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Article: Whole-body PET/CT scanning: Estimation of radiation dose and cancer risk

TitleWhole-body PET/CT scanning: Estimation of radiation dose and cancer risk
Authors
Issue Date2009
PublisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
Citation
Radiology, 2009, v. 251 n. 1, p. 166-174 How to Cite?
AbstractPurpose: To estimate the radiation dose from whole-body fluorine 18 ( 18F)-fluorodeoxyglucose (FDG) positron emission tomographic (PET)/computed tomographic (CT) studies and to evaluate the induced cancer risk to U.S. and Hong Kong populations. Materials and Methods: Fluorine 18-FDG PET/CT studies obtained by using a 64-detector CT unit and one of three CT protocols were evaluated. CT protocol A consisted of 120 kV; rotation time, 0.5 second; pitch, 0.984; 100-300 mA; and noise level, 20. CT protocol B was the same as A, except for a fixed tube current of 250 mA. CT protocol C consisted of 140 kV; rotation time, 0.5 second; pitch, 0.984; 150-350 mA; and noise level, 3.5. CT doses were measured in a humanoid phantom equipped with thermoluminescent dosimeters. Doses from 18F-FDG PET scanning were estimated by multiplying the 18F-FDG radioactivity (370 MBq) with dose coefficients. Effective doses were calculated according to International Commission on Radiological Protection publication 103. Lifetime attributable risk (LAR) of cancer incidence was estimated according to the National Academies' Biological Effects of Ionizing Radiation VII Report. Results: Effective doses with protocols A, B, and C, respectively, were 13.45, 24.79, and 31.91 mSv for female patients and 13.65, 24.80, and 32.18 mSv for male patients. The LAR of cancer incidence associated with the dose was higher in the Hong Kong population than in the U.S. population. For 20-year-old U.S. women, LARs of cancer incidence were between 0.231% and 0.514%, and for 20-year-old U.S. men, LARs of cancer incidence were between 0.163% and 0.323%; LARs were 5.5%-20.9% higher for the Hong Kong population. The induced cancer risks decreased when age at exposure increased. Conclusion: Whole-body PET/CT scanning is accompanied by substantial radiation dose and cancer risk. Thus, examinations should be clinically justified, and measures should be taken to reduce the dose. © RSNA, 2009.
Persistent Identifierhttp://hdl.handle.net/10722/150908
ISSN
2014 Impact Factor: 6.867
2014 SCImago Journal Rankings: 3.148
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHuang, Ben_US
dc.contributor.authorLaw, MWMen_US
dc.contributor.authorKhong, PLen_US
dc.date.accessioned2012-06-26T06:14:19Z-
dc.date.available2012-06-26T06:14:19Z-
dc.date.issued2009en_US
dc.identifier.citationRadiology, 2009, v. 251 n. 1, p. 166-174en_US
dc.identifier.issn0033-8419en_US
dc.identifier.urihttp://hdl.handle.net/10722/150908-
dc.description.abstractPurpose: To estimate the radiation dose from whole-body fluorine 18 ( 18F)-fluorodeoxyglucose (FDG) positron emission tomographic (PET)/computed tomographic (CT) studies and to evaluate the induced cancer risk to U.S. and Hong Kong populations. Materials and Methods: Fluorine 18-FDG PET/CT studies obtained by using a 64-detector CT unit and one of three CT protocols were evaluated. CT protocol A consisted of 120 kV; rotation time, 0.5 second; pitch, 0.984; 100-300 mA; and noise level, 20. CT protocol B was the same as A, except for a fixed tube current of 250 mA. CT protocol C consisted of 140 kV; rotation time, 0.5 second; pitch, 0.984; 150-350 mA; and noise level, 3.5. CT doses were measured in a humanoid phantom equipped with thermoluminescent dosimeters. Doses from 18F-FDG PET scanning were estimated by multiplying the 18F-FDG radioactivity (370 MBq) with dose coefficients. Effective doses were calculated according to International Commission on Radiological Protection publication 103. Lifetime attributable risk (LAR) of cancer incidence was estimated according to the National Academies' Biological Effects of Ionizing Radiation VII Report. Results: Effective doses with protocols A, B, and C, respectively, were 13.45, 24.79, and 31.91 mSv for female patients and 13.65, 24.80, and 32.18 mSv for male patients. The LAR of cancer incidence associated with the dose was higher in the Hong Kong population than in the U.S. population. For 20-year-old U.S. women, LARs of cancer incidence were between 0.231% and 0.514%, and for 20-year-old U.S. men, LARs of cancer incidence were between 0.163% and 0.323%; LARs were 5.5%-20.9% higher for the Hong Kong population. The induced cancer risks decreased when age at exposure increased. Conclusion: Whole-body PET/CT scanning is accompanied by substantial radiation dose and cancer risk. Thus, examinations should be clinically justified, and measures should be taken to reduce the dose. © RSNA, 2009.en_US
dc.languageengen_US
dc.publisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.orgen_US
dc.relation.ispartofRadiologyen_US
dc.subject.meshAdulten_US
dc.subject.meshBody Burdenen_US
dc.subject.meshComputer Simulationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshNeoplasms, Radiation-Induced - Epidemiologyen_US
dc.subject.meshPhantoms, Imagingen_US
dc.subject.meshPositron-Emission Tomography - Statistics & Numerical Dataen_US
dc.subject.meshProportional Hazards Modelsen_US
dc.subject.meshRadiometryen_US
dc.subject.meshTomography, X-Ray Computed - Statistics & Numerical Dataen_US
dc.subject.meshUnited States - Epidemiologyen_US
dc.subject.meshWhole Body Imaging - Statistics & Numerical Dataen_US
dc.titleWhole-body PET/CT scanning: Estimation of radiation dose and cancer risken_US
dc.typeArticleen_US
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_US
dc.identifier.authorityKhong, PL=rp00467en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1148/radiol.2511081300en_US
dc.identifier.pmid19251940en_US
dc.identifier.scopuseid_2-s2.0-64949109919en_US
dc.identifier.hkuros148770-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-64949109919&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume251en_US
dc.identifier.issue1en_US
dc.identifier.spage166en_US
dc.identifier.epage174en_US
dc.identifier.eissn1527-1315-
dc.identifier.isiWOS:000265643000020-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHuang, B=36087446500en_US
dc.identifier.scopusauthoridLaw, MWM=8663654000en_US
dc.identifier.scopusauthoridKhong, PL=7006693233en_US
dc.identifier.citeulike5839719-

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