File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Severe Acute Respiratory Syndrome: temporal lung changes at thin-section CT in 30 patients
  • Basic View
  • Metadata View
  • XML View
TitleSevere Acute Respiratory Syndrome: temporal lung changes at thin-section CT in 30 patients
 
AuthorsOoi, GC1
Khong, PL1
Müller, NL3
Yiu, WC2
Zhou, LJ1
Ho, JCM1
Lam, B1
Nicolaou, S3
Tsang, KWT1
 
KeywordsLung, CT
Lung, infection
Severe acute respiratory syndrome (SARS)
 
Issue Date2004
 
PublisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
 
CitationRadiology, 2004, v. 230 n. 3, p. 836-844 [How to Cite?]
DOI: http://dx.doi.org/10.1148/radiol.2303030853
 
AbstractPURPOSE: To evaluate lung abnormalities on serial thin-section computed tomographic (CT) scans in patients with severe acute respiratory syndrome (SARS) during acute and convalescent periods. MATERIALS AND METHODS: Serial thin-section CT scans in 30 patients (17 men, aged 42.5 years ± 12.2 [SD]) with SARS were reviewed by two radiologists together for predominant patterns of lung abnormalities: ground-glass opacities, ground-glass opacities with superimposed linear opacities, consolidation, reticular pattern, and mixed pattern (consolidation, ground-glass opacities, and reticular pattern). Scans were classified according to duration in weeks after symptom onset. Longitudinal changes of specific abnormalities were documented in 17 patients with serial scans obtained during 3 weeks. Each lung was divided into three zones; each zone was evaluated for percentage of lung involvement. Summation of scores from all six lung zones provided overall CT score (maximal CT score, 24). RESULTS: Median CT scores increased from 1 in the 1st week to 12.5 in the 2nd week. Ground-glass opacities with or without smooth interlobular septal thickening and consolidation were predominant patterns found during the 1st week. Ground-glass opacities with superimposed irregular reticular opacities, mixed pattern, and reticular opacities were noted from the 2nd week and peaked at or after the 4th week. After the 4th week, 12 (55%) of 22 patients had irregular linear opacities with or without associated ground-glass opacities and CT scores greater than 5; five of these patients had bronchial dilatation. When specific opacities were analyzed in 17 patients, consolidation generally resolved completely (n = 4) or to minimal residual opacities; six (55%) of 11 patients with ground-glass opacities had substantial residual disease (CT scores > 5) on final scans. CONCLUSION: There is a temporal pattern of lung abnormalities at thin-section CT in SARS. Predominant findings at presentation are ground-glass opacities and consolidation. Reticulation is evident after the 2nd week and persists in half of all patients evaluated after 4 weeks. Long-term follow-up is required to determine whether the reticulation represents irreversible fibrosis. © RSNA, 2004.
 
ISSN0033-8419
2013 Impact Factor: 6.214
 
DOIhttp://dx.doi.org/10.1148/radiol.2303030853
 
ISI Accession Number IDWOS:000189186500035
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorOoi, GC
 
dc.contributor.authorKhong, PL
 
dc.contributor.authorMüller, NL
 
dc.contributor.authorYiu, WC
 
dc.contributor.authorZhou, LJ
 
dc.contributor.authorHo, JCM
 
dc.contributor.authorLam, B
 
dc.contributor.authorNicolaou, S
 
dc.contributor.authorTsang, KWT
 
dc.date.accessioned2012-06-26T06:13:54Z
 
dc.date.available2012-06-26T06:13:54Z
 
dc.date.issued2004
 
dc.description.abstractPURPOSE: To evaluate lung abnormalities on serial thin-section computed tomographic (CT) scans in patients with severe acute respiratory syndrome (SARS) during acute and convalescent periods. MATERIALS AND METHODS: Serial thin-section CT scans in 30 patients (17 men, aged 42.5 years ± 12.2 [SD]) with SARS were reviewed by two radiologists together for predominant patterns of lung abnormalities: ground-glass opacities, ground-glass opacities with superimposed linear opacities, consolidation, reticular pattern, and mixed pattern (consolidation, ground-glass opacities, and reticular pattern). Scans were classified according to duration in weeks after symptom onset. Longitudinal changes of specific abnormalities were documented in 17 patients with serial scans obtained during 3 weeks. Each lung was divided into three zones; each zone was evaluated for percentage of lung involvement. Summation of scores from all six lung zones provided overall CT score (maximal CT score, 24). RESULTS: Median CT scores increased from 1 in the 1st week to 12.5 in the 2nd week. Ground-glass opacities with or without smooth interlobular septal thickening and consolidation were predominant patterns found during the 1st week. Ground-glass opacities with superimposed irregular reticular opacities, mixed pattern, and reticular opacities were noted from the 2nd week and peaked at or after the 4th week. After the 4th week, 12 (55%) of 22 patients had irregular linear opacities with or without associated ground-glass opacities and CT scores greater than 5; five of these patients had bronchial dilatation. When specific opacities were analyzed in 17 patients, consolidation generally resolved completely (n = 4) or to minimal residual opacities; six (55%) of 11 patients with ground-glass opacities had substantial residual disease (CT scores > 5) on final scans. CONCLUSION: There is a temporal pattern of lung abnormalities at thin-section CT in SARS. Predominant findings at presentation are ground-glass opacities and consolidation. Reticulation is evident after the 2nd week and persists in half of all patients evaluated after 4 weeks. Long-term follow-up is required to determine whether the reticulation represents irreversible fibrosis. © RSNA, 2004.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationRadiology, 2004, v. 230 n. 3, p. 836-844 [How to Cite?]
DOI: http://dx.doi.org/10.1148/radiol.2303030853
 
dc.identifier.doihttp://dx.doi.org/10.1148/radiol.2303030853
 
dc.identifier.epage844
 
dc.identifier.hkuros87699
 
dc.identifier.isiWOS:000189186500035
 
dc.identifier.issn0033-8419
2013 Impact Factor: 6.214
 
dc.identifier.issue3
 
dc.identifier.pmid14990845
 
dc.identifier.scopuseid_2-s2.0-1342329986
 
dc.identifier.spage836
 
dc.identifier.urihttp://hdl.handle.net/10722/150886
 
dc.identifier.volume230
 
dc.languageeng
 
dc.publisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofRadiology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshFemale
 
dc.subject.meshHong Kong
 
dc.subject.meshHumans
 
dc.subject.meshLongitudinal Studies
 
dc.subject.meshLung - Radiography
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPulmonary Fibrosis - Radiography
 
dc.subject.meshRemission, Spontaneous
 
dc.subject.meshSevere Acute Respiratory Syndrome - Radiography
 
dc.subject.meshTomography, Spiral Computed
 
dc.subjectLung, CT
 
dc.subjectLung, infection
 
dc.subjectSevere acute respiratory syndrome (SARS)
 
dc.titleSevere Acute Respiratory Syndrome: temporal lung changes at thin-section CT in 30 patients
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Ooi, GC</contributor.author>
<contributor.author>Khong, PL</contributor.author>
<contributor.author>M&#252;ller, NL</contributor.author>
<contributor.author>Yiu, WC</contributor.author>
<contributor.author>Zhou, LJ</contributor.author>
<contributor.author>Ho, JCM</contributor.author>
<contributor.author>Lam, B</contributor.author>
<contributor.author>Nicolaou, S</contributor.author>
<contributor.author>Tsang, KWT</contributor.author>
<date.accessioned>2012-06-26T06:13:54Z</date.accessioned>
<date.available>2012-06-26T06:13:54Z</date.available>
<date.issued>2004</date.issued>
<identifier.citation>Radiology, 2004, v. 230 n. 3, p. 836-844</identifier.citation>
<identifier.issn>0033-8419</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/150886</identifier.uri>
<description.abstract>PURPOSE: To evaluate lung abnormalities on serial thin-section computed tomographic (CT) scans in patients with severe acute respiratory syndrome (SARS) during acute and convalescent periods. MATERIALS AND METHODS: Serial thin-section CT scans in 30 patients (17 men, aged 42.5 years &#177; 12.2 [SD]) with SARS were reviewed by two radiologists together for predominant patterns of lung abnormalities: ground-glass opacities, ground-glass opacities with superimposed linear opacities, consolidation, reticular pattern, and mixed pattern (consolidation, ground-glass opacities, and reticular pattern). Scans were classified according to duration in weeks after symptom onset. Longitudinal changes of specific abnormalities were documented in 17 patients with serial scans obtained during 3 weeks. Each lung was divided into three zones; each zone was evaluated for percentage of lung involvement. Summation of scores from all six lung zones provided overall CT score (maximal CT score, 24). RESULTS: Median CT scores increased from 1 in the 1st week to 12.5 in the 2nd week. Ground-glass opacities with or without smooth interlobular septal thickening and consolidation were predominant patterns found during the 1st week. Ground-glass opacities with superimposed irregular reticular opacities, mixed pattern, and reticular opacities were noted from the 2nd week and peaked at or after the 4th week. After the 4th week, 12 (55%) of 22 patients had irregular linear opacities with or without associated ground-glass opacities and CT scores greater than 5; five of these patients had bronchial dilatation. When specific opacities were analyzed in 17 patients, consolidation generally resolved completely (n = 4) or to minimal residual opacities; six (55%) of 11 patients with ground-glass opacities had substantial residual disease (CT scores &gt; 5) on final scans. CONCLUSION: There is a temporal pattern of lung abnormalities at thin-section CT in SARS. Predominant findings at presentation are ground-glass opacities and consolidation. Reticulation is evident after the 2nd week and persists in half of all patients evaluated after 4 weeks. Long-term follow-up is required to determine whether the reticulation represents irreversible fibrosis. &#169; RSNA, 2004.</description.abstract>
<language>eng</language>
<publisher>Radiological Society of North America, Inc. The Journal&apos;s web site is located at http://radiology.rsnajnls.org</publisher>
<relation.ispartof>Radiology</relation.ispartof>
<subject>Lung, CT</subject>
<subject>Lung, infection</subject>
<subject>Severe acute respiratory syndrome (SARS)</subject>
<subject.mesh>Adult</subject.mesh>
<subject.mesh>Aged</subject.mesh>
<subject.mesh>Female</subject.mesh>
<subject.mesh>Hong Kong</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Longitudinal Studies</subject.mesh>
<subject.mesh>Lung - Radiography</subject.mesh>
<subject.mesh>Male</subject.mesh>
<subject.mesh>Middle Aged</subject.mesh>
<subject.mesh>Pulmonary Fibrosis - Radiography</subject.mesh>
<subject.mesh>Remission, Spontaneous</subject.mesh>
<subject.mesh>Severe Acute Respiratory Syndrome - Radiography</subject.mesh>
<subject.mesh>Tomography, Spiral Computed</subject.mesh>
<title>Severe Acute Respiratory Syndrome: temporal lung changes at thin-section CT in 30 patients</title>
<type>Article</type>
<description.nature>link_to_OA_fulltext</description.nature>
<identifier.doi>10.1148/radiol.2303030853</identifier.doi>
<identifier.pmid>14990845</identifier.pmid>
<identifier.scopus>eid_2-s2.0-1342329986</identifier.scopus>
<identifier.hkuros>87699</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-1342329986&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>230</identifier.volume>
<identifier.issue>3</identifier.issue>
<identifier.spage>836</identifier.spage>
<identifier.epage>844</identifier.epage>
<identifier.isi>WOS:000189186500035</identifier.isi>
<publisher.place>United States</publisher.place>
<bitstream.url>http://hub.hku.hk/bitstream/10722/150886/1/re01.htm</bitstream.url>
</item>
Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong
  3. The University of British Columbia