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Article: Determination of cotinine in human urine with gas chromatograph-mass spectrometry

TitleDetermination of cotinine in human urine with gas chromatograph-mass spectrometry
Authors
Issue Date2006
PublisherZhonghua Laodong Weisheng Zhiyebing Zazhi. The Journal's web site is located at http://zhldwszyb.periodicals.net.cn/default.html
Citation
Chinese Journal Of Industrial Hygiene And Occupational Diseases, 2006, v. 24 n. 1, p. 39-41 How to Cite?
AbstractOBJECTIVE: To establish the method of gas chromatograph-mass spectrometry (GC-MS) for the determination of the cotinine (COT) in human urine. METHODS: The conjugated trans-3'-hydroxycotinine (THOC) and COT were hydrolyzed in human urine with beta-glucuronidase. The composition of COT was extracted with the mixture of dichloromethane and n-butyl acetate (2:1) and was separated with HP-5MS fused-silica capillary column. The GC-MS was used for determining its content. RESULTS: The monitoring limit of this method was 0.02 microg/L. Its recovery rate was higher than 90%, Its accuracy rate was 4.30%. It was used for the determination of the cotinine in human urine in Guangzhou Biological Bank the Elderly Cohort. CONCLUSION: The GC-MS method is a good microanalysis for monitoring the cotinine in human urine rapidly and accurately with little background disturbance. It has been applied in our Guangzhou Cohort Study for determining cotinine in human urine.
Persistent Identifierhttp://hdl.handle.net/10722/151631
ISSN
2015 SCImago Journal Rankings: 0.117

 

DC FieldValueLanguage
dc.contributor.authorCao, Men_US
dc.contributor.authorZhang, YLen_US
dc.contributor.authorJiang, CQen_US
dc.contributor.authorLam, THen_US
dc.contributor.authorCheng, KKen_US
dc.contributor.authorZhang, WSen_US
dc.date.accessioned2012-06-26T06:25:41Z-
dc.date.available2012-06-26T06:25:41Z-
dc.date.issued2006en_US
dc.identifier.citationChinese Journal Of Industrial Hygiene And Occupational Diseases, 2006, v. 24 n. 1, p. 39-41en_US
dc.identifier.issn1001-9391en_US
dc.identifier.urihttp://hdl.handle.net/10722/151631-
dc.description.abstractOBJECTIVE: To establish the method of gas chromatograph-mass spectrometry (GC-MS) for the determination of the cotinine (COT) in human urine. METHODS: The conjugated trans-3'-hydroxycotinine (THOC) and COT were hydrolyzed in human urine with beta-glucuronidase. The composition of COT was extracted with the mixture of dichloromethane and n-butyl acetate (2:1) and was separated with HP-5MS fused-silica capillary column. The GC-MS was used for determining its content. RESULTS: The monitoring limit of this method was 0.02 microg/L. Its recovery rate was higher than 90%, Its accuracy rate was 4.30%. It was used for the determination of the cotinine in human urine in Guangzhou Biological Bank the Elderly Cohort. CONCLUSION: The GC-MS method is a good microanalysis for monitoring the cotinine in human urine rapidly and accurately with little background disturbance. It has been applied in our Guangzhou Cohort Study for determining cotinine in human urine.en_US
dc.languageengen_US
dc.publisherZhonghua Laodong Weisheng Zhiyebing Zazhi. The Journal's web site is located at http://zhldwszyb.periodicals.net.cn/default.htmlen_US
dc.relation.ispartofChinese Journal Of Industrial Hygiene And Occupational Diseasesen_US
dc.subject.meshCotinine - Urineen_US
dc.subject.meshFemaleen_US
dc.subject.meshGas Chromatography-Mass Spectrometry - Methodsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshSmoking - Urineen_US
dc.titleDetermination of cotinine in human urine with gas chromatograph-mass spectrometryen_US
dc.typeArticleen_US
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid16600093-
dc.identifier.scopuseid_2-s2.0-33749623701en_US
dc.identifier.hkuros115458-
dc.identifier.volume24en_US
dc.identifier.issue1en_US
dc.identifier.spage39en_US
dc.identifier.epage41en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridCao, M=35226290200en_US
dc.identifier.scopusauthoridZhang, YL=22982069800en_US
dc.identifier.scopusauthoridJiang, CQ=10639500500en_US
dc.identifier.scopusauthoridLam, TH=7202522876en_US
dc.identifier.scopusauthoridCheng, KK=7402997800en_US
dc.identifier.scopusauthoridZhang, WS=13410704100en_US

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