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Article: Protection of vascular endothelial cells from high glucose injury induced by quercetin

TitleProtection of vascular endothelial cells from high glucose injury induced by quercetin
Authors
Issue Date2002
Citation
Zhong Yao Cai = Zhongyaocai = Journal Of Chinese Medicinal Materials, 2002, v. 25 n. 4, p. 268-270 How to Cite?
AbstractOBJECTIVE: To evaluate the effects of quercetin on the high glucose-injured vascular endothelial cells (VECs). METHODS: Experiments were divided into control group, injured group and quercetin group. The cultured VECs were injured by high glucose. The proliferation of VECs was assessed by MTT assay. The amount of NO and lipid peroxidation (monitored as maloraldehyde, MDA) of VECs were assessed by fluorometric assay. The amount of lactate dehydrogenase (LDH) was assessed by spectrophotometric method. RESULTS: 10(-2), 10(-3), 10(-4), 10(-5) mg/ml quercetin increased the proliferation of high glucose-injured VECs. 10(-2), 10(-3) mg/ml quercetin reduced LDH release and MDA production, increased NO release. CONCLUSION: Quercetin can protect cultured VECs from being injured by high glucose.
Persistent Identifierhttp://hdl.handle.net/10722/151142
ISSN
2015 SCImago Journal Rankings: 0.133

 

DC FieldValueLanguage
dc.contributor.authorLi, Gen_US
dc.contributor.authorZhang, Hen_US
dc.contributor.authorLi, Yen_US
dc.contributor.authorWang, Yen_US
dc.date.accessioned2012-06-26T06:17:37Z-
dc.date.available2012-06-26T06:17:37Z-
dc.date.issued2002en_US
dc.identifier.citationZhong Yao Cai = Zhongyaocai = Journal Of Chinese Medicinal Materials, 2002, v. 25 n. 4, p. 268-270en_US
dc.identifier.issn1001-4454en_US
dc.identifier.urihttp://hdl.handle.net/10722/151142-
dc.description.abstractOBJECTIVE: To evaluate the effects of quercetin on the high glucose-injured vascular endothelial cells (VECs). METHODS: Experiments were divided into control group, injured group and quercetin group. The cultured VECs were injured by high glucose. The proliferation of VECs was assessed by MTT assay. The amount of NO and lipid peroxidation (monitored as maloraldehyde, MDA) of VECs were assessed by fluorometric assay. The amount of lactate dehydrogenase (LDH) was assessed by spectrophotometric method. RESULTS: 10(-2), 10(-3), 10(-4), 10(-5) mg/ml quercetin increased the proliferation of high glucose-injured VECs. 10(-2), 10(-3) mg/ml quercetin reduced LDH release and MDA production, increased NO release. CONCLUSION: Quercetin can protect cultured VECs from being injured by high glucose.en_US
dc.languageengen_US
dc.relation.ispartofZhong yao cai = Zhongyaocai = Journal of Chinese medicinal materialsen_US
dc.subject.meshAntioxidants - Pharmacologyen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshDrugs, Chinese Herbal - Pharmacologyen_US
dc.subject.meshEndothelium, Vascular - Cytology - Drug Effects - Metabolismen_US
dc.subject.meshGlucoseen_US
dc.subject.meshL-Lactate Dehydrogenase - Metabolismen_US
dc.subject.meshMalondialdehyde - Metabolismen_US
dc.subject.meshNitric Oxide - Metabolismen_US
dc.subject.meshQuercetin - Pharmacologyen_US
dc.titleProtection of vascular endothelial cells from high glucose injury induced by quercetinen_US
dc.typeArticleen_US
dc.identifier.emailLi, Y:yiliang@hkucc.hku.hken_US
dc.identifier.authorityLi, Y=rp01354en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12583178-
dc.identifier.scopuseid_2-s2.0-1542441005en_US
dc.identifier.volume25en_US
dc.identifier.issue4en_US
dc.identifier.spage268en_US
dc.identifier.epage270en_US
dc.identifier.scopusauthoridLi, G=15135942300en_US
dc.identifier.scopusauthoridZhang, H=16306030700en_US
dc.identifier.scopusauthoridLi, Y=27171876700en_US
dc.identifier.scopusauthoridWang, Y=12779283000en_US

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