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Article: Lipoperoxidative injury to macrophages by oxidatively modified low density lipoprotein may play an important role in foam cell formation

TitleLipoperoxidative injury to macrophages by oxidatively modified low density lipoprotein may play an important role in foam cell formation
Authors
Issue Date1996
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis
Citation
Atherosclerosis, 1996, v. 121 n. 1, p. 55-61 How to Cite?
AbstractBoth oxidatively and malondialdehyde modified low density lipoprotein (Ox-LDL and MDA-LDL) could be recognized by the scavenger receptor and induce intracellular cholesteryl ester accumulation of macrophage. The cholesteryl ester accumulation caused by MDA-LDL could be largely cleared by high density lipoprotein (HDL 3), but that caused by Ox-LDL could not be. Further studies showed that Ox-LDL and MDA-LDL all could decrease the binding capacity of HDL, and increase intracellular thiobarbituric acid reactive substances (TEARS). When macrophages were first cultured with MDA-LDL and then in medium without LDL, the decreased binding capacity of HDL, was somewhat recovered and the intracellular TEARS did not increase any more. However, if macrophages were first cultured with Ox-LDL, the binding capacity of H DL 3 continued to decrease and intracellular TEARS continued to increase. There was a negative correlation (r = -0.81, P < 0.01) between the decreased binding capacity of HDL 3, and the increased intracellular TEARS caused by Ox-LDL. These results imply that lipid peroxidative injury to macrophages caused by Ox-LDL play an important role in foam cell formation.
Persistent Identifierhttp://hdl.handle.net/10722/150985
ISSN
2015 Impact Factor: 3.942
2015 SCImago Journal Rankings: 1.819
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, SXen_US
dc.contributor.authorZhou, Men_US
dc.contributor.authorChen, Yen_US
dc.contributor.authorWen, WYen_US
dc.contributor.authorSun, MJen_US
dc.date.accessioned2012-06-26T06:15:31Z-
dc.date.available2012-06-26T06:15:31Z-
dc.date.issued1996en_US
dc.identifier.citationAtherosclerosis, 1996, v. 121 n. 1, p. 55-61en_US
dc.identifier.issn0021-9150en_US
dc.identifier.urihttp://hdl.handle.net/10722/150985-
dc.description.abstractBoth oxidatively and malondialdehyde modified low density lipoprotein (Ox-LDL and MDA-LDL) could be recognized by the scavenger receptor and induce intracellular cholesteryl ester accumulation of macrophage. The cholesteryl ester accumulation caused by MDA-LDL could be largely cleared by high density lipoprotein (HDL 3), but that caused by Ox-LDL could not be. Further studies showed that Ox-LDL and MDA-LDL all could decrease the binding capacity of HDL, and increase intracellular thiobarbituric acid reactive substances (TEARS). When macrophages were first cultured with MDA-LDL and then in medium without LDL, the decreased binding capacity of HDL, was somewhat recovered and the intracellular TEARS did not increase any more. However, if macrophages were first cultured with Ox-LDL, the binding capacity of H DL 3 continued to decrease and intracellular TEARS continued to increase. There was a negative correlation (r = -0.81, P < 0.01) between the decreased binding capacity of HDL 3, and the increased intracellular TEARS caused by Ox-LDL. These results imply that lipid peroxidative injury to macrophages caused by Ox-LDL play an important role in foam cell formation.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosisen_US
dc.relation.ispartofAtherosclerosisen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshCholesterol Esters - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshFoam Cells - Cytologyen_US
dc.subject.meshLipid Peroxidationen_US
dc.subject.meshLipoproteins, Hdl - Pharmacologyen_US
dc.subject.meshLipoproteins, Ldl - Pharmacologyen_US
dc.subject.meshMacrophages, Peritoneal - Drug Effectsen_US
dc.subject.meshMalondialdehyde - Pharmacologyen_US
dc.subject.meshMembrane Proteinsen_US
dc.subject.meshMiceen_US
dc.subject.meshOxidation-Reductionen_US
dc.subject.meshReceptors, Immunologic - Drug Effectsen_US
dc.subject.meshReceptors, Lipoproteinen_US
dc.subject.meshReceptors, Scavengeren_US
dc.subject.meshScavenger Receptors, Class Ben_US
dc.subject.meshThiobarbituric Acid Reactive Substances - Analysisen_US
dc.titleLipoperoxidative injury to macrophages by oxidatively modified low density lipoprotein may play an important role in foam cell formationen_US
dc.typeArticleen_US
dc.identifier.emailZhou, M:mfzhou@hkucc.hku.hken_US
dc.identifier.authorityZhou, M=rp00844en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0021-9150(95)05683-1en_US
dc.identifier.pmid8678924-
dc.identifier.scopuseid_2-s2.0-0030031024en_US
dc.identifier.volume121en_US
dc.identifier.issue1en_US
dc.identifier.spage55en_US
dc.identifier.epage61en_US
dc.identifier.isiWOS:A1996TZ59600006-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridLiu, SX=16747119900en_US
dc.identifier.scopusauthoridZhou, M=7403506005en_US
dc.identifier.scopusauthoridChen, Y=16745998900en_US
dc.identifier.scopusauthoridWen, WY=36911569800en_US
dc.identifier.scopusauthoridSun, MJ=16747776600en_US

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