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Article: Patients' attitudes to participation in clinical trials

TitlePatients' attitudes to participation in clinical trials
Authors
Issue Date1993
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJCP
Citation
British Journal Of Clinical Pharmacology, 1993, v. 35 n. 2, p. 204-207 How to Cite?
AbstractIn order to assess attitudes of patients to participation in therapeutic trials 197 patients underwent structured interviews conducted by a single observer. Of these patients 66 were previous or current participants in clinical trials (group A), 12 had declined participation in a trial (group B), and 119 had never been invited to participate in research (group C). In group A, 62% stated their motivation for participation was to help others and 39% to improve their own treatment, but in 38% participation was to comply with the doctor's request. Two-thirds of group C patients would or might participate in a future hypothetical trial; of these more than half (57%) would do so to help others, and 42% to improve their own treatment. Of the 12 patients who had declined entry into a study (group B) three did not want to alter their current therapy, three had insufficient time to participate in the particular trial, and in three cases relatives objected to their participation. Group C patients who stated they would not participate in trials gave being too ill (22%), not wanting to change treatment (22%), and fear of side-effects (17%) as the commonest reasons for declining. In group A, 83% felt they had adequate time to consider their participation. Nearly two-thirds of patients (60%) would have liked written information to retain for reference, whereas only 38% were provided with information in this form. Over half of these patients (54%) disliked no aspect of the study in which they participated. Venepuncture and other uncomfortable procedures were least popular. Among unselected UK out-patients about two-thirds might be expected to consent to a simple therapeutic trial, with mainly altruistic motives. These findings differ from those reported in healthy American volunteers, but not from those reported in patient studies from the US or Sweden.
Persistent Identifierhttp://hdl.handle.net/10722/151514
ISSN
2015 Impact Factor: 3.83
2015 SCImago Journal Rankings: 1.486
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBevan, EGen_US
dc.contributor.authorChee, LCen_US
dc.contributor.authorMcghee, SMen_US
dc.contributor.authorMcinnes, GTen_US
dc.date.accessioned2012-06-26T06:24:09Z-
dc.date.available2012-06-26T06:24:09Z-
dc.date.issued1993en_US
dc.identifier.citationBritish Journal Of Clinical Pharmacology, 1993, v. 35 n. 2, p. 204-207en_US
dc.identifier.issn0306-5251en_US
dc.identifier.urihttp://hdl.handle.net/10722/151514-
dc.description.abstractIn order to assess attitudes of patients to participation in therapeutic trials 197 patients underwent structured interviews conducted by a single observer. Of these patients 66 were previous or current participants in clinical trials (group A), 12 had declined participation in a trial (group B), and 119 had never been invited to participate in research (group C). In group A, 62% stated their motivation for participation was to help others and 39% to improve their own treatment, but in 38% participation was to comply with the doctor's request. Two-thirds of group C patients would or might participate in a future hypothetical trial; of these more than half (57%) would do so to help others, and 42% to improve their own treatment. Of the 12 patients who had declined entry into a study (group B) three did not want to alter their current therapy, three had insufficient time to participate in the particular trial, and in three cases relatives objected to their participation. Group C patients who stated they would not participate in trials gave being too ill (22%), not wanting to change treatment (22%), and fear of side-effects (17%) as the commonest reasons for declining. In group A, 83% felt they had adequate time to consider their participation. Nearly two-thirds of patients (60%) would have liked written information to retain for reference, whereas only 38% were provided with information in this form. Over half of these patients (54%) disliked no aspect of the study in which they participated. Venepuncture and other uncomfortable procedures were least popular. Among unselected UK out-patients about two-thirds might be expected to consent to a simple therapeutic trial, with mainly altruistic motives. These findings differ from those reported in healthy American volunteers, but not from those reported in patient studies from the US or Sweden.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJCPen_US
dc.relation.ispartofBritish Journal of Clinical Pharmacologyen_US
dc.subject.meshAttitude To Healthen_US
dc.subject.meshClinical Trials As Topicen_US
dc.subject.meshFemaleen_US
dc.subject.meshHospital-Patient Relationsen_US
dc.subject.meshHumansen_US
dc.subject.meshInterviews As Topicen_US
dc.subject.meshMaleen_US
dc.subject.meshMotivationen_US
dc.subject.meshSocioeconomic Factorsen_US
dc.titlePatients' attitudes to participation in clinical trialsen_US
dc.typeArticleen_US
dc.identifier.emailMcGhee, SM:smmcghee@hkucc.hku.hken_US
dc.identifier.authorityMcGhee, SM=rp00393en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8443040-
dc.identifier.scopuseid_2-s2.0-0027400087en_US
dc.identifier.volume35en_US
dc.identifier.issue2en_US
dc.identifier.spage204en_US
dc.identifier.epage207en_US
dc.identifier.isiWOS:A1993KL51400018-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridBevan, EG=7003433012en_US
dc.identifier.scopusauthoridChee, LC=36916807400en_US
dc.identifier.scopusauthoridMcGhee, SM=7003288588en_US
dc.identifier.scopusauthoridMcInnes, GT=18735269900en_US

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