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Article: Severe Acute Respiratory Syndrome: temporal lung changes at thin-section CT in 30 patients

TitleSevere Acute Respiratory Syndrome: temporal lung changes at thin-section CT in 30 patients
Authors
KeywordsLung, CT
Lung, infection
Severe acute respiratory syndrome (SARS)
Issue Date2004
PublisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
Citation
Radiology, 2004, v. 230 n. 3, p. 836-844 How to Cite?
Abstract
PURPOSE: To evaluate lung abnormalities on serial thin-section computed tomographic (CT) scans in patients with severe acute respiratory syndrome (SARS) during acute and convalescent periods. MATERIALS AND METHODS: Serial thin-section CT scans in 30 patients (17 men, aged 42.5 years ± 12.2 [SD]) with SARS were reviewed by two radiologists together for predominant patterns of lung abnormalities: ground-glass opacities, ground-glass opacities with superimposed linear opacities, consolidation, reticular pattern, and mixed pattern (consolidation, ground-glass opacities, and reticular pattern). Scans were classified according to duration in weeks after symptom onset. Longitudinal changes of specific abnormalities were documented in 17 patients with serial scans obtained during 3 weeks. Each lung was divided into three zones; each zone was evaluated for percentage of lung involvement. Summation of scores from all six lung zones provided overall CT score (maximal CT score, 24). RESULTS: Median CT scores increased from 1 in the 1st week to 12.5 in the 2nd week. Ground-glass opacities with or without smooth interlobular septal thickening and consolidation were predominant patterns found during the 1st week. Ground-glass opacities with superimposed irregular reticular opacities, mixed pattern, and reticular opacities were noted from the 2nd week and peaked at or after the 4th week. After the 4th week, 12 (55%) of 22 patients had irregular linear opacities with or without associated ground-glass opacities and CT scores greater than 5; five of these patients had bronchial dilatation. When specific opacities were analyzed in 17 patients, consolidation generally resolved completely (n = 4) or to minimal residual opacities; six (55%) of 11 patients with ground-glass opacities had substantial residual disease (CT scores > 5) on final scans. CONCLUSION: There is a temporal pattern of lung abnormalities at thin-section CT in SARS. Predominant findings at presentation are ground-glass opacities and consolidation. Reticulation is evident after the 2nd week and persists in half of all patients evaluated after 4 weeks. Long-term follow-up is required to determine whether the reticulation represents irreversible fibrosis. © RSNA, 2004.
Persistent Identifierhttp://hdl.handle.net/10722/150886
ISSN
2013 Impact Factor: 6.214
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOoi, GCen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorMüller, NLen_HK
dc.contributor.authorYiu, WCen_HK
dc.contributor.authorZhou, LJen_HK
dc.contributor.authorHo, JCMen_HK
dc.contributor.authorLam, Ben_HK
dc.contributor.authorNicolaou, Sen_HK
dc.contributor.authorTsang, KWTen_HK
dc.date.accessioned2012-06-26T06:13:54Z-
dc.date.available2012-06-26T06:13:54Z-
dc.date.issued2004en_HK
dc.identifier.citationRadiology, 2004, v. 230 n. 3, p. 836-844en_HK
dc.identifier.issn0033-8419en_HK
dc.identifier.urihttp://hdl.handle.net/10722/150886-
dc.description.abstractPURPOSE: To evaluate lung abnormalities on serial thin-section computed tomographic (CT) scans in patients with severe acute respiratory syndrome (SARS) during acute and convalescent periods. MATERIALS AND METHODS: Serial thin-section CT scans in 30 patients (17 men, aged 42.5 years ± 12.2 [SD]) with SARS were reviewed by two radiologists together for predominant patterns of lung abnormalities: ground-glass opacities, ground-glass opacities with superimposed linear opacities, consolidation, reticular pattern, and mixed pattern (consolidation, ground-glass opacities, and reticular pattern). Scans were classified according to duration in weeks after symptom onset. Longitudinal changes of specific abnormalities were documented in 17 patients with serial scans obtained during 3 weeks. Each lung was divided into three zones; each zone was evaluated for percentage of lung involvement. Summation of scores from all six lung zones provided overall CT score (maximal CT score, 24). RESULTS: Median CT scores increased from 1 in the 1st week to 12.5 in the 2nd week. Ground-glass opacities with or without smooth interlobular septal thickening and consolidation were predominant patterns found during the 1st week. Ground-glass opacities with superimposed irregular reticular opacities, mixed pattern, and reticular opacities were noted from the 2nd week and peaked at or after the 4th week. After the 4th week, 12 (55%) of 22 patients had irregular linear opacities with or without associated ground-glass opacities and CT scores greater than 5; five of these patients had bronchial dilatation. When specific opacities were analyzed in 17 patients, consolidation generally resolved completely (n = 4) or to minimal residual opacities; six (55%) of 11 patients with ground-glass opacities had substantial residual disease (CT scores > 5) on final scans. CONCLUSION: There is a temporal pattern of lung abnormalities at thin-section CT in SARS. Predominant findings at presentation are ground-glass opacities and consolidation. Reticulation is evident after the 2nd week and persists in half of all patients evaluated after 4 weeks. Long-term follow-up is required to determine whether the reticulation represents irreversible fibrosis. © RSNA, 2004.en_HK
dc.languageengen_US
dc.publisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.orgen_HK
dc.relation.ispartofRadiologyen_HK
dc.subjectLung, CTen_HK
dc.subjectLung, infectionen_HK
dc.subjectSevere acute respiratory syndrome (SARS)en_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshFemaleen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshLongitudinal Studiesen_US
dc.subject.meshLung - Radiographyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPulmonary Fibrosis - Radiographyen_US
dc.subject.meshRemission, Spontaneousen_US
dc.subject.meshSevere Acute Respiratory Syndrome - Radiographyen_US
dc.subject.meshTomography, Spiral Computeden_US
dc.titleSevere Acute Respiratory Syndrome: temporal lung changes at thin-section CT in 30 patientsen_HK
dc.typeArticleen_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.emailHo, JCM:jhocm@hku.hken_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityHo, JCM=rp00258en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1148/radiol.2303030853en_HK
dc.identifier.pmid14990845en_HK
dc.identifier.scopuseid_2-s2.0-1342329986en_HK
dc.identifier.hkuros87699-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1342329986&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume230en_HK
dc.identifier.issue3en_HK
dc.identifier.spage836en_HK
dc.identifier.epage844en_HK
dc.identifier.isiWOS:000189186500035-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridOoi, GC=7006176119en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridMüller, NL=35377797100en_HK
dc.identifier.scopusauthoridYiu, WC=6602810849en_HK
dc.identifier.scopusauthoridZhou, LJ=7404125958en_HK
dc.identifier.scopusauthoridHo, JCM=7402649981en_HK
dc.identifier.scopusauthoridLam, B=9246012800en_HK
dc.identifier.scopusauthoridNicolaou, S=7004239134en_HK
dc.identifier.scopusauthoridTsang, KWT=7201555024en_HK
dc.customcontrol.immutablejt 130510-

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