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Article: Irritant contact dermatitis due to a Chinese herbal medicine Lu-Shen-Wan

TitleIrritant contact dermatitis due to a Chinese herbal medicine Lu-Shen-Wan
Authors
Issue Date1988
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/COD
Citation
Contact Dermatitis, 1988, v. 18 n. 4, p. 213-218 How to Cite?
AbstractA Chinese herbal medicine Lu-Shen-Wan, which contains 6 ingredients, is sometimes applied topically to treat boils, carbuncles and other skin infections. 2 elderly women developed a rash after applying Lu-Shen-Wan. Patch tests showed positive reactions to Lu-Shen-Wan and to one of its 6 ingredients, Venenum Bufonis. A study in 15 control patients showed that 13 had positive reactions to 50% Lu-Shen-Wan and 50% Venenum Bufonis but that only 2 showed mild reactions when the concentration of the latter was reduced to 5%. The results suggest that Veneneum Bufonis in Lu-Shen-Wan can cause irritant contact dermatitis. The present paper demonstrates that a Western dermatological investigative method, the patch test, is applicable to traditional medicine in confirming the cause of contact dermatitis from a Chinese herbal preparation and in identifying the causative ingredient. Such knowledge is very useful for the improvement of the preparation by reducing the concentration of the irritant, by removing it or by substituting it with an alternative non-irritant substance.
Persistent Identifierhttp://hdl.handle.net/10722/151467
ISSN
2015 Impact Factor: 5.692
2015 SCImago Journal Rankings: 1.010
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, TYen_US
dc.contributor.authorLam, THen_US
dc.date.accessioned2012-06-26T06:23:41Z-
dc.date.available2012-06-26T06:23:41Z-
dc.date.issued1988en_US
dc.identifier.citationContact Dermatitis, 1988, v. 18 n. 4, p. 213-218en_US
dc.identifier.issn0105-1873en_US
dc.identifier.urihttp://hdl.handle.net/10722/151467-
dc.description.abstractA Chinese herbal medicine Lu-Shen-Wan, which contains 6 ingredients, is sometimes applied topically to treat boils, carbuncles and other skin infections. 2 elderly women developed a rash after applying Lu-Shen-Wan. Patch tests showed positive reactions to Lu-Shen-Wan and to one of its 6 ingredients, Venenum Bufonis. A study in 15 control patients showed that 13 had positive reactions to 50% Lu-Shen-Wan and 50% Venenum Bufonis but that only 2 showed mild reactions when the concentration of the latter was reduced to 5%. The results suggest that Veneneum Bufonis in Lu-Shen-Wan can cause irritant contact dermatitis. The present paper demonstrates that a Western dermatological investigative method, the patch test, is applicable to traditional medicine in confirming the cause of contact dermatitis from a Chinese herbal preparation and in identifying the causative ingredient. Such knowledge is very useful for the improvement of the preparation by reducing the concentration of the irritant, by removing it or by substituting it with an alternative non-irritant substance.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CODen_US
dc.relation.ispartofContact Dermatitisen_US
dc.subject.meshAdministration, Cutaneousen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAmphibian Venoms - Adverse Effectsen_US
dc.subject.meshChilden_US
dc.subject.meshDermatitis, Contact - Diagnosis - Drug Therapy - Etiologyen_US
dc.subject.meshDrugs, Chinese Herbal - Adverse Effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluocinolone Acetonide - Therapeutic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshIrritantsen_US
dc.subject.meshMaleen_US
dc.subject.meshPatch Tests - Methodsen_US
dc.titleIrritant contact dermatitis due to a Chinese herbal medicine Lu-Shen-Wanen_US
dc.typeArticleen_US
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3378429-
dc.identifier.scopuseid_2-s2.0-0023905045en_US
dc.identifier.volume18en_US
dc.identifier.issue4en_US
dc.identifier.spage213en_US
dc.identifier.epage218en_US
dc.identifier.isiWOS:A1988N123500006-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridLee, TY=16072414300en_US
dc.identifier.scopusauthoridLam, TH=7202522876en_US

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