Article: Whole-body PET/CT scanning: Estimation of radiation dose and cancer risk

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TitleWhole-body PET/CT scanning: Estimation of radiation dose and cancer risk
AuthorsHuang, B1
Law, MWM1
Khong, PL1
Issue Date2009
PublisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
CitationRadiology, 2009, v. 251 n. 1, p. 166-174 [How to Cite?]
DOI: http://dx.doi.org/10.1148/radiol.2511081300
AbstractPurpose: To estimate the radiation dose from whole-body fluorine 18 ( 18F)-fluorodeoxyglucose (FDG) positron emission tomographic (PET)/computed tomographic (CT) studies and to evaluate the induced cancer risk to U.S. and Hong Kong populations. Materials and Methods: Fluorine 18-FDG PET/CT studies obtained by using a 64-detector CT unit and one of three CT protocols were evaluated. CT protocol A consisted of 120 kV; rotation time, 0.5 second; pitch, 0.984; 100-300 mA; and noise level, 20. CT protocol B was the same as A, except for a fixed tube current of 250 mA. CT protocol C consisted of 140 kV; rotation time, 0.5 second; pitch, 0.984; 150-350 mA; and noise level, 3.5. CT doses were measured in a humanoid phantom equipped with thermoluminescent dosimeters. Doses from 18F-FDG PET scanning were estimated by multiplying the 18F-FDG radioactivity (370 MBq) with dose coefficients. Effective doses were calculated according to International Commission on Radiological Protection publication 103. Lifetime attributable risk (LAR) of cancer incidence was estimated according to the National Academies' Biological Effects of Ionizing Radiation VII Report. Results: Effective doses with protocols A, B, and C, respectively, were 13.45, 24.79, and 31.91 mSv for female patients and 13.65, 24.80, and 32.18 mSv for male patients. The LAR of cancer incidence associated with the dose was higher in the Hong Kong population than in the U.S. population. For 20-year-old U.S. women, LARs of cancer incidence were between 0.231% and 0.514%, and for 20-year-old U.S. men, LARs of cancer incidence were between 0.163% and 0.323%; LARs were 5.5%-20.9% higher for the Hong Kong population. The induced cancer risks decreased when age at exposure increased. Conclusion: Whole-body PET/CT scanning is accompanied by substantial radiation dose and cancer risk. Thus, examinations should be clinically justified, and measures should be taken to reduce the dose. © RSNA, 2009.
ISSN0033-8419
2011 Impact Factor: 5.726
2011 SCImago Journal Rankings: 0.475
DOIhttp://dx.doi.org/10.1148/radiol.2511081300
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorHuang, B
dc.contributor.authorLaw, MWM
dc.contributor.authorKhong, PL
dc.date.accessioned2012-06-26T06:14:19Z
dc.date.available2012-06-26T06:14:19Z
dc.date.issued2009
dc.description.abstractPurpose: To estimate the radiation dose from whole-body fluorine 18 ( 18F)-fluorodeoxyglucose (FDG) positron emission tomographic (PET)/computed tomographic (CT) studies and to evaluate the induced cancer risk to U.S. and Hong Kong populations. Materials and Methods: Fluorine 18-FDG PET/CT studies obtained by using a 64-detector CT unit and one of three CT protocols were evaluated. CT protocol A consisted of 120 kV; rotation time, 0.5 second; pitch, 0.984; 100-300 mA; and noise level, 20. CT protocol B was the same as A, except for a fixed tube current of 250 mA. CT protocol C consisted of 140 kV; rotation time, 0.5 second; pitch, 0.984; 150-350 mA; and noise level, 3.5. CT doses were measured in a humanoid phantom equipped with thermoluminescent dosimeters. Doses from 18F-FDG PET scanning were estimated by multiplying the 18F-FDG radioactivity (370 MBq) with dose coefficients. Effective doses were calculated according to International Commission on Radiological Protection publication 103. Lifetime attributable risk (LAR) of cancer incidence was estimated according to the National Academies' Biological Effects of Ionizing Radiation VII Report. Results: Effective doses with protocols A, B, and C, respectively, were 13.45, 24.79, and 31.91 mSv for female patients and 13.65, 24.80, and 32.18 mSv for male patients. The LAR of cancer incidence associated with the dose was higher in the Hong Kong population than in the U.S. population. For 20-year-old U.S. women, LARs of cancer incidence were between 0.231% and 0.514%, and for 20-year-old U.S. men, LARs of cancer incidence were between 0.163% and 0.323%; LARs were 5.5%-20.9% higher for the Hong Kong population. The induced cancer risks decreased when age at exposure increased. Conclusion: Whole-body PET/CT scanning is accompanied by substantial radiation dose and cancer risk. Thus, examinations should be clinically justified, and measures should be taken to reduce the dose. © RSNA, 2009.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationRadiology, 2009, v. 251 n. 1, p. 166-174 [How to Cite?]
DOI: http://dx.doi.org/10.1148/radiol.2511081300
dc.identifier.citeulike5839719
dc.identifier.doihttp://dx.doi.org/10.1148/radiol.2511081300
dc.identifier.epage174
dc.identifier.isiWOS:000265643000020
dc.identifier.issn0033-8419
2011 Impact Factor: 5.726
2011 SCImago Journal Rankings: 0.475
dc.identifier.issue1
dc.identifier.pmid19251940
dc.identifier.scopuseid_2-s2.0-64949109919
dc.identifier.spage166
dc.identifier.urihttp://hdl.handle.net/10722/150908
dc.identifier.volume251
dc.languageeng
dc.publisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
dc.publisher.placeUnited States
dc.relation.ispartofRadiology
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshBody Burden
dc.subject.meshComputer Simulation
dc.subject.meshFemale
dc.subject.meshHong Kong - Epidemiology
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshModels, Biological
dc.subject.meshNeoplasms, Radiation-Induced - Epidemiology
dc.subject.meshPhantoms, Imaging
dc.subject.meshPositron-Emission Tomography - Statistics & Numerical Data
dc.subject.meshProportional Hazards Models
dc.subject.meshRadiometry
dc.subject.meshTomography, X-Ray Computed - Statistics & Numerical Data
dc.subject.meshUnited States - Epidemiology
dc.subject.meshWhole Body Imaging - Statistics & Numerical Data
dc.titleWhole-body PET/CT scanning: Estimation of radiation dose and cancer risk
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong