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Article: Interstitial lung disease in systemic sclerosis: An HRCT-clinical correlative study

TitleInterstitial lung disease in systemic sclerosis: An HRCT-clinical correlative study
Authors
KeywordsHRCT
Interstitial lung disease
Systemic sclerosis
Issue Date2003
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/02841851.asp
Citation
Acta Radiologica, 2003, v. 44 n. 3, p. 258-264 How to Cite?
AbstractPurpose: To evaluate high-resolution CT (HRCT) parameters of inflammation and fibrosis in systemic sclerosis (SSc), for correlation with lung function, skin scores and exercise tolerance. Material and Methods: 45 SSc patients (40 women, 48.5±13.4 years), under-went thoracic HRCT, lung function assessment, and modified Rodnan skin scores. Exercise tolerance was also graded. HRCT were scored for extent of 4 HRCT patterns of interstitial lung disease (ILD): ground glass opacification (GGO), reticular, mixed and honeycomb pattern in each lobe. Total HRCT score, inflammation index (GGO and mixed score) and fibrosis index (reticular and honeycomb scores) were correlated with lung function and clinical parameters. Results: ILD was present in 39/45 (86.7%) patients. Abnormal (<80% predicted) forced vital capacity (FVC), total lung capacity (TLC) and carbon monoxide diffusion factor (DL CO) were detected in 30%, 22% and 46% of patients. Total HRCT score correlated with FVC (r=-0.43, p=0.008), FEV 1 (forced expiratory volume) (r=-0.37, p=0.03), TLC (r=-0.47, p=0.003), and DL CO (r=-0.43, p=0.008); inflammatory index with DL CO (r=-0.43, p=0.008) and exercise tolerance (r=-0.39, p < 0.05); and fibrosis index with FVC (r=-0.31, p=0.05) and TLC (r=-0.38, p=0.02). Higher total HRCT score, and inflammation and fibrosis indices were found in patients with abnormal lung function. Conclusion: Qualitative HRCT is able to evaluate inflammation and fibrosis, showing important relationships with diffusion capacity and lung volume, respectively.
Persistent Identifierhttp://hdl.handle.net/10722/150879
ISSN
2015 Impact Factor: 2.009
2015 SCImago Journal Rankings: 0.728
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorOoi, GCen_HK
dc.contributor.authorMok, MYen_HK
dc.contributor.authorTsang, KWTen_HK
dc.contributor.authorWong, Yen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorFung, PCWen_HK
dc.contributor.authorChan, Sen_HK
dc.contributor.authorTse, HFen_HK
dc.contributor.authorWong, RWSen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorLau, CSen_HK
dc.date.accessioned2012-06-26T06:13:45Z-
dc.date.available2012-06-26T06:13:45Z-
dc.date.issued2003en_HK
dc.identifier.citationActa Radiologica, 2003, v. 44 n. 3, p. 258-264en_HK
dc.identifier.issn0284-1851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/150879-
dc.description.abstractPurpose: To evaluate high-resolution CT (HRCT) parameters of inflammation and fibrosis in systemic sclerosis (SSc), for correlation with lung function, skin scores and exercise tolerance. Material and Methods: 45 SSc patients (40 women, 48.5±13.4 years), under-went thoracic HRCT, lung function assessment, and modified Rodnan skin scores. Exercise tolerance was also graded. HRCT were scored for extent of 4 HRCT patterns of interstitial lung disease (ILD): ground glass opacification (GGO), reticular, mixed and honeycomb pattern in each lobe. Total HRCT score, inflammation index (GGO and mixed score) and fibrosis index (reticular and honeycomb scores) were correlated with lung function and clinical parameters. Results: ILD was present in 39/45 (86.7%) patients. Abnormal (<80% predicted) forced vital capacity (FVC), total lung capacity (TLC) and carbon monoxide diffusion factor (DL CO) were detected in 30%, 22% and 46% of patients. Total HRCT score correlated with FVC (r=-0.43, p=0.008), FEV 1 (forced expiratory volume) (r=-0.37, p=0.03), TLC (r=-0.47, p=0.003), and DL CO (r=-0.43, p=0.008); inflammatory index with DL CO (r=-0.43, p=0.008) and exercise tolerance (r=-0.39, p < 0.05); and fibrosis index with FVC (r=-0.31, p=0.05) and TLC (r=-0.38, p=0.02). Higher total HRCT score, and inflammation and fibrosis indices were found in patients with abnormal lung function. Conclusion: Qualitative HRCT is able to evaluate inflammation and fibrosis, showing important relationships with diffusion capacity and lung volume, respectively.en_HK
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/02841851.aspen_HK
dc.relation.ispartofActa Radiologicaen_HK
dc.rightsActa Radiologica. Copyright © Informa Healthcare.-
dc.subjectHRCTen_HK
dc.subjectInterstitial lung diseaseen_HK
dc.subjectSystemic sclerosisen_HK
dc.titleInterstitial lung disease in systemic sclerosis: An HRCT-clinical correlative studyen_HK
dc.typeArticleen_HK
dc.identifier.emailMok, MY:temy@hkucc.hku.hken_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.authorityMok, MY=rp00490en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1034/j.1600-0455.2003.00058.xen_HK
dc.identifier.pmid12751995-
dc.identifier.scopuseid_2-s2.0-0037630050en_HK
dc.identifier.hkuros99474-
dc.identifier.hkuros81032-
dc.identifier.volume44en_HK
dc.identifier.issue3en_HK
dc.identifier.spage258en_HK
dc.identifier.epage264en_HK
dc.identifier.isiWOS:000182833500005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridOoi, GC=7006176119en_HK
dc.identifier.scopusauthoridMok, MY=7006024184en_HK
dc.identifier.scopusauthoridTsang, KWT=7201555024en_HK
dc.identifier.scopusauthoridWong, Y=7403041884en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridFung, PCW=7101613315en_HK
dc.identifier.scopusauthoridChan, S=36901171600en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.scopusauthoridWong, RWS=34875928200en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK

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