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Article: Neural correlates of attention biases of people with major depressive disorder: A voxel-based morphometric study

TitleNeural correlates of attention biases of people with major depressive disorder: A voxel-based morphometric study
Authors
KeywordsAttention biases
Depression
Neuroimaging
Priming
Voxel-based morphometry
Issue Date2009
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
Citation
Psychological Medicine, 2009, v. 39 n. 7, p. 1097-1106 How to Cite?
AbstractBackground. Patients with major depressive disorder are found to show selective attention biases towards mood-congruent information. Although previous studies have identified various structural changes in the brains of these patients, it remains unclear whether the structural abnormalities are associated with these attention biases. In this study, we used voxel-based morphometry (VBM) to explore the structural correlates of attention biases towards depression-related stimuli. Method. Seventeen female patients with major depressive disorder and 17 female healthy controls, matched on age and intelligence, underwent magnetic resonance imaging (MRI). They also performed positive-priming (PP) and negative-priming (NP) tasks involving neutral and negative words that assessed selective attention biases. The reaction time (RT) to a target word that had been attended to or ignored in a preceding trial was measured on the PP and NP tasks respectively. The structural differences between the two groups were correlated with the indexes of attention biases towards the negative words. Results. The enhanced facilitation of attention to stimuli in the PP task by the negative valence was only found in the depressed patients, not in the healthy controls. Such attention biases towards negative stimuli were found to be associated with reduced gray-matter concentration (GMC) in the right superior frontal gyrus, the right anterior cingulate gyrus and the right fusiform gyrus. No differential effect in inhibition of attention towards negative stimuli in the NP task was found between the depressed patients and the healthy controls. Conclusions. Specific structural abnormalities in depression are associated with their attention biases towards mood-congruent information. © 2008 Cambridge University Press.
Persistent Identifierhttp://hdl.handle.net/10722/150913
ISSN
2015 Impact Factor: 5.491
2015 SCImago Journal Rankings: 2.843
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China30828012
CRCG200507176026
Funding Information:

This project was supported by the National Natural Science Foundation of China (no. 30828012) as well as the Research Output Prize and the CRCG (ref. 200507176026) of The University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorLeung, KKen_HK
dc.contributor.authorLee, TMCen_HK
dc.contributor.authorWong, MMCen_HK
dc.contributor.authorLi, LSWen_HK
dc.contributor.authorYip, PSFen_HK
dc.contributor.authorKhong, PLen_HK
dc.date.accessioned2012-06-26T06:14:22Z-
dc.date.available2012-06-26T06:14:22Z-
dc.date.issued2009en_HK
dc.identifier.citationPsychological Medicine, 2009, v. 39 n. 7, p. 1097-1106en_HK
dc.identifier.issn0033-2917en_HK
dc.identifier.urihttp://hdl.handle.net/10722/150913-
dc.description.abstractBackground. Patients with major depressive disorder are found to show selective attention biases towards mood-congruent information. Although previous studies have identified various structural changes in the brains of these patients, it remains unclear whether the structural abnormalities are associated with these attention biases. In this study, we used voxel-based morphometry (VBM) to explore the structural correlates of attention biases towards depression-related stimuli. Method. Seventeen female patients with major depressive disorder and 17 female healthy controls, matched on age and intelligence, underwent magnetic resonance imaging (MRI). They also performed positive-priming (PP) and negative-priming (NP) tasks involving neutral and negative words that assessed selective attention biases. The reaction time (RT) to a target word that had been attended to or ignored in a preceding trial was measured on the PP and NP tasks respectively. The structural differences between the two groups were correlated with the indexes of attention biases towards the negative words. Results. The enhanced facilitation of attention to stimuli in the PP task by the negative valence was only found in the depressed patients, not in the healthy controls. Such attention biases towards negative stimuli were found to be associated with reduced gray-matter concentration (GMC) in the right superior frontal gyrus, the right anterior cingulate gyrus and the right fusiform gyrus. No differential effect in inhibition of attention towards negative stimuli in the NP task was found between the depressed patients and the healthy controls. Conclusions. Specific structural abnormalities in depression are associated with their attention biases towards mood-congruent information. © 2008 Cambridge University Press.en_HK
dc.languageengen_US
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSMen_HK
dc.relation.ispartofPsychological Medicineen_HK
dc.rightsPsychological Medicine. Copyright © Cambridge University Press.-
dc.subjectAttention biasesen_HK
dc.subjectDepressionen_HK
dc.subjectNeuroimagingen_HK
dc.subjectPrimingen_HK
dc.subjectVoxel-based morphometryen_HK
dc.subject.meshAdulten_US
dc.subject.meshAffect - Physiologyen_US
dc.subject.meshAttention - Physiologyen_US
dc.subject.meshBrain - Physiopathologyen_US
dc.subject.meshBrain Mappingen_US
dc.subject.meshCuesen_US
dc.subject.meshDepressive Disorder, Major - Physiopathologyen_US
dc.subject.meshDominance, Cerebral - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFrontal Lobe - Physiopathologyen_US
dc.subject.meshGyrus Cinguli - Physiopathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImage Processing, Computer-Assisteden_US
dc.subject.meshLimbic System - Physiopathologyen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNerve Net - Physiopathologyen_US
dc.subject.meshPersonality Inventory - Statistics & Numerical Dataen_US
dc.subject.meshPsychometricsen_US
dc.subject.meshReaction Time - Physiologyen_US
dc.subject.meshReadingen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshSemanticsen_US
dc.subject.meshTemporal Lobe - Physiopathologyen_US
dc.titleNeural correlates of attention biases of people with major depressive disorder: A voxel-based morphometric studyen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, TMC: tmclee@hku.hken_HK
dc.identifier.emailYip, PSF: sfpyip@hku.hken_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.authorityLee, TMC=rp00564en_HK
dc.identifier.authorityYip, PSF=rp00596en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1017/S0033291708004546en_HK
dc.identifier.pmid18945378-
dc.identifier.scopuseid_2-s2.0-69249216538en_HK
dc.identifier.hkuros150737-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-69249216538&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume39en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1097en_HK
dc.identifier.epage1106en_HK
dc.identifier.isiWOS:000267296100006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLeung, KK=23493091300en_HK
dc.identifier.scopusauthoridLee, TMC=7501437381en_HK
dc.identifier.scopusauthoridWong, MMC=25960495800en_HK
dc.identifier.scopusauthoridLi, LSW=7501450364en_HK
dc.identifier.scopusauthoridYip, PSF=7102503720en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK

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