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Article: Occupational cancer genetics: Infrequent ras oncogenes point mutations in lung cancer samples from chromate workers

TitleOccupational cancer genetics: Infrequent ras oncogenes point mutations in lung cancer samples from chromate workers
Authors
Issue Date2001
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34471
Citation
American Journal Of Industrial Medicine, 2001, v. 40 n. 1, p. 92-97 How to Cite?
AbstractBackground: Chromium carcinogenicity and mutagenicity are no longer disputed. However, although chromium has various genetic effects that induce cancer, its mechanism of inducing lung cancer in humans is still not fully understood. p53, a tumor suppressor gene, was found to be infrequently mutated in samples of lung cancer in workers with long occupational exposure to chromium, suggesting other cancer-related genes to be targeted in such tumors. Methods: To assess the contribution of the ras oncogenes in the pathogenesis of chromate-related lung cancer, we studied point mutations at the critical positions of codons 12, 13, and 61 of the Ha-ras and Ki-ras oncogenes in 38 lung cancer samples derived from Japanese patients who worked in the chromate industry for long periods. We used both radioactive isotope and non-radioisotope PCR-SSCP techniques. Results: The results of this study demonstrated that activation of ras genes due to point mutations in chromate-related lung cancer is a rare event. Conclusion: Ras oncogenes activated by point mutations do not have a major role in the process of tumorigenesis of chromate-related lung cancer. © 2001 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/151557
ISSN
2015 Impact Factor: 1.632
2015 SCImago Journal Rankings: 0.993
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJiang, CQen_US
dc.contributor.authorXiao, LWen_US
dc.contributor.authorLam, THen_US
dc.contributor.authorXie, NWen_US
dc.contributor.authorZhu, CQen_US
dc.date.accessioned2012-06-26T06:24:38Z-
dc.date.available2012-06-26T06:24:38Z-
dc.date.issued2001en_US
dc.identifier.citationAmerican Journal Of Industrial Medicine, 2001, v. 40 n. 1, p. 92-97en_US
dc.identifier.issn0271-3586en_US
dc.identifier.urihttp://hdl.handle.net/10722/151557-
dc.description.abstractBackground: Chromium carcinogenicity and mutagenicity are no longer disputed. However, although chromium has various genetic effects that induce cancer, its mechanism of inducing lung cancer in humans is still not fully understood. p53, a tumor suppressor gene, was found to be infrequently mutated in samples of lung cancer in workers with long occupational exposure to chromium, suggesting other cancer-related genes to be targeted in such tumors. Methods: To assess the contribution of the ras oncogenes in the pathogenesis of chromate-related lung cancer, we studied point mutations at the critical positions of codons 12, 13, and 61 of the Ha-ras and Ki-ras oncogenes in 38 lung cancer samples derived from Japanese patients who worked in the chromate industry for long periods. We used both radioactive isotope and non-radioisotope PCR-SSCP techniques. Results: The results of this study demonstrated that activation of ras genes due to point mutations in chromate-related lung cancer is a rare event. Conclusion: Ras oncogenes activated by point mutations do not have a major role in the process of tumorigenesis of chromate-related lung cancer. © 2001 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34471en_US
dc.relation.ispartofAmerican Journal of Industrial Medicineen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChromates - Adverse Effectsen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshGenes, Ras - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshJapanen_US
dc.subject.meshLung Neoplasms - Etiology - Genetics - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOccupational Diseases - Etiology - Genetics - Pathologyen_US
dc.subject.meshPoint Mutationen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Single-Stranded Conformationalen_US
dc.titleOccupational cancer genetics: Infrequent ras oncogenes point mutations in lung cancer samples from chromate workersen_US
dc.typeArticleen_US
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajim.1075en_US
dc.identifier.pmid11439401-
dc.identifier.scopuseid_2-s2.0-0034934645en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034934645&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume40en_US
dc.identifier.issue1en_US
dc.identifier.spage92en_US
dc.identifier.epage97en_US
dc.identifier.isiWOS:000169657500011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridJiang, CQ=10639500500en_US
dc.identifier.scopusauthoridXiao, LW=8580487900en_US
dc.identifier.scopusauthoridLam, TH=7202522876en_US
dc.identifier.scopusauthoridXie, NW=23108243300en_US
dc.identifier.scopusauthoridZhu, CQ=8537385600en_US

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