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Article: Independent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer

TitleIndependent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer
Authors
Issue Date1996
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 1996, v. 56 n. 15, p. 3441-3445 How to Cite?
AbstractDNA amplification at 20q13.2 is common in breast cancer, correlates with poor prognosis, and may reflect location of an important oncogene. Recently, other regions along 20q were also found to undergo amplification. Here, amplification levels and patterns of co-amplification were analyzed by interphase fluorescence in situ hybridization at 14 loci along 20q in 146 uncultured breast carcinomas and 14 cell lines. Three regions were independently amplified in uncultured tumors: RMC20C001 region at 20q13.2 (highly amplified in 9.6% of the cases), PTPN1 region 3 Mb proximal (6.2%), and A1B3 region at 20q11 (6.2%). Co-amplifications involving two or three of these regions were seen in 11 of the 19 highly amplified tumors. The results suggest that three distinct nonsyntenic regions along 20q may be important and that complex chromosomal rearrangements underlie their frequent co- amplification in breast cancer.
Persistent Identifierhttp://hdl.handle.net/10722/150860
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTanner, MMen_US
dc.contributor.authorTirkkonen, Men_US
dc.contributor.authorKallioniemi, Aen_US
dc.contributor.authorIsola, Jen_US
dc.contributor.authorKuukasjärvi, Ten_US
dc.contributor.authorCollins, Cen_US
dc.contributor.authorKowbel, Den_US
dc.contributor.authorGuan, XYen_US
dc.contributor.authorTrent, Jen_US
dc.contributor.authorGray, JWen_US
dc.contributor.authorMeltzer, Pen_US
dc.contributor.authorKallioniemi, OPen_US
dc.date.accessioned2012-06-26T06:12:48Z-
dc.date.available2012-06-26T06:12:48Z-
dc.date.issued1996en_US
dc.identifier.citationCancer Research, 1996, v. 56 n. 15, p. 3441-3445en_US
dc.identifier.issn0008-5472en_US
dc.identifier.urihttp://hdl.handle.net/10722/150860-
dc.description.abstractDNA amplification at 20q13.2 is common in breast cancer, correlates with poor prognosis, and may reflect location of an important oncogene. Recently, other regions along 20q were also found to undergo amplification. Here, amplification levels and patterns of co-amplification were analyzed by interphase fluorescence in situ hybridization at 14 loci along 20q in 146 uncultured breast carcinomas and 14 cell lines. Three regions were independently amplified in uncultured tumors: RMC20C001 region at 20q13.2 (highly amplified in 9.6% of the cases), PTPN1 region 3 Mb proximal (6.2%), and A1B3 region at 20q11 (6.2%). Co-amplifications involving two or three of these regions were seen in 11 of the 19 highly amplified tumors. The results suggest that three distinct nonsyntenic regions along 20q may be important and that complex chromosomal rearrangements underlie their frequent co- amplification in breast cancer.en_US
dc.languageengen_US
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_US
dc.relation.ispartofCancer Researchen_US
dc.subject.meshBreast Neoplasms - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 20en_US
dc.subject.meshDna, Neoplasm - Geneticsen_US
dc.subject.meshGene Amplificationen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshInterphase - Physiologyen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleIndependent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast canceren_US
dc.typeArticleen_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8758909-
dc.identifier.scopuseid_2-s2.0-8944227502en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-8944227502&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume56en_US
dc.identifier.issue15en_US
dc.identifier.spage3441en_US
dc.identifier.epage3445en_US
dc.identifier.isiWOS:A1996UZ28800012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTanner, MM=7202127762en_US
dc.identifier.scopusauthoridTirkkonen, M=6602417426en_US
dc.identifier.scopusauthoridKallioniemi, A=7004959670en_US
dc.identifier.scopusauthoridIsola, J=7006138553en_US
dc.identifier.scopusauthoridKuukasjärvi, T=6602137418en_US
dc.identifier.scopusauthoridCollins, C=35396364600en_US
dc.identifier.scopusauthoridKowbel, D=7004013795en_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US
dc.identifier.scopusauthoridTrent, J=7201692482en_US
dc.identifier.scopusauthoridGray, JW=7404300313en_US
dc.identifier.scopusauthoridMeltzer, P=7102464641en_US
dc.identifier.scopusauthoridKallioniemi, OP=7005031465en_US

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