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Article: Risk factors for hyperbilirubinemia and gallstones in Chinese patients with β thalassemia syndrome

TitleRisk factors for hyperbilirubinemia and gallstones in Chinese patients with β thalassemia syndrome
Authors
KeywordsChinese
Gallstones
Gilbert alleles
Hyperbilirubinemia
Thalassemia
Issue Date2003
Citation
Haematologica, 2003, v. 88 n. 2, p. 220-222 How to Cite?
Abstract
We studied the relationship between jaundice and gallstones and Gilbert alleles (Gly71Arg: 27.8% and (TA)7: 19.6%) in 94 Chinese patients with thalassemia major (TM) and 33 with thalassemia intermedia (TI). Determinants of bilirubin level included age, transfusion (TI>TM) and genetic profile ααα/β0 > β +/β0 in TI, β+/β0 > β0/β0 in adult TM, Gilbert homozygotes > others in TM and TI, Gilbert heterozygotes > wild type in TM). Determinants of gallstones (39%) included age, TI and Gilbert alleles. We conclude that the finding of unusually high bilirubin may indicate either homozygous Gilbert genotype or hemolytic thalassemia genotypes.
Persistent Identifierhttp://hdl.handle.net/10722/150877
ISSN
2013 Impact Factor: 5.868
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorCheung, WCen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorMa, ESKen_HK
dc.date.accessioned2012-06-26T06:13:39Z-
dc.date.available2012-06-26T06:13:39Z-
dc.date.issued2003en_HK
dc.identifier.citationHaematologica, 2003, v. 88 n. 2, p. 220-222en_HK
dc.identifier.issn0390-6078en_HK
dc.identifier.urihttp://hdl.handle.net/10722/150877-
dc.description.abstractWe studied the relationship between jaundice and gallstones and Gilbert alleles (Gly71Arg: 27.8% and (TA)7: 19.6%) in 94 Chinese patients with thalassemia major (TM) and 33 with thalassemia intermedia (TI). Determinants of bilirubin level included age, transfusion (TI>TM) and genetic profile ααα/β0 > β +/β0 in TI, β+/β0 > β0/β0 in adult TM, Gilbert homozygotes > others in TM and TI, Gilbert heterozygotes > wild type in TM). Determinants of gallstones (39%) included age, TI and Gilbert alleles. We conclude that the finding of unusually high bilirubin may indicate either homozygous Gilbert genotype or hemolytic thalassemia genotypes.en_HK
dc.languageengen_US
dc.relation.ispartofHaematologicaen_HK
dc.subjectChineseen_HK
dc.subjectGallstonesen_HK
dc.subjectGilbert allelesen_HK
dc.subjectHyperbilirubinemiaen_HK
dc.subjectThalassemiaen_HK
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshCholelithiasis - Epidemiology - Etiology - Geneticsen_US
dc.subject.meshGenotypeen_US
dc.subject.meshGilbert Disease - Complications - Epidemiology - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMonosaccharide Transport Proteins - Geneticsen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshBeta-Thalassemia - Complications - Epidemiology - Geneticsen_US
dc.titleRisk factors for hyperbilirubinemia and gallstones in Chinese patients with β thalassemia syndromeen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid12604413en_HK
dc.identifier.scopuseid_2-s2.0-0037608696en_HK
dc.identifier.hkuros76221-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037608696&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume88en_HK
dc.identifier.issue2en_HK
dc.identifier.spage220en_HK
dc.identifier.epage222en_HK
dc.identifier.isiWOS:000181037700016-
dc.publisher.placeItalyen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridCheung, WC=36934683800en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridHa, SY=36945554500en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridMa, ESK=7202039934en_HK

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