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Article: Practical data acquisition method for human brain tumor amide proton transfer (APT) imaging

TitlePractical data acquisition method for human brain tumor amide proton transfer (APT) imaging
Authors
Issue Date2008
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/
Citation
Magnetic Resonance In Medicine, 2008, v. 60 n. 4, p. 842-849 How to Cite?
AbstractAmide proton transfer (APT) imaging is a type of chemical exchange-dependent saturation transfer (CEST) magnetic resonance imaging (MRI) in which amide protons of endogenous mobile proteins and peptides in tissue are detected. Initial studies have shown promising results for distinguishing tumor from surrounding brain in patients, but these data were hampered by magnetic field inhomogeneity and a low signal-to-noise ratio (SNR). Here a practical six-offset APT data acquisition scheme is presented that, together with a separately acquired CEST spectrum, can provide B0-inhomogeneity corrected human brain APT images of sufficient SNR within a clinically relevant time frame. Data from nine brain tumor patients at 3T shows that APT intensities were significantly higher in the tumor core, as assigned by gadolinium-enhancement, than in contralateral normal-appearing white matter (CNAWM) in patients with high-grade tumors. Conversely, APT intensities in tumor were indistinguishable from CNAWM in patients with low-grade tumors. In high-grade tumors, regions of increased APT extended outside of the core into peripheral zones, indicating the potential of this technique for more accurate delineation of the heterogeneous areas of brain cancers. © 2008 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/150904
ISSN
2015 Impact Factor: 3.782
2015 SCImago Journal Rankings: 2.197
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Institutes of HealthRR015241
EB002634
EB002666
Whitaker Foundation
Dana Foundation
Funding Information:

Grant sponsor: National Institutes of Health; Grant numbers: RR015241, EB002634, EB002666; Grant sponsors: Whitaker Foundation; Dana Foundation.

References

 

DC FieldValueLanguage
dc.contributor.authorZhou, Jen_US
dc.contributor.authorBlakeley, JOen_US
dc.contributor.authorHua, Jen_US
dc.contributor.authorKim, Men_US
dc.contributor.authorLaterra, Jen_US
dc.contributor.authorPomper, MGen_US
dc.contributor.authorVan Zijl, PCMen_US
dc.date.accessioned2012-06-26T06:14:13Z-
dc.date.available2012-06-26T06:14:13Z-
dc.date.issued2008en_US
dc.identifier.citationMagnetic Resonance In Medicine, 2008, v. 60 n. 4, p. 842-849en_US
dc.identifier.issn0740-3194en_US
dc.identifier.urihttp://hdl.handle.net/10722/150904-
dc.description.abstractAmide proton transfer (APT) imaging is a type of chemical exchange-dependent saturation transfer (CEST) magnetic resonance imaging (MRI) in which amide protons of endogenous mobile proteins and peptides in tissue are detected. Initial studies have shown promising results for distinguishing tumor from surrounding brain in patients, but these data were hampered by magnetic field inhomogeneity and a low signal-to-noise ratio (SNR). Here a practical six-offset APT data acquisition scheme is presented that, together with a separately acquired CEST spectrum, can provide B0-inhomogeneity corrected human brain APT images of sufficient SNR within a clinically relevant time frame. Data from nine brain tumor patients at 3T shows that APT intensities were significantly higher in the tumor core, as assigned by gadolinium-enhancement, than in contralateral normal-appearing white matter (CNAWM) in patients with high-grade tumors. Conversely, APT intensities in tumor were indistinguishable from CNAWM in patients with low-grade tumors. In high-grade tumors, regions of increased APT extended outside of the core into peripheral zones, indicating the potential of this technique for more accurate delineation of the heterogeneous areas of brain cancers. © 2008 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/en_US
dc.relation.ispartofMagnetic Resonance in Medicineen_US
dc.subject.meshAmides - Analysisen_US
dc.subject.meshBrain Neoplasms - Diagnosis - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlioma - Diagnosis - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshImage Enhancement - Methodsen_US
dc.subject.meshImage Interpretation, Computer-Assisted - Methodsen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshProtons - Diagnostic Useen_US
dc.subject.meshReproducibility Of Resultsen_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshTumor Markers, Biological - Analysisen_US
dc.titlePractical data acquisition method for human brain tumor amide proton transfer (APT) imagingen_US
dc.typeArticleen_US
dc.identifier.emailKim, M:minakim@hku.hken_US
dc.identifier.authorityKim, M=rp00292en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1002/mrm.21712en_US
dc.identifier.pmid18816868-
dc.identifier.pmcidPMC2579754-
dc.identifier.scopuseid_2-s2.0-53549091343en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-53549091343&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume60en_US
dc.identifier.issue4en_US
dc.identifier.spage842en_US
dc.identifier.epage849en_US
dc.identifier.isiWOS:000259651200011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhou, J=7405550363en_US
dc.identifier.scopusauthoridBlakeley, JO=15055270800en_US
dc.identifier.scopusauthoridHua, J=36725108400en_US
dc.identifier.scopusauthoridKim, M=8146283400en_US
dc.identifier.scopusauthoridLaterra, J=7006682302en_US
dc.identifier.scopusauthoridPomper, MG=35248909800en_US
dc.identifier.scopusauthoridVan Zijl, PCM=7006760849en_US

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