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Article: Inherited thrombophilic factors do not increase central venous catheter blockage in children with malignancy

TitleInherited thrombophilic factors do not increase central venous catheter blockage in children with malignancy
Authors
KeywordsCentral venous catheter blockage
Chinese children
Inherited thrombophilic factors
Malignancy
Issue Date2008
Citation
Pediatric Blood And Cancer, 2008, v. 51 n. 4, p. 509-512 How to Cite?
AbstractBackground. Central venous catheter (CVC) blockage is a common complication in pediatric oncology patients. We investigated whether inherited thrombophilic factors may predispose Chinese children with cancer to CVC blockage. Method. Newly diagnosed patients with CVC inserted were recruited during a 30-month period and prospectively followed until CVC removal, end of treatment or death. Protein C (PC), protein S (PS), anti-thrombin III (AT-III), Factor V Leiden (FVL), prothrombin 20210 variant (p20210), and methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T), were studied with other acquired factors. The primary endpoint was CVC blockage and symptomatic thromboembolic events (TE) were recorded. Result. Thirty-six patients were recruited. CVC blockage was found in 3/36 (8.3%) and the incidence was 0.23 per 1,000 catheter-days. Among the 3 with CVC blockage, 2 were heterozygous for MTHFR polymorphism and 1 was heterozygous for PC deficiency. One with ALL developed superior saggital sinus thrombosis while on asparaginase and he was heterozygous for MTHFR polymorphism. One ALL patient with combined heterozygous MTHFR polymorphism, PC and PS deficiency did not develop any CVC blockage during a median follow-up of 3.8 years. AT-III deficiency, FVL and p20210 were not found in all patients. Conclusion. Compared to previous studies, our cohort had a much lower incidence of CVC blockage. A different pattern of inherited thrombophilic factors was found with heterozygous MTHFR polymorphism being the most common. We concluded that inherited thrombophilic factors alone were not associated with CVC blockage in our pediatric cancer patient population. © 2008 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/150903
ISSN
2015 Impact Factor: 2.634
2015 SCImago Journal Rankings: 1.505
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChung, BHYen_HK
dc.contributor.authorMa, ESKen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorChan, GCFen_HK
dc.date.accessioned2012-06-26T06:14:12Z-
dc.date.available2012-06-26T06:14:12Z-
dc.date.issued2008en_HK
dc.identifier.citationPediatric Blood And Cancer, 2008, v. 51 n. 4, p. 509-512en_HK
dc.identifier.issn1545-5009en_HK
dc.identifier.urihttp://hdl.handle.net/10722/150903-
dc.description.abstractBackground. Central venous catheter (CVC) blockage is a common complication in pediatric oncology patients. We investigated whether inherited thrombophilic factors may predispose Chinese children with cancer to CVC blockage. Method. Newly diagnosed patients with CVC inserted were recruited during a 30-month period and prospectively followed until CVC removal, end of treatment or death. Protein C (PC), protein S (PS), anti-thrombin III (AT-III), Factor V Leiden (FVL), prothrombin 20210 variant (p20210), and methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T), were studied with other acquired factors. The primary endpoint was CVC blockage and symptomatic thromboembolic events (TE) were recorded. Result. Thirty-six patients were recruited. CVC blockage was found in 3/36 (8.3%) and the incidence was 0.23 per 1,000 catheter-days. Among the 3 with CVC blockage, 2 were heterozygous for MTHFR polymorphism and 1 was heterozygous for PC deficiency. One with ALL developed superior saggital sinus thrombosis while on asparaginase and he was heterozygous for MTHFR polymorphism. One ALL patient with combined heterozygous MTHFR polymorphism, PC and PS deficiency did not develop any CVC blockage during a median follow-up of 3.8 years. AT-III deficiency, FVL and p20210 were not found in all patients. Conclusion. Compared to previous studies, our cohort had a much lower incidence of CVC blockage. A different pattern of inherited thrombophilic factors was found with heterozygous MTHFR polymorphism being the most common. We concluded that inherited thrombophilic factors alone were not associated with CVC blockage in our pediatric cancer patient population. © 2008 Wiley-Liss, Inc.en_HK
dc.languageengen_US
dc.relation.ispartofPediatric Blood and Canceren_HK
dc.rightsPediatric Blood & Cancer. Copyright © John Wiley & Sons, Inc.-
dc.subjectCentral venous catheter blockageen_HK
dc.subjectChinese childrenen_HK
dc.subjectInherited thrombophilic factorsen_HK
dc.subjectMalignancyen_HK
dc.subject.meshAdolescenten_US
dc.subject.meshCatheterization, Central Venousen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshNeoplasms - Metabolism - Therapyen_US
dc.subject.meshThrombophilia - Metabolismen_US
dc.titleInherited thrombophilic factors do not increase central venous catheter blockage in children with malignancyen_HK
dc.typeArticleen_HK
dc.identifier.emailChung, BHY:bhychung@hku.hken_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.authorityChung, BHY=rp00473en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/pbc.21617en_HK
dc.identifier.pmid18561172en_HK
dc.identifier.scopuseid_2-s2.0-50249126512en_HK
dc.identifier.hkuros145663-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-50249126512&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume51en_HK
dc.identifier.issue4en_HK
dc.identifier.spage509en_HK
dc.identifier.epage512en_HK
dc.identifier.isiWOS:000258748000015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChung, BHY=7203043997en_HK
dc.identifier.scopusauthoridMa, ESK=7202039934en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK

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