Article: Severe Acute Respiratory Syndrome: Relationship between Radiologic and Clinical Parameters

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TitleSevere Acute Respiratory Syndrome: Relationship between Radiologic and Clinical Parameters
AuthorsOoi, CGC1
Khong, PL1
Lam, B1
Ho, JCM1
Yiu, WC2
Wong, WM1
Wang, T1
Ho, PL1
Wong, PC1
Chan, RH1
Lam, WK1
Lai, KN1
Tsang, KWT1
KeywordsLung, infection
Severe acute respiratory syndrome (SARS)
Issue Date2003
PublisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
CitationRadiology, 2003, v. 229 n. 2, p. 492-499 [How to Cite?]
DOI: http://dx.doi.org/10.1148/radiol.2292030736
AbstractPURPOSE: To quantify severity of severe acute respiratory syndrome (SARS) on chest radiographs and to determine its relationship with clinical parameters. MATERIALS AND METHODS: Forty patients (mean age, 42.90 years ± 14.01 [SD]; median age, 41.5 years; age range, 25-82 years) with clinically diagnosed SARS were evaluated. Heart rate, oxygen saturation, temperature, and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were recorded daily. Severity of lung changes on chest radiographs was scored according to percentage of involved lung. Radiographic scores at days of admission, treatment, and maximal radiographic score were extracted for statistical analysis with clinical parameters. Time to maximal radiographic score from admission and days between onset and beginning of treatment were determined. Correlations between radiographic and clinical parameters were evaluated with Spearman rank correlation. Sex differences with respect to clinical and radiographic parameters were evaluated with Mann-Whitney test. RESULTS: Median chest radiographic scores peaked 5 days after beginning of treatment before they declined. Maximal and treatment radiographic scores were inversely related to oxygen saturation (r = -0.67, P < .001; r = -0.35, P = .03). Admission radiographic score was correlated with admission AST level (r = 0.53, P = .003); treatment radiographic score, with treatment ALT and AST levels (r = 0.43, P = .007; r = 0.42, P = .019); and time to maximal radiographic score, with AST level at maximal radiographic score (r = -0.45, P = .006), admission radiographic score (r = -0.55, P < .001), treatment radiographic score (r = -0.58, P < .001), and admission ALT and AST levels (r = -0.44, P = .007; r = -0.58, P = .001). Treatment delay was associated with AST level at maximal radiographic score (r = 0.53, P = .001), treatment radiographic score (r = 0.60, P < .001), and time to maximal radiographic score (r = -0.36, P = .02). No sex differences occurred with respect to radiographic and clinical parameters (P > .05). CONCLUSION: Severity of lung abnormalities quantified on chest radiographs correlates with clinical and laboratory parameters. © RSNA, 2003.
ISSN0033-8419
2011 Impact Factor: 5.726
2011 SCImago Journal Rankings: 0.475
DOIhttp://dx.doi.org/10.1148/radiol.2292030736
ISI Accession Number IDWOS:000186169700029
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorOoi, CGC
dc.contributor.authorKhong, PL
dc.contributor.authorLam, B
dc.contributor.authorHo, JCM
dc.contributor.authorYiu, WC
dc.contributor.authorWong, WM
dc.contributor.authorWang, T
dc.contributor.authorHo, PL
dc.contributor.authorWong, PC
dc.contributor.authorChan, RH
dc.contributor.authorLam, WK
dc.contributor.authorLai, KN
dc.contributor.authorTsang, KWT
dc.date.accessioned2012-06-26T06:13:52Z
dc.date.available2012-06-26T06:13:52Z
dc.date.issued2003
dc.description.abstractPURPOSE: To quantify severity of severe acute respiratory syndrome (SARS) on chest radiographs and to determine its relationship with clinical parameters. MATERIALS AND METHODS: Forty patients (mean age, 42.90 years ± 14.01 [SD]; median age, 41.5 years; age range, 25-82 years) with clinically diagnosed SARS were evaluated. Heart rate, oxygen saturation, temperature, and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were recorded daily. Severity of lung changes on chest radiographs was scored according to percentage of involved lung. Radiographic scores at days of admission, treatment, and maximal radiographic score were extracted for statistical analysis with clinical parameters. Time to maximal radiographic score from admission and days between onset and beginning of treatment were determined. Correlations between radiographic and clinical parameters were evaluated with Spearman rank correlation. Sex differences with respect to clinical and radiographic parameters were evaluated with Mann-Whitney test. RESULTS: Median chest radiographic scores peaked 5 days after beginning of treatment before they declined. Maximal and treatment radiographic scores were inversely related to oxygen saturation (r = -0.67, P < .001; r = -0.35, P = .03). Admission radiographic score was correlated with admission AST level (r = 0.53, P = .003); treatment radiographic score, with treatment ALT and AST levels (r = 0.43, P = .007; r = 0.42, P = .019); and time to maximal radiographic score, with AST level at maximal radiographic score (r = -0.45, P = .006), admission radiographic score (r = -0.55, P < .001), treatment radiographic score (r = -0.58, P < .001), and admission ALT and AST levels (r = -0.44, P = .007; r = -0.58, P = .001). Treatment delay was associated with AST level at maximal radiographic score (r = 0.53, P = .001), treatment radiographic score (r = 0.60, P < .001), and time to maximal radiographic score (r = -0.36, P = .02). No sex differences occurred with respect to radiographic and clinical parameters (P > .05). CONCLUSION: Severity of lung abnormalities quantified on chest radiographs correlates with clinical and laboratory parameters. © RSNA, 2003.
dc.description.natureLink_to_OA_fulltext
dc.identifier.citationRadiology, 2003, v. 229 n. 2, p. 492-499 [How to Cite?]
DOI: http://dx.doi.org/10.1148/radiol.2292030736
dc.identifier.doihttp://dx.doi.org/10.1148/radiol.2292030736
dc.identifier.epage499
dc.identifier.hkuros87540
dc.identifier.isiWOS:000186169700029
dc.identifier.issn0033-8419
2011 Impact Factor: 5.726
2011 SCImago Journal Rankings: 0.475
dc.identifier.issue2
dc.identifier.pmid14526098
dc.identifier.scopuseid_2-s2.0-0142179002
dc.identifier.spage492
dc.identifier.urihttp://hdl.handle.net/10722/150883
dc.identifier.volume229
dc.languageeng
dc.publisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
dc.publisher.placeUnited States
dc.relation.ispartofRadiology
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 And Over
dc.subject.meshAlanine Transaminase - Blood
dc.subject.meshAspartate Aminotransferases - Blood
dc.subject.meshBiological Markers - Blood
dc.subject.meshBody Temperature
dc.subject.meshFemale
dc.subject.meshHeart Rate
dc.subject.meshHumans
dc.subject.meshLung - Radiography
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshOxygen - Blood
dc.subject.meshSevere Acute Respiratory Syndrome - Diagnosis - Radiography - Therapy
dc.subjectLung, infection
dc.subjectSevere acute respiratory syndrome (SARS)
dc.titleSevere Acute Respiratory Syndrome: Relationship between Radiologic and Clinical Parameters
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong