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Article: Risk factors for hyperbilirubinemia and gallstones in Chinese patients with β thalassemia syndrome
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TitleRisk factors for hyperbilirubinemia and gallstones in Chinese patients with β thalassemia syndrome
 
AuthorsAu, WY1 2
Cheung, WC1
Chan, GCF1
Ha, SY1
Khong, PL1
Ma, ESK1
 
KeywordsChinese
Gallstones
Gilbert alleles
Hyperbilirubinemia
Thalassemia
 
Issue Date2003
 
CitationHaematologica, 2003, v. 88 n. 2, p. 220-222 [How to Cite?]
 
AbstractWe studied the relationship between jaundice and gallstones and Gilbert alleles (Gly71Arg: 27.8% and (TA)7: 19.6%) in 94 Chinese patients with thalassemia major (TM) and 33 with thalassemia intermedia (TI). Determinants of bilirubin level included age, transfusion (TI>TM) and genetic profile ααα/β0 > β +/β0 in TI, β+/β0 > β0/β0 in adult TM, Gilbert homozygotes > others in TM and TI, Gilbert heterozygotes > wild type in TM). Determinants of gallstones (39%) included age, TI and Gilbert alleles. We conclude that the finding of unusually high bilirubin may indicate either homozygous Gilbert genotype or hemolytic thalassemia genotypes.
 
ISSN0390-6078
2013 Impact Factor: 5.868
 
ISI Accession Number IDWOS:000181037700016
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorAu, WY
 
dc.contributor.authorCheung, WC
 
dc.contributor.authorChan, GCF
 
dc.contributor.authorHa, SY
 
dc.contributor.authorKhong, PL
 
dc.contributor.authorMa, ESK
 
dc.date.accessioned2012-06-26T06:13:39Z
 
dc.date.available2012-06-26T06:13:39Z
 
dc.date.issued2003
 
dc.description.abstractWe studied the relationship between jaundice and gallstones and Gilbert alleles (Gly71Arg: 27.8% and (TA)7: 19.6%) in 94 Chinese patients with thalassemia major (TM) and 33 with thalassemia intermedia (TI). Determinants of bilirubin level included age, transfusion (TI>TM) and genetic profile ααα/β0 > β +/β0 in TI, β+/β0 > β0/β0 in adult TM, Gilbert homozygotes > others in TM and TI, Gilbert heterozygotes > wild type in TM). Determinants of gallstones (39%) included age, TI and Gilbert alleles. We conclude that the finding of unusually high bilirubin may indicate either homozygous Gilbert genotype or hemolytic thalassemia genotypes.
 
dc.description.natureLink_to_OA_fulltext
 
dc.identifier.citationHaematologica, 2003, v. 88 n. 2, p. 220-222 [How to Cite?]
 
dc.identifier.epage222
 
dc.identifier.hkuros76221
 
dc.identifier.isiWOS:000181037700016
 
dc.identifier.issn0390-6078
2013 Impact Factor: 5.868
 
dc.identifier.issue2
 
dc.identifier.pmid12604413
 
dc.identifier.scopuseid_2-s2.0-0037608696
 
dc.identifier.spage220
 
dc.identifier.urihttp://hdl.handle.net/10722/150877
 
dc.identifier.volume88
 
dc.languageeng
 
dc.publisher.placeItaly
 
dc.relation.ispartofHaematologica
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAsian Continental Ancestry Group - Genetics
 
dc.subject.meshChina - Epidemiology
 
dc.subject.meshCholelithiasis - Epidemiology - Etiology - Genetics
 
dc.subject.meshGenotype
 
dc.subject.meshGilbert Disease - Complications - Epidemiology - Genetics
 
dc.subject.meshHumans
 
dc.subject.meshMonosaccharide Transport Proteins - Genetics
 
dc.subject.meshRisk Factors
 
dc.subject.meshBeta-Thalassemia - Complications - Epidemiology - Genetics
 
dc.subjectChinese
 
dc.subjectGallstones
 
dc.subjectGilbert alleles
 
dc.subjectHyperbilirubinemia
 
dc.subjectThalassemia
 
dc.titleRisk factors for hyperbilirubinemia and gallstones in Chinese patients with β thalassemia syndrome
 
dc.typeArticle
 
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<contributor.author>Chan, GCF</contributor.author>
<contributor.author>Ha, SY</contributor.author>
<contributor.author>Khong, PL</contributor.author>
<contributor.author>Ma, ESK</contributor.author>
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<subject.mesh>China - Epidemiology</subject.mesh>
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Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong