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Article: Fluorine-18 fluorodeoxyglucose positron emission tomography in mature T-cell and natural killer cell malignancies
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TitleFluorine-18 fluorodeoxyglucose positron emission tomography in mature T-cell and natural killer cell malignancies
 
AuthorsKhong, PL2
Pang, CBY2
Liang, R2
Kwong, YL2 1
Au, WY2
 
KeywordsComputed tomography
Naturalkiller cell lymphoma
Positron emission tomography
T-cell
 
Issue Date2008
 
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00277/index.htm
 
CitationAnnals Of Hematology, 2008, v. 87 n. 8, p. 613-621 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00277-008-0494-8
 
AbstractFluorine-18 fluorodeoxyglucose (FDG)-positron emission tomography (PET) is useful in Hodgkin and B-cell lymphomas. Few data exist on T-cell and natural killer (NK)-cell lymphomas. Thirty consecutive T-cell and NK-cell lymphomas were investigated with PET-computerized tomography (CT). In 12 NK-cell lymphomas, all nasal/extranasal lesions were FDG-avid. In nasal/maxillary areas, FDG-avid tumours were consistently more localised than on CT, suggesting that soft tissue masses on CT were partly due to inflammation. These findings have important implications in radiotherapy planning. In two NK-cell lymphomas, PET did not detect morphologically occult marrow infiltration uncovered by in situ hybridisation for Epstein-Barr-virus-encoded small RNA. In angioimmunoblastic lymphoma (n = 7), peripheral T-cell lymphoma, unspecified (PTCL-U, n = 4) and anaplastic large cell lymphoma (ALCL, n = 3), involved nodal/extranodal sites shown on CT and/or biopsy were concordantly PET-positive. In one PTCL-U, PET detected FDG-avid marrow infiltrations not shown on biopsies. In contrast, cutaneous ALCL (n = 1) and mycosis fungoides (n = 2) showed minimal FDG uptake. In one case of T-cell large granular lymphocyte leukaemia, marrow, nodal and bowel infiltrations were not FDG-avid. PET maximum standardised uptake value did not correlate with clinicopathological features and prognosis. These observations defined the pre-treatment value of PET-CT in T-cell and NK-cell lymphomas. The post-treatment role requires further studies. © Springer-Verlag 2008.
 
ISSN0939-5555
2012 Impact Factor: 2.866
2012 SCImago Journal Rankings: 0.804
 
DOIhttp://dx.doi.org/10.1007/s00277-008-0494-8
 
ISI Accession Number IDWOS:000257200500002
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorKhong, PL
 
dc.contributor.authorPang, CBY
 
dc.contributor.authorLiang, R
 
dc.contributor.authorKwong, YL
 
dc.contributor.authorAu, WY
 
dc.date.accessioned2012-06-26T06:14:11Z
 
dc.date.available2012-06-26T06:14:11Z
 
dc.date.issued2008
 
dc.description.abstractFluorine-18 fluorodeoxyglucose (FDG)-positron emission tomography (PET) is useful in Hodgkin and B-cell lymphomas. Few data exist on T-cell and natural killer (NK)-cell lymphomas. Thirty consecutive T-cell and NK-cell lymphomas were investigated with PET-computerized tomography (CT). In 12 NK-cell lymphomas, all nasal/extranasal lesions were FDG-avid. In nasal/maxillary areas, FDG-avid tumours were consistently more localised than on CT, suggesting that soft tissue masses on CT were partly due to inflammation. These findings have important implications in radiotherapy planning. In two NK-cell lymphomas, PET did not detect morphologically occult marrow infiltration uncovered by in situ hybridisation for Epstein-Barr-virus-encoded small RNA. In angioimmunoblastic lymphoma (n = 7), peripheral T-cell lymphoma, unspecified (PTCL-U, n = 4) and anaplastic large cell lymphoma (ALCL, n = 3), involved nodal/extranodal sites shown on CT and/or biopsy were concordantly PET-positive. In one PTCL-U, PET detected FDG-avid marrow infiltrations not shown on biopsies. In contrast, cutaneous ALCL (n = 1) and mycosis fungoides (n = 2) showed minimal FDG uptake. In one case of T-cell large granular lymphocyte leukaemia, marrow, nodal and bowel infiltrations were not FDG-avid. PET maximum standardised uptake value did not correlate with clinicopathological features and prognosis. These observations defined the pre-treatment value of PET-CT in T-cell and NK-cell lymphomas. The post-treatment role requires further studies. © Springer-Verlag 2008.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationAnnals Of Hematology, 2008, v. 87 n. 8, p. 613-621 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00277-008-0494-8
 
dc.identifier.doihttp://dx.doi.org/10.1007/s00277-008-0494-8
 
dc.identifier.epage621
 
dc.identifier.hkuros145626
 
dc.identifier.hkuros160117
 
dc.identifier.isiWOS:000257200500002
 
dc.identifier.issn0939-5555
2012 Impact Factor: 2.866
2012 SCImago Journal Rankings: 0.804
 
dc.identifier.issue8
 
dc.identifier.pmid18509641
 
dc.identifier.scopuseid_2-s2.0-46949093658
 
dc.identifier.spage613
 
dc.identifier.urihttp://hdl.handle.net/10722/150902
 
dc.identifier.volume87
 
dc.languageeng
 
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00277/index.htm
 
dc.publisher.placeGermany
 
dc.relation.ispartofAnnals of Hematology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdolescent
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshCohort Studies
 
dc.subject.meshDisease Progression
 
dc.subject.meshFemale
 
dc.subject.meshFluorodeoxyglucose F18 - Diagnostic Use
 
dc.subject.meshHumans
 
dc.subject.meshKiller Cells, Natural - Radionuclide Imaging
 
dc.subject.meshLymphoma, T-Cell - Pathology - Radionuclide Imaging
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPositron-Emission Tomography
 
dc.subjectComputed tomography
 
dc.subjectNaturalkiller cell lymphoma
 
dc.subjectPositron emission tomography
 
dc.subjectT-cell
 
dc.titleFluorine-18 fluorodeoxyglucose positron emission tomography in mature T-cell and natural killer cell malignancies
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong