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Article: High-resolution CT quantification of bronchiectasis: Clinical and functional correlation

TitleHigh-resolution CT quantification of bronchiectasis: Clinical and functional correlation
Authors
KeywordsBronchiectasis
Lung, CT
Issue Date2002
PublisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
Citation
Radiology, 2002, v. 225 n. 3, p. 663-672 How to Cite?
Abstract
Purpose: To evaluate clinical relevance of high-resolution computed tomographic (CT) findings in patients with bronchiectasis by using a quantitative high-resolution CT protocol to assess extent of bronchiectasis, severity of bronchial wall thickening, and presence of small-airway abnormalities and mosaic pattern. Materials and methods: Sixty Chinese patients with steady-state bronchiectasis underwent thoracic high-resolution CT and lung function tests. Exacerbation frequency per year and 24-hour sputum volume were determined. Extent of bronchiectasis, severity of bronchial wall thickening, and presence of small-airway abnormalities and mosaic attenuation were evaluated in each lobe, including the lingula. Differences between sex and smoking status with respect to high-resolution CT, lung function, and clinical parameters were tested with either the independent sample t test or the Mann-Whitney test. Spearman rank correlation was used to evaluate associations between clinical, lung function, and high-resolution CT scores. Multiple regression analyses were performed to determine which high-resolution CT parameters would best predict lung function and clinical parameters, adjusted for smoking. Results: Exacerbation frequency was associated with bronchial wall thickening (r = 0.32, P = .03); 24-hour sputum volume with bronchial wall thickening and small-airway abnormalities (r = 0.30 and 0.39, respectively; P < .05); and forced expiratory volume in 1 second (FEV1), ratio of FEV1 to forced vital capacity (FVC), and midexpiratory phase of forced expiratory flow (FEF25%-75%) (r = -0.33, -0.29, and -0.32, respectively; P < .05). Extent of bronchiectasis, bronchial wall thickening, and mosaic attenuation, respectively, were related to FEV1 (r = -0.43 to -0.60, P < .001), FEF25%-75% (r = -0.38 to -0.57, P < .001), FVC (r = -0.36 to -0.46, P < .01), and FEV1/FVC ratio (r = -0.31 to -0.49, P < .01). After multiple regression analysis, bronchial wall thickening remained a significant determinant of airflow obstruction, whereas small-airway abnormalities remained associated with 24-hour sputum volume. Women had milder disease than men but showed more high-resolution CT functional correlations. Conclusion: Findings of this study establish a link between morphologic highresolution CT parameters and clinical activity and emphasize the role of bronchial wall thickening in patients with bronchiectasis. © RSNA, 2002.
Persistent Identifierhttp://hdl.handle.net/10722/150875
ISSN
2013 Impact Factor: 6.214
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOoi, GCen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorChanYeung, Men_HK
dc.contributor.authorHo, JCMen_HK
dc.contributor.authorChan, PKSen_HK
dc.contributor.authorLee, JCKen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorTsang, KWTen_HK
dc.date.accessioned2012-06-26T06:13:38Z-
dc.date.available2012-06-26T06:13:38Z-
dc.date.issued2002en_HK
dc.identifier.citationRadiology, 2002, v. 225 n. 3, p. 663-672en_HK
dc.identifier.issn0033-8419en_HK
dc.identifier.urihttp://hdl.handle.net/10722/150875-
dc.description.abstractPurpose: To evaluate clinical relevance of high-resolution computed tomographic (CT) findings in patients with bronchiectasis by using a quantitative high-resolution CT protocol to assess extent of bronchiectasis, severity of bronchial wall thickening, and presence of small-airway abnormalities and mosaic pattern. Materials and methods: Sixty Chinese patients with steady-state bronchiectasis underwent thoracic high-resolution CT and lung function tests. Exacerbation frequency per year and 24-hour sputum volume were determined. Extent of bronchiectasis, severity of bronchial wall thickening, and presence of small-airway abnormalities and mosaic attenuation were evaluated in each lobe, including the lingula. Differences between sex and smoking status with respect to high-resolution CT, lung function, and clinical parameters were tested with either the independent sample t test or the Mann-Whitney test. Spearman rank correlation was used to evaluate associations between clinical, lung function, and high-resolution CT scores. Multiple regression analyses were performed to determine which high-resolution CT parameters would best predict lung function and clinical parameters, adjusted for smoking. Results: Exacerbation frequency was associated with bronchial wall thickening (r = 0.32, P = .03); 24-hour sputum volume with bronchial wall thickening and small-airway abnormalities (r = 0.30 and 0.39, respectively; P < .05); and forced expiratory volume in 1 second (FEV1), ratio of FEV1 to forced vital capacity (FVC), and midexpiratory phase of forced expiratory flow (FEF25%-75%) (r = -0.33, -0.29, and -0.32, respectively; P < .05). Extent of bronchiectasis, bronchial wall thickening, and mosaic attenuation, respectively, were related to FEV1 (r = -0.43 to -0.60, P < .001), FEF25%-75% (r = -0.38 to -0.57, P < .001), FVC (r = -0.36 to -0.46, P < .01), and FEV1/FVC ratio (r = -0.31 to -0.49, P < .01). After multiple regression analysis, bronchial wall thickening remained a significant determinant of airflow obstruction, whereas small-airway abnormalities remained associated with 24-hour sputum volume. Women had milder disease than men but showed more high-resolution CT functional correlations. Conclusion: Findings of this study establish a link between morphologic highresolution CT parameters and clinical activity and emphasize the role of bronchial wall thickening in patients with bronchiectasis. © RSNA, 2002.en_HK
dc.languageengen_US
dc.publisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.orgen_HK
dc.relation.ispartofRadiologyen_HK
dc.subjectBronchiectasisen_HK
dc.subjectLung, CTen_HK
dc.subject.meshBronchiectasis - Radiographyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLung - Radiographyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshObserver Variationen_US
dc.subject.meshRegression Analysisen_US
dc.subject.meshRespiratory Function Testsen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshSmoking - Epidemiologyen_US
dc.subject.meshSputumen_US
dc.subject.meshTomography, X-Ray Computed - Methodsen_US
dc.titleHigh-resolution CT quantification of bronchiectasis: Clinical and functional correlationen_HK
dc.typeArticleen_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.emailHo, JCM:jhocm@hku.hken_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityHo, JCM=rp00258en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12461244en_HK
dc.identifier.scopuseid_2-s2.0-0036892738en_HK
dc.identifier.hkuros80970-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036892738&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume225en_HK
dc.identifier.issue3en_HK
dc.identifier.spage663en_HK
dc.identifier.epage672en_HK
dc.identifier.isiWOS:000179420800008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridOoi, GC=7006176119en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridChanYeung, M=54790582200en_HK
dc.identifier.scopusauthoridHo, JCM=7402649981en_HK
dc.identifier.scopusauthoridChan, PKS=36944286000en_HK
dc.identifier.scopusauthoridLee, JCK=7601456889en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridTsang, KWT=7201555024en_HK

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