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Article: Age and the daily dose of thyroxine replacement therapy for hypothyroidism

TitleAge and the daily dose of thyroxine replacement therapy for hypothyroidism
Authors
Issue Date1984
PublisherOxford University Press. The Journal's web site is located at http://ageing.oxfordjournals.org/
Citation
Age And Ageing, 1984, v. 13 n. 5, p. 299-303 How to Cite?
AbstractThe initial prescriptions and later adjustments of thyroxine (T 4) replacement have been analysed in 2246 hypothyroid patients who have been monitored by a thyroid follow-up register for a mean period of 6 years (range 1-13 years). In 465 (21%) patients of 65 years or over, initial T 4 doses were on average only 20 μg lower than in younger patients. However, only 40% of the elderly were taking 200 μg of T 4/day or more, compared with 60% of the younger patients. Over 10 years, the predicted proportion of patients who have a downward adjustment of their T 4 prescription is 3%, but there is no difference in recognized overtreatment between older and younger patients. The findings suggest that the majority of the elderly may receive larger doses of T 4 than are required for optimal replacement. There are strong reasons for the standardization of thyroxine prescribing in the elderly and for the provision of routine surveillance of thyroxine replacement through the type of follow-up system used in this study.
Persistent Identifierhttp://hdl.handle.net/10722/151440
ISSN
2015 Impact Factor: 4.201
2015 SCImago Journal Rankings: 1.611

 

DC FieldValueLanguage
dc.contributor.authorYoung, REen_US
dc.contributor.authorJones, SJen_US
dc.contributor.authorBewsher, PDen_US
dc.contributor.authorHedley, AJen_US
dc.date.accessioned2012-06-26T06:23:26Z-
dc.date.available2012-06-26T06:23:26Z-
dc.date.issued1984en_US
dc.identifier.citationAge And Ageing, 1984, v. 13 n. 5, p. 299-303en_US
dc.identifier.issn0002-0729en_US
dc.identifier.urihttp://hdl.handle.net/10722/151440-
dc.description.abstractThe initial prescriptions and later adjustments of thyroxine (T 4) replacement have been analysed in 2246 hypothyroid patients who have been monitored by a thyroid follow-up register for a mean period of 6 years (range 1-13 years). In 465 (21%) patients of 65 years or over, initial T 4 doses were on average only 20 μg lower than in younger patients. However, only 40% of the elderly were taking 200 μg of T 4/day or more, compared with 60% of the younger patients. Over 10 years, the predicted proportion of patients who have a downward adjustment of their T 4 prescription is 3%, but there is no difference in recognized overtreatment between older and younger patients. The findings suggest that the majority of the elderly may receive larger doses of T 4 than are required for optimal replacement. There are strong reasons for the standardization of thyroxine prescribing in the elderly and for the provision of routine surveillance of thyroxine replacement through the type of follow-up system used in this study.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://ageing.oxfordjournals.org/en_US
dc.relation.ispartofAge and Ageingen_US
dc.titleAge and the daily dose of thyroxine replacement therapy for hypothyroidismen_US
dc.typeArticleen_US
dc.identifier.emailHedley, AJ:hrmrajh@hkucc.hku.hken_US
dc.identifier.authorityHedley, AJ=rp00357en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6496241-
dc.identifier.scopuseid_2-s2.0-0021490271en_US
dc.identifier.volume13en_US
dc.identifier.issue5en_US
dc.identifier.spage299en_US
dc.identifier.epage303en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridYoung, RE=7405925753en_US
dc.identifier.scopusauthoridJones, SJ=7405931706en_US
dc.identifier.scopusauthoridBewsher, PD=7004559702en_US
dc.identifier.scopusauthoridHedley, AJ=7102584095en_US

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