Article: High-resolution CT quantification of bronchiectasis: Clinical and functional correlation

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TitleHigh-resolution CT quantification of bronchiectasis: Clinical and functional correlation
AuthorsOoi, GC1
Khong, PL1
ChanYeung, M1
Ho, JCM1
Chan, PKS1
Lee, JCK1
Lam, WK1
Tsang, KWT1
KeywordsBronchiectasis
Lung, CT
Issue Date2002
PublisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
CitationRadiology, 2002, v. 225 n. 3, p. 663-672 [How to Cite?]
AbstractPurpose: To evaluate clinical relevance of high-resolution computed tomographic (CT) findings in patients with bronchiectasis by using a quantitative high-resolution CT protocol to assess extent of bronchiectasis, severity of bronchial wall thickening, and presence of small-airway abnormalities and mosaic pattern. Materials and methods: Sixty Chinese patients with steady-state bronchiectasis underwent thoracic high-resolution CT and lung function tests. Exacerbation frequency per year and 24-hour sputum volume were determined. Extent of bronchiectasis, severity of bronchial wall thickening, and presence of small-airway abnormalities and mosaic attenuation were evaluated in each lobe, including the lingula. Differences between sex and smoking status with respect to high-resolution CT, lung function, and clinical parameters were tested with either the independent sample t test or the Mann-Whitney test. Spearman rank correlation was used to evaluate associations between clinical, lung function, and high-resolution CT scores. Multiple regression analyses were performed to determine which high-resolution CT parameters would best predict lung function and clinical parameters, adjusted for smoking. Results: Exacerbation frequency was associated with bronchial wall thickening (r = 0.32, P = .03); 24-hour sputum volume with bronchial wall thickening and small-airway abnormalities (r = 0.30 and 0.39, respectively; P < .05); and forced expiratory volume in 1 second (FEV1), ratio of FEV1 to forced vital capacity (FVC), and midexpiratory phase of forced expiratory flow (FEF25%-75%) (r = -0.33, -0.29, and -0.32, respectively; P < .05). Extent of bronchiectasis, bronchial wall thickening, and mosaic attenuation, respectively, were related to FEV1 (r = -0.43 to -0.60, P < .001), FEF25%-75% (r = -0.38 to -0.57, P < .001), FVC (r = -0.36 to -0.46, P < .01), and FEV1/FVC ratio (r = -0.31 to -0.49, P < .01). After multiple regression analysis, bronchial wall thickening remained a significant determinant of airflow obstruction, whereas small-airway abnormalities remained associated with 24-hour sputum volume. Women had milder disease than men but showed more high-resolution CT functional correlations. Conclusion: Findings of this study establish a link between morphologic highresolution CT parameters and clinical activity and emphasize the role of bronchial wall thickening in patients with bronchiectasis. © RSNA, 2002.
ISSN0033-8419
2011 Impact Factor: 5.726
2011 SCImago Journal Rankings: 0.475
ISI Accession Number IDWOS:000179420800008
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorOoi, GC
dc.contributor.authorKhong, PL
dc.contributor.authorChanYeung, M
dc.contributor.authorHo, JCM
dc.contributor.authorChan, PKS
dc.contributor.authorLee, JCK
dc.contributor.authorLam, WK
dc.contributor.authorTsang, KWT
dc.date.accessioned2012-06-26T06:13:38Z
dc.date.available2012-06-26T06:13:38Z
dc.date.issued2002
dc.description.abstractPurpose: To evaluate clinical relevance of high-resolution computed tomographic (CT) findings in patients with bronchiectasis by using a quantitative high-resolution CT protocol to assess extent of bronchiectasis, severity of bronchial wall thickening, and presence of small-airway abnormalities and mosaic pattern. Materials and methods: Sixty Chinese patients with steady-state bronchiectasis underwent thoracic high-resolution CT and lung function tests. Exacerbation frequency per year and 24-hour sputum volume were determined. Extent of bronchiectasis, severity of bronchial wall thickening, and presence of small-airway abnormalities and mosaic attenuation were evaluated in each lobe, including the lingula. Differences between sex and smoking status with respect to high-resolution CT, lung function, and clinical parameters were tested with either the independent sample t test or the Mann-Whitney test. Spearman rank correlation was used to evaluate associations between clinical, lung function, and high-resolution CT scores. Multiple regression analyses were performed to determine which high-resolution CT parameters would best predict lung function and clinical parameters, adjusted for smoking. Results: Exacerbation frequency was associated with bronchial wall thickening (r = 0.32, P = .03); 24-hour sputum volume with bronchial wall thickening and small-airway abnormalities (r = 0.30 and 0.39, respectively; P < .05); and forced expiratory volume in 1 second (FEV1), ratio of FEV1 to forced vital capacity (FVC), and midexpiratory phase of forced expiratory flow (FEF25%-75%) (r = -0.33, -0.29, and -0.32, respectively; P < .05). Extent of bronchiectasis, bronchial wall thickening, and mosaic attenuation, respectively, were related to FEV1 (r = -0.43 to -0.60, P < .001), FEF25%-75% (r = -0.38 to -0.57, P < .001), FVC (r = -0.36 to -0.46, P < .01), and FEV1/FVC ratio (r = -0.31 to -0.49, P < .01). After multiple regression analysis, bronchial wall thickening remained a significant determinant of airflow obstruction, whereas small-airway abnormalities remained associated with 24-hour sputum volume. Women had milder disease than men but showed more high-resolution CT functional correlations. Conclusion: Findings of this study establish a link between morphologic highresolution CT parameters and clinical activity and emphasize the role of bronchial wall thickening in patients with bronchiectasis. © RSNA, 2002.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationRadiology, 2002, v. 225 n. 3, p. 663-672 [How to Cite?]
dc.identifier.epage672
dc.identifier.isiWOS:000179420800008
dc.identifier.issn0033-8419
2011 Impact Factor: 5.726
2011 SCImago Journal Rankings: 0.475
dc.identifier.issue3
dc.identifier.pmid12461244
dc.identifier.scopuseid_2-s2.0-0036892738
dc.identifier.spage663
dc.identifier.urihttp://hdl.handle.net/10722/150875
dc.identifier.volume225
dc.languageeng
dc.publisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
dc.publisher.placeUnited States
dc.relation.ispartofRadiology
dc.relation.referencesReferences in Scopus
dc.subject.meshBronchiectasis - Radiography
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLung - Radiography
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshObserver Variation
dc.subject.meshRegression Analysis
dc.subject.meshRespiratory Function Tests
dc.subject.meshSex Factors
dc.subject.meshSmoking - Epidemiology
dc.subject.meshSputum
dc.subject.meshTomography, X-Ray Computed - Methods
dc.subjectBronchiectasis
dc.subjectLung, CT
dc.titleHigh-resolution CT quantification of bronchiectasis: Clinical and functional correlation
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong