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Article: Silicosis in 76 men: Qualitative and quantitative CT evaluation - Clinical-radiologic correlation study

TitleSilicosis in 76 men: Qualitative and quantitative CT evaluation - Clinical-radiologic correlation study
Authors
KeywordsCT
Emphysema
Fibrosis
Function Silicosis
Lung
Pulmonary
Issue Date2003
PublisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
Citation
Radiology, 2003, v. 228 n. 3, p. 816-825 How to Cite?
AbstractPURPOSE: To use qualitative and quantitative computed tomography (CT) to test the hypothesis that impaired lung function with silicosis is due to progressive massive fibrosis (PMF) and associated emphysema. MATERIALS AND METHODS: Seventy-six men with silicosis underwent volumetric and thin-section CT of the thorax. Lung function, Borg scale dyspnea grade, silica exposure duration, and cigarette consumption were determined. Nodular profusion (NP) at chest radiography was graded according to the International Labor Organization radiographic classification system; NP and PMF at CT were visually graded by using five-point (ie, grades 0-4) and four-point (grades 0-3) scales, respectively. Emphysema and NP, which together are defined as the NP index, were quantified by using attenuation threshold values of less than -950 HU and greater than -100 HU, respectively. Mean lung attenuation was also determined. Relationships among the CT, chest radiographic, and clinical parameters were analyzed by using Spearman correlation. RESULTS: NP at chest radiography correlated (r > 0.50) with all CT parameters of nodularity. CT PMF had the highest correlation with emphysema (r = 0.58, P < .001). NP at chest radiography and all CT parameters were inversely related to lung function. At multiple regression analysis, PMF and emphysema index (both at CT) were significant determinants of forced expiratory volume in 1 second (FEV 1) (P = .006 and .03, respectively) and FEV1 to forced vital capacity (FVC) ratio (P = .007 and .02, respectively). Mean lung attenuation remained related to FVC (P = .03), diffusing capacity of lung for carbon monoxide (P = .04), and Borg scale grade (P = .01). Cigarette consumption and silica exposure duration had no independent effects on lung function. CONCLUSION: Qualitative and quantitative CT parameters can be used as indirect measures of functional impairment in silicosis. PMF and emphysema are independently related to airflow obstruction, whereas mean lung attenuation is related to clinical dyspnea and reduced lung volume. © RSNA, 2003.
Persistent Identifierhttp://hdl.handle.net/10722/150881
ISSN
2015 Impact Factor: 6.798
2015 SCImago Journal Rankings: 3.414
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOoi, GCen_HK
dc.contributor.authorTsang, KWTen_HK
dc.contributor.authorCheung, TFen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorHo, IWTen_HK
dc.contributor.authorIp, MSMen_HK
dc.contributor.authorTam, CMen_HK
dc.contributor.authorNgan, Hen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorChan, FLen_HK
dc.contributor.authorChan-Yeung, Men_HK
dc.date.accessioned2012-06-26T06:13:47Z-
dc.date.available2012-06-26T06:13:47Z-
dc.date.issued2003en_HK
dc.identifier.citationRadiology, 2003, v. 228 n. 3, p. 816-825en_HK
dc.identifier.issn0033-8419en_HK
dc.identifier.urihttp://hdl.handle.net/10722/150881-
dc.description.abstractPURPOSE: To use qualitative and quantitative computed tomography (CT) to test the hypothesis that impaired lung function with silicosis is due to progressive massive fibrosis (PMF) and associated emphysema. MATERIALS AND METHODS: Seventy-six men with silicosis underwent volumetric and thin-section CT of the thorax. Lung function, Borg scale dyspnea grade, silica exposure duration, and cigarette consumption were determined. Nodular profusion (NP) at chest radiography was graded according to the International Labor Organization radiographic classification system; NP and PMF at CT were visually graded by using five-point (ie, grades 0-4) and four-point (grades 0-3) scales, respectively. Emphysema and NP, which together are defined as the NP index, were quantified by using attenuation threshold values of less than -950 HU and greater than -100 HU, respectively. Mean lung attenuation was also determined. Relationships among the CT, chest radiographic, and clinical parameters were analyzed by using Spearman correlation. RESULTS: NP at chest radiography correlated (r > 0.50) with all CT parameters of nodularity. CT PMF had the highest correlation with emphysema (r = 0.58, P < .001). NP at chest radiography and all CT parameters were inversely related to lung function. At multiple regression analysis, PMF and emphysema index (both at CT) were significant determinants of forced expiratory volume in 1 second (FEV 1) (P = .006 and .03, respectively) and FEV1 to forced vital capacity (FVC) ratio (P = .007 and .02, respectively). Mean lung attenuation remained related to FVC (P = .03), diffusing capacity of lung for carbon monoxide (P = .04), and Borg scale grade (P = .01). Cigarette consumption and silica exposure duration had no independent effects on lung function. CONCLUSION: Qualitative and quantitative CT parameters can be used as indirect measures of functional impairment in silicosis. PMF and emphysema are independently related to airflow obstruction, whereas mean lung attenuation is related to clinical dyspnea and reduced lung volume. © RSNA, 2003.en_HK
dc.languageengen_US
dc.publisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.orgen_HK
dc.relation.ispartofRadiologyen_HK
dc.subjectCTen_HK
dc.subjectEmphysemaen_HK
dc.subjectFibrosisen_HK
dc.subjectFunction Silicosisen_HK
dc.subjectLungen_HK
dc.subjectPulmonaryen_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshForced Expiratory Volumeen_US
dc.subject.meshHumansen_US
dc.subject.meshLung - Physiopathology - Radiographyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPulmonary Diffusing Capacity - Physiologyen_US
dc.subject.meshPulmonary Emphysema - Physiopathology - Radiographyen_US
dc.subject.meshPulmonary Fibrosis - Physiopathology - Radiographyen_US
dc.subject.meshRadiography, Thoracicen_US
dc.subject.meshSilicosis - Physiopathology - Radiographyen_US
dc.subject.meshSmokingen_US
dc.subject.meshTomography, X-Ray Computeden_US
dc.subject.meshVital Capacityen_US
dc.titleSilicosis in 76 men: Qualitative and quantitative CT evaluation - Clinical-radiologic correlation studyen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, TF:rtcheung@hku.hken_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.emailIp, MSM:msmip@hku.hken_HK
dc.identifier.authorityCheung, TF=rp00434en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1148/radiol.2283020557en_HK
dc.identifier.pmid12954899-
dc.identifier.scopuseid_2-s2.0-0041429141en_HK
dc.identifier.hkuros95615-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0041429141&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume228en_HK
dc.identifier.issue3en_HK
dc.identifier.spage816en_HK
dc.identifier.epage825en_HK
dc.identifier.isiWOS:000184966400032-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridOoi, GC=7006176119en_HK
dc.identifier.scopusauthoridTsang, KWT=7201555024en_HK
dc.identifier.scopusauthoridCheung, TF=7202397498en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridHo, IWT=7201606415en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK
dc.identifier.scopusauthoridTam, CM=7201442970en_HK
dc.identifier.scopusauthoridNgan, H=7102173824en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridChan, FL=7202586444en_HK
dc.identifier.scopusauthoridChanYeung, M=54790582200en_HK
dc.identifier.citeulike590927-

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