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Article: Longitudinal diffusion tensor magnetic resonance imaging study of radiation-induced white matter damage in a rat model

TitleLongitudinal diffusion tensor magnetic resonance imaging study of radiation-induced white matter damage in a rat model
Authors
Issue Date2009
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 2009, v. 69 n. 3, p. 1190-1198 How to Cite?
AbstractRadiation-induced white matter (WM) damage is a major side effect of whole brain irradiation among childhood cancer survivors. We evaluate longitudinally the diffusion characteristics of the late radiation-induced WM damage in a rat model after 25 and 30 Gy irradiation to the hemibrain at 8 time points from 2 to 48 weeks postradiation. We hypothesize that diffusion tensor magnetic resonance imaging (DTI) indices including fractional anisotropy (FA), trace, axial diffusivity (λ∥), and radial diffusivity (λ⊥) can accurately detect and monitor the histopathologic changes of radiation-induced WM damage, measured at the EC, and that these changes are dose and time dependent. Results showed a progressive reduction of FA, which was driven by reduction in λ∥ from 4 to 40 weeks postradiation, and an increase in λ⊥ with return to baseline in λ∥ at 48 weeks postradiation. Histologic evaluation of irradiated WM showed reactive astrogliosis from 4 weeks postradiation with reversal at 36 weeks, and demyelination, axonal degeneration, and necrosis at 48 weeks postradiation. Moreover, changes in λ∥ correlated with reactive astrogliosis (P < 0.01) and λ⊥ correlated with demyelination (P < 0.01). Higher radiation dose (30 Gy) induced earlier and more severe histologic changes than lower radiation dose (25 Gy), and these differences were reflected by the magnitude of changes in λ∥ and λ⊥. DTI indices reflected the histopathologic changes of WM damage and our results support the use of DTI as a biomarker to noninvasively monitor radiation-induced WM damage. ©2009 American Association for Cancer Research.
Persistent Identifierhttp://hdl.handle.net/10722/150906
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong Committee on Research and Conference grantsHKU7587/06M
Funding Information:

Grant support: University of Hong Kong Committee on Research and Conference grants (HKU7587/06M).

References

 

DC FieldValueLanguage
dc.contributor.authorWang, Sen_HK
dc.contributor.authorWu, EXen_HK
dc.contributor.authorQiu, Den_HK
dc.contributor.authorLeung, LHTen_HK
dc.contributor.authorLau, HFen_HK
dc.contributor.authorKhong, PLen_HK
dc.date.accessioned2012-06-26T06:14:16Z-
dc.date.available2012-06-26T06:14:16Z-
dc.date.issued2009en_HK
dc.identifier.citationCancer Research, 2009, v. 69 n. 3, p. 1190-1198en_HK
dc.identifier.issn0008-5472en_HK
dc.identifier.urihttp://hdl.handle.net/10722/150906-
dc.description.abstractRadiation-induced white matter (WM) damage is a major side effect of whole brain irradiation among childhood cancer survivors. We evaluate longitudinally the diffusion characteristics of the late radiation-induced WM damage in a rat model after 25 and 30 Gy irradiation to the hemibrain at 8 time points from 2 to 48 weeks postradiation. We hypothesize that diffusion tensor magnetic resonance imaging (DTI) indices including fractional anisotropy (FA), trace, axial diffusivity (λ∥), and radial diffusivity (λ⊥) can accurately detect and monitor the histopathologic changes of radiation-induced WM damage, measured at the EC, and that these changes are dose and time dependent. Results showed a progressive reduction of FA, which was driven by reduction in λ∥ from 4 to 40 weeks postradiation, and an increase in λ⊥ with return to baseline in λ∥ at 48 weeks postradiation. Histologic evaluation of irradiated WM showed reactive astrogliosis from 4 weeks postradiation with reversal at 36 weeks, and demyelination, axonal degeneration, and necrosis at 48 weeks postradiation. Moreover, changes in λ∥ correlated with reactive astrogliosis (P < 0.01) and λ⊥ correlated with demyelination (P < 0.01). Higher radiation dose (30 Gy) induced earlier and more severe histologic changes than lower radiation dose (25 Gy), and these differences were reflected by the magnitude of changes in λ∥ and λ⊥. DTI indices reflected the histopathologic changes of WM damage and our results support the use of DTI as a biomarker to noninvasively monitor radiation-induced WM damage. ©2009 American Association for Cancer Research.en_HK
dc.languageengen_US
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_HK
dc.relation.ispartofCancer Researchen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshBrain Diseases - Etiology - Pathologyen_US
dc.subject.meshDose-Response Relationship, Radiationen_US
dc.subject.meshFemaleen_US
dc.subject.meshLongitudinal Studiesen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshRadiation Injuries, Experimental - Etiology - Pathologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshRhombencephalon - Radiation Effectsen_US
dc.titleLongitudinal diffusion tensor magnetic resonance imaging study of radiation-induced white matter damage in a rat modelen_HK
dc.typeArticleen_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1158/0008-5472.CAN-08-2661en_HK
dc.identifier.pmid19155304-
dc.identifier.scopuseid_2-s2.0-59149103069en_HK
dc.identifier.hkuros155350-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-59149103069&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume69en_HK
dc.identifier.issue3en_HK
dc.identifier.spage1190en_HK
dc.identifier.epage1198en_HK
dc.identifier.eissn1538-7445-
dc.identifier.isiWOS:000263048700058-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWang, S=24598284300en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.scopusauthoridQiu, D=12778150600en_HK
dc.identifier.scopusauthoridLeung, LHT=7202048113en_HK
dc.identifier.scopusauthoridLau, HF=23004851000en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK

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