.contributor.authorFuh, JLen_US
dc.contributor.authorKita, Yen_US
dc.contributor.authorChoudhury, SRen_US
dc.contributor.authorSuh, Ien_US
dc.contributor.authorKim, ISen_US
dc.contributor.authorGiles, Gen_US
dc.contributor.authorHashimoto, Ten_US
dc.contributor.authorSakata, Ken_US
dc.contributor.authorDobson, Aen_US
dc.contributor.authorImai, Yen_US
dc.contributor.authorHozawa, Aen_US
dc.contributor.authorJamrozik, Ken_US
dc.contributor.authorHobbs, Men_US
dc.contributor.authorBroadhurst, Ren_US
dc.contributor.authorNakachi, Ken_US
dc.contributor.authorFang, XHen_US
dc.contributor.authorLi, SCen_US
dc.contributor.authorYang, QDen_US
dc.contributor.authorChen, ZMen_US
dc.contributor.authorTanaka, Hen_US
dc.contributor.authorNozaki, Aen_US
dc.contributor.authorHoribe, Hen_US
dc.contributor.authorMatsutani, Yen_US
dc.contributor.authorKagaya, Men_US
dc.contributor.authorHughes, Ken_US
dc.contributor.authorLee, Jen_US
dc.contributor.authorHeng, Den_US
dc.contributor.authorChew, SKen_US
dc.contributor.authorZhou, BFen_US
dc.contributor.authorZhang, HYen_US
dc.contributor.authorShimamoto, Ken_US
dc.contributor.authorSaitoh, Sen_US
dc.contributor.authorLi, ZZen_US
dc.contributor.authorNorman, Pen_US
dc.contributor.authorHe, Yen_US
dc.contributor.authorYao, SXen_US
dc.date.accessioned2012-06-26T06:25:47Z-
dc.date.available2012-06-26T06:25:47Z-
dc.date.issued2006en_US
dc.identifier.citationCancer Epidemiology Biomarkers And Prevention, 2006, v. 15 n. 12, p. 2435-2440en_US
dc.identifier.issn1055-9965en_US
dc.identifier.urihttp://hdl.handle.net/10722/151634-
dc.description.abstractBackground: Pancreatic cancer accounts for about 220,000 deaths each year. Known risk factors are smoking and type 2 diabetes. It remains to be seen whether these risk factors are equally important in Asia and whether other modifiable risk factors have important associations with pancreatic cancer. Methods: An individual participant data analysis of 30 cohort studies was carried out, involving 420,310 Asian participants (33% female) and 99,333 from Australia/New Zealand (45% female). Cox proportional hazard models, stratified by study and sex and adjusted for age, were used to quantify risk factors for death from pancreatic cancer. Results: During 3,558,733 person-years of follow-up, there were 324 deaths from pancreatic cancer (54% Asia and 33% female). Mortality rates (per 100,000 person-years) from pancreatic cancer were 10 for men and 8 for women. The following are age-adjusted hazard ratios (95% confidence interval) for death from pancreatic cancer: for current smoking, 1.61 (1.12-2.32); for diabetes, 1.76 (1.15-2.69); for a 2-cm increase in waist circumference, 1.08 (1.02-1.14). All three relationships remained significant (P < 0.05) after adjustment for other risk factors. There was no evidence of heterogeneity in the strength of these associations between either cohorts from Asia and Australia/New Zealand or between the sexes. In men, the combination of cigarette smoking and diabetes more than doubled the likelihood of pancreatic cancer (2.47; 95% confidence interval, 1.17-5.21) in both regions. Conclusions: Smoking, obesity, and diabetes are important and are potentially modifiable risk factors for pancreatic cancer in populations of the Asia-Pacific region. Activities to prevent them can be expected to lead to a major reduction in the number of deaths from this cancer, particularly in Asia with its enormous population. Copyright © 2006 American Association for Cancer Research.en_US
dc.languageengen_US
dc.relation.ispartofCancer Epidemiology Biomarkers and Preventionen_US
dc.subject.meshAsia - Epidemiologyen_US
dc.subject.meshAustralia - Epidemiologyen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshDiabetes Complications - Epidemiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNew Zealand - Epidemiologyen_US
dc.subject.meshObesity - Epidemiologyen_US
dc.subject.meshPancreatic Neoplasms - Epidemiology - Etiology - Mortalityen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSmoking - Epidemiologyen_US
dc.titleThe effect of modifiable risk factors on pancreatic cancer mortality in populations of the Asia-Pacific regionen_US
dc.typeArticleen_US
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1158/1055-9965.EPI-06-0368en_US
dc.identifier.pmid17164367en_US
dc.identifier.scopuseid_2-s2.0-33846026720en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846026720&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume15en_US
dc.identifier.issue12en_US
dc.identifier.spage2435en_US
dc.identifier.epage2440en_US
dc.identifier.isiWOS:000242984400019-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridAnsaryMoghaddam, A=8608489600en_US
dc.identifier.scopusauthoridHuxley, R=6701828350en_US
dc.identifier.scopusauthoridBarzi, F=7003545543en_US
dc.identifier.scopusauthoridLawes, C=6602516713en_US
dc.identifier.scopusauthoridOhkubo, T=7201618716en_US
dc.identifier.scopusauthoridFang, X=15834725000en_US
dc.identifier.scopusauthoridJee, SH=16039275900en_US
dc.identifier.scopusauthoridWoodward, M=7102510958en_US
dc.identifier.scopusauthoridOkayama, A=35300529100en_US
dc.identifier.scopusauthoridUeshima, H=7005129002en_US
dc.identifier.scopusauthoridMaegawa, H=7005198303en_US
dc.identifier.scopusauthoridAoki, N=7401716495en_US
dc.identifier.scopusauthoridNakamura, M=7405345581en_US
dc.identifier.scopusauthoridKubo, N=7102513194en_US
dc.identifier.scopusauthoridYamada, T=53869779900en_US
dc.identifier.scopusauthoridWu, ZS=7501411359en_US
dc.identifier.scopusauthoridYao, CH=7201495948en_US
dc.identifier.scopusauthoridAndrews, G=53868664800en_US
dc.identifier.scopusauthoridWelborn, TA=7005408607en_US
dc.identifier.scopusauthoridTang, Z=53869479100en_US
dc.identifier.scopusauthoridLiu, LS=53869232800en_US
dc.identifier.scopusauthoridXie, JX=7402994954en_US
dc.identifier.scopusauthoridNorton, R=18344863600en_US
dc.identifier.scopusauthoridAmeratunga, S=6701716378en_US
dc.identifier.scopusauthoridMacMahon, S=24312201200en_US
dc.identifier.scopusauthoridWhitlock, G=7004159442en_US
dc.identifier.scopusauthoridKnuiman, MW=7005404334en_US
dc.identifier.scopusauthoridChristensen, H=7401664499en_US
dc.identifier.scopusauthoridZhou, J=53869700900en_US
dc.identifier.scopusauthoridYu, XH=7404114656en_US
dc.identifier.scopusauthoridWu, XG=53869736100en_US
dc.identifier.scopusauthoridTamakoshi, A=7006797376en_US
dc.identifier.scopusauthoridPan, WH=7402219783en_US
dc.identifier.scopusauthoridSritara, P=6602366631en_US
dc.identifier.scopusauthoridWu, ZL=15053584200en_US
dc.identifier.scopusauthoridChen, LQ=53868723200en_US
dc.identifier.scopusauthoridShan, GL=7005942365en_US
dc.identifier.scopusauthoridGu, DF=7202151958en_US
dc.identifier.scopusauthoridDuan, XF=7202708945en_US
dc.identifier.scopusauthoridJackson, R=21737108700en_US
dc.identifier.scopusauthoridLi, YH=53869373600en_US
dc.identifier.scopusauthoridLam, TH=7202522876en_US
dc.identifier.scopusauthoridJiang, CQ=10639500500en_US
dc.identifier.scopusauthoridFujishima, M=35352934700en_US
dc.identifier.scopusauthoridKiyohara, Y=7005335984en_US
dc.identifier.scopusauthoridIwamoto, H=7202028291en_US
dc.identifier.scopusauthoridWoo, J=36040369400en_US
dc.identifier.scopusauthoridHo, SC=53869094600en_US
dc.identifier.scopusauthoridHong, Z=7201414497en_US
dc.identifier.scopusauthoridHuang, MS=8902885500en_US
dc.identifier.scopusauthoridZhou, B=7401907215en_US
dc.identifier.scopusauthoridFuh, JL=35227302000en_US
dc.identifier.scopusauthoridKita, Y=7202729333en_US
dc.identifier.scopusauthoridChoudhury, SR=53868728900en_US
dc.identifier.scopusauthoridSuh, I=7101988200en_US
dc.identifier.scopusauthoridKim, IS=36079546600en_US
dc.identifier.scopusauthoridGiles, G=7103091133en_US
dc.identifier.scopusauthoridHashimoto, T=26426009500en_US
dc.identifier.scopusauthoridSakata, K=35227840700en_US
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dc.identifier.scopusauthoridHozawa, A=7003868341en_US
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dc.identifier.scopusauthoridFang, XH=53869067400en_US
dc.identifier.scopusauthoridLi, SC=53869194100en_US
dc.identifier.scopusauthoridYang, QD=7404076103en_US
dc.identifier.scopusauthoridChen, ZM=53868653200en_US
dc.identifier.scopusauthoridTanaka, H=7406596794en_US
dc.identifier.scopusauthoridNozaki, A=7006414963en_US
dc.identifier.scopusauthoridHoribe, H=7005739955en_US
dc.identifier.scopusauthoridMatsutani, Y=8892298100en_US
dc.identifier.scopusauthoridKagaya, M=7006577657en_US
dc.identifier.scopusauthoridHughes, K=7202448794en_US
dc.identifier.scopusauthoridLee, J=7601468324en_US
dc.identifier.scopusauthoridHeng, D=6701509730en_US
dc.identifier.scopusauthoridChew, SK=7202524627en_US
dc.identifier.scopusauthoridZhou, BF=7401906952en_US
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dc.identifier.scopusauthoridHe, Y=53868903200en_US
dc.identifier.scopusauthoridYao, SX=35231647800en_US

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