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Article: Severe Acute Respiratory Syndrome: Relationship between Radiologic and Clinical Parameters

TitleSevere Acute Respiratory Syndrome: Relationship between Radiologic and Clinical Parameters
Authors
KeywordsLung, infection
Severe acute respiratory syndrome (SARS)
Issue Date2003
PublisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
Citation
Radiology, 2003, v. 229 n. 2, p. 492-499 How to Cite?
AbstractPURPOSE: To quantify severity of severe acute respiratory syndrome (SARS) on chest radiographs and to determine its relationship with clinical parameters. MATERIALS AND METHODS: Forty patients (mean age, 42.90 years ± 14.01 [SD]; median age, 41.5 years; age range, 25-82 years) with clinically diagnosed SARS were evaluated. Heart rate, oxygen saturation, temperature, and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were recorded daily. Severity of lung changes on chest radiographs was scored according to percentage of involved lung. Radiographic scores at days of admission, treatment, and maximal radiographic score were extracted for statistical analysis with clinical parameters. Time to maximal radiographic score from admission and days between onset and beginning of treatment were determined. Correlations between radiographic and clinical parameters were evaluated with Spearman rank correlation. Sex differences with respect to clinical and radiographic parameters were evaluated with Mann-Whitney test. RESULTS: Median chest radiographic scores peaked 5 days after beginning of treatment before they declined. Maximal and treatment radiographic scores were inversely related to oxygen saturation (r = -0.67, P < .001; r = -0.35, P = .03). Admission radiographic score was correlated with admission AST level (r = 0.53, P = .003); treatment radiographic score, with treatment ALT and AST levels (r = 0.43, P = .007; r = 0.42, P = .019); and time to maximal radiographic score, with AST level at maximal radiographic score (r = -0.45, P = .006), admission radiographic score (r = -0.55, P < .001), treatment radiographic score (r = -0.58, P < .001), and admission ALT and AST levels (r = -0.44, P = .007; r = -0.58, P = .001). Treatment delay was associated with AST level at maximal radiographic score (r = 0.53, P = .001), treatment radiographic score (r = 0.60, P < .001), and time to maximal radiographic score (r = -0.36, P = .02). No sex differences occurred with respect to radiographic and clinical parameters (P > .05). CONCLUSION: Severity of lung abnormalities quantified on chest radiographs correlates with clinical and laboratory parameters. © RSNA, 2003.
Persistent Identifierhttp://hdl.handle.net/10722/150883
ISSN
2014 Impact Factor: 6.867
2014 SCImago Journal Rankings: 3.148
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOoi, CGCen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorLam, Ben_HK
dc.contributor.authorHo, JCMen_HK
dc.contributor.authorYiu, WCen_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorWang, Ten_HK
dc.contributor.authorHo, PLen_HK
dc.contributor.authorWong, PCen_HK
dc.contributor.authorChan, RHen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorLai, KNen_HK
dc.contributor.authorTsang, KWTen_HK
dc.date.accessioned2012-06-26T06:13:52Z-
dc.date.available2012-06-26T06:13:52Z-
dc.date.issued2003en_HK
dc.identifier.citationRadiology, 2003, v. 229 n. 2, p. 492-499en_HK
dc.identifier.issn0033-8419en_HK
dc.identifier.urihttp://hdl.handle.net/10722/150883-
dc.description.abstractPURPOSE: To quantify severity of severe acute respiratory syndrome (SARS) on chest radiographs and to determine its relationship with clinical parameters. MATERIALS AND METHODS: Forty patients (mean age, 42.90 years ± 14.01 [SD]; median age, 41.5 years; age range, 25-82 years) with clinically diagnosed SARS were evaluated. Heart rate, oxygen saturation, temperature, and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were recorded daily. Severity of lung changes on chest radiographs was scored according to percentage of involved lung. Radiographic scores at days of admission, treatment, and maximal radiographic score were extracted for statistical analysis with clinical parameters. Time to maximal radiographic score from admission and days between onset and beginning of treatment were determined. Correlations between radiographic and clinical parameters were evaluated with Spearman rank correlation. Sex differences with respect to clinical and radiographic parameters were evaluated with Mann-Whitney test. RESULTS: Median chest radiographic scores peaked 5 days after beginning of treatment before they declined. Maximal and treatment radiographic scores were inversely related to oxygen saturation (r = -0.67, P < .001; r = -0.35, P = .03). Admission radiographic score was correlated with admission AST level (r = 0.53, P = .003); treatment radiographic score, with treatment ALT and AST levels (r = 0.43, P = .007; r = 0.42, P = .019); and time to maximal radiographic score, with AST level at maximal radiographic score (r = -0.45, P = .006), admission radiographic score (r = -0.55, P < .001), treatment radiographic score (r = -0.58, P < .001), and admission ALT and AST levels (r = -0.44, P = .007; r = -0.58, P = .001). Treatment delay was associated with AST level at maximal radiographic score (r = 0.53, P = .001), treatment radiographic score (r = 0.60, P < .001), and time to maximal radiographic score (r = -0.36, P = .02). No sex differences occurred with respect to radiographic and clinical parameters (P > .05). CONCLUSION: Severity of lung abnormalities quantified on chest radiographs correlates with clinical and laboratory parameters. © RSNA, 2003.en_HK
dc.languageengen_US
dc.publisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.orgen_HK
dc.relation.ispartofRadiologyen_HK
dc.subjectLung, infectionen_HK
dc.subjectSevere acute respiratory syndrome (SARS)en_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAlanine Transaminase - Blooden_US
dc.subject.meshAspartate Aminotransferases - Blooden_US
dc.subject.meshBiological Markers - Blooden_US
dc.subject.meshBody Temperatureen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart Rateen_US
dc.subject.meshHumansen_US
dc.subject.meshLung - Radiographyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOxygen - Blooden_US
dc.subject.meshSevere Acute Respiratory Syndrome - Diagnosis - Radiography - Therapyen_US
dc.titleSevere Acute Respiratory Syndrome: Relationship between Radiologic and Clinical Parametersen_HK
dc.typeArticleen_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.emailHo, JCM: jhocm@hku.hken_HK
dc.identifier.emailHo, PL: plho@hkucc.hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityHo, JCM=rp00258en_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1148/radiol.2292030736en_HK
dc.identifier.pmid14526098en_HK
dc.identifier.scopuseid_2-s2.0-0142179002en_HK
dc.identifier.hkuros87540-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0142179002&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume229en_HK
dc.identifier.issue2en_HK
dc.identifier.spage492en_HK
dc.identifier.epage499en_HK
dc.identifier.isiWOS:000186169700029-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridOoi, CGC=7007084909en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridLam, B=9246012800en_HK
dc.identifier.scopusauthoridHo, JCM=7402649981en_HK
dc.identifier.scopusauthoridYiu, WC=6602810849en_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridWang, T=7405566621en_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridWong, PC=7403979916en_HK
dc.identifier.scopusauthoridChan, RH=7403110832en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridTsang, KWT=7201555024en_HK

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