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Article: Mapping radiation dose distribution on the fractional anisotropy map: Applications in the assessment of treatment-induced white matter injury

TitleMapping radiation dose distribution on the fractional anisotropy map: Applications in the assessment of treatment-induced white matter injury
Authors
Issue Date2006
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
Neuroimage, 2006, v. 31 n. 1, p. 109-115 How to Cite?
AbstractWe describe a method to map whole brain radiation dose distribution on to diffusion tensor MR (DT-MR) fractional anisotropy (FA) images and illustrate its applications for studying dose-effect relationships and regional susceptibility in two childhood medulloblastoma survivors. To determine the FA changes voxel-by-voxel in white matter, the post-treatment follow-up FA maps were coregistered to baseline pre-treatment FA maps and automatic segmentation for white matter was carried out. ΔFA maps representing relative FA change in white matter were hence generated for visual inspection and quantitative analysis. The radiation dose distribution, calculated from radiotherapy plan and exported as images, was coregistered to baseline FA images. DT-MR imaging and processing noise was small with root mean square value of 1.49% for mean ΔFA. We evaluated the mean ΔFA changes of regions-of-interest according to radiation dose regions to provide an estimate of the dose-response and found increasing reduction in mean ΔFA with increasing radiation dose up to 45 Gy after which there was a reversal in the mean FA trend and mean FA approached baseline value. We also found more severe mean FA reduction in the frontal lobes compared to the parietal lobes despite the same radiation dose, suggesting regional susceptibility in the frontal lobe, and mean FA increase in the brainstem after radiation in both patients. We conclude that the method described may be useful in estimating dose-effect relationships and studying regional susceptibility of the brain to radiation in medulloblastoma survivors. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/150892
ISSN
2015 Impact Factor: 5.463
2015 SCImago Journal Rankings: 4.464
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorQiu, Den_US
dc.contributor.authorLeung, LHTen_US
dc.contributor.authorKwong, DLWen_US
dc.contributor.authorChan, GCFen_US
dc.contributor.authorKhong, PLen_US
dc.date.accessioned2012-06-26T06:13:58Z-
dc.date.available2012-06-26T06:13:58Z-
dc.date.issued2006en_US
dc.identifier.citationNeuroimage, 2006, v. 31 n. 1, p. 109-115en_US
dc.identifier.issn1053-8119en_US
dc.identifier.urihttp://hdl.handle.net/10722/150892-
dc.description.abstractWe describe a method to map whole brain radiation dose distribution on to diffusion tensor MR (DT-MR) fractional anisotropy (FA) images and illustrate its applications for studying dose-effect relationships and regional susceptibility in two childhood medulloblastoma survivors. To determine the FA changes voxel-by-voxel in white matter, the post-treatment follow-up FA maps were coregistered to baseline pre-treatment FA maps and automatic segmentation for white matter was carried out. ΔFA maps representing relative FA change in white matter were hence generated for visual inspection and quantitative analysis. The radiation dose distribution, calculated from radiotherapy plan and exported as images, was coregistered to baseline FA images. DT-MR imaging and processing noise was small with root mean square value of 1.49% for mean ΔFA. We evaluated the mean ΔFA changes of regions-of-interest according to radiation dose regions to provide an estimate of the dose-response and found increasing reduction in mean ΔFA with increasing radiation dose up to 45 Gy after which there was a reversal in the mean FA trend and mean FA approached baseline value. We also found more severe mean FA reduction in the frontal lobes compared to the parietal lobes despite the same radiation dose, suggesting regional susceptibility in the frontal lobe, and mean FA increase in the brainstem after radiation in both patients. We conclude that the method described may be useful in estimating dose-effect relationships and studying regional susceptibility of the brain to radiation in medulloblastoma survivors. © 2005 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_US
dc.relation.ispartofNeuroImageen_US
dc.subject.meshAnisotropyen_US
dc.subject.meshBrain - Radiation Effectsen_US
dc.subject.meshBrain Mappingen_US
dc.subject.meshBrain Stem - Radiation Effectsen_US
dc.subject.meshCerebellar Neoplasms - Drug Therapy - Radiotherapy - Surgeryen_US
dc.subject.meshChilden_US
dc.subject.meshCombined Modality Therapyen_US
dc.subject.meshCranial Irradiationen_US
dc.subject.meshDiffusion Magnetic Resonance Imagingen_US
dc.subject.meshDose-Response Relationship, Radiationen_US
dc.subject.meshFemaleen_US
dc.subject.meshFrontal Lobe - Radiation Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshImage Processing, Computer-Assisteden_US
dc.subject.meshMaleen_US
dc.subject.meshMedulloblastoma - Drug Therapy - Radiotherapy - Surgeryen_US
dc.subject.meshParietal Lobe - Radiation Effectsen_US
dc.subject.meshRadiation Injuries - Diagnosisen_US
dc.subject.meshRadiotherapy Dosageen_US
dc.subject.meshRadiotherapy, Adjuvanten_US
dc.subject.meshReference Valuesen_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshSurvivorsen_US
dc.titleMapping radiation dose distribution on the fractional anisotropy map: Applications in the assessment of treatment-induced white matter injuryen_US
dc.typeArticleen_US
dc.identifier.emailKwong, DLW:dlwkwong@hku.hken_US
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_US
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_US
dc.identifier.authorityKwong, DLW=rp00414en_US
dc.identifier.authorityChan, GCF=rp00431en_US
dc.identifier.authorityKhong, PL=rp00467en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neuroimage.2005.12.007en_US
dc.identifier.pmid16448821-
dc.identifier.scopuseid_2-s2.0-33646716240en_US
dc.identifier.hkuros114484-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646716240&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume31en_US
dc.identifier.issue1en_US
dc.identifier.spage109en_US
dc.identifier.epage115en_US
dc.identifier.isiWOS:000238012200010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridQiu, D=12778150600en_US
dc.identifier.scopusauthoridLeung, LHT=7202048113en_US
dc.identifier.scopusauthoridKwong, DLW=15744231600en_US
dc.identifier.scopusauthoridChan, GCF=16160154400en_US
dc.identifier.scopusauthoridKhong, PL=7006693233en_US

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