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Article: Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length

TitleHuman MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length
Authors
Issue Date2004
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2004, v. 316 n. 4, p. 1116-1123 How to Cite?
AbstractHuman LPTS/PinX1 is a telomerase-inhibitory protein, which binds to the telomere protein Pin2/TRF1 and the catalytic subunit hTERT of telomerase. To explore the proteins that might be involved in the telomerase pathway, we performed a yeast two-hybrid screening with LPTS/PinX1 as the bait. A novel gene, MCRS2, encoding for an isoform of MCRS1/p78 and MSP58 was isolated. The expression of MCRS2 protein is cell-cycle dependent, accumulating in the very early S phase. MCRS2 interacts with LPTS/PinX1 in vitro, in vivo and colocalizes with LPTS/PinX1 in cells. MCRS2 and its amino terminus inhibit telomerase activity in vitro and long-term overexpression of MCRS2 in SMMC-7721 cells results in a gradual and progressive shortening of telomeres. Our findings suggest that MCRS2 might be a linker between telomere maintenance and cell-cycle regulation. © 2004 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/151144
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSong, Hen_US
dc.contributor.authorLi, Yen_US
dc.contributor.authorChen, Gen_US
dc.contributor.authorXing, Zen_US
dc.contributor.authorZhao, Jen_US
dc.contributor.authorYokoyama, KKen_US
dc.contributor.authorLi, Ten_US
dc.contributor.authorZhao, Men_US
dc.date.accessioned2012-06-26T06:17:40Z-
dc.date.available2012-06-26T06:17:40Z-
dc.date.issued2004en_US
dc.identifier.citationBiochemical And Biophysical Research Communications, 2004, v. 316 n. 4, p. 1116-1123en_US
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/151144-
dc.description.abstractHuman LPTS/PinX1 is a telomerase-inhibitory protein, which binds to the telomere protein Pin2/TRF1 and the catalytic subunit hTERT of telomerase. To explore the proteins that might be involved in the telomerase pathway, we performed a yeast two-hybrid screening with LPTS/PinX1 as the bait. A novel gene, MCRS2, encoding for an isoform of MCRS1/p78 and MSP58 was isolated. The expression of MCRS2 protein is cell-cycle dependent, accumulating in the very early S phase. MCRS2 interacts with LPTS/PinX1 in vitro, in vivo and colocalizes with LPTS/PinX1 in cells. MCRS2 and its amino terminus inhibit telomerase activity in vitro and long-term overexpression of MCRS2 in SMMC-7721 cells results in a gradual and progressive shortening of telomeres. Our findings suggest that MCRS2 might be a linker between telomere maintenance and cell-cycle regulation. © 2004 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_US
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshBrain - Metabolismen_US
dc.subject.meshCarcinoma, Hepatocellular - Genetics - Metabolismen_US
dc.subject.meshCell Cycleen_US
dc.subject.meshCell Cycle Proteins - Genetics - Metabolismen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshGene Expression Regulation, Neoplastic - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver - Metabolismen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshNuclear Proteinsen_US
dc.subject.meshProteins - Genetics - Metabolismen_US
dc.subject.meshRna-Binding Proteinsen_US
dc.subject.meshTelomere - Genetics - Metabolismen_US
dc.subject.meshTumor Suppressor Proteins - Genetics - Metabolismen_US
dc.titleHuman MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere lengthen_US
dc.typeArticleen_US
dc.identifier.emailLi, Y:yiliang@hkucc.hku.hken_US
dc.identifier.authorityLi, Y=rp01354en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.bbrc.2004.02.166en_US
dc.identifier.pmid15044100-
dc.identifier.scopuseid_2-s2.0-1642338831en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1642338831&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume316en_US
dc.identifier.issue4en_US
dc.identifier.spage1116en_US
dc.identifier.epage1123en_US
dc.identifier.isiWOS:000220579300022-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSong, H=36984932000en_US
dc.identifier.scopusauthoridLi, Y=27171876700en_US
dc.identifier.scopusauthoridChen, G=15051784500en_US
dc.identifier.scopusauthoridXing, Z=7201601380en_US
dc.identifier.scopusauthoridZhao, J=7410312823en_US
dc.identifier.scopusauthoridYokoyama, KK=7401877315en_US
dc.identifier.scopusauthoridLi, T=7406375403en_US
dc.identifier.scopusauthoridZhao, M=7403535359en_US

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