Article: Risk factors for hyperbilirubinemia and gallstones in Chinese patients with β thalassemia syndrome

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TitleRisk factors for hyperbilirubinemia and gallstones in Chinese patients with β thalassemia syndrome
AuthorsAu, WY1 2
Cheung, WC1
Chan, GCF1
Ha, SY1
Khong, PL1
Ma, ESK1
KeywordsChinese
Gallstones
Gilbert alleles
Hyperbilirubinemia
Thalassemia
Issue Date2003
CitationHaematologica, 2003, v. 88 n. 2, p. 220-222 [How to Cite?]
AbstractWe studied the relationship between jaundice and gallstones and Gilbert alleles (Gly71Arg: 27.8% and (TA)7: 19.6%) in 94 Chinese patients with thalassemia major (TM) and 33 with thalassemia intermedia (TI). Determinants of bilirubin level included age, transfusion (TI>TM) and genetic profile ααα/β0 > β +/β0 in TI, β+/β0 > β0/β0 in adult TM, Gilbert homozygotes > others in TM and TI, Gilbert heterozygotes > wild type in TM). Determinants of gallstones (39%) included age, TI and Gilbert alleles. We conclude that the finding of unusually high bilirubin may indicate either homozygous Gilbert genotype or hemolytic thalassemia genotypes.
ISSN0390-6078
2011 Impact Factor: 6.424
2011 SCImago Journal Rankings: 0.681
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorAu, WY
dc.contributor.authorCheung, WC
dc.contributor.authorChan, GCF
dc.contributor.authorHa, SY
dc.contributor.authorKhong, PL
dc.contributor.authorMa, ESK
dc.date.accessioned2012-06-26T06:13:39Z
dc.date.available2012-06-26T06:13:39Z
dc.date.issued2003
dc.description.abstractWe studied the relationship between jaundice and gallstones and Gilbert alleles (Gly71Arg: 27.8% and (TA)7: 19.6%) in 94 Chinese patients with thalassemia major (TM) and 33 with thalassemia intermedia (TI). Determinants of bilirubin level included age, transfusion (TI>TM) and genetic profile ααα/β0 > β +/β0 in TI, β+/β0 > β0/β0 in adult TM, Gilbert homozygotes > others in TM and TI, Gilbert heterozygotes > wild type in TM). Determinants of gallstones (39%) included age, TI and Gilbert alleles. We conclude that the finding of unusually high bilirubin may indicate either homozygous Gilbert genotype or hemolytic thalassemia genotypes.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationHaematologica, 2003, v. 88 n. 2, p. 220-222 [How to Cite?]
dc.identifier.epage222
dc.identifier.hkuros76221
dc.identifier.isiWOS:000181037700016
dc.identifier.issn0390-6078
2011 Impact Factor: 6.424
2011 SCImago Journal Rankings: 0.681
dc.identifier.issue2
dc.identifier.pmid12604413
dc.identifier.scopuseid_2-s2.0-0037608696
dc.identifier.spage220
dc.identifier.urihttp://hdl.handle.net/10722/150877
dc.identifier.volume88
dc.languageeng
dc.publisher.placeItaly
dc.relation.ispartofHaematologica
dc.relation.referencesReferences in Scopus
dc.subject.meshAsian Continental Ancestry Group - Genetics
dc.subject.meshChina - Epidemiology
dc.subject.meshCholelithiasis - Epidemiology - Etiology - Genetics
dc.subject.meshGenotype
dc.subject.meshGilbert Disease - Complications - Epidemiology - Genetics
dc.subject.meshHumans
dc.subject.meshMonosaccharide Transport Proteins - Genetics
dc.subject.meshRisk Factors
dc.subject.meshBeta-Thalassemia - Complications - Epidemiology - Genetics
dc.subjectChinese
dc.subjectGallstones
dc.subjectGilbert alleles
dc.subjectHyperbilirubinemia
dc.subjectThalassemia
dc.titleRisk factors for hyperbilirubinemia and gallstones in Chinese patients with β thalassemia syndrome
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong