File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Whole-body PET/CT scanning: Estimation of radiation dose and cancer risk
  • Basic View
  • Metadata View
  • XML View
TitleWhole-body PET/CT scanning: Estimation of radiation dose and cancer risk
 
AuthorsHuang, B1
Law, MWM1
Khong, PL1
 
Issue Date2009
 
PublisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
 
CitationRadiology, 2009, v. 251 n. 1, p. 166-174 [How to Cite?]
DOI: http://dx.doi.org/10.1148/radiol.2511081300
 
AbstractPurpose: To estimate the radiation dose from whole-body fluorine 18 ( 18F)-fluorodeoxyglucose (FDG) positron emission tomographic (PET)/computed tomographic (CT) studies and to evaluate the induced cancer risk to U.S. and Hong Kong populations. Materials and Methods: Fluorine 18-FDG PET/CT studies obtained by using a 64-detector CT unit and one of three CT protocols were evaluated. CT protocol A consisted of 120 kV; rotation time, 0.5 second; pitch, 0.984; 100-300 mA; and noise level, 20. CT protocol B was the same as A, except for a fixed tube current of 250 mA. CT protocol C consisted of 140 kV; rotation time, 0.5 second; pitch, 0.984; 150-350 mA; and noise level, 3.5. CT doses were measured in a humanoid phantom equipped with thermoluminescent dosimeters. Doses from 18F-FDG PET scanning were estimated by multiplying the 18F-FDG radioactivity (370 MBq) with dose coefficients. Effective doses were calculated according to International Commission on Radiological Protection publication 103. Lifetime attributable risk (LAR) of cancer incidence was estimated according to the National Academies' Biological Effects of Ionizing Radiation VII Report. Results: Effective doses with protocols A, B, and C, respectively, were 13.45, 24.79, and 31.91 mSv for female patients and 13.65, 24.80, and 32.18 mSv for male patients. The LAR of cancer incidence associated with the dose was higher in the Hong Kong population than in the U.S. population. For 20-year-old U.S. women, LARs of cancer incidence were between 0.231% and 0.514%, and for 20-year-old U.S. men, LARs of cancer incidence were between 0.163% and 0.323%; LARs were 5.5%-20.9% higher for the Hong Kong population. The induced cancer risks decreased when age at exposure increased. Conclusion: Whole-body PET/CT scanning is accompanied by substantial radiation dose and cancer risk. Thus, examinations should be clinically justified, and measures should be taken to reduce the dose. © RSNA, 2009.
 
ISSN0033-8419
2013 Impact Factor: 6.214
 
DOIhttp://dx.doi.org/10.1148/radiol.2511081300
 
ISI Accession Number IDWOS:000265643000020
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHuang, B
 
dc.contributor.authorLaw, MWM
 
dc.contributor.authorKhong, PL
 
dc.date.accessioned2012-06-26T06:14:19Z
 
dc.date.available2012-06-26T06:14:19Z
 
dc.date.issued2009
 
dc.description.abstractPurpose: To estimate the radiation dose from whole-body fluorine 18 ( 18F)-fluorodeoxyglucose (FDG) positron emission tomographic (PET)/computed tomographic (CT) studies and to evaluate the induced cancer risk to U.S. and Hong Kong populations. Materials and Methods: Fluorine 18-FDG PET/CT studies obtained by using a 64-detector CT unit and one of three CT protocols were evaluated. CT protocol A consisted of 120 kV; rotation time, 0.5 second; pitch, 0.984; 100-300 mA; and noise level, 20. CT protocol B was the same as A, except for a fixed tube current of 250 mA. CT protocol C consisted of 140 kV; rotation time, 0.5 second; pitch, 0.984; 150-350 mA; and noise level, 3.5. CT doses were measured in a humanoid phantom equipped with thermoluminescent dosimeters. Doses from 18F-FDG PET scanning were estimated by multiplying the 18F-FDG radioactivity (370 MBq) with dose coefficients. Effective doses were calculated according to International Commission on Radiological Protection publication 103. Lifetime attributable risk (LAR) of cancer incidence was estimated according to the National Academies' Biological Effects of Ionizing Radiation VII Report. Results: Effective doses with protocols A, B, and C, respectively, were 13.45, 24.79, and 31.91 mSv for female patients and 13.65, 24.80, and 32.18 mSv for male patients. The LAR of cancer incidence associated with the dose was higher in the Hong Kong population than in the U.S. population. For 20-year-old U.S. women, LARs of cancer incidence were between 0.231% and 0.514%, and for 20-year-old U.S. men, LARs of cancer incidence were between 0.163% and 0.323%; LARs were 5.5%-20.9% higher for the Hong Kong population. The induced cancer risks decreased when age at exposure increased. Conclusion: Whole-body PET/CT scanning is accompanied by substantial radiation dose and cancer risk. Thus, examinations should be clinically justified, and measures should be taken to reduce the dose. © RSNA, 2009.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationRadiology, 2009, v. 251 n. 1, p. 166-174 [How to Cite?]
DOI: http://dx.doi.org/10.1148/radiol.2511081300
 
dc.identifier.citeulike5839719
 
dc.identifier.doihttp://dx.doi.org/10.1148/radiol.2511081300
 
dc.identifier.eissn1527-1315
 
dc.identifier.epage174
 
dc.identifier.hkuros148770
 
dc.identifier.isiWOS:000265643000020
 
dc.identifier.issn0033-8419
2013 Impact Factor: 6.214
 
dc.identifier.issue1
 
dc.identifier.pmid19251940
 
dc.identifier.scopuseid_2-s2.0-64949109919
 
dc.identifier.spage166
 
dc.identifier.urihttp://hdl.handle.net/10722/150908
 
dc.identifier.volume251
 
dc.languageeng
 
dc.publisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofRadiology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshBody Burden
 
dc.subject.meshComputer Simulation
 
dc.subject.meshFemale
 
dc.subject.meshHong Kong - Epidemiology
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshModels, Biological
 
dc.subject.meshNeoplasms, Radiation-Induced - Epidemiology
 
dc.subject.meshPhantoms, Imaging
 
dc.subject.meshPositron-Emission Tomography - Statistics & Numerical Data
 
dc.subject.meshProportional Hazards Models
 
dc.subject.meshRadiometry
 
dc.subject.meshTomography, X-Ray Computed - Statistics & Numerical Data
 
dc.subject.meshUnited States - Epidemiology
 
dc.subject.meshWhole Body Imaging - Statistics & Numerical Data
 
dc.titleWhole-body PET/CT scanning: Estimation of radiation dose and cancer risk
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Huang, B</contributor.author>
<contributor.author>Law, MWM</contributor.author>
<contributor.author>Khong, PL</contributor.author>
<date.accessioned>2012-06-26T06:14:19Z</date.accessioned>
<date.available>2012-06-26T06:14:19Z</date.available>
<date.issued>2009</date.issued>
<identifier.citation>Radiology, 2009, v. 251 n. 1, p. 166-174</identifier.citation>
<identifier.issn>0033-8419</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/150908</identifier.uri>
<description.abstract>Purpose: To estimate the radiation dose from whole-body fluorine 18 ( 18F)-fluorodeoxyglucose (FDG) positron emission tomographic (PET)/computed tomographic (CT) studies and to evaluate the induced cancer risk to U.S. and Hong Kong populations. Materials and Methods: Fluorine 18-FDG PET/CT studies obtained by using a 64-detector CT unit and one of three CT protocols were evaluated. CT protocol A consisted of 120 kV; rotation time, 0.5 second; pitch, 0.984; 100-300 mA; and noise level, 20. CT protocol B was the same as A, except for a fixed tube current of 250 mA. CT protocol C consisted of 140 kV; rotation time, 0.5 second; pitch, 0.984; 150-350 mA; and noise level, 3.5. CT doses were measured in a humanoid phantom equipped with thermoluminescent dosimeters. Doses from 18F-FDG PET scanning were estimated by multiplying the 18F-FDG radioactivity (370 MBq) with dose coefficients. Effective doses were calculated according to International Commission on Radiological Protection publication 103. Lifetime attributable risk (LAR) of cancer incidence was estimated according to the National Academies&apos; Biological Effects of Ionizing Radiation VII Report. Results: Effective doses with protocols A, B, and C, respectively, were 13.45, 24.79, and 31.91 mSv for female patients and 13.65, 24.80, and 32.18 mSv for male patients. The LAR of cancer incidence associated with the dose was higher in the Hong Kong population than in the U.S. population. For 20-year-old U.S. women, LARs of cancer incidence were between 0.231% and 0.514%, and for 20-year-old U.S. men, LARs of cancer incidence were between 0.163% and 0.323%; LARs were 5.5%-20.9% higher for the Hong Kong population. The induced cancer risks decreased when age at exposure increased. Conclusion: Whole-body PET/CT scanning is accompanied by substantial radiation dose and cancer risk. Thus, examinations should be clinically justified, and measures should be taken to reduce the dose. &#169; RSNA, 2009.</description.abstract>
<language>eng</language>
<publisher>Radiological Society of North America, Inc. The Journal&apos;s web site is located at http://radiology.rsnajnls.org</publisher>
<relation.ispartof>Radiology</relation.ispartof>
<subject.mesh>Adult</subject.mesh>
<subject.mesh>Body Burden</subject.mesh>
<subject.mesh>Computer Simulation</subject.mesh>
<subject.mesh>Female</subject.mesh>
<subject.mesh>Hong Kong - Epidemiology</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Male</subject.mesh>
<subject.mesh>Models, Biological</subject.mesh>
<subject.mesh>Neoplasms, Radiation-Induced - Epidemiology</subject.mesh>
<subject.mesh>Phantoms, Imaging</subject.mesh>
<subject.mesh>Positron-Emission Tomography - Statistics &amp; Numerical Data</subject.mesh>
<subject.mesh>Proportional Hazards Models</subject.mesh>
<subject.mesh>Radiometry</subject.mesh>
<subject.mesh>Tomography, X-Ray Computed - Statistics &amp; Numerical Data</subject.mesh>
<subject.mesh>United States - Epidemiology</subject.mesh>
<subject.mesh>Whole Body Imaging - Statistics &amp; Numerical Data</subject.mesh>
<title>Whole-body PET/CT scanning: Estimation of radiation dose and cancer risk</title>
<type>Article</type>
<description.nature>link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1148/radiol.2511081300</identifier.doi>
<identifier.pmid>19251940</identifier.pmid>
<identifier.scopus>eid_2-s2.0-64949109919</identifier.scopus>
<identifier.hkuros>148770</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-64949109919&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>251</identifier.volume>
<identifier.issue>1</identifier.issue>
<identifier.spage>166</identifier.spage>
<identifier.epage>174</identifier.epage>
<identifier.eissn>1527-1315</identifier.eissn>
<identifier.isi>WOS:000265643000020</identifier.isi>
<publisher.place>United States</publisher.place>
<identifier.citeulike>5839719</identifier.citeulike>
</item>
Author Affiliations
  1. The University of Hong Kong